JP2016538574A - ジアンヒドロガラクチトール中の不純物のｈｐｌｃ分析 - Google Patents

ジアンヒドロガラクチトール中の不純物のｈｐｌｃ分析 Download PDF

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JP2016538574A
JP2016538574A JP2016554543A JP2016554543A JP2016538574A JP 2016538574 A JP2016538574 A JP 2016538574A JP 2016554543 A JP2016554543 A JP 2016554543A JP 2016554543 A JP2016554543 A JP 2016554543A JP 2016538574 A JP2016538574 A JP 2016538574A
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Prior art keywords
dianhydrogalactitol
dulcitol
water
minutes
hplc
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JP2016554543A
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English (en)
Japanese (ja)
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JP2016538574A5 (zh
Inventor
ルー、シャオユン
− ピン リー、マイク、ツォー
− ピン リー、マイク、ツォー
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デル マー ファーマシューティカルズ
デル マー ファーマシューティカルズ
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Priority claimed from US14/083,135 external-priority patent/US9029164B2/en
Application filed by デル マー ファーマシューティカルズ, デル マー ファーマシューティカルズ filed Critical デル マー ファーマシューティカルズ
Publication of JP2016538574A publication Critical patent/JP2016538574A/ja
Publication of JP2016538574A5 publication Critical patent/JP2016538574A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8447—Nebulising, aerosol formation or ionisation
    • G01N2030/8494—Desolvation chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2016554543A 2013-11-18 2014-11-18 ジアンヒドロガラクチトール中の不純物のｈｐｌｃ分析 Pending JP2016538574A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/083,135 US9029164B2 (en) 2012-02-27 2013-11-18 Analytical methods for analyzing and determining impurities in dianhydrogalactitol
US14/083,135 2013-11-18
PCT/US2014/066087 WO2015074025A1 (en) 2013-11-18 2014-11-18 Hplc analysis of impurities in dianhydrogalactitol

Publications (2)

Publication Number Publication Date
JP2016538574A true JP2016538574A (ja) 2016-12-08
JP2016538574A5 JP2016538574A5 (zh) 2017-12-28

Family

ID=53058168

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016554543A Pending JP2016538574A (ja) 2013-11-18 2014-11-18 ジアンヒドロガラクチトール中の不純物のｈｐｌｃ分析

Country Status (10)

Country Link
EP (1) EP3071555A4 (zh)
JP (1) JP2016538574A (zh)
KR (1) KR20160108315A (zh)
CN (1) CN107529337B (zh)
AU (1) AU2014348232A1 (zh)
CA (1) CA2931088A1 (zh)
CL (1) CL2016001197A1 (zh)
IL (1) IL245713A0 (zh)
MX (1) MX2016006457A (zh)
WO (1) WO2015074025A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106397360A (zh) * 2015-07-29 2017-02-15 广西梧州制药（集团）股份有限公司 叔丁醇在去水卫矛醇或其组合物冷冻干燥过程中的应用
MX2018006425A (es) 2015-11-25 2018-11-09 Del Mar Pharmaceuticals Bc Ltd Metodos para analisis y resolucion de preparaciones de dianhidrogalactitol y derivados o analogos del mismo.
CN105445407B (zh) * 2015-12-29 2017-04-19 成都普思生物科技股份有限公司 一种山桐子中脂肪酸和维生素e的检测方法
JP6954644B2 (ja) 2016-04-04 2021-10-27 国立大学法人三重大学 アルギン酸リアーゼ及び当該酵素を用いる不飽和ウロン酸単糖の製造方法
KR102270026B1 (ko) * 2020-01-31 2021-06-28 현대약품 주식회사 (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법
CN114113352A (zh) * 2020-08-28 2022-03-01 深圳波顿香料有限公司 发酵液中内酯型槐糖酯含量的测定方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04297868A (ja) * 1991-03-27 1992-10-21 Tonen Corp オリゴ糖の分析方法
JPH09229920A (ja) * 1996-02-26 1997-09-05 Kao Corp グラジェント液体クロマトグラフィー溶離液の処理方法
JP2000506969A (ja) * 1996-03-01 2000-06-06 ダイオネックス コーポレイション クロマトグラフィーでのボレートの除去
WO2000042225A1 (en) * 1999-01-14 2000-07-20 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Process for the separation of sugars
JP2004517131A (ja) * 2000-11-17 2004-06-10 リサーチ　ディベロップメント　ファンデーション トリテルペン組成物によるＮＦ−κＢの抑制
JP2004294384A (ja) * 2003-03-28 2004-10-21 National Agriculture & Bio-Oriented Research Organization １−デオキシノジリマイシンの測定方法
JP2007538251A (ja) * 2004-05-20 2007-12-27 カイロン ソチエタ ア レスポンサビリタ リミタータ 液体クロマトグラフィー溶出液の分析
JP2008076340A (ja) * 2006-09-25 2008-04-03 Toppan Printing Co Ltd 高感度検出方法およびその検出装置
JP2008518881A (ja) * 2003-07-18 2008-06-05 オークウッド ラボラトリーズ，エル．エル．シー． 高分子組成物中の高分子の分子量低下、不純物形成およびゲル化の防止
WO2011092120A1 (en) * 2010-01-29 2011-08-04 Nerviano Medical Sciences S.R.L. 6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators
WO2012024368A2 (en) * 2010-08-18 2012-02-23 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0818893B8 (pt) * 2007-10-25 2021-05-25 Exelixis Inc compostos de tropano, suas composições farmacêuticas, seus usos e método in vitro de inibição de hsp90 em uma célula
CN102008541B (zh) * 2010-10-08 2012-07-04 广西中医学院 无糖型复方扶芳藤制剂中3种主要活性成分的同时检测方法
MX2014010312A (es) * 2012-02-27 2015-04-14 Del Mar Pharmaceuticals Metodos analiticos mejorados para analizar y determinar impurezas en dianhidrogalactitol.
BE1020835A5 (nl) * 2012-03-20 2014-06-03 Maes Francis N V Werkwijze voor het vervaardigen van een plantenextract, i.h.b. uit desmodium.

