JP2016526576A5 - - Google Patents
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- JP2016526576A5 JP2016526576A5 JP2016527011A JP2016527011A JP2016526576A5 JP 2016526576 A5 JP2016526576 A5 JP 2016526576A5 JP 2016527011 A JP2016527011 A JP 2016527011A JP 2016527011 A JP2016527011 A JP 2016527011A JP 2016526576 A5 JP2016526576 A5 JP 2016526576A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- indol
- methoxy
- piperidin
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361846355P | 2013-07-15 | 2013-07-15 | |
| US61/846,355 | 2013-07-15 | ||
| US201461977028P | 2014-04-08 | 2014-04-08 | |
| US61/977,028 | 2014-04-08 | ||
| PCT/US2014/046515 WO2015009616A1 (en) | 2013-07-15 | 2014-07-14 | Piperidinyl indole derivatives and their use as complement factor b inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526576A JP2016526576A (ja) | 2016-09-05 |
| JP2016526576A5 true JP2016526576A5 (https=) | 2018-05-31 |
| JP6378761B2 JP6378761B2 (ja) | 2018-08-22 |
Family
ID=51230246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527011A Active JP6378761B2 (ja) | 2013-07-15 | 2014-07-14 | ピペリジニル−インドール誘導体および補体因子ｂ阻害剤としてのその使用 |
Country Status (40)
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3425B1 (ar) | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| EP3472129A4 (en) * | 2016-06-21 | 2019-12-04 | X4 Pharmaceuticals, Inc. | CXCR4 INHIBITORS AND USES THEREOF |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| SG11201811491YA (en) * | 2016-06-27 | 2019-01-30 | Achillion Pharmaceuticals Inc | Quinazoline and indole compounds to treat medical disorders |
| CN113444046B (zh) * | 2016-07-20 | 2023-10-27 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| CN110603252A (zh) | 2017-03-01 | 2019-12-20 | 艾其林医药公司 | 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物 |
| KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
| RS66635B1 (sr) | 2017-08-31 | 2025-04-30 | Novartis Ag | Derivati piperidinil-indola za upotrebu u lečenju c3 glomerulopatije |
| CN120118068A (zh) * | 2018-07-16 | 2025-06-10 | 诺华股份有限公司 | 用于制备苯基哌啶基吲哚衍生物的化学方法 |
| US20230022157A1 (en) | 2018-08-20 | 2023-01-26 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| WO2020051538A1 (en) | 2018-09-06 | 2020-03-12 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor d inhibitors |
| JP7443375B2 (ja) | 2018-09-06 | 2024-03-05 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 医学的障害の治療のための大環状化合物 |
| KR20210093855A (ko) | 2018-09-25 | 2021-07-28 | 아칠리온 파르마세우티칼스 인코포레이티드 | 보체 인자 d 억제제의 형태체 형태 |
| CN113271964A (zh) | 2019-01-11 | 2021-08-17 | 诺华股份有限公司 | 化脓性汗腺炎治疗中使用的抗cd40抗体 |
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| JP7761567B2 (ja) | 2020-02-18 | 2025-10-28 | ノヴォ ノルディスク アー／エス | 医薬製剤 |
| CN115362162A (zh) | 2020-02-20 | 2022-11-18 | 艾其林医药公司 | 用于治疗补体因子d介导的障碍的杂芳基化合物 |
| CN120208923A (zh) | 2020-05-18 | 2025-06-27 | 诺华股份有限公司 | Lnp023的结晶形式 |
| JP7293513B2 (ja) | 2020-07-16 | 2023-06-19 | ノバルティス アーゲー | Ｂ因子阻害剤の使用方法 |
| US11951101B2 (en) | 2020-07-16 | 2024-04-09 | Novartis Ag | Methods of using factor B inhibitors |
