JP2016540017A5 - - Google Patents
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- JP2016540017A5 JP2016540017A5 JP2016539132A JP2016539132A JP2016540017A5 JP 2016540017 A5 JP2016540017 A5 JP 2016540017A5 JP 2016539132 A JP2016539132 A JP 2016539132A JP 2016539132 A JP2016539132 A JP 2016539132A JP 2016540017 A5 JP2016540017 A5 JP 2016540017A5
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- alkyl
- ring
- membered heterocyclic
- membered heteroaryl
- independently selected
- Prior art date
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| EP2588465B1 (en) | 2010-06-30 | 2017-01-25 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP2897953B8 (en) | 2012-09-19 | 2019-06-26 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
| EA033168B1 (ru) | 2013-03-15 | 2019-09-30 | Сайклерион Терапьютикс, Инк. | СТИМУЛЯТОРЫ sGC |
| US20170298055A1 (en) * | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| EP3194382B1 (en) * | 2014-09-17 | 2021-09-08 | Cyclerion Therapeutics, Inc. | Pyrazole derivatives as sgc stimulators |
| EP3194386A2 (en) * | 2014-09-17 | 2017-07-26 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| US20180344735A1 (en) | 2015-12-14 | 2018-12-06 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION |
| CN109563077B (zh) | 2016-07-07 | 2026-03-10 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 |
| SI3507291T1 (sl) | 2016-09-02 | 2021-11-30 | Cyclerion Therapeutics, Inc. | Kondenzirani biciklični SGS stimulatorji |
| CN109890379A (zh) | 2016-10-11 | 2019-06-14 | 拜耳制药股份公司 | 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品 |
| EP3525779B1 (de) | 2016-10-11 | 2024-06-05 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend den sgc stimulator vericuguat und den mineralcorticoid-rezeptor-antagonist finerenone |
| EP3554488A2 (en) | 2016-12-13 | 2019-10-23 | Cyclerion Therapeutics, Inc. | Use of sgc stimulators for the treatment of esophageal motility disorders |
| CN108203396B (zh) * | 2016-12-19 | 2020-12-08 | 江西东邦药业有限公司 | 一种脑啡肽酶抑制剂的合成 |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| MX2020006433A (es) * | 2017-12-19 | 2020-09-17 | Cyclerion Therapeutics Inc | Estimuladores de guanilato ciclasa soluble (sgc). |
| EP3787610A1 (en) | 2018-04-30 | 2021-03-10 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
| EP3793553A1 (en) | 2018-05-15 | 2021-03-24 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| EP3574905A1 (en) | 2018-05-30 | 2019-12-04 | Adverio Pharma GmbH | Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group |
| KR20250141845A (ko) | 2018-07-11 | 2025-09-29 | 티센토 쎄라퓨틱스 인크. | 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도 |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| JP7411875B2 (ja) * | 2020-10-08 | 2024-01-12 | 株式会社 キュロム・バイオサイエンス | ベータ－ラパコンを有効成分として含む胆汁うっ滞性肝疾患予防又は治療用薬学組成物 |
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-
2014
- 2014-12-10 CA CA2933250A patent/CA2933250A1/en not_active Abandoned
- 2014-12-10 WO PCT/US2014/069537 patent/WO2015089182A1/en not_active Ceased
- 2014-12-10 CN CN201480074810.XA patent/CN106304835A/zh active Pending
- 2014-12-10 EP EP14824644.0A patent/EP3092231B1/en active Active
- 2014-12-10 EA EA201691194A patent/EA032028B1/ru not_active IP Right Cessation
- 2014-12-10 JP JP2016539132A patent/JP2016540017A/ja active Pending
- 2014-12-10 US US15/103,178 patent/US20160311826A1/en not_active Abandoned
- 2014-12-10 MX MX2016007522A patent/MX2016007522A/es unknown
-
2020
- 2020-12-15 US US17/122,542 patent/US20210214364A1/en not_active Abandoned
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