HRP20220898T1 - Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima - Google Patents
Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima Download PDFInfo
- Publication number
- HRP20220898T1 HRP20220898T1 HRP20220898TT HRP20220898T HRP20220898T1 HR P20220898 T1 HRP20220898 T1 HR P20220898T1 HR P20220898T T HRP20220898T T HR P20220898TT HR P20220898 T HRP20220898 T HR P20220898T HR P20220898 T1 HRP20220898 T1 HR P20220898T1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201309248A GB201309248D0 (en) | 2013-05-22 | 2013-05-22 | Compounds and combinations |
| GB201404301A GB201404301D0 (en) | 2014-03-11 | 2014-03-11 | Compounds and combinations |
| EP14726731.4A EP2999711B1 (en) | 2013-05-22 | 2014-05-21 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
| PCT/GB2014/051547 WO2014188178A1 (en) | 2013-05-22 | 2014-05-21 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220898T1 true HRP20220898T1 (hr) | 2022-10-14 |
Family
ID=50829204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220898TT HRP20220898T1 (hr) | 2013-05-22 | 2014-05-21 | Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10407467B2 (enExample) |
| EP (1) | EP2999711B1 (enExample) |
| JP (1) | JP6643758B2 (enExample) |
| KR (1) | KR102354902B1 (enExample) |
| CN (1) | CN105308065B (enExample) |
| BR (1) | BR112015029309A2 (enExample) |
| CA (1) | CA2939061C (enExample) |
| CY (1) | CY1125479T1 (enExample) |
| DK (1) | DK2999711T3 (enExample) |
| ES (1) | ES2923762T3 (enExample) |
| HR (1) | HRP20220898T1 (enExample) |
| HU (1) | HUE059544T2 (enExample) |
| LT (1) | LT2999711T (enExample) |
| PL (1) | PL2999711T3 (enExample) |
| PT (1) | PT2999711T (enExample) |
| RS (1) | RS63484B1 (enExample) |
| RU (1) | RU2730012C2 (enExample) |
| SI (1) | SI2999711T1 (enExample) |
| TW (1) | TWI665218B (enExample) |
| WO (1) | WO2014188178A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX355217B (es) | 2011-11-18 | 2018-04-10 | New Pharma Licence Holdings Ltd | Derivados de polimixina. |
| HUE059544T2 (hu) | 2013-05-22 | 2022-11-28 | Spero Therapeutics Inc | Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal |
| EP3038615A4 (en) * | 2013-08-28 | 2017-04-12 | The Medicines Company | Methods for treating bacterial infections using oritavancin and polymyxins |
| KR20160135739A (ko) * | 2014-03-11 | 2016-11-28 | 뉴 파마 라이센스 홀딩스 리미티드 | 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 |
| CN107108699A (zh) | 2014-11-26 | 2017-08-29 | 新药物许可控股有限公司 | 化合物 |
| EP3233889B1 (en) * | 2014-12-16 | 2022-07-06 | Shanghai MicuRx Pharmaceutical Co., Ltd. | Antimicrobial polymyxins for treatment of bacterial infections |
| FI126143B (en) | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| KR101790296B1 (ko) * | 2015-03-26 | 2017-10-26 | 한국생명공학연구원 | 네트롭신을 유효성분으로 포함하는 그람음성 세균에 대한 폴리믹신의 항균 활성을 증가시키는 조성물 |
| WO2016166103A1 (en) * | 2015-04-13 | 2016-10-20 | Xellia Pharmaceuticals Aps | Polymyxin derivatives |
| JP7367950B2 (ja) * | 2015-09-29 | 2023-10-24 | モナッシュ ユニバーシティ | 抗菌性ポリミキシン誘導体化合物 |
| CN109789125B (zh) * | 2016-08-16 | 2022-10-18 | 罗切斯特大学 | 含有基于多粘菌素b/甲氧苄啶的治疗剂的药物组合物 |
| CN106631902A (zh) * | 2016-09-23 | 2017-05-10 | 上海步越化工科技有限公司 | 一种特拉万星侧链癸基(2‑氧代乙基)氨基甲酸9h‑芴‑9‑甲基酯的制备方法 |
| US11191773B2 (en) | 2017-07-17 | 2021-12-07 | President And Fellows Of Harvard College | Methods of treatment for bacterial infections |