| KR20230049115A (ko) * | 2020-08-07 | 2023-04-12 | 상하이 메이유에 바이오테크 디벨롭먼트 컴퍼니 리미티드 | 보체 인자 b 억제제 및 이의 약학적 조성물, 제조 방법 및 용도 |
| WO2022028507A1 (zh) * | 2020-08-07 | 2022-02-10 | 上海美悦生物科技发展有限公司 | 一种杂环类化合物、其制备方法及用途 |
| CN116437913A (zh) | 2020-09-23 | 2023-07-14 | 艾其林医药公司 | 用于治疗补体介导的病症的药物化合物 |
| AU2021414253B2 (en) * | 2020-12-30 | 2024-05-16 | Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. | Series of piperidine-substituted benzoic acid compounds, and use thereof |
| CA3203320A1 (en) * | 2020-12-30 | 2022-07-07 | Xin Li | Nitrogen-containing bridged heterocyclic compound, preparation method therefor, and medical use thereof |
| CN116848238A (zh) * | 2021-01-14 | 2023-10-03 | 阿雷克森制药公司 | 大环补体因子b抑制剂 |
| US20240217953A1 (en) * | 2021-04-16 | 2024-07-04 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bicyclic substituted aromatic carboxylic acid compounds |
| MX2023013148A (es) * | 2021-05-07 | 2023-11-28 | Novartis Ag | Iptacopan para el tratamiento del sindrome uremico hemolitico atipico. |
| CN120081822A (zh) * | 2021-06-03 | 2025-06-03 | 诺瓦提斯药物公司 | 经取代的吲哚化合物及其使用方法 |
| JP2024522769A (ja) | 2021-06-18 | 2024-06-21 | ノバルティス アーゲー | 自己免疫性血液学的疾患を治療する方法 |
| EP4362933A4 (en) * | 2021-06-30 | 2025-06-04 | Apellis Pharmaceuticals, Inc. | COMPLEMENT INHIBITION |
| EP4389742A4 (en) | 2021-08-18 | 2026-01-14 | Xizang Haisco Pharmaceutical Co Ltd | HETEROAROMATIC CYCLE DERIVATIVE CONTAINING BENZO NITROGEN AND ITS USE IN MEDICINE |
| WO2023037218A1 (en) | 2021-09-07 | 2023-03-16 | Novartis Ag | Use of factor b inhibitors for the treatment of age-related macular degeneration |
| TW202334121A (zh) * | 2021-10-27 | 2023-09-01 | 美商翰森生物有限責任公司 | 哌啶基吲哚衍生物、其製備方法及醫藥用途 |
| CA3247772A1 (en) | 2022-01-24 | 2023-07-27 | Novartis Ag | Spirocyclic piperidinyl derivatives as complement factor B inhibitors and their uses |
| WO2023143293A1 (zh) | 2022-01-26 | 2023-08-03 | 上海美悦生物科技发展有限公司 | 补体因子b抑制剂的盐型、晶型及其制备方法和应用 |
| TW202342048A (zh) | 2022-02-28 | 2023-11-01 | 瑞士商諾華公司 | 使用ｌｏｕ０６４治療化膿性汗腺炎之方法 |
| IL314494A (en) | 2022-03-04 | 2024-09-01 | Novartis Ag | Use of iptacopan for the treatment of lupus nephritis |
| UY40204A (es) | 2022-04-01 | 2023-10-31 | Novartis Ag | Inhibidores del Factor B del Complemento y Usos de los mismos |
| WO2023246677A1 (zh) * | 2022-06-20 | 2023-12-28 | 深圳信立泰药业股份有限公司 | 一种吲哚-苯基哌啶化合物及其制备方法与应用 |
| WO2023246870A1 (zh) * | 2022-06-23 | 2023-12-28 | 上海济煜医药科技有限公司 | 吲哚化合物的制备、应用及用途 |
| JP7849520B2 (ja) * | 2022-06-30 | 2026-04-21 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 含窒素架橋複素環誘導体の薬学的に許容される塩、結晶形及びその調製方法 |
| CN117327070A (zh) * | 2022-06-30 | 2024-01-02 | 江苏恒瑞医药股份有限公司 | 一种含氮桥杂环衍生物的晶型及其制备方法 |
| TWI879050B (zh) * | 2022-08-29 | 2025-04-01 | 新加坡商康哲研發有限公司 | 一系列含氮橋雜環化合物及其製備方法 |
| TW202423426A (zh) * | 2022-08-31 | 2024-06-16 | 美商奇努克醫療股份有限公司 | 經取代之吲哚化合物及其使用方法 |
| CA3266935A1 (en) | 2022-09-10 | 2024-03-14 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Piperidine derivatives substituted at position 2, their preparation methods and medicinal uses |
| JP2025541667A (ja) * | 2022-11-11 | 2025-12-23 | シャンハイ イーシェン バイオファーマシューティカル カンパニー リミテッド | ピペリジン置換安息香酸系化合物、その医薬組成物および使用 |
