JP2016527186A5 - - Google Patents
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- JP2016527186A5 JP2016527186A5 JP2016514479A JP2016514479A JP2016527186A5 JP 2016527186 A5 JP2016527186 A5 JP 2016527186A5 JP 2016514479 A JP2016514479 A JP 2016514479A JP 2016514479 A JP2016514479 A JP 2016514479A JP 2016527186 A5 JP2016527186 A5 JP 2016527186A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- independently
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201309248A GB201309248D0 (en) | 2013-05-22 | 2013-05-22 | Compounds and combinations |
| GB1309248.1 | 2013-05-22 | ||
| GB201404301A GB201404301D0 (en) | 2014-03-11 | 2014-03-11 | Compounds and combinations |
| GB1404301.2 | 2014-03-11 | ||
| PCT/GB2014/051547 WO2014188178A1 (en) | 2013-05-22 | 2014-05-21 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016527186A JP2016527186A (ja) | 2016-09-08 |
| JP2016527186A5 true JP2016527186A5 (enExample) | 2017-07-20 |
| JP6643758B2 JP6643758B2 (ja) | 2020-02-12 |
Family
ID=50829204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514479A Active JP6643758B2 (ja) | 2013-05-22 | 2014-05-21 | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10407467B2 (enExample) |
| EP (1) | EP2999711B1 (enExample) |
| JP (1) | JP6643758B2 (enExample) |
| KR (1) | KR102354902B1 (enExample) |
| CN (1) | CN105308065B (enExample) |
| BR (1) | BR112015029309A2 (enExample) |
| CA (1) | CA2939061C (enExample) |
| DK (1) | DK2999711T3 (enExample) |
| ES (1) | ES2923762T3 (enExample) |
| HR (1) | HRP20220898T1 (enExample) |
| HU (1) | HUE059544T2 (enExample) |
| LT (1) | LT2999711T (enExample) |
| PL (1) | PL2999711T3 (enExample) |
| PT (1) | PT2999711T (enExample) |
| RS (1) | RS63484B1 (enExample) |
| RU (1) | RU2730012C2 (enExample) |
| SI (1) | SI2999711T1 (enExample) |
| TW (1) | TWI665218B (enExample) |
| WO (1) | WO2014188178A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX355217B (es) * | 2011-11-18 | 2018-04-10 | New Pharma Licence Holdings Ltd | Derivados de polimixina. |
| RU2730012C2 (ru) | 2013-05-22 | 2020-08-14 | Сперо Терапьютикс, Инк. | Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками |
| EP3038615A4 (en) * | 2013-08-28 | 2017-04-12 | The Medicines Company | Methods for treating bacterial infections using oritavancin and polymyxins |
| SI3116897T1 (sl) * | 2014-03-11 | 2022-06-30 | Spero Therapeutics, Inc. | Derivati polimiksina in njihova uporaba v kombinacijskem zdravljenju skupaj z različnimi antibiotiki |
| EP3224273A1 (en) | 2014-11-26 | 2017-10-04 | New Pharma Licence Holdings Limited | Compounds |
| CN107257803B (zh) * | 2014-12-16 | 2021-02-05 | 上海盟科药业股份有限公司 | 用于治疗细菌感染的多粘菌素类抗菌剂 |
| FI126143B (en) | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| KR101790296B1 (ko) * | 2015-03-26 | 2017-10-26 | 한국생명공학연구원 | 네트롭신을 유효성분으로 포함하는 그람음성 세균에 대한 폴리믹신의 항균 활성을 증가시키는 조성물 |
| WO2016166103A1 (en) * | 2015-04-13 | 2016-10-20 | Xellia Pharmaceuticals Aps | Polymyxin derivatives |
| JP7367950B2 (ja) * | 2015-09-29 | 2023-10-24 | モナッシュ ユニバーシティ | 抗菌性ポリミキシン誘導体化合物 |
| CN109789125B (zh) * | 2016-08-16 | 2022-10-18 | 罗切斯特大学 | 含有基于多粘菌素b/甲氧苄啶的治疗剂的药物组合物 |
| CN106631902A (zh) * | 2016-09-23 | 2017-05-10 | 上海步越化工科技有限公司 | 一种特拉万星侧链癸基(2‑氧代乙基)氨基甲酸9h‑芴‑9‑甲基酯的制备方法 |
| US11191773B2 (en) | 2017-07-17 | 2021-12-07 | President And Fellows Of Harvard College | Methods of treatment for bacterial infections |
| WO2019085926A1 (zh) * | 2017-10-31 | 2019-05-09 | 上海医药工业研究院 | 多黏菌素类似物及其制备方法 |
| EP3704135A4 (en) | 2017-11-02 | 2022-04-27 | The University of Queensland | PEPTIDE ANTIBIOTICS |
| WO2019178119A1 (en) | 2018-03-12 | 2019-09-19 | President And Fellows Of Harvard College | Aminocoumarin compounds and methods of their use |
| TWI851584B (zh) | 2018-06-25 | 2024-08-11 | 新加坡商雲頂新耀股份有限公司 | 化合物 |
| CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| CN115298198A (zh) | 2020-01-21 | 2022-11-04 | 上海盟科药业股份有限公司 | 用于肾相关癌症靶向治疗的新型化合物和组合物 |
| US12472195B2 (en) | 2020-07-02 | 2025-11-18 | Purdue Research Foundation | Inhalation formulations of antimicrobial compounds |
| WO2022098950A1 (en) | 2020-11-06 | 2022-05-12 | Spero Therapeutics, Inc. | Compounds |
| EP4289272A4 (en) * | 2021-02-02 | 2024-07-17 | Korea Research Institute of Bioscience and Biotechnology | ANTIMICROBIAL ADJUVANT WITH BIPHENYL DERIVATIVE COMPOUND AS ACTIVE INGREDIENT AND USES THEREOF |
