JP2016527186A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016527186A5 JP2016527186A5 JP2016514479A JP2016514479A JP2016527186A5 JP 2016527186 A5 JP2016527186 A5 JP 2016527186A5 JP 2016514479 A JP2016514479 A JP 2016514479A JP 2016514479 A JP2016514479 A JP 2016514479A JP 2016527186 A5 JP2016527186 A5 JP 2016527186A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- independently
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201309248A GB201309248D0 (en) | 2013-05-22 | 2013-05-22 | Compounds and combinations |
| GB1309248.1 | 2013-05-22 | ||
| GB201404301A GB201404301D0 (en) | 2014-03-11 | 2014-03-11 | Compounds and combinations |
| GB1404301.2 | 2014-03-11 | ||
| PCT/GB2014/051547 WO2014188178A1 (en) | 2013-05-22 | 2014-05-21 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016527186A JP2016527186A (ja) | 2016-09-08 |
| JP2016527186A5 true JP2016527186A5 (enExample) | 2017-07-20 |
| JP6643758B2 JP6643758B2 (ja) | 2020-02-12 |
Family
ID=50829204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514479A Active JP6643758B2 (ja) | 2013-05-22 | 2014-05-21 | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10407467B2 (enExample) |
| EP (1) | EP2999711B1 (enExample) |
| JP (1) | JP6643758B2 (enExample) |
| KR (1) | KR102354902B1 (enExample) |
| CN (1) | CN105308065B (enExample) |
| BR (1) | BR112015029309A2 (enExample) |
| CA (1) | CA2939061C (enExample) |
| CY (1) | CY1125479T1 (enExample) |
| DK (1) | DK2999711T3 (enExample) |
| ES (1) | ES2923762T3 (enExample) |
| HR (1) | HRP20220898T1 (enExample) |
| HU (1) | HUE059544T2 (enExample) |
| LT (1) | LT2999711T (enExample) |
| PL (1) | PL2999711T3 (enExample) |
| PT (1) | PT2999711T (enExample) |
| RS (1) | RS63484B1 (enExample) |
| RU (1) | RU2730012C2 (enExample) |
| SI (1) | SI2999711T1 (enExample) |
| TW (1) | TWI665218B (enExample) |
| WO (1) | WO2014188178A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX355217B (es) | 2011-11-18 | 2018-04-10 | New Pharma Licence Holdings Ltd | Derivados de polimixina. |
| HUE059544T2 (hu) | 2013-05-22 | 2022-11-28 | Spero Therapeutics Inc | Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal |
| EP3038615A4 (en) * | 2013-08-28 | 2017-04-12 | The Medicines Company | Methods for treating bacterial infections using oritavancin and polymyxins |
| KR20160135739A (ko) * | 2014-03-11 | 2016-11-28 | 뉴 파마 라이센스 홀딩스 리미티드 | 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 |
| CN107108699A (zh) | 2014-11-26 | 2017-08-29 | 新药物许可控股有限公司 | 化合物 |
| EP3233889B1 (en) * | 2014-12-16 | 2022-07-06 | Shanghai MicuRx Pharmaceutical Co., Ltd. | Antimicrobial polymyxins for treatment of bacterial infections |
| FI126143B (en) | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| KR101790296B1 (ko) * | 2015-03-26 | 2017-10-26 | 한국생명공학연구원 | 네트롭신을 유효성분으로 포함하는 그람음성 세균에 대한 폴리믹신의 항균 활성을 증가시키는 조성물 |
| WO2016166103A1 (en) * | 2015-04-13 | 2016-10-20 | Xellia Pharmaceuticals Aps | Polymyxin derivatives |
| JP7367950B2 (ja) * | 2015-09-29 | 2023-10-24 | モナッシュ ユニバーシティ | 抗菌性ポリミキシン誘導体化合物 |
| CN109789125B (zh) * | 2016-08-16 | 2022-10-18 | 罗切斯特大学 | 含有基于多粘菌素b/甲氧苄啶的治疗剂的药物组合物 |
| CN106631902A (zh) * | 2016-09-23 | 2017-05-10 | 上海步越化工科技有限公司 | 一种特拉万星侧链癸基(2‑氧代乙基)氨基甲酸9h‑芴‑9‑甲基酯的制备方法 |
| US11191773B2 (en) | 2017-07-17 | 2021-12-07 | President And Fellows Of Harvard College | Methods of treatment for bacterial infections |
| CN111247162B (zh) * | 2017-10-31 | 2022-02-18 | 正大天晴药业集团股份有限公司 | 多黏菌素类似物及其制备方法 |
| WO2019084628A1 (en) | 2017-11-02 | 2019-05-09 | The University Of Queensland | Peptide antibiotics |
