EP3071555A4 - Hplc analysis of impurities in dianhydrogalactitol - Google Patents

Hplc analysis of impurities in dianhydrogalactitol Download PDF

Info

Publication number
EP3071555A4
EP3071555A4 EP14862051.1A EP14862051A EP3071555A4 EP 3071555 A4 EP3071555 A4 EP 3071555A4 EP 14862051 A EP14862051 A EP 14862051A EP 3071555 A4 EP3071555 A4 EP 3071555A4
Authority
EP
European Patent Office
Prior art keywords
dianhydrogalactitol
impurities
hplc analysis
hplc
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14862051.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3071555A1 (en
Inventor
Xiaoyun LU
Mike Tso-Ping Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Del Mar Pharmaceuticals
Original Assignee
Del Mar Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/083,135 external-priority patent/US9029164B2/en
Application filed by Del Mar Pharmaceuticals filed Critical Del Mar Pharmaceuticals
Publication of EP3071555A1 publication Critical patent/EP3071555A1/en
Publication of EP3071555A4 publication Critical patent/EP3071555A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8447—Nebulising, aerosol formation or ionisation
    • G01N2030/8494—Desolvation chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
EP14862051.1A 2013-11-18 2014-11-18 Hplc analysis of impurities in dianhydrogalactitol Withdrawn EP3071555A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/083,135 US9029164B2 (en) 2012-02-27 2013-11-18 Analytical methods for analyzing and determining impurities in dianhydrogalactitol
PCT/US2014/066087 WO2015074025A1 (en) 2013-11-18 2014-11-18 Hplc analysis of impurities in dianhydrogalactitol

Publications (2)

Publication Number Publication Date
EP3071555A1 EP3071555A1 (en) 2016-09-28
EP3071555A4 true EP3071555A4 (en) 2017-05-31

Family

ID=53058168

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14862051.1A Withdrawn EP3071555A4 (en) 2013-11-18 2014-11-18 Hplc analysis of impurities in dianhydrogalactitol

Country Status (10)

Country Link
EP (1) EP3071555A4 (zh)
JP (1) JP2016538574A (zh)
KR (1) KR20160108315A (zh)
CN (1) CN107529337B (zh)
AU (1) AU2014348232A1 (zh)
CA (1) CA2931088A1 (zh)
CL (1) CL2016001197A1 (zh)
IL (1) IL245713A0 (zh)
MX (1) MX2016006457A (zh)
WO (1) WO2015074025A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106397360A (zh) * 2015-07-29 2017-02-15 广西梧州制药（集团）股份有限公司 叔丁醇在去水卫矛醇或其组合物冷冻干燥过程中的应用
EP3380462B1 (en) 2015-11-25 2021-02-17 Del Mar Pharmaceuticals (BC) Ltd. Methods for analysis and resolution of preparations of dianhydrogalactitol and derivatives or analogs thereof
CN105445407B (zh) * 2015-12-29 2017-04-19 成都普思生物科技股份有限公司 一种山桐子中脂肪酸和维生素e的检测方法
WO2017175694A1 (ja) * 2016-04-04 2017-10-12 国立大学法人三重大学 アルギン酸リアーゼ及び当該酵素を用いる不飽和ウロン酸単糖の製造方法
KR102270026B1 (ko) * 2020-01-31 2021-06-28 현대약품 주식회사 (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법
CN114113352A (zh) * 2020-08-28 2022-03-01 深圳波顿香料有限公司 发酵液中内酯型槐糖酯含量的测定方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140017798A1 (en) * 2012-02-27 2014-01-16 Del Mar Pharmaceuticals Analytical methods for analyzing and determining impurities in dianhydrogalactitol

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04297868A (ja) * 1991-03-27 1992-10-21 Tonen Corp オリゴ糖の分析方法
JPH09229920A (ja) * 1996-02-26 1997-09-05 Kao Corp グラジェント液体クロマトグラフィー溶離液の処理方法
US6060525A (en) * 1996-03-01 2000-05-09 Dionix Corporation Removal of borate in chromatography
CA2359337C (en) * 1999-01-14 2005-09-13 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Process for the separation of sugars
US20060148732A1 (en) * 2000-11-17 2006-07-06 Gutterman Jordan U Inhibition of NF-kappaB by triterpene compositions
JP2004294384A (ja) * 2003-03-28 2004-10-21 National Agriculture & Bio-Oriented Research Organization １−デオキシノジリマイシンの測定方法
CA2819769C (en) * 2003-07-18 2016-06-28 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
BRPI0511442A (pt) * 2004-05-20 2007-12-26 Chiron Srl análise de eluatos por cromatografia lìquida
JP2008076340A (ja) * 2006-09-25 2008-04-03 Toppan Printing Co Ltd 高感度検出方法およびその検出装置
MX2010004493A (es) * 2007-10-25 2010-06-11 Exelixis Inc Compuestos de tropano.
WO2011092120A1 (en) * 2010-01-29 2011-08-04 Nerviano Medical Sciences S.R.L. 6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators
KR20140037005A (ko) * 2010-08-18 2014-03-26 델 마 파마슈티컬스 인코포레이티드 디안하이드로갈락티톨과 같은 치환된 헥시톨을 제조하는 방법
CN102008541B (zh) * 2010-10-08 2012-07-04 广西中医学院 无糖型复方扶芳藤制剂中3种主要活性成分的同时检测方法
BE1020835A5 (nl) * 2012-03-20 2014-06-03 Maes Francis N V Werkwijze voor het vervaardigen van een plantenextract, i.h.b. uit desmodium.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140017798A1 (en) * 2012-02-27 2014-01-16 Del Mar Pharmaceuticals Analytical methods for analyzing and determining impurities in dianhydrogalactitol

Also Published As

Publication number Publication date
WO2015074025A9 (en) 2015-12-17
WO2015074025A1 (en) 2015-05-21
KR20160108315A (ko) 2016-09-19
EP3071555A1 (en) 2016-09-28
JP2016538574A (ja) 2016-12-08
AU2014348232A1 (en) 2016-06-30
IL245713A0 (en) 2016-08-02
CN107529337A (zh) 2017-12-29
CL2016001197A1 (es) 2017-06-30
CN107529337B (zh) 2021-11-16
MX2016006457A (es) 2017-01-06
CA2931088A1 (en) 2015-05-21

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RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 30/88 20060101ALI20170426BHEP

Ipc: C07D 301/02 20060101AFI20170426BHEP

Ipc: C07D 303/14 20060101ALI20170426BHEP

Ipc: G01N 30/84 20060101ALN20170426BHEP

Ipc: G01N 30/74 20060101ALI20170426BHEP

Ipc: G01N 30/22 20060101ALI20170426BHEP

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