JP7411875B2 - ベータ-ラパコンを有効成分として含む胆汁うっ滞性肝疾患予防又は治療用薬学組成物 - Google Patents
ベータ-ラパコンを有効成分として含む胆汁うっ滞性肝疾患予防又は治療用薬学組成物 Download PDFInfo
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Claims (11)
- ベータ-ラパコン(β-lapachone)又はその薬学的に許容可能な塩を有効成分として含む胆汁うっ滞性肝疾患の予防又は治療用薬学組成物であって、
前記胆汁うっ滞性肝疾患は、 原発性胆汁性肝硬変症(Primary Biliary Cirrhosis,PBC)、原発性硬化性胆管炎(Primary Sclerosing Cholangitis,PSC)及び進行性家族性肝内胆汁うっ滞症(Progressive Familial Intrahepatic Cholestasis,PFIC)からなる群から選ばれる1以上である
ことを特徴とする胆汁うっ滞性肝疾患予防又は治療用薬学組成物。 - 前記組成物は、胆管細胞の線維化抑制及び炎症抑制をする
請求項1に記載の胆汁うっ滞性肝疾患予防又は治療用薬学組成物。 - 前記組成物は、血中のAST、ALT、ALP及びビリルビンからなる群から選ばれる1つ以上の血液指標の数値を改善する
請求項1に記載の胆汁うっ滞性肝疾患予防又は治療用薬学組成物。 - 前記線維化抑制は、Col1α1(Collagen Type I Alpha 1)、Col4α1(Collagen Type IV Alpha 1)、α-SMA(Alpha-Smooth Muscle Actin)、フィブロネクチン、TGF-β1(Transforming growth factor beta 1)、Col1α2(Collagen Type I Alpha 2)及びTGF-β2(Transforming growth factor beta 2)から選ばれる少なくとも1つの線維化因子を抑制する
請求項2に記載の胆汁うっ滞性肝疾患予防又は治療用薬学組成物。 - 前記炎症抑制は、IL-1β(Interleukin-1beta)、IL-6(Interleukin-6)、IL-18(Interleukin-18)、INF-γ((Interferon-γ)、TNF-α(Tumor necrosis factor-α)、TNF-β(Tumor necrosis factor-β)、MCP-1(Monocyte Chemoattractant Protein-1)から選ばれる少なくとも1つの炎症性サイトカイン因子を抑制する
請求項2に記載の胆汁うっ滞性肝疾患予防又は治療用薬学組成物。 - 前記胆汁うっ滞性肝疾患は、炎症性腸疾患を伴う
請求項1に記載の胆汁うっ滞性肝疾患予防又は治療用薬学組成物。 - 前記炎症性腸疾患は、クローン病又は潰瘍性大腸炎である
請求項6に記載の胆汁うっ滞性肝疾患予防又は治療用薬学組成物。 - 前記組成物は、腸組織の線維化抑制及び炎症性サイトカイン抑制をする
請求項6に記載の胆汁うっ滞性肝疾患予防又は治療用薬学組成物。 - ベータ-ラパコン(β-lapachone)又はその薬学的に許容可能な塩を有効成分として含む胆汁うっ滞性肝疾患の予防又は改善用健康機能食品であって、
前記胆汁うっ滞性肝疾患は、 原発性胆汁性肝硬変症(Primary Biliary Cirrhosis,PBC)、原発性硬化性胆管炎(Primary Sclerosing Cholangitis,PSC)及び進行性家族性肝内胆汁うっ滞症(Progressive Familial Intrahepatic Cholestasis,PFIC)からなる群から選ばれる1以上である
ことを特徴とする胆汁うっ滞性肝疾患予防又は改善用健康機能食品。 - 前記胆汁うっ滞性肝疾患は、炎症性腸疾患を伴う
請求項9に記載の胆汁うっ滞性肝疾患予防又は改善用健康機能食品。 - 前記炎症性腸疾患は、クローン病又は潰瘍性大腸炎である
請求項10に記載の胆汁うっ滞性肝疾患予防又は改善用健康機能食品。
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