JP2015107945A5 - - Google Patents
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- JP2015107945A5 JP2015107945A5 JP2013252443A JP2013252443A JP2015107945A5 JP 2015107945 A5 JP2015107945 A5 JP 2015107945A5 JP 2013252443 A JP2013252443 A JP 2013252443A JP 2013252443 A JP2013252443 A JP 2013252443A JP 2015107945 A5 JP2015107945 A5 JP 2015107945A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- composition according
- hydrogen atom
- active ingredient
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- MOVHBYQABFWGEO-LCYFTJDESA-N CCN(C(C1C=COC1(C)C=C1)=C1S1)/C1=C/C(C)=O Chemical compound CCN(C(C1C=COC1(C)C=C1)=C1S1)/C1=C/C(C)=O MOVHBYQABFWGEO-LCYFTJDESA-N 0.000 description 1
- IZNKZNXIXHLRGY-JYRVWZFOSA-N CCN1c(c2c(cc3)OCC2)c3S/C1=C\C(C)=O Chemical compound CCN1c(c2c(cc3)OCC2)c3S/C1=C\C(C)=O IZNKZNXIXHLRGY-JYRVWZFOSA-N 0.000 description 1
- WJCUXFRHZYIEOR-YVLHZVERSA-N CCN1c(c2c(cc3)[o]c4c2ccc(C)c4)c3S/C1=C\C(C)=O Chemical compound CCN1c(c2c(cc3)[o]c4c2ccc(C)c4)c3S/C1=C\C(C)=O WJCUXFRHZYIEOR-YVLHZVERSA-N 0.000 description 1
- QIAFGVQZUDBBOX-YBEGLDIGSA-N CCN1c(c2c(cc3)[o]c4ccccc24)c3S/C1=C\C(C)=O Chemical compound CCN1c(c2c(cc3)[o]c4ccccc24)c3S/C1=C\C(C)=O QIAFGVQZUDBBOX-YBEGLDIGSA-N 0.000 description 1
- NHDNXYLLAQDNEW-PXNMLYILSA-N CCN1c2c(c(cc(cc3)Cl)c3[o]3)c3ccc2S/C1=C\C(C)=O Chemical compound CCN1c2c(c(cc(cc3)Cl)c3[o]3)c3ccc2S/C1=C\C(C)=O NHDNXYLLAQDNEW-PXNMLYILSA-N 0.000 description 1
- RUQRAQTVHSATEP-PXNMLYILSA-N CCN1c2c(c(ccc(Cl)c3)c3[o]3)c3ccc2S/C1=C\C(C)=O Chemical compound CCN1c2c(c(ccc(Cl)c3)c3[o]3)c3ccc2S/C1=C\C(C)=O RUQRAQTVHSATEP-PXNMLYILSA-N 0.000 description 1
- KAOGHERYRZIKQY-YVLHZVERSA-N CCN1c2c(c3cc(C)ccc3[o]3)c3ccc2S/C1=C\C(C)=O Chemical compound CCN1c2c(c3cc(C)ccc3[o]3)c3ccc2S/C1=C\C(C)=O KAOGHERYRZIKQY-YVLHZVERSA-N 0.000 description 1
- 0 Cc(nccc1c2ccc3OC)c1[n]c2c3C#C[Si](C)(C)* Chemical compound Cc(nccc1c2ccc3OC)c1[n]c2c3C#C[Si](C)(C)* 0.000 description 1
- NRBGMOGXBQRJJI-UHFFFAOYSA-N Cc1c2[nH]c(c(-c3cc(C(F)(F)F)ccc3)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(-c3cc(C(F)(F)F)ccc3)c(cc3)OC)c3c2ccn1 NRBGMOGXBQRJJI-UHFFFAOYSA-N 0.000 description 1
- XRKAGOQTYZDWCD-UHFFFAOYSA-N Cc1c2[nH]c(c(-c3ccc(C(F)(F)F)cc3)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(-c3ccc(C(F)(F)F)cc3)c(cc3)OC)c3c2ccn1 XRKAGOQTYZDWCD-UHFFFAOYSA-N 0.000 description 1
- FZIYPGBZXZEVAD-UHFFFAOYSA-N Cc1c2[nH]c(c(C#CC3(CC(C4)C5)CC5CC4C3)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(C#CC3(CC(C4)C5)CC5CC4C3)c(cc3)OC)c3c2ccn1 FZIYPGBZXZEVAD-UHFFFAOYSA-N 0.000 description 1
- HNEPVENUEAVPDF-UHFFFAOYSA-N Cc1c2[nH]c(c(C#CC3(CCCCC3)O)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(C#CC3(CCCCC3)O)c(cc3)OC)c3c2ccn1 HNEPVENUEAVPDF-UHFFFAOYSA-N 0.000 description 1
- NNBDGHSCJXGLIV-UHFFFAOYSA-N Cc1c2[nH]c(c(C#Cc3ccccc3)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(C#Cc3ccccc3)c(cc3)OC)c3c2ccn1 NNBDGHSCJXGLIV-UHFFFAOYSA-N 0.000 description 1
- XSJFNYCFKORWJZ-UHFFFAOYSA-N Cc1cc(C)cc(-c(c2c(cc3)c4ccnc(C)c4[nH]2)c3OC)c1 Chemical compound Cc1cc(C)cc(-c(c2c(cc3)c4ccnc(C)c4[nH]2)c3OC)c1 XSJFNYCFKORWJZ-UHFFFAOYSA-N 0.000 description 1
- IIUIFEXOMDUOPE-UHFFFAOYSA-N Cc1cccc(-c(c2c(cc3)c4ccnc(C)c4[nH]2)c3OC)c1 Chemical compound Cc1cccc(-c(c2c(cc3)c4ccnc(C)c4[nH]2)c3OC)c1 IIUIFEXOMDUOPE-UHFFFAOYSA-N 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013252443A JP2015107945A (ja) | 2013-12-05 | 2013-12-05 | 神経新生に関する化合物及び医薬組成物 |
