PT2999711T - Derivados de polimixina e a sua utilização em terapia de combinação em conjunto com antibióticos diferentes - Google Patents
Derivados de polimixina e a sua utilização em terapia de combinação em conjunto com antibióticos diferentesInfo
- Publication number
- PT2999711T PT2999711T PT147267314T PT14726731T PT2999711T PT 2999711 T PT2999711 T PT 2999711T PT 147267314 T PT147267314 T PT 147267314T PT 14726731 T PT14726731 T PT 14726731T PT 2999711 T PT2999711 T PT 2999711T
- Authority
- PT
- Portugal
- Prior art keywords
- combination therapy
- different antibiotics
- therapy together
- polymyxin derivatives
- polymyxin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201309248A GB201309248D0 (en) | 2013-05-22 | 2013-05-22 | Compounds and combinations |
| GB201404301A GB201404301D0 (en) | 2014-03-11 | 2014-03-11 | Compounds and combinations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2999711T true PT2999711T (pt) | 2022-07-29 |
Family
ID=50829204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT147267314T PT2999711T (pt) | 2013-05-22 | 2014-05-21 | Derivados de polimixina e a sua utilização em terapia de combinação em conjunto com antibióticos diferentes |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10407467B2 (enExample) |
| EP (1) | EP2999711B1 (enExample) |
| JP (1) | JP6643758B2 (enExample) |
| KR (1) | KR102354902B1 (enExample) |
| CN (1) | CN105308065B (enExample) |
| BR (1) | BR112015029309A2 (enExample) |
| CA (1) | CA2939061C (enExample) |
| DK (1) | DK2999711T3 (enExample) |
| ES (1) | ES2923762T3 (enExample) |
| HR (1) | HRP20220898T1 (enExample) |
| HU (1) | HUE059544T2 (enExample) |
| LT (1) | LT2999711T (enExample) |
| PL (1) | PL2999711T3 (enExample) |
| PT (1) | PT2999711T (enExample) |
| RS (1) | RS63484B1 (enExample) |
| RU (1) | RU2730012C2 (enExample) |
| SI (1) | SI2999711T1 (enExample) |
| TW (1) | TWI665218B (enExample) |
| WO (1) | WO2014188178A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013072695A1 (en) | 2011-11-18 | 2013-05-23 | Novacta Biosystems Limited | Polymyxin derivatives |
| PL2999711T3 (pl) | 2013-05-22 | 2022-09-26 | Spero Therapeutics, Inc. | Pochodne polimyksyny i ich zastosowanie w terapii skojarzonej razem z różnymi antybiotykami |
| US9775878B2 (en) | 2013-08-28 | 2017-10-03 | The Medicines Company | Methods for treating bacterial infections using oritavancin and polymyxins |
| LT3116897T (lt) * | 2014-03-11 | 2022-05-10 | Spero Therapeutics, Inc. | Polimiksino dariniai ir jų panaudojimas kompleksinėje terapijoje kartu su skirtingais antibiotikais |
| EP3224273A1 (en) | 2014-11-26 | 2017-10-04 | New Pharma Licence Holdings Limited | Compounds |
| CN107257803B (zh) * | 2014-12-16 | 2021-02-05 | 上海盟科药业股份有限公司 | 用于治疗细菌感染的多粘菌素类抗菌剂 |
| FI126143B (en) | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| KR101790296B1 (ko) * | 2015-03-26 | 2017-10-26 | 한국생명공학연구원 | 네트롭신을 유효성분으로 포함하는 그람음성 세균에 대한 폴리믹신의 항균 활성을 증가시키는 조성물 |
| WO2016166103A1 (en) * | 2015-04-13 | 2016-10-20 | Xellia Pharmaceuticals Aps | Polymyxin derivatives |
| AU2016331658B2 (en) * | 2015-09-29 | 2021-04-01 | Monash University | Antimicrobial polymyxin derivative compounds |