| CN111247162B (zh) * | 2017-10-31 | 2022-02-18 | 正大天晴药业集团股份有限公司 | 多黏菌素类似物及其制备方法 |
| WO2019084628A1 (en) | 2017-11-02 | 2019-05-09 | The University Of Queensland | Peptide antibiotics |
| US11713335B2 (en) | 2018-03-12 | 2023-08-01 | President And Fellows Of Harvard College | Aminocoumarin compounds and methods of their use |
| DK3810633T3 (da) | 2018-06-25 | 2024-01-15 | Spero Therapeutics Inc | Forbindelser |
| CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| US20220395555A1 (en) * | 2020-06-11 | 2022-12-15 | Boris Farber | Derivatives of antibiotics |
| US12472195B2 (en) | 2020-07-02 | 2025-11-18 | Purdue Research Foundation | Inhalation formulations of antimicrobial compounds |
| TW202233649A (zh) | 2020-11-06 | 2022-09-01 | 美商斯佩羅治療學股份有限公司 | 化合物 |
| CN116847735B (zh) * | 2021-02-02 | 2026-02-03 | 韩国生命工学研究院 | 含有联苯基衍生物化合物作为有效成分的抗菌佐剂及其用途 |
| WO2023283256A1 (en) | 2021-07-09 | 2023-01-12 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2024003042A1 (en) | 2022-06-28 | 2024-01-04 | Breakthrough Biotech Drift Aps | Novel combinations of sesquiterpene alcohols, polymyxins and nisin compounds as antimicobial and/or antifungal compounds |
| AU2023303408A1 (en) | 2022-07-06 | 2024-12-19 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| EP4611762A1 (en) * | 2022-11-14 | 2025-09-10 | Cipla Limited | Novel ophthalmic composition |
| KR102952821B1 (ko) * | 2022-11-23 | 2026-04-16 | 웰펩 주식회사 | 폴리믹신 e 및 폴리믹신 b의 제조방법 |
| CN116212004A (zh) * | 2022-12-07 | 2023-06-06 | 东南大学 | 一种复合抗生素吸入用粉剂及其制备方法与应用 |
| IL326320A (en) * | 2023-08-03 | 2026-04-01 | Arcum Vision Inc | Enhanced formulation of polymyxin b/ trimethoprim and rifampin and methods for ophthalmic uses |
| KR20250037611A (ko) * | 2023-09-07 | 2025-03-18 | 웰펩 주식회사 | 그람 음성균 및 다제내성 그람 음성균에 우수한 항균 활성을 갖는 신규 폴리믹신 유사체, 이를 포함하는 항균용 조성물 |
| WO2025236916A1 (en) * | 2024-05-16 | 2025-11-20 | Brii Biosciences, Inc. | Compositions and methods for treating infections |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| AU7753787A (en) | 1986-08-06 | 1988-02-24 | Jean-Luc Fauchere | Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b |
| US20010021697A1 (en) | 1987-09-14 | 2001-09-13 | Henning Lowenstein | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components |
| TW274552B (enExample) | 1992-05-26 | 1996-04-21 | Hoechst Ag | |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| JP4583559B2 (ja) * | 2000-07-24 | 2010-11-17 | 栄研化学株式会社 | Ｍｒｓａスクリーニング用培地 |
| JP2007507512A (ja) | 2003-09-30 | 2007-03-29 | コーヒ コーポレーション | 熱傷を治療するための組成物および方法 |
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| WO2008001773A1 (fr) | 2006-06-27 | 2008-01-03 | Toyo Tire & Rubber Co., Ltd. | pneu apte à rouler dégonflé |
| BRPI0715095B8 (pt) * | 2006-08-11 | 2021-05-25 | Northern Antibiotics Oy | derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i). |
| US8193148B2 (en) | 2008-02-08 | 2012-06-05 | Northern Antibiotics Ltd. | Short fatty acid tail polymyxin derivatives and uses thereof |
| US8329645B2 (en) | 2008-02-08 | 2012-12-11 | Northern Antibiotics Ltd. | Polymyxin derivatives and uses thereof |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| ES2334547B1 (es) | 2008-09-10 | 2010-12-03 | Universidad De Barcelona | Compuestos peptidicos antibacterianos. |