| US15/101,862 US20160303089A1 (en) | 2013-12-05 | 2014-12-03 | Compound pertaining to neuropoiesis and drug composition |
| PCT/JP2014/082035 WO2015083750A1 (ja) | 2013-12-05 | 2014-12-03 | 神経新生に関する化合物及び医薬組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013252443A JP2015107945A (ja) | 2013-12-05 | 2013-12-05 | 神経新生に関する化合物及び医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015107945A JP2015107945A (ja) | 2015-06-11 |
| JP2015107945A5 true JP2015107945A5 (enExample) | 2017-01-19 |
Family
ID=53273511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013252443A Pending JP2015107945A (ja) | 2013-12-05 | 2013-12-05 | 神経新生に関する化合物及び医薬組成物 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20160303089A1 (enExample) |
| JP (1) | JP2015107945A (enExample) |
| WO (1) | WO2015083750A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2673489C2 (ru) * | 2013-09-12 | 2018-11-27 | Ф. Хоффманн-Ля Рош Аг | Производные индолкарбоксамида |
| WO2018043674A1 (ja) * | 2016-08-31 | 2018-03-08 | 国立大学法人京都大学 | 神経新生を活性化するための組成物 |
| EP3318563A1 (en) | 2016-11-07 | 2018-05-09 | Sanofi | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders |
| WO2018151326A1 (ja) * | 2017-02-20 | 2018-08-23 | 国立大学法人京都大学 | スプライシング異常に起因する遺伝性疾病のための医薬組成物及び治療方法 |
| US20230138851A1 (en) * | 2020-01-30 | 2023-05-04 | Carna Biosciences, Inc. | Novel alkyne derivatives |
| JP7699831B2 (ja) * | 2020-04-01 | 2025-06-30 | 国立大学法人京都大学 | 神経炎症の抑制、そのための組成物及び方法 |
| EP4215534A4 (en) * | 2020-09-18 | 2024-10-02 | Carna Biosciences, Inc. | AMINE DERIVATIVE |
| JP7800929B2 (ja) * | 2021-03-03 | 2026-01-16 | 国立研究開発法人理化学研究所 | 神経変性疾患治療のためのポリヌクレオチド、ベクター、細胞、医薬組成物及びスクリーニング方法 |
| WO2022255411A1 (ja) | 2021-06-01 | 2022-12-08 | 国立大学法人京都大学 | 自然免疫応答を増強させる方法 |
| JPWO2023008472A1 (enExample) * | 2021-07-28 | 2023-02-02 | ||
| WO2023008470A1 (ja) * | 2021-07-28 | 2023-02-02 | 住友ファーマ株式会社 | 縮環アミン誘導体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003273351A1 (en) * | 2002-09-24 | 2004-04-19 | Isis Pharmaceutical, Inc. | Methods for blocking adipocyte differentiation and triglyceride accumulation with dual-specificity tyrosine- (y) - phosphorylation regulated kinase 4 (dyrk4) inhibitors |
| WO2008150837A1 (en) * | 2007-06-01 | 2008-12-11 | Smithkline Beecham Corporation | Methods of treatment |
| KR20100010894A (ko) * | 2008-07-23 | 2010-02-02 | 가부시키가이샤 키노파마 | Ｄｙｒｋ를 저해하는 화합물을 함유하는 의약 조성물 |
| RU2015108907A (ru) * | 2009-09-22 | 2015-08-20 | Ньюронасент, Инк. | Способы и фармацевтические композиции для лечения синдрома дауна |
| WO2011068990A1 (en) * | 2009-12-04 | 2011-06-09 | Medipropharma, Inc. | Compositions and methods for inhibiting dyrk1a to treat central nervous system diseases and disorders |
| WO2011133795A2 (en) * | 2010-04-22 | 2011-10-27 | The Brigham And Women's Hospital, Inc. | Beta-carbolines as inhibitors of haspin and dyrk kinases |
| US9446044B2 (en) * | 2011-08-19 | 2016-09-20 | Diaxonhit | DYRK1 inhibitors and uses thereof |
| US20150133467A1 (en) * | 2012-06-06 | 2015-05-14 | Kyoto University | Screening method, protein instability and/or stability inducers, and protein activity assessment |
| US9745323B2 (en) * | 2012-07-30 | 2017-08-29 | Kyoto University | Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor |
-
2013
- 2013-12-05 JP JP2013252443A patent/JP2015107945A/ja active Pending
-
2014
- 2014-12-03 WO PCT/JP2014/082035 patent/WO2015083750A1/ja not_active Ceased
- 2014-12-03 US US15/101,862 patent/US20160303089A1/en not_active Abandoned
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