PE20110344A1 - Derivados de etanodiamida como inhibidores de la integrasa del vih - Google Patents

Derivados de etanodiamida como inhibidores de la integrasa del vih

Info

Publication number
PE20110344A1
PE20110344A1 PE2011000840A PE2011000840A PE20110344A1 PE 20110344 A1 PE20110344 A1 PE 20110344A1 PE 2011000840 A PE2011000840 A PE 2011000840A PE 2011000840 A PE2011000840 A PE 2011000840A PE 20110344 A1 PE20110344 A1 PE 20110344A1
Authority
PE
Peru
Prior art keywords
alkyl
ethanodiamide
inhibitors
hiv integrase
trimethylethanodiamide
Prior art date
Application number
PE2011000840A
Other languages
English (en)
Inventor
Richard C A Isaacs
Wayne J Thompson
Peter D Williams
Dai-Shi Su
Shankar Venkatraman
Mark W Embrey
Thorsten E Fisher
John S Wai
David C Dubost
Richard G Ball
Eric J Choi
Tao Pei
Sarah L Trice
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PE20110344A1 publication Critical patent/PE20110344A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/0001—Technical content checked by a classifier
    • H01L2924/0002—Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE ETANODIAMIDA DE FORMULA (I), DONDE X1 Y X2 SON H, HALOGENO, ALQUILO C1-C3; Y ES CH2 U O; R1A ES H O ALQUILO C1-C3; R1B ES H, ALQUILO C1-C3, O-ALQUILO C1-C4; R2 ES H O ALQUILO C1-C3; R3 ES ALQUILO C1-C3. SON COMPUESTOS PREFERIDOS: N-((10R)-2-{[4-FLUORO-3-METILBENCIL)AMINO]CARBONIL}-3-HIDROXI-7,7-DIMETIL-4-OXO-4,6,7,8,9,10-HEXAHIDROPIRIMIDO[1,2-a]AZEPIN-10-IL)-N,N',N'-TRIMETILETANODIAMIDA, N-((6S,10S)-2-{[(4-FLUORO-3-METILBENCIL)AMINO]CARBONIL}-3-HIDROXI-6-METIL-4-OXO-6,7,9,10-TETRAHIDRO-4H-PIRIMIDO[1,2-d][1,4]OXAZEPIN-10-IL)-N,N',N'-TRIMETILETANODIAMIDA, N-((6S,10S)-6-ETIL-2-{[(4-FLUOROBENCIL)AMINO]CARBONIL}-3-HIDROXI-4-OXO-6,7,9,10-TETRAHIDRO-4-PIRIMIDO[1,2-d][1,4]OXAZEPIN-10-IL)-N,N',N'-TRIMETILETANODIAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA INTEGRASA DEL VIH Y SON UTILES EN EL TRATAMIENTO DE LA INFECCION POR VIH
PE2011000840A 2008-10-06 2009-10-02 Derivados de etanodiamida como inhibidores de la integrasa del vih PE20110344A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19527108P 2008-10-06 2008-10-06

Publications (1)

Publication Number Publication Date
PE20110344A1 true PE20110344A1 (es) 2011-06-22

Family

ID=41682332

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000840A PE20110344A1 (es) 2008-10-06 2009-10-02 Derivados de etanodiamida como inhibidores de la integrasa del vih

Country Status (22)

Country Link
US (2) US8513234B2 (es)
EP (1) EP2349276B1 (es)
JP (2) JP4880097B1 (es)
KR (1) KR20110066224A (es)
CN (1) CN102239172A (es)
AR (1) AR073769A1 (es)
AU (1) AU2009302663B2 (es)
BR (1) BRPI0920605A8 (es)
CA (1) CA2738814C (es)
CO (1) CO6382127A2 (es)
CR (1) CR20110184A (es)
DO (1) DOP2011000093A (es)
EA (1) EA201170537A1 (es)
EC (1) ECSP11010959A (es)
IL (1) IL212019A0 (es)
MA (1) MA32764B1 (es)
MX (1) MX2011003637A (es)
NI (1) NI201100069A (es)
PE (1) PE20110344A1 (es)
TW (1) TW201020251A (es)
WO (2) WO2010042391A2 (es)
ZA (1) ZA201102620B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
WO2014008636A1 (en) * 2012-07-11 2014-01-16 Merck Sharp & Dohme Corp. Macrocyclic compounds as hiv integrase inhibitors
CN102936188B (zh) * 2012-11-19 2015-07-15 湖北吉和昌化工科技有限公司 一种丙炔醇缩水甘油醚的合成方法
EP2986291B1 (en) 2013-04-16 2020-05-27 Merck Sharp & Dohme Corp. 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
CN107722106A (zh) * 2016-08-11 2018-02-23 重庆大学 Hiv抑制剂
JP7181470B2 (ja) 2018-02-08 2022-12-01 株式会社ソシオネクスト 加算回路、受信回路及び集積回路
WO2020197991A1 (en) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
CA3166480A1 (en) 2020-02-24 2021-09-02 Lan Jiang Tetracyclic compounds for treating hiv infection
CN111454214B (zh) * 2020-05-27 2023-04-07 龙曦宁（上海）医药科技有限公司 一种2-甲氧基1-嘧啶乙胺盐酸盐的合成方法
PE20231297A1 (es) 2021-01-19 2023-08-22 Gilead Sciences Inc Compuestos de piridotriazina sustituidos y usos de estos