| EP4366831A4 (en) | 2021-07-09 | 2025-06-11 | Aligos Therapeutics, Inc. | ANTI-VIRAL COMPOUNDS |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2024003042A1 (en) | 2022-06-28 | 2024-01-04 | Breakthrough Biotech Drift Aps | Novel combinations of sesquiterpene alcohols, polymyxins and nisin compounds as antimicobial and/or antifungal compounds |
| WO2024105689A1 (en) * | 2022-11-14 | 2024-05-23 | Cipla Limited | Novel ophthalmic composition |
| WO2025030169A2 (en) * | 2023-08-03 | 2025-02-06 | Arcum Vision Inc. | Enhanced formulation of polymyxin b/ trimethoprim and rifampin and methods for ophthalmic uses |
| KR20250037611A (ko) * | 2023-09-07 | 2025-03-18 | 웰펩 주식회사 | 그람 음성균 및 다제내성 그람 음성균에 우수한 항균 활성을 갖는 신규 폴리믹신 유사체, 이를 포함하는 항균용 조성물 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| WO1988000950A2 (fr) | 1986-08-06 | 1988-02-11 | Fauchere Jean Luc | Fabrication de conjugues a liaisons de covalence a partir d'un antibiotique et d'un derive non toxique de la polymyxine b |
| US20010021697A1 (en) | 1987-09-14 | 2001-09-13 | Henning Lowenstein | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components |
| TW274552B (enExample) | 1992-05-26 | 1996-04-21 | Hoechst Ag | |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| JP4583559B2 (ja) * | 2000-07-24 | 2010-11-17 | 栄研化学株式会社 | Ｍｒｓａスクリーニング用培地 |
| WO2005032470A2 (en) | 2003-09-30 | 2005-04-14 | Kohi Corporation | Compositions and methods for treating burns |
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| WO2008001773A1 (fr) | 2006-06-27 | 2008-01-03 | Toyo Tire & Rubber Co., Ltd. | pneu apte à rouler dégonflé |
| BRPI0715095B8 (pt) * | 2006-08-11 | 2021-05-25 | Northern Antibiotics Oy | derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i). |
| US8193148B2 (en) | 2008-02-08 | 2012-06-05 | Northern Antibiotics Ltd. | Short fatty acid tail polymyxin derivatives and uses thereof |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| US8329645B2 (en) | 2008-02-08 | 2012-12-11 | Northern Antibiotics Ltd. | Polymyxin derivatives and uses thereof |
| ES2334547B1 (es) | 2008-09-10 | 2010-12-03 | Universidad De Barcelona | Compuestos peptidicos antibacterianos. |
| NZ593892A (en) | 2008-12-23 | 2013-11-29 | Biosource Pharm Inc | Antibiotic compositions for the treatment of gram negative infections |
| JP5493387B2 (ja) * | 2009-02-25 | 2014-05-14 | 国立大学法人 東京大学 | 選択培地の製造方法及びその利用 |
| CN101851270A (zh) | 2009-04-03 | 2010-10-06 | 梁浩 | 一种多粘菌素衍生物及其制备方法 |
| WO2010130007A1 (en) | 2009-05-14 | 2010-11-18 | Monash University | Antimicrobial compounds |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| US9226786B2 (en) * | 2011-03-22 | 2016-01-05 | Lexion Medical Llc | Medical devices for clearing a surgical site |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| MX355217B (es) * | 2011-11-18 | 2018-04-10 | New Pharma Licence Holdings Ltd | Derivados de polimixina. |
| RU2730012C2 (ru) | 2013-05-22 | 2020-08-14 | Сперо Терапьютикс, Инк. | Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками |
| WO2015149131A1 (en) | 2014-04-01 | 2015-10-08 | Monash University | Polymyxin derivatives as antimicrobial compounds |
-
2014
- 2014-05-21 RU RU2015148032A patent/RU2730012C2/ru active
- 2014-05-21 BR BR112015029309A patent/BR112015029309A2/pt active Search and Examination
- 2014-05-21 DK DK14726731.4T patent/DK2999711T3/da active
- 2014-05-21 HR HRP20220898TT patent/HRP20220898T1/hr unknown
- 2014-05-21 CN CN201480029145.2A patent/CN105308065B/zh active Active
- 2014-05-21 LT LTEPPCT/GB2014/051547T patent/LT2999711T/lt unknown
- 2014-05-21 JP JP2016514479A patent/JP6643758B2/ja active Active
- 2014-05-21 WO PCT/GB2014/051547 patent/WO2014188178A1/en not_active Ceased
- 2014-05-21 EP EP14726731.4A patent/EP2999711B1/en active Active
- 2014-05-21 SI SI201431984T patent/SI2999711T1/sl unknown
- 2014-05-21 CA CA2939061A patent/CA2939061C/en active Active
- 2014-05-21 RS RS20220760A patent/RS63484B1/sr unknown
- 2014-05-21 KR KR1020157035048A patent/KR102354902B1/ko active Active
- 2014-05-21 TW TW103117787A patent/TWI665218B/zh active
- 2014-05-21 US US14/892,757 patent/US10407467B2/en active Active
- 2014-05-21 PT PT147267314T patent/PT2999711T/pt unknown
- 2014-05-21 HU HUE14726731A patent/HUE059544T2/hu unknown
- 2014-05-21 PL PL14726731.4T patent/PL2999711T3/pl unknown
- 2014-05-21 ES ES14726731T patent/ES2923762T3/es active Active
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