| US11713335B2 (en) | 2018-03-12 | 2023-08-01 | President And Fellows Of Harvard College | Aminocoumarin compounds and methods of their use |
| DK3810633T3 (da) | 2018-06-25 | 2024-01-15 | Spero Therapeutics Inc | Forbindelser |
| CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| US20220395555A1 (en) * | 2020-06-11 | 2022-12-15 | Boris Farber | Derivatives of antibiotics |
| US12472195B2 (en) | 2020-07-02 | 2025-11-18 | Purdue Research Foundation | Inhalation formulations of antimicrobial compounds |
| TW202233649A (zh) | 2020-11-06 | 2022-09-01 | 美商斯佩羅治療學股份有限公司 | 化合物 |
| CN116847735B (zh) * | 2021-02-02 | 2026-02-03 | 韩国生命工学研究院 | 含有联苯基衍生物化合物作为有效成分的抗菌佐剂及其用途 |
| WO2023283256A1 (en) | 2021-07-09 | 2023-01-12 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2024003042A1 (en) | 2022-06-28 | 2024-01-04 | Breakthrough Biotech Drift Aps | Novel combinations of sesquiterpene alcohols, polymyxins and nisin compounds as antimicobial and/or antifungal compounds |
| AU2023303408A1 (en) | 2022-07-06 | 2024-12-19 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| EP4611762A1 (en) * | 2022-11-14 | 2025-09-10 | Cipla Limited | Novel ophthalmic composition |
| KR102952821B1 (ko) * | 2022-11-23 | 2026-04-16 | 웰펩 주식회사 | 폴리믹신 e 및 폴리믹신 b의 제조방법 |
| CN116212004A (zh) * | 2022-12-07 | 2023-06-06 | 东南大学 | 一种复合抗生素吸入用粉剂及其制备方法与应用 |
| IL326320A (en) * | 2023-08-03 | 2026-04-01 | Arcum Vision Inc | Enhanced formulation of polymyxin b/ trimethoprim and rifampin and methods for ophthalmic uses |
| KR20250037611A (ko) * | 2023-09-07 | 2025-03-18 | 웰펩 주식회사 | 그람 음성균 및 다제내성 그람 음성균에 우수한 항균 활성을 갖는 신규 폴리믹신 유사체, 이를 포함하는 항균용 조성물 |
| WO2025236916A1 (en) * | 2024-05-16 | 2025-11-20 | Brii Biosciences, Inc. | Compositions and methods for treating infections |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| AU7753787A (en) | 1986-08-06 | 1988-02-24 | Jean-Luc Fauchere | Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b |
| US20010021697A1 (en) | 1987-09-14 | 2001-09-13 | Henning Lowenstein | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components |
| TW274552B (enExample) | 1992-05-26 | 1996-04-21 | Hoechst Ag | |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| JP4583559B2 (ja) * | 2000-07-24 | 2010-11-17 | 栄研化学株式会社 | Ｍｒｓａスクリーニング用培地 |
| JP2007507512A (ja) | 2003-09-30 | 2007-03-29 | コーヒ コーポレーション | 熱傷を治療するための組成物および方法 |
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| WO2008001773A1 (fr) | 2006-06-27 | 2008-01-03 | Toyo Tire & Rubber Co., Ltd. | pneu apte à rouler dégonflé |
| BRPI0715095B8 (pt) * | 2006-08-11 | 2021-05-25 | Northern Antibiotics Oy | derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i). |
| US8193148B2 (en) | 2008-02-08 | 2012-06-05 | Northern Antibiotics Ltd. | Short fatty acid tail polymyxin derivatives and uses thereof |
| US8329645B2 (en) | 2008-02-08 | 2012-12-11 | Northern Antibiotics Ltd. | Polymyxin derivatives and uses thereof |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| ES2334547B1 (es) | 2008-09-10 | 2010-12-03 | Universidad De Barcelona | Compuestos peptidicos antibacterianos. |
| WO2010075416A1 (en) | 2008-12-23 | 2010-07-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| JP5493387B2 (ja) * | 2009-02-25 | 2014-05-14 | 国立大学法人 東京大学 | 選択培地の製造方法及びその利用 |
| CN101851270A (zh) | 2009-04-03 | 2010-10-06 | 梁浩 | 一种多粘菌素衍生物及其制备方法 |
