JP6730183B2 - シストバクトアミド(Cystobactamides) - Google Patents
シストバクトアミド(Cystobactamides) Download PDFInfo
- Publication number
- JP6730183B2 JP6730183B2 JP2016524705A JP2016524705A JP6730183B2 JP 6730183 B2 JP6730183 B2 JP 6730183B2 JP 2016524705 A JP2016524705 A JP 2016524705A JP 2016524705 A JP2016524705 A JP 2016524705A JP 6730183 B2 JP6730183 B2 JP 6730183B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- alkyl
- cystobactamide
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(C(Nc1ccc(C(Nc(c(OC)c2)ccc2C(O)=O)=O)c(O)c1OC)=O)=CC=C(C)NC(C(C(C(N)=O)OC)NC(c1ccc(*C(c(cc2)ccc2[N+]([O-])=O)=O)cc1)=O)=O Chemical compound CC(C(Nc1ccc(C(Nc(c(OC)c2)ccc2C(O)=O)=O)c(O)c1OC)=O)=CC=C(C)NC(C(C(C(N)=O)OC)NC(c1ccc(*C(c(cc2)ccc2[N+]([O-])=O)=O)cc1)=O)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003539 | 2013-07-12 | ||
| EP13003539.7 | 2013-07-12 | ||
| PCT/EP2014/001925 WO2015003816A2 (en) | 2013-07-12 | 2014-07-14 | Cystobactamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016527215A JP2016527215A (ja) | 2016-09-08 |
| JP2016527215A5 JP2016527215A5 (enExample) | 2017-08-03 |
| JP6730183B2 true JP6730183B2 (ja) | 2020-07-29 |
Family
ID=48792948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524705A Active JP6730183B2 (ja) | 2013-07-12 | 2014-07-14 | シストバクトアミド(Cystobactamides) |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20160145304A1 (enExample) |
| EP (1) | EP3019615B1 (enExample) |
| JP (1) | JP6730183B2 (enExample) |
| CN (1) | CN105793424B (enExample) |
| AU (1) | AU2014289663B2 (enExample) |
| CA (1) | CA2917767C (enExample) |
| WO (1) | WO2015003816A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3019615B1 (en) | 2013-07-12 | 2021-04-07 | Helmholtz-Zentrum für Infektionsforschung GmbH | Cystobactamides |
| GB201402277D0 (en) | 2014-02-10 | 2014-03-26 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| KR101747702B1 (ko) | 2014-05-15 | 2017-06-19 | 한국생명공학연구원 | 신규한 항균성 화합물 및 이의 용도 |
| WO2016082934A1 (en) * | 2014-11-26 | 2016-06-02 | Helmholtz-Zentrum für Infektionsforschung GmbH | Novel cystobactamides |
| CN105712894A (zh) * | 2016-03-23 | 2016-06-29 | 叶芳 | 一种3-甲氧基-4-氨基苯甲酸及其制备方法 |
| TWI725236B (zh) * | 2016-09-28 | 2021-04-21 | 日產化學工業股份有限公司 | 二胺及其之利用 |
| CN111065383A (zh) | 2017-07-11 | 2020-04-24 | 沃泰克斯药物股份有限公司 | 用作钠通道调节剂的羧酰胺 |
| CA3070240A1 (en) * | 2017-07-18 | 2019-01-24 | Technische Universitat Berlin | Novel albicidin derivatives, their use and synthesis |
| AU2018321152B2 (en) * | 2017-08-23 | 2023-07-06 | Helmholtz-Zentrum für Infektionsforschung GmbH | Novel cystobactamide derivatives |
| KR102717600B1 (ko) | 2017-10-06 | 2024-10-15 | 포르마 세라퓨틱스 인크. | 유비퀴틴 특이적 펩티다제 30의 억제 |
| WO2019139902A1 (en) | 2018-01-10 | 2019-07-18 | Zeno Royalties & Milestones, LLC | Benzamide compounds |
| MY196582A (en) | 2018-02-13 | 2023-04-19 | Gilead Sciences Inc | PD-1/PD-L1 Inhibitors |
| WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| CN112513036B (zh) | 2018-05-17 | 2024-05-24 | 福马治疗有限公司 | 用作泛素特异性肽酶30抑制剂的稠合双环化合物 |
| PT3820572T (pt) | 2018-07-13 | 2023-11-10 | Gilead Sciences Inc | Inibidores pd-1/pd-l1 |
| ES2945834T3 (es) | 2018-10-05 | 2023-07-07 | Forma Therapeutics Inc | Pirrolinas fusionadas que actúan como inhibidores de la proteasa 30 específica de ubiquitina (USP30) |
| EP3870566A1 (en) | 2018-10-24 | 2021-09-01 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US12440481B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| EP3994132A1 (en) | 2019-07-03 | 2022-05-11 | Sumitomo Dainippon Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof |
| LT4069691T (lt) | 2019-12-06 | 2024-12-10 | Vertex Pharmaceuticals Incorporated | Pakeistieji tetrahidrofuranai kaip natrio kanalų moduliatoriai |