| WO2010075416A1 (en) | 2008-12-23 | 2010-07-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| JP5493387B2 (ja) * | 2009-02-25 | 2014-05-14 | 国立大学法人 東京大学 | 選択培地の製造方法及びその利用 |
| CN101851270A (zh) | 2009-04-03 | 2010-10-06 | 梁浩 | 一种多粘菌素衍生物及其制备方法 |
| WO2010130007A1 (en) | 2009-05-14 | 2010-11-18 | Monash University | Antimicrobial compounds |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| US9226786B2 (en) * | 2011-03-22 | 2016-01-05 | Lexion Medical Llc | Medical devices for clearing a surgical site |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| MX355217B (es) * | 2011-11-18 | 2018-04-10 | New Pharma Licence Holdings Ltd | Derivados de polimixina. |
| HUE059544T2 (hu) | 2013-05-22 | 2022-11-28 | Spero Therapeutics Inc | Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal |
| US10047126B2 (en) | 2014-04-01 | 2018-08-14 | Monash University | Polymyxin derivatives as antimicrobial compounds |
-
2014
- 2014-05-21 HU HUE14726731A patent/HUE059544T2/hu unknown
- 2014-05-21 PT PT147267314T patent/PT2999711T/pt unknown
- 2014-05-21 LT LTEPPCT/GB2014/051547T patent/LT2999711T/lt unknown
- 2014-05-21 HR HRP20220898TT patent/HRP20220898T1/hr unknown
- 2014-05-21 CN CN201480029145.2A patent/CN105308065B/zh active Active
- 2014-05-21 CA CA2939061A patent/CA2939061C/en active Active
- 2014-05-21 TW TW103117787A patent/TWI665218B/zh active
- 2014-05-21 RU RU2015148032A patent/RU2730012C2/ru active
- 2014-05-21 WO PCT/GB2014/051547 patent/WO2014188178A1/en not_active Ceased
- 2014-05-21 US US14/892,757 patent/US10407467B2/en active Active
- 2014-05-21 JP JP2016514479A patent/JP6643758B2/ja active Active
- 2014-05-21 RS RS20220760A patent/RS63484B1/sr unknown
- 2014-05-21 BR BR112015029309A patent/BR112015029309A2/pt active Search and Examination
- 2014-05-21 ES ES14726731T patent/ES2923762T3/es active Active
- 2014-05-21 KR KR1020157035048A patent/KR102354902B1/ko active Active
- 2014-05-21 DK DK14726731.4T patent/DK2999711T3/da active
- 2014-05-21 PL PL14726731.4T patent/PL2999711T3/pl unknown
- 2014-05-21 SI SI201431984T patent/SI2999711T1/sl unknown
- 2014-05-21 EP EP14726731.4A patent/EP2999711B1/en active Active
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2022
- 2022-08-11 CY CY20221100550T patent/CY1125479T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE059544T2 (hu) | 2022-11-28 |
| PT2999711T (pt) | 2022-07-29 |
| PL2999711T3 (pl) | 2022-09-26 |
| US10407467B2 (en) | 2019-09-10 |
| CA2939061A1 (en) | 2014-11-27 |
| CN105308065B (zh) | 2021-10-15 |
| CA2939061C (en) | 2023-10-24 |
| KR20160009041A (ko) | 2016-01-25 |
| SI2999711T1 (sl) | 2022-10-28 |
| HK1221474A1 (en) | 2017-06-02 |
| DK2999711T3 (da) | 2022-07-18 |
| EP2999711B1 (en) | 2022-06-29 |
| TW201444876A (zh) | 2014-12-01 |
| KR102354902B1 (ko) | 2022-01-24 |
| WO2014188178A9 (en) | 2015-01-08 |
| JP2016527186A (ja) | 2016-09-08 |
| RU2015148032A (ru) | 2017-06-27 |
| JP6643758B2 (ja) | 2020-02-12 |
| EP2999711A1 (en) | 2016-03-30 |
| CN105308065A (zh) | 2016-02-03 |
| US20160222061A1 (en) | 2016-08-04 |
| TWI665218B (zh) | 2019-07-11 |
| CY1125479T1 (el) | 2026-02-25 |
| LT2999711T (lt) | 2022-09-12 |
| RS63484B1 (sr) | 2022-09-30 |
| RU2730012C2 (ru) | 2020-08-14 |
| ES2923762T3 (es) | 2022-09-30 |
| WO2014188178A1 (en) | 2014-11-27 |
| BR112015029309A2 (pt) | 2017-07-25 |
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