| WO2010130007A1 (en) | 2009-05-14 | 2010-11-18 | Monash University | Antimicrobial compounds |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| US9226786B2 (en) * | 2011-03-22 | 2016-01-05 | Lexion Medical Llc | Medical devices for clearing a surgical site |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| MX355217B (es) * | 2011-11-18 | 2018-04-10 | New Pharma Licence Holdings Ltd | Derivados de polimixina. |
| HUE059544T2 (hu) | 2013-05-22 | 2022-11-28 | Spero Therapeutics Inc | Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal |
| US10047126B2 (en) | 2014-04-01 | 2018-08-14 | Monash University | Polymyxin derivatives as antimicrobial compounds |
-
2014
- 2014-05-21 HU HUE14726731A patent/HUE059544T2/hu unknown
- 2014-05-21 PT PT147267314T patent/PT2999711T/pt unknown
- 2014-05-21 LT LTEPPCT/GB2014/051547T patent/LT2999711T/lt unknown
- 2014-05-21 HR HRP20220898TT patent/HRP20220898T1/hr unknown
- 2014-05-21 CN CN201480029145.2A patent/CN105308065B/zh active Active
- 2014-05-21 CA CA2939061A patent/CA2939061C/en active Active
- 2014-05-21 TW TW103117787A patent/TWI665218B/zh active
- 2014-05-21 RU RU2015148032A patent/RU2730012C2/ru active
- 2014-05-21 WO PCT/GB2014/051547 patent/WO2014188178A1/en not_active Ceased
- 2014-05-21 US US14/892,757 patent/US10407467B2/en active Active
- 2014-05-21 JP JP2016514479A patent/JP6643758B2/ja active Active
- 2014-05-21 RS RS20220760A patent/RS63484B1/sr unknown
- 2014-05-21 BR BR112015029309A patent/BR112015029309A2/pt active Search and Examination
- 2014-05-21 ES ES14726731T patent/ES2923762T3/es active Active
- 2014-05-21 KR KR1020157035048A patent/KR102354902B1/ko active Active
- 2014-05-21 DK DK14726731.4T patent/DK2999711T3/da active
- 2014-05-21 PL PL14726731.4T patent/PL2999711T3/pl unknown
- 2014-05-21 SI SI201431984T patent/SI2999711T1/sl unknown
- 2014-05-21 EP EP14726731.4A patent/EP2999711B1/en active Active
-
2022
- 2022-08-11 CY CY20221100550T patent/CY1125479T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015148032A (ru) | Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками | |
| AU2021201636B2 (en) | Self-stabilizing linker conjugates | |
| US20250288640A1 (en) | Glycopeptide compositions | |
| RU2012108874A (ru) | Композиции, содержащие расщепляемые ферментами опиоидные пролекарства с модифицированным кетоном и их дополнительные ингибиторы | |
| CN118434765A (zh) | Bcma单克隆抗体和抗体-药物偶联物 | |
| RU2013144368A (ru) | Пролекарства действующих веществ гетероциклическими линкерами | |
| JP2013155195A5 (enExample) | ||
| JP2012512898A (ja) | ジペプチド結合薬用剤 | |
| RU2010106877A (ru) | Дипептидные пролекарства и их применение | |
| JP2013533864A5 (enExample) | ||
| RU2014131370A (ru) | Терапевтические соединения, содержащие бор | |
| WO2011038066A4 (en) | Novel npr-b agonists | |
| EP1878429B1 (en) | Trenadermal absorption preparation | |
| EP3823630A1 (en) | Peptides for activation of cell signaling in osteoprogenitor cells | |
| CN110582506A (zh) | 新抗菌产品 | |
| WO2012031228A2 (en) | Llp2a-bisphosphonate conjugates for osteoporosis treatment | |
| KR20220041152A (ko) | 뼈-결합 화합물 | |
| CN1633300A (zh) | 透皮制剂 | |
| RU2013102588A (ru) | Новые октапептидные соединения и их терапевтическое применение | |
| CA2549890A1 (en) | Mri contrast medium composition for oral administration | |
| WO2000027374B1 (en) | The use of excitatory amino acid transporter inhibitors to reduce cns white matter injury | |
| US20250064955A1 (en) | Drug conjugates and methods of preparing and using the same | |
| CN109476704B (zh) | 抗菌环脂肽 | |
| HK40115431A (en) | Drug conjugates and methods of preparing and using the same | |
| EP4304721A1 (en) | Stapled antimicrobial peptides (stamps) and uses thereof |