| EP3500254B1 (en) * | 2016-08-16 | 2022-03-23 | University of Rochester | Pharmaceutical composition containing polymyxin b/trimethoprim based therapeutics |
| CN106631902A (zh) * | 2016-09-23 | 2017-05-10 | 上海步越化工科技有限公司 | 一种特拉万星侧链癸基(2‑氧代乙基)氨基甲酸9h‑芴‑9‑甲基酯的制备方法 |
| WO2019018286A1 (en) * | 2017-07-17 | 2019-01-24 | President And Fellows Of Harvard College | METHODS OF TREATING BACTERIAL INFECTIONS |
| WO2019085926A1 (zh) * | 2017-10-31 | 2019-05-09 | 上海医药工业研究院 | 多黏菌素类似物及其制备方法 |
| US11279733B2 (en) | 2017-11-02 | 2022-03-22 | The University Of Queensland | Peptide antibiotics |
| WO2019178119A1 (en) | 2018-03-12 | 2019-09-19 | President And Fellows Of Harvard College | Aminocoumarin compounds and methods of their use |
| PL3810633T3 (pl) | 2018-06-25 | 2024-04-08 | Spero Therapeutics, Inc. | Związki |
| CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| CN116437929B (zh) * | 2020-07-02 | 2025-11-11 | 普渡研究基金会 | 抗微生物化合物的吸入制剂 |
| TW202233649A (zh) | 2020-11-06 | 2022-09-01 | 美商斯佩羅治療學股份有限公司 | 化合物 |
| JP7621502B2 (ja) * | 2021-02-02 | 2025-01-24 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー | ビフェニル誘導体化合物を有効成分として含有する抗菌補助剤及びこの用途 |
| US11851422B2 (en) | 2021-07-09 | 2023-12-26 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2024003042A1 (en) | 2022-06-28 | 2024-01-04 | Breakthrough Biotech Drift Aps | Novel combinations of sesquiterpene alcohols, polymyxins and nisin compounds as antimicobial and/or antifungal compounds |
| CN120548184A (zh) * | 2022-11-14 | 2025-08-26 | 希普拉有限公司 | 新型眼科组合物 |
| WO2025030169A2 (en) * | 2023-08-03 | 2025-02-06 | Arcum Vision Inc. | Enhanced formulation of polymyxin b/ trimethoprim and rifampin and methods for ophthalmic uses |
| KR20250037611A (ko) * | 2023-09-07 | 2025-03-18 | 웰펩 주식회사 | 그람 음성균 및 다제내성 그람 음성균에 우수한 항균 활성을 갖는 신규 폴리믹신 유사체, 이를 포함하는 항균용 조성물 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| AU7753787A (en) | 1986-08-06 | 1988-02-24 | Jean-Luc Fauchere | Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b |
| US20010021697A1 (en) | 1987-09-14 | 2001-09-13 | Henning Lowenstein | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components |
| TW274552B (enExample) | 1992-05-26 | 1996-04-21 | Hoechst Ag | |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| JP4583559B2 (ja) * | 2000-07-24 | 2010-11-17 | 栄研化学株式会社 | Ｍｒｓａスクリーニング用培地 |
| CA2540742A1 (en) | 2003-09-30 | 2005-04-14 | Terry Hicks | Compositions and methods for treating burns |
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| WO2008001773A1 (fr) | 2006-06-27 | 2008-01-03 | Toyo Tire & Rubber Co., Ltd. | pneu apte à rouler dégonflé |
| CN103059106B (zh) | 2006-08-11 | 2015-01-14 | 北方抗生素有限公司 | 多粘菌素衍生物及其用途 |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| US8193148B2 (en) | 2008-02-08 | 2012-06-05 | Northern Antibiotics Ltd. | Short fatty acid tail polymyxin derivatives and uses thereof |
| US8329645B2 (en) | 2008-02-08 | 2012-12-11 | Northern Antibiotics Ltd. | Polymyxin derivatives and uses thereof |
| ES2334547B1 (es) | 2008-09-10 | 2010-12-03 | Universidad De Barcelona | Compuestos peptidicos antibacterianos. |
