JP2016539994A - α，ω‐二置換ジヒドロキシシクロペンチル化合物の固体形態、並びにその製造及び使用方法 - Google Patents

α，ω‐二置換ジヒドロキシシクロペンチル化合物の固体形態、並びにその製造及び使用方法 Download PDF

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Publication number
JP2016539994A
JP2016539994A JP2016538513A JP2016538513A JP2016539994A JP 2016539994 A JP2016539994 A JP 2016539994A JP 2016538513 A JP2016538513 A JP 2016538513A JP 2016538513 A JP2016538513 A JP 2016538513A JP 2016539994 A JP2016539994 A JP 2016539994A
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JP
Japan
Prior art keywords
compound
crystal
crystalline form
cyclopentyl
pentenyl
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JP2016538513A
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English (en)
Japanese (ja)
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JP2016539994A5 (enExample
Inventor
ケ ウ
ケ ウ
ジョルジュ アンブラス
ジョルジュ アンブラス
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Allergan Inc
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Allergan Inc
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Publication of JP2016539994A5 publication Critical patent/JP2016539994A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2016538513A 2013-12-13 2014-12-12 α，ω‐二置換ジヒドロキシシクロペンチル化合物の固体形態、並びにその製造及び使用方法 Pending JP2016539994A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361915575P 2013-12-13 2013-12-13
US61/915,575 2013-12-13
PCT/US2014/070156 WO2015089475A1 (en) 2013-12-13 2014-12-12 Solid forms of an alpha, omega di-substituted dihydroxy cyclopentyl compound and methods for the preparation and use thereof

Related Child Applications (1)

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JP2019231685A Division JP2020073513A (ja) 2013-12-13 2019-12-23 α，ω‐二置換ジヒドロキシシクロペンチル化合物の固体形態、並びにその製造及び使用方法

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JP2016539994A true JP2016539994A (ja) 2016-12-22
JP2016539994A5 JP2016539994A5 (enExample) 2019-05-09

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JP2016538513A Pending JP2016539994A (ja) 2013-12-13 2014-12-12 α，ω‐二置換ジヒドロキシシクロペンチル化合物の固体形態、並びにその製造及び使用方法
JP2019231685A Pending JP2020073513A (ja) 2013-12-13 2019-12-23 α，ω‐二置換ジヒドロキシシクロペンチル化合物の固体形態、並びにその製造及び使用方法

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US (2) US9353079B2 (enExample)
EP (1) EP3080096A1 (enExample)
JP (2) JP2016539994A (enExample)
KR (1) KR20160097310A (enExample)
CN (1) CN105814033B (enExample)
AU (1) AU2014361794B2 (enExample)
BR (1) BR112016013594A8 (enExample)
CA (1) CA2933556A1 (enExample)
CL (2) CL2016001448A1 (enExample)
IL (2) IL245917B (enExample)
MX (1) MX2016007717A (enExample)
RU (1) RU2730520C2 (enExample)
SA (1) SA516371307B1 (enExample)
SG (2) SG11201604787SA (enExample)
UA (1) UA121108C2 (enExample)
WO (1) WO2015089475A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP3658149B1 (en) 2017-07-25 2021-11-10 Allergan, Inc. Solid complex comprising (z)-7-((1r,2r,3r,5s)-2-((s,e)-5-(2,5-dichlorothiophen-3-yl)-3-hydroxypent-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enamide, preparation and uses thereof
WO2021152473A1 (en) * 2020-01-29 2021-08-05 Kci Licensing, Inc. Multiple fluid pathway connector with foam supports

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11505802A (ja) * 1995-05-18 1999-05-25 アラーガン 高眼圧処置剤としてのシクロペンタンヘプタン（エン）酸，２−ヘテロアリールアルケニル誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES416865A1 (es) * 1972-07-13 1976-03-01 Pfizer Procedimiento para preparar w-pentanorprostaglandinas sus- tituidas en la posicion 15.
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US6602900B2 (en) * 1992-09-21 2003-08-05 Allergan, Inc. Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5834498A (en) * 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US6124344A (en) * 1993-12-28 2000-09-26 Allergan Sales, Inc. Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11505802A (ja) * 1995-05-18 1999-05-25 アラーガン 高眼圧処置剤としてのシクロペンタンヘプタン（エン）酸，２−ヘテロアリールアルケニル誘導体

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
仲井由宣 花野学編, 新製剤学, vol. 第１版第２刷, JPN6016032041, 25 April 1984 (1984-04-25), pages 102 - 104, ISSN: 0004100441 *
塩路雄作, 固形製剤の製造技術, vol. 普及版第１刷, JPN6016031894, 27 January 2003 (2003-01-27), pages 9 - 14, ISSN: 0004100442 *
平山令明編著, 有機化合物結晶作製ハンドブック−原理とノウハウ−, JPN6016031902, 25 July 2008 (2008-07-25), pages 37 - 84, ISSN: 0004100443 *
社団法人日本化学会編, 第４版 実験化学講座１ 基本操作Ｉ, vol. 第２刷, JPN6016031896, 5 April 1996 (1996-04-05), pages 184 - 186, ISSN: 0004100444 *

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SA516371307B1 (ar) 2018-10-04
SG11201604787SA (en) 2016-07-28
RU2730520C2 (ru) 2020-08-24
UA121108C2 (uk) 2020-04-10
AU2014361794B2 (en) 2019-04-04
CN105814033B (zh) 2019-10-25
US20150166504A1 (en) 2015-06-18
US9353079B2 (en) 2016-05-31
KR20160097310A (ko) 2016-08-17
CL2016001448A1 (es) 2017-03-03
IL245917B (en) 2021-06-30
MX2016007717A (es) 2016-09-09
BR112016013594A8 (pt) 2020-05-19
BR112016013594A2 (enExample) 2017-08-08
US20170087163A1 (en) 2017-03-30
JP2020073513A (ja) 2020-05-14
EP3080096A1 (en) 2016-10-19
IL283810A (en) 2021-07-29
IL245917A0 (en) 2016-08-02
CA2933556A1 (en) 2015-06-18
SG10201709702UA (en) 2018-01-30
WO2015089475A1 (en) 2015-06-18
CN105814033A (zh) 2016-07-27
AU2014361794A1 (en) 2016-06-16
CL2019000471A1 (es) 2019-07-12

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