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4338192B2 (ja) * 2001-08-10 2009-10-07 塩野義製薬株式会社 抗ウイルス剤
SI1441734T1 (sl) * 2001-10-26 2007-08-31 Angeletti P Ist Richerche Bio Dihidropirimidin karboksamidni inhibitorji HIV-integraze
ATE318140T1 (de) * 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio N-substituierte hydroxypyrimidinoncarboxamid- hemmer der hiv-integrase
AU2003216049B2 (en) * 2002-01-17 2008-07-17 Merck Sharp & Dohme Corp. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
WO2004058757A1 (en) * 2002-12-27 2004-07-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
WO2004062613A2 (en) * 2003-01-13 2004-07-29 Bristol-Myers Squibb Company Hiv integrase inhibitors
US7037908B2 (en) * 2003-04-24 2006-05-02 Bristol-Myers Squibb Company HIV integrase inhibitors
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
AR046938A1 (es) * 2003-12-12 2006-01-04 Merck & Co Inc Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares
TW200526635A (en) * 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
JP4895220B2 (ja) * 2004-04-06 2012-03-14 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド キネシン有糸分裂インヒビター
US7273859B2 (en) * 2004-05-12 2007-09-25 Bristol-Myers Squibb Company HIV integrase inhibitors: cyclic pyrimidinone compounds
US7115601B2 (en) * 2004-05-18 2006-10-03 Bristol-Myers Squibb Company HIV integrase inhibitors
US7192948B2 (en) * 2004-05-28 2007-03-20 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7176196B2 (en) * 2004-05-28 2007-02-13 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7157447B2 (en) * 2004-05-28 2007-01-02 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
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WO2006060225A2 (en) * 2004-11-23 2006-06-08 Merck & Co., Inc. Process for asymmetric synthesis of hexahydropyrimido[1,2-a] azepine-2-carboxamides and related compounds
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US7494984B2 (en) * 2005-08-31 2009-02-24 Bristol-Myers Squibb Company Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors
WO2007059125A2 (en) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors
WO2007058646A1 (en) 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors: cyclic pyrimidinone compounds
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
US8039458B2 (en) * 2005-11-17 2011-10-18 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007064316A1 (en) 2005-11-30 2007-06-07 Bristol-Myers Squibb Company Bicyclic heterocycles as hiv integrase inhibitors
US7897593B2 (en) * 2006-05-30 2011-03-01 Bristol-Myers Squibb Company HIV integrase inhibitors
US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors

Also Published As

Publication number Publication date
BRPI0920605A2 (pt) 2015-12-22
US8513234B2 (en) 2013-08-20
EP2349276B1 (en) 2019-11-27
US20100087419A1 (en) 2010-04-08
KR20110066224A (ko) 2011-06-16
WO2010042391A3 (en) 2010-06-03
WO2010042391A2 (en) 2010-04-15
CN102239172A (zh) 2011-11-09
ZA201102620B (en) 2011-12-28
EP2349276A2 (en) 2011-08-03
ECSP11010959A (es) 2011-05-31
JP2012036207A (ja) 2012-02-23
JP2012504648A (ja) 2012-02-23
MA32764B1 (fr) 2011-11-01
US20130338141A1 (en) 2013-12-19
NI201100069A (es) 2012-08-08
WO2010042392A2 (en) 2010-04-15
CA2738814A1 (en) 2010-04-15
JP5600311B2 (ja) 2014-10-01
IL212019A0 (en) 2011-06-30
MX2011003637A (es) 2011-04-27
EA201170537A1 (ru) 2011-12-30
TW201020251A (en) 2010-06-01
AR073769A1 (es) 2010-12-01
JP4880097B1 (ja) 2012-02-22
WO2010042392A3 (en) 2010-06-03
DOP2011000093A (es) 2011-07-15
CO6382127A2 (es) 2012-02-15
CR20110184A (es) 2011-06-08
AU2009302663A1 (en) 2010-04-15
BRPI0920605A8 (pt) 2016-04-26
CA2738814C (en) 2014-01-28
AU2009302663B2 (en) 2012-11-08

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