| CN117222438A (zh) * | 2021-03-31 | 2023-12-12 | 麦迪贝肯有限公司 | 取代的二氨基吡嗪二甲酸的纯化 |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| CN113563220B (zh) * | 2021-06-25 | 2023-08-29 | 华中农业大学 | 一种抗菌化合物及其应用 |
| WO2025003147A1 (en) | 2023-06-26 | 2025-01-02 | Helmholtz-Zentrum für Infektionsforschung GmbH | Cystobactamid derivatives |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4525354A (en) * | 1983-09-14 | 1985-06-25 | University Of Hawaii | Antibiotic and process for the production thereof |
| US7020622B1 (en) * | 1997-06-10 | 2006-03-28 | Linkshare Corporation | Transaction tracking, managing, assessment, and auditing data processing system and network |
| FR2772025B1 (fr) | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
| MXPA02010565A (es) * | 2000-04-28 | 2004-05-17 | Kosan Biosciences Inc | Produccion de policetidos. |
| KR20080015888A (ko) | 2000-06-28 | 2008-02-20 | 테바 파마슈티컬 인더스트리즈 리미티드 | 카르베딜올 |
| AU2003286498A1 (en) * | 2002-10-18 | 2004-05-04 | Centre De Cooperation Internationale En Recherche Agronomique Pour Le Developpement (Cirad) | Complete biosynthetic gene set for biosynthesis of albicidin, resistance genes, and uses thereof |
| US7803822B2 (en) | 2005-04-06 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Triazole derivative and use thereof |
| JP5379965B2 (ja) * | 2006-09-26 | 2013-12-25 | 株式会社半導体エネルギー研究所 | スチルベン誘導体、発光素子および発光装置 |
| US7758972B2 (en) * | 2006-09-26 | 2010-07-20 | Semiconductor Energy Laboratory Co., Ltd. | Stilbene derivative, light emitting element, light emitting device, and electronic appliance |
| US7816324B2 (en) * | 2007-03-13 | 2010-10-19 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by a peptide receptor |
| US8236983B2 (en) * | 2008-03-13 | 2012-08-07 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by apoptosis |
| WO2013078277A1 (en) * | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
| WO2014125075A1 (en) * | 2013-02-15 | 2014-08-21 | Technische Universität Berlin | Albicidin derivatives, their use and synthesis |
| EP3019615B1 (en) * | 2013-07-12 | 2021-04-07 | Helmholtz-Zentrum für Infektionsforschung GmbH | Cystobactamides |
| KR101747702B1 (ko) | 2014-05-15 | 2017-06-19 | 한국생명공학연구원 | 신규한 항균성 화합물 및 이의 용도 |
| WO2016082934A1 (en) | 2014-11-26 | 2016-06-02 | Helmholtz-Zentrum für Infektionsforschung GmbH | Novel cystobactamides |
-
2014
- 2014-07-14 EP EP14747296.3A patent/EP3019615B1/en active Active
- 2014-07-14 US US14/904,654 patent/US20160145304A1/en not_active Abandoned
- 2014-07-14 AU AU2014289663A patent/AU2014289663B2/en active Active
- 2014-07-14 CN CN201480050439.3A patent/CN105793424B/zh active Active
- 2014-07-14 JP JP2016524705A patent/JP6730183B2/ja active Active
- 2014-07-14 CA CA2917767A patent/CA2917767C/en active Active
- 2014-07-14 WO PCT/EP2014/001925 patent/WO2015003816A2/en not_active Ceased
-
2018
- 2018-07-23 US US16/042,753 patent/US10793600B2/en active Active
-
2020
- 2020-06-10 US US16/897,497 patent/US11225503B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2917767C (en) | 2022-05-03 |
| EP3019615A2 (en) | 2016-05-18 |
| JP2016527215A (ja) | 2016-09-08 |
| AU2014289663B2 (en) | 2019-03-07 |
| AU2014289663A1 (en) | 2016-02-04 |
| CA2917767A1 (en) | 2015-01-15 |
| US20200331964A1 (en) | 2020-10-22 |
| US11225503B2 (en) | 2022-01-18 |
| US20160145304A1 (en) | 2016-05-26 |
| WO2015003816A3 (en) | 2015-03-12 |
| CN105793424A (zh) | 2016-07-20 |
| CN105793424B (zh) | 2021-02-19 |
| US10793600B2 (en) | 2020-10-06 |
| WO2015003816A2 (en) | 2015-01-15 |
| EP3019615B1 (en) | 2021-04-07 |
| US20190185514A1 (en) | 2019-06-20 |
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