JP2018507204A5 - - Google Patents
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- Publication number
- JP2018507204A5 JP2018507204A5 JP2017543381A JP2017543381A JP2018507204A5 JP 2018507204 A5 JP2018507204 A5 JP 2018507204A5 JP 2017543381 A JP2017543381 A JP 2017543381A JP 2017543381 A JP2017543381 A JP 2017543381A JP 2018507204 A5 JP2018507204 A5 JP 2018507204A5
- Authority
- JP
- Japan
- Prior art keywords
- antibiotic
- decomposer
- zinc
- seq
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003115 biocidal effect Effects 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 241000588724 Escherichia coli Species 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 239000011701 zinc Substances 0.000 claims 5
- 229910052725 zinc Inorganic materials 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 108010068385 carbapenemase Proteins 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000000593 degrading effect Effects 0.000 claims 2
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000000805 cytoplasm Anatomy 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 210000003000 inclusion body Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000001322 periplasm Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562119602P | 2015-02-23 | 2015-02-23 | |
| US62/119,602 | 2015-02-23 | ||
| US201562155621P | 2015-05-01 | 2015-05-01 | |
| US62/155,621 | 2015-05-01 | ||
| US201562190806P | 2015-07-10 | 2015-07-10 | |
| US62/190,806 | 2015-07-10 | ||
| PCT/US2016/019129 WO2016137993A1 (en) | 2015-02-23 | 2016-02-23 | Carbapenemases for use with antibiotics for the protection of the intestinal microbiome |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018507204A JP2018507204A (ja) | 2018-03-15 |
| JP2018507204A5 true JP2018507204A5 (enExample) | 2019-03-28 |
| JP6810697B2 JP6810697B2 (ja) | 2021-01-13 |
Family
ID=56789859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017543381A Active JP6810697B2 (ja) | 2015-02-23 | 2016-02-23 | 腸内マイクロバイオームの保護のために抗生物質と共に使用するカルバペネマーゼ |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20160250304A1 (enExample) |
| EP (1) | EP3261662B1 (enExample) |
| JP (1) | JP6810697B2 (enExample) |
| CN (1) | CN107530406B (enExample) |
| AU (1) | AU2016222936B2 (enExample) |
| CA (1) | CA2977385C (enExample) |
| WO (1) | WO2016137993A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016137993A1 (en) * | 2015-02-23 | 2016-09-01 | Synthetic Biologics, Inc. | Carbapenemases for use with antibiotics for the protection of the intestinal microbiome |
| CN109562147B (zh) * | 2016-06-28 | 2023-09-01 | 特里瓦生物制剂有限公司 | 保护微生物组免受口服抗生素 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| CN109486802B (zh) * | 2018-12-26 | 2020-08-04 | 广州白云山拜迪生物医药有限公司 | 一种酶活提高的青霉素酶突变体及其构建方法 |
| CN112980803B (zh) * | 2021-05-12 | 2021-07-30 | 天津一瑞生物科技股份有限公司 | 抗vim型碳青霉烯酶杂交瘤细胞株，单克隆抗体及应用 |
| EP4148136A1 (en) * | 2021-09-08 | 2023-03-15 | Da Volterra | An engineered yeast cell for the delivery of antibiotic-inactivating enzymes |
| CN114149988B (zh) * | 2022-02-10 | 2022-05-06 | 丹娜(天津)生物科技股份有限公司 | 一种碳青霉烯酶保守抗原、抗体及其应用 |
| WO2024012487A1 (en) * | 2022-07-14 | 2024-01-18 | The Hong Kong Polytechnic University | Biosensor comprising a modified beta-lactamase and uses thereof |
| EP4553166A1 (en) * | 2023-11-07 | 2025-05-14 | MinervaX ApS | Method for preparing a sample for analysis |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL89987C (enExample) | 1954-05-29 | |||
| US2941995A (en) | 1957-08-02 | 1960-06-21 | Beecham Res Lab | Recovery of solid 6-aminopenicillanic acid |
| US2982696A (en) | 1959-05-01 | 1961-05-02 | Schenley Ind Inc | Ion-exchange procedures for the purification of penicillinase |
| US3070511A (en) | 1960-02-10 | 1962-12-25 | Lepetit Spa | Process for preparing 6-aminopenicillanic acid |
| US3150059A (en) | 1962-12-26 | 1964-09-22 | Lilly Co Eli | Penicillin deacylation via actinoplanaceae fermentation |
| US3239394A (en) | 1964-06-15 | 1966-03-08 | Merck & Co Inc | Process for producing 7-amino-cephalosporanic acid |