| US8343912B2 (en) | 2008-12-23 | 2013-01-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| JP5493387B2 (ja) * | 2009-02-25 | 2014-05-14 | 国立大学法人 東京大学 | 選択培地の製造方法及びその利用 |
| CN101851270A (zh) | 2009-04-03 | 2010-10-06 | 梁浩 | 一种多粘菌素衍生物及其制备方法 |
| WO2010130007A1 (en) | 2009-05-14 | 2010-11-18 | Monash University | Antimicrobial compounds |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| US9226786B2 (en) * | 2011-03-22 | 2016-01-05 | Lexion Medical Llc | Medical devices for clearing a surgical site |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| WO2013072695A1 (en) * | 2011-11-18 | 2013-05-23 | Novacta Biosystems Limited | Polymyxin derivatives |
| PL2999711T3 (pl) | 2013-05-22 | 2022-09-26 | Spero Therapeutics, Inc. | Pochodne polimyksyny i ich zastosowanie w terapii skojarzonej razem z różnymi antybiotykami |
| US10047126B2 (en) | 2014-04-01 | 2018-08-14 | Monash University | Polymyxin derivatives as antimicrobial compounds |
-
2014
- 2014-05-21 PL PL14726731.4T patent/PL2999711T3/pl unknown
- 2014-05-21 TW TW103117787A patent/TWI665218B/zh active
- 2014-05-21 JP JP2016514479A patent/JP6643758B2/ja active Active
- 2014-05-21 HR HRP20220898TT patent/HRP20220898T1/hr unknown
- 2014-05-21 US US14/892,757 patent/US10407467B2/en active Active
- 2014-05-21 KR KR1020157035048A patent/KR102354902B1/ko active Active
- 2014-05-21 RS RS20220760A patent/RS63484B1/sr unknown
- 2014-05-21 HU HUE14726731A patent/HUE059544T2/hu unknown
- 2014-05-21 EP EP14726731.4A patent/EP2999711B1/en active Active
- 2014-05-21 BR BR112015029309A patent/BR112015029309A2/pt active Search and Examination
- 2014-05-21 CN CN201480029145.2A patent/CN105308065B/zh active Active
- 2014-05-21 ES ES14726731T patent/ES2923762T3/es active Active
- 2014-05-21 DK DK14726731.4T patent/DK2999711T3/da active
- 2014-05-21 SI SI201431984T patent/SI2999711T1/sl unknown
- 2014-05-21 PT PT147267314T patent/PT2999711T/pt unknown
- 2014-05-21 CA CA2939061A patent/CA2939061C/en active Active
- 2014-05-21 WO PCT/GB2014/051547 patent/WO2014188178A1/en not_active Ceased
- 2014-05-21 RU RU2015148032A patent/RU2730012C2/ru active
- 2014-05-21 LT LTEPPCT/GB2014/051547T patent/LT2999711T/lt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2999711A1 (en) | 2016-03-30 |
| TW201444876A (zh) | 2014-12-01 |
| SI2999711T1 (sl) | 2022-10-28 |
| DK2999711T3 (da) | 2022-07-18 |
| RS63484B1 (sr) | 2022-09-30 |
| WO2014188178A1 (en) | 2014-11-27 |
| US20160222061A1 (en) | 2016-08-04 |
| ES2923762T3 (es) | 2022-09-30 |
| RU2730012C2 (ru) | 2020-08-14 |
| KR20160009041A (ko) | 2016-01-25 |
| LT2999711T (lt) | 2022-09-12 |
| PL2999711T3 (pl) | 2022-09-26 |
| TWI665218B (zh) | 2019-07-11 |
| CN105308065B (zh) | 2021-10-15 |
| HK1221474A1 (en) | 2017-06-02 |
| CA2939061C (en) | 2023-10-24 |
| JP2016527186A (ja) | 2016-09-08 |
| KR102354902B1 (ko) | 2022-01-24 |
| HUE059544T2 (hu) | 2022-11-28 |
| HRP20220898T1 (hr) | 2022-10-14 |
| WO2014188178A9 (en) | 2015-01-08 |
| BR112015029309A2 (pt) | 2017-07-25 |
| RU2015148032A (ru) | 2017-06-27 |
| CA2939061A1 (en) | 2014-11-27 |
| CN105308065A (zh) | 2016-02-03 |
| US10407467B2 (en) | 2019-09-10 |
| EP2999711B1 (en) | 2022-06-29 |
| JP6643758B2 (ja) | 2020-02-12 |
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