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04297868A (ja) * 1991-03-27 1992-10-21 Tonen Corp オリゴ糖の分析方法
JPH09229920A (ja) * 1996-02-26 1997-09-05 Kao Corp グラジェント液体クロマトグラフィー溶離液の処理方法
JP2000506969A (ja) * 1996-03-01 2000-06-06 ダイオネックス コーポレイション クロマトグラフィーでのボレートの除去
WO2000042225A1 (en) * 1999-01-14 2000-07-20 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Process for the separation of sugars
JP2004517131A (ja) * 2000-11-17 2004-06-10 リサーチ　ディベロップメント　ファンデーション トリテルペン組成物によるＮＦ−κＢの抑制
JP2004294384A (ja) * 2003-03-28 2004-10-21 National Agriculture & Bio-Oriented Research Organization １−デオキシノジリマイシンの測定方法
JP2008518881A (ja) * 2003-07-18 2008-06-05 オークウッド ラボラトリーズ，エル．エル．シー． 高分子組成物中の高分子の分子量低下、不純物形成およびゲル化の防止
JP2007538251A (ja) * 2004-05-20 2007-12-27 カイロン ソチエタ ア レスポンサビリタ リミタータ 液体クロマトグラフィー溶出液の分析
JP2008076340A (ja) * 2006-09-25 2008-04-03 Toppan Printing Co Ltd 高感度検出方法およびその検出装置
WO2011092120A1 (en) * 2010-01-29 2011-08-04 Nerviano Medical Sciences S.R.L. 6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators
JP2013518072A (ja) * 2010-01-29 2013-05-20 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ タンパク質キナーゼモジュレーターとしての６，７−ジヒドロイミダゾ［１，５−ａ］ピラジン−８（５ｈ）−オン誘導体
WO2012024368A2 (en) * 2010-08-18 2012-02-23 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
JP2013534250A (ja) * 2010-08-18 2013-09-02 デル マー ファーマスーティカルズ ジアンヒドロガラクチトール等の置換ヘキシトールの合成方法

Also Published As

Publication number Publication date
KR20160108315A (ko) 2016-09-19
AU2014348232A1 (en) 2016-06-30
WO2015074025A9 (en) 2015-12-17
IL245713A0 (en) 2016-08-02
CL2016001197A1 (es) 2017-06-30
MX2016006457A (es) 2017-01-06
EP3071555A1 (en) 2016-09-28
CA2931088A1 (en) 2015-05-21
CN107529337A (zh) 2017-12-29
EP3071555A4 (en) 2017-05-31
WO2015074025A1 (en) 2015-05-21
CN107529337B (zh) 2021-11-16

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