JP2016527215A5 - - Google Patents

Info

Publication number

JP2016527215A5

JP2016527215A5 JP2016524705A JP2016524705A JP2016527215A5 JP 2016527215 A5 JP2016527215 A5 JP 2016527215A5 JP 2016524705 A JP2016524705 A JP 2016524705A JP 2016524705 A JP2016524705 A JP 2016524705A JP 2016527215 A5 JP2016527215 A5 JP 2016527215A5

Authority

JP

Japan

Prior art keywords

group

alkyl

formula

optionally substituted

oxygen

Prior art date

2014-07-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 38
• 229910052757 nitrogen Chemical group 0.000 claims 24
• 229910052717 sulfur Inorganic materials 0.000 claims 23
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 22
• 229910052760 oxygen Inorganic materials 0.000 claims 22
• 239000001301 oxygen Substances 0.000 claims 22
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 20
• 125000005842 heteroatom Chemical group 0.000 claims 20
• 239000011593 sulfur Chemical group 0.000 claims 20
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 18
• 125000006413 ring segment Chemical group 0.000 claims 18
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 15
• 125000000217 alkyl group Chemical group 0.000 claims 11
• 125000005549 heteroarylene group Chemical group 0.000 claims 11
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
• 125000005651 substituted 1,4-phenylene group Chemical group 0.000 claims 10
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 9
• 150000001875 compounds Chemical class 0.000 claims 8
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 7
• 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 6
• 238000009472 formulation Methods 0.000 claims 4
• 125000005843 halogen group Chemical group 0.000 claims 4
• 125000001072 heteroaryl group Chemical group 0.000 claims 4
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 150000007523 nucleic acids Chemical group 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• 125000004474 heteroalkylene group Chemical group 0.000 claims 3
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 125000004430 oxygen atom Chemical group O* 0.000 claims 3
• 125000005650 substituted phenylene group Chemical group 0.000 claims 3
• 125000004434 sulfur atom Chemical group 0.000 claims 3
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 2
• 125000000304 alkynyl group Chemical group 0.000 claims 2
• 150000001408 amides Chemical class 0.000 claims 2
• 125000003277 amino group Chemical group 0.000 claims 2
• 125000003710 aryl alkyl group Chemical group 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 230000001851 biosynthetic effect Effects 0.000 claims 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims 2
• 125000000753 cycloalkyl group Chemical group 0.000 claims 2
• 208000031513 cyst Diseases 0.000 claims 2
• 125000004404 heteroalkyl group Chemical group 0.000 claims 2
• 125000004475 heteroaralkyl group Chemical group 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 2
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
• 208000035143 Bacterial infection Diseases 0.000 claims 1
• 206010011732 Cyst Diseases 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 0 COC(C(C(Nc(cc1)ccc1C(*)=O)=O)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)C([Rn])=O Chemical compound COC(C(C(Nc(cc1)ccc1C(*)=O)=O)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)C([Rn])=O 0.000 description 2
• WMLWGVVLDSEQNF-UHFFFAOYSA-N CC(C)Oc(c(NC(c(cc1)ccc1NC(C(C(C(N)=O)OC)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)=O)=O)ccc1C(Nc(c(OC)c2)ccc2C(O)=O)=O)c1O Chemical compound CC(C)Oc(c(NC(c(cc1)ccc1NC(C(C(C(N)=O)OC)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)=O)=O)ccc1C(Nc(c(OC)c2)ccc2C(O)=O)=O)c1O WMLWGVVLDSEQNF-UHFFFAOYSA-N 0.000 description 1
• NGSYXDCEERWVTK-UHFFFAOYSA-N CC(C)Oc(c(NC(c(cc1)ccc1NC(C(C(C(N)=O)OC)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)=O)=O)ccc1C(Nc(cc2)ccc2C(O)=O)=O)c1O Chemical compound CC(C)Oc(c(NC(c(cc1)ccc1NC(C(C(C(N)=O)OC)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)=O)=O)ccc1C(Nc(cc2)ccc2C(O)=O)=O)c1O NGSYXDCEERWVTK-UHFFFAOYSA-N 0.000 description 1