JP2014517037A5 - - Google Patents
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- Publication number
- JP2014517037A5 JP2014517037A5 JP2014515915A JP2014515915A JP2014517037A5 JP 2014517037 A5 JP2014517037 A5 JP 2014517037A5 JP 2014515915 A JP2014515915 A JP 2014515915A JP 2014515915 A JP2014515915 A JP 2014515915A JP 2014517037 A5 JP2014517037 A5 JP 2014517037A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- group
- composition according
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 102100026437 Branched-chain-amino-acid aminotransferase, cytosolic Human genes 0.000 claims 3
- 101000766268 Homo sapiens Branched-chain-amino-acid aminotransferase, cytosolic Proteins 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 206010065687 Bone loss Diseases 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- IEHMHYAHHVRZIF-UHFFFAOYSA-N 4-methyl-5-oxohexanoic acid Chemical group CC(=O)C(C)CCC(O)=O IEHMHYAHHVRZIF-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161520645P | 2011-06-13 | 2011-06-13 | |
| US61/520,645 | 2011-06-13 | ||
| PCT/US2012/042046 WO2012173987A2 (en) | 2011-06-13 | 2012-06-12 | Methods of treatment using a bcat1 inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016228528A Division JP6243996B2 (ja) | 2011-06-13 | 2016-11-25 | Ｂｃａｔ１阻害剤を使用する治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517037A JP2014517037A (ja) | 2014-07-17 |
| JP2014517037A5 true JP2014517037A5 (enExample) | 2015-07-23 |
| JP6053768B2 JP6053768B2 (ja) | 2016-12-27 |
Family
ID=47357689
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014515915A Expired - Fee Related JP6053768B2 (ja) | 2011-06-13 | 2012-06-12 | Ｂｃａｔ１阻害剤を使用する治療方法 |
| JP2016228528A Expired - Fee Related JP6243996B2 (ja) | 2011-06-13 | 2016-11-25 | Ｂｃａｔ１阻害剤を使用する治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016228528A Expired - Fee Related JP6243996B2 (ja) | 2011-06-13 | 2016-11-25 | Ｂｃａｔ１阻害剤を使用する治療方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9422224B2 (enExample) |
| EP (1) | EP2717869B1 (enExample) |
| JP (2) | JP6053768B2 (enExample) |
| WO (1) | WO2012173987A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10941109B2 (en) | 2011-06-13 | 2021-03-09 | Ergon Pharmaceuticals Llc | Compositions and methods of treatment using a BCAT1 inhibitor |
| KR101775761B1 (ko) * | 2014-07-30 | 2017-09-19 | 주식회사 엘지화학 | 변성 공액 디엔계 중합체, 이를 포함하는 변성 고무 조성물 및 변성 공액 디엔계 중합체의 제조방법 |
| ITUB20151014A1 (it) * | 2015-05-27 | 2016-11-27 | Univ Degli Studi Del Piemonte Orientale Amedeo Avogadro | Ligandi del recettore b7h nel trattamento di osteopenia e osteoporosi |
| US10738334B2 (en) * | 2015-09-23 | 2020-08-11 | Pfizer Inc. | Cells having reduced BCAT1 |
| JP7256509B2 (ja) * | 2016-08-22 | 2023-04-12 | エルゴン ファーマシューティカルズ エルエルシー | Ｂｃａｔ１阻害剤を使用する組成物及び治療方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE200100416A (et) * | 1999-12-08 | 2002-12-16 | Warner-Lambert Company | Hargneva ahelaga aminohappe-sõltuvad aminotransferaasinhibiitorid ja nende kasutamine diabeetilise retinopaatia ravis |
| JP2004509880A (ja) * | 2000-09-19 | 2004-04-02 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 分枝鎖アミノ酸依存性アミノトランスフェラーゼ阻害剤及び神経退行性疾患の治療におけるそれらの使用 |
| CA2565188C (en) * | 2004-05-14 | 2014-03-04 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US7842467B1 (en) * | 2005-05-12 | 2010-11-30 | Celera Corporation | Breast disease targets and uses thereof |
| GB0705400D0 (en) * | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| WO2010127452A1 (en) | 2009-05-04 | 2010-11-11 | The Royal Institution For The Advancement Of Learning/Mcgill University | 5-oxo-ete receptor antagonist compounds |
| EP2481801A1 (en) | 2011-01-28 | 2012-08-01 | Deutsches Krebsforschungszentrum | Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of neoplasia |
-
2012
- 2012-06-12 US US14/125,687 patent/US9422224B2/en not_active Expired - Fee Related
- 2012-06-12 WO PCT/US2012/042046 patent/WO2012173987A2/en not_active Ceased
- 2012-06-12 EP EP12800655.8A patent/EP2717869B1/en not_active Not-in-force
- 2012-06-12 JP JP2014515915A patent/JP6053768B2/ja not_active Expired - Fee Related
-
2016
- 2016-11-25 JP JP2016228528A patent/JP6243996B2/ja not_active Expired - Fee Related
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