| US3499909A (en) | 1966-05-18 | 1970-03-10 | Koninklijke Gist Spiritus | Process for production of 6-aminopenicillanic acid |
| US3488729A (en) | 1966-08-22 | 1970-01-06 | Lilly Co Eli | Cephalothin ester |
| GB1241844A (en) | 1968-08-23 | 1971-08-04 | Beecham Group Ltd | Penicillins |
| GB1463513A (en) | 1974-08-13 | 1977-02-02 | Beecham Group Ltd | Enzymes |
| FI59265C (fi) | 1974-08-13 | 1981-07-10 | Beecham Group Ltd | Foerfarande foer framstaellning av 6-aminopenicillansyra |
| GB2199582A (en) | 1987-01-07 | 1988-07-13 | Bayer Ag | Analogues of pancreatic secretory trypsin inhibitor |
| FR2613624B1 (fr) | 1987-04-10 | 1990-11-23 | Roussy Inst Gustave | Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines |
| CA2007083A1 (en) | 1989-01-09 | 1990-07-09 | Nobuhiko Katunuma | Pharmaceutical use of trypstatin |
| CS275231B2 (en) | 1989-09-29 | 1992-02-19 | Ustav Makormolekularni Chemie | Medicine bottle |
| FI920206A0 (fi) | 1992-01-17 | 1992-01-17 | Pekka Untamo Heino | Medicinsk anvaendning, medicinskt foerfarande och preparat. |
| CN1190434A (zh) | 1995-07-07 | 1998-08-12 | 诺沃挪第克公司 | 用不能形成芽孢的芽孢杆菌生产蛋白质的方法 |
| US6630510B1 (en) * | 1999-10-28 | 2003-10-07 | Merck & Co., Inc. | Substituted succinic acid metallo-β-lactamase inhibitors and their use in treating bacterial infections |
| US7585674B2 (en) | 2001-05-29 | 2009-09-08 | Kao Corporation | Host microorganisms |
| FI112666B (fi) | 2001-11-06 | 2003-12-31 | Ipsat Therapies Oy | Itiöimätön Bacillus subtilis, sen valmistus ja käyttö |
| FR2843302B1 (fr) | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
| EP1564286A1 (en) | 2004-02-11 | 2005-08-17 | Université de Liège | Hybrid proteins of beta-lactamase class A |
| WO2006122835A1 (en) | 2005-05-18 | 2006-11-23 | Da Volterra | Colonic delivery of adsorbents |
| FI119190B (fi) * | 2006-06-21 | 2008-08-29 | Ipsat Therapies Oy | Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi |
| FI119678B (fi) | 2006-11-28 | 2009-02-13 | Ipsat Therapies Oy | Beta-laktamaasin käyttö |
| WO2011042454A1 (en) * | 2009-10-06 | 2011-04-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Carbapenemase and antibacterial treatment |
| FI20105572A0 (fi) * | 2010-05-24 | 2010-05-24 | Prevab R Lcc | Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt |
| CN102757950A (zh) * | 2011-04-25 | 2012-10-31 | 天津市国际生物医药联合研究院 | 超级细菌新德里金属依赖型β-内酰胺酶NDM-1的表达纯化及β-内酰胺酶NDM-1的晶体结构 |
| US9328374B2 (en) * | 2011-07-05 | 2016-05-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Selective culture medium and method for detecting carbapenem-resistant bacteria in a test sample |
| WO2013011072A1 (en) * | 2011-07-20 | 2013-01-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Carbapenemase and antibacterial treatment |
| US9129039B2 (en) * | 2011-10-18 | 2015-09-08 | Ut-Battelle, Llc | Scenario driven data modelling: a method for integrating diverse sources of data and data streams |
| WO2013122888A2 (en) * | 2012-02-15 | 2013-08-22 | Rempex Pharmaceuticals, Inc. | Methods of treating bacterial infections |
| KR102467968B1 (ko) | 2014-10-08 | 2022-11-16 | 신세틱 바이오로직스, 인코퍼레이티드 | 베타-락타마제 제형 및 이의 용도 |
| WO2016137993A1 (en) * | 2015-02-23 | 2016-09-01 | Synthetic Biologics, Inc. | Carbapenemases for use with antibiotics for the protection of the intestinal microbiome |
-
2016
- 2016-02-23 WO PCT/US2016/019129 patent/WO2016137993A1/en not_active Ceased
- 2016-02-23 US US15/051,187 patent/US20160250304A1/en not_active Abandoned
- 2016-02-23 AU AU2016222936A patent/AU2016222936B2/en not_active Ceased
- 2016-02-23 CN CN201680023209.7A patent/CN107530406B/zh active Active
- 2016-02-23 EP EP16756186.9A patent/EP3261662B1/en active Active
- 2016-02-23 CA CA2977385A patent/CA2977385C/en active Active
- 2016-02-23 JP JP2017543381A patent/JP6810697B2/ja active Active
-
2018
- 2018-01-09 US US15/866,044 patent/US10548955B2/en active Active
-
2019
- 2019-12-19 US US16/720,999 patent/US11123413B2/en active Active
-
2021
- 2021-08-19 US US17/406,266 patent/US20220000991A1/en not_active Abandoned
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