CN109310676A - 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 - Google Patents

一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 Download PDF

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Publication number
CN109310676A
CN109310676A CN201780035396.5A CN201780035396A CN109310676A CN 109310676 A CN109310676 A CN 109310676A CN 201780035396 A CN201780035396 A CN 201780035396A CN 109310676 A CN109310676 A CN 109310676A
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CN
China
Prior art keywords
compound
etomidate
logical formula
pharmaceutical preparation
pharmaceutical
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Pending
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CN201780035396.5A
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English (en)
Inventor
严庞科
郑伟
倪佳
余彦
莫毅
陈娅姝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan Haisco Pharmaceutical Co Ltd
Original Assignee
Sichuan Haisco Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sichuan Haisco Pharmaceutical Co Ltd filed Critical Sichuan Haisco Pharmaceutical Co Ltd
Priority to CN202011151583.XA priority Critical patent/CN112245426A/zh
Publication of CN109310676A publication Critical patent/CN109310676A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

本发明涉及一种含苯酚衍生物和依托咪酯的药物组合物及其制备方法和在中枢神经领域的应用，所述苯酚衍生物为式(I)化合物或者其立体异构体、药学上可接受的盐或前药。

Description

PCT国内申请，说明书已公开。

Claims (34)

  1. PCT国内申请，权利要求书已公开。
CN201780035396.5A 2016-07-22 2017-07-13 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 Pending CN109310676A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011151583.XA CN112245426A (zh) 2016-07-22 2017-07-13 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610584338 2016-07-22
CN2016105843385 2016-07-22
PCT/CN2017/092722 WO2018014770A1 (zh) 2016-07-22 2017-07-13 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202011151583.XA Division CN112245426A (zh) 2016-07-22 2017-07-13 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途

Publications (1)

Publication Number Publication Date
CN109310676A true CN109310676A (zh) 2019-02-05

Family

ID=60991913

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202011151583.XA Pending CN112245426A (zh) 2016-07-22 2017-07-13 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途
CN201780035396.5A Pending CN109310676A (zh) 2016-07-22 2017-07-13 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN202011151583.XA Pending CN112245426A (zh) 2016-07-22 2017-07-13 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途

Country Status (2)

Country Link
CN (2) CN112245426A (zh)
WO (1) WO2018014770A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110063947A (zh) * 2018-01-24 2019-07-30 四川海思科制药有限公司 苯酚衍生物用于制备麻醉药物中的用途
CN114073675A (zh) * 2020-08-10 2022-02-22 复旦大学 一种丙泊酚混合胶束及其制备方法
CN114668720A (zh) * 2020-12-24 2022-06-28 远大生命科学(武汉)有限公司 一种依托咪酯乳状注射液及其制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115175887B (zh) * 2021-01-28 2023-08-01 天地恒一制药股份有限公司 苯酚衍生物及其在医药上的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103356609A (zh) * 2012-03-28 2013-10-23 陈希璇 一种复方静脉麻醉剂
WO2016034079A1 (zh) * 2014-09-04 2016-03-10 四川海思科制药有限公司 一种gabaa受体增强剂用于制备镇静麻醉的药物中的用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103356609A (zh) * 2012-03-28 2013-10-23 陈希璇 一种复方静脉麻醉剂
WO2016034079A1 (zh) * 2014-09-04 2016-03-10 四川海思科制药有限公司 一种gabaa受体增强剂用于制备镇静麻醉的药物中的用途

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110063947A (zh) * 2018-01-24 2019-07-30 四川海思科制药有限公司 苯酚衍生物用于制备麻醉药物中的用途
CN114073675A (zh) * 2020-08-10 2022-02-22 复旦大学 一种丙泊酚混合胶束及其制备方法
CN114668720A (zh) * 2020-12-24 2022-06-28 远大生命科学(武汉)有限公司 一种依托咪酯乳状注射液及其制备方法

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Publication number Publication date
WO2018014770A1 (zh) 2018-01-25
CN112245426A (zh) 2021-01-22

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