| IL320661A (en) * | 2022-11-14 | 2025-07-01 | Novartis Pharma Ag | Solid forms of complement factor B inhibitors |
| TWI869080B (zh) * | 2022-11-29 | 2025-01-01 | 大陸商上海濟煜醫藥科技有限公司 | 苯並螺環吲哚化合物的製備及用途 |
| WO2024141011A1 (zh) * | 2022-12-31 | 2024-07-04 | 深圳晶泰科技有限公司 | 补体因子b抑制剂及其药物组合物和应用 |
| WO2024148274A1 (en) * | 2023-01-05 | 2024-07-11 | Apellis Pharmaceuticals, Inc. | Complement inhibition |
| EP4670719A1 (en) | 2023-02-22 | 2025-12-31 | Haisco Pharmaceutical Group Co., Ltd. | PHARMACEUTICAL COMPOSITION OF A HETEROAROMATIC BENZO-NITROGEN RING DERIVATIVE AND ITS USE IN MEDICINE |
| WO2024176169A1 (en) | 2023-02-23 | 2024-08-29 | Novartis Ag | Methods of using factor b inhibitors |
| CN118684668A (zh) * | 2023-03-21 | 2024-09-24 | 上海美悦生物科技发展有限公司 | 螺环类化合物及其药物组合物、制备方法和用途 |
| TW202506657A (zh) | 2023-04-27 | 2025-02-16 | 大陸商上海翰森生物醫藥科技有限公司 | 一種哌啶基吲哚化合物的鹽及其製備方法 |
| IL325760A (en) | 2023-07-04 | 2026-03-01 | Sitala Bio Ltd | History of 2-(1H-indol-4-yl)methyl)-isoindoline as factor B inhibitors |
| CN121889385A (zh) | 2023-07-04 | 2026-04-17 | 希塔拉生物有限公司 | 作为因子b抑制剂的2-(1h-吲哚-4-基)甲基)2h-吲唑衍生物 |
| WO2025008516A2 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Novel compounds |
| WO2025008517A1 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Indole derivatives with factor b inhibitory activity |
| CN119371402A (zh) | 2023-07-26 | 2025-01-28 | 上海美悦生物科技发展有限公司 | 螺环烯基类或氮杂烯基类化合物及其药物组合物、制备方法和用途 |
| TW202508580A (zh) | 2023-08-25 | 2025-03-01 | 瑞士商諾華公司 | 使用因子b抑制劑之方法 |
| TW202515541A (zh) | 2023-09-29 | 2025-04-16 | 瑞士商諾華公司 | 補體因子ｂ抑制劑及其用途 |
| WO2025083621A1 (en) | 2023-10-20 | 2025-04-24 | Novartis Ag | Treatment of hidradenitis suppurativa using anti-baff-r antibodies |
| WO2025119266A1 (zh) * | 2023-12-05 | 2025-06-12 | 西藏海思科制药有限公司 | 苯并氮杂芳环衍生物在治疗补体因子b介导的疾病中的用途 |
| WO2025148628A1 (zh) * | 2024-01-10 | 2025-07-17 | 河北以岭医药研究院有限公司 | 哌啶基吲哚衍生物及其制备方法和应用 |
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
| TW202533829A (zh) | 2024-02-16 | 2025-09-01 | 瑞士商諾華公司 | 用於治療anca相關性血管炎的因子b抑制劑 |
| WO2025185734A1 (zh) * | 2024-03-08 | 2025-09-12 | 江苏豪森药业集团有限公司 | 一种多元螺环化合物的盐及其晶型、其制备方法和医药用途 |
| CN121532400A (zh) * | 2024-05-11 | 2026-02-13 | 礼邦医药(香港)有限公司 | 补体因子b抑制剂 |
| WO2025252133A1 (zh) * | 2024-06-07 | 2025-12-11 | 润尔眼科药物（广州）有限公司 | 一种含吲哚基团的化合物及其用途 |
| WO2025256647A1 (zh) * | 2024-06-14 | 2025-12-18 | 润尔眼科药物（广州）有限公司 | 化合物及其医药用途 |
| WO2026002007A1 (zh) * | 2024-06-25 | 2026-01-02 | 珠海联邦制药股份有限公司 | 补体因子b抑制剂及其药物组合物和应用 |
| WO2026003809A1 (en) * | 2024-06-29 | 2026-01-02 | Assia Chemical Industries Ltd. | Solid state forms of iptacopan hydrochloride |
| WO2026008074A1 (zh) * | 2024-07-05 | 2026-01-08 | 南京正大天晴制药有限公司 | 补体因子b抑制剂的晶型、其制备方法及用途 |
| WO2026069246A1 (en) | 2024-09-30 | 2026-04-02 | Novartis Ag | Complement factor b inhibitors and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR030357A1 (es) | 2000-08-18 | 2003-08-20 | Lundbeck & Co As H | Derivados 4 -, 5 -, 6 - y 7-indol |
| DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
| DE10237723A1 (de) | 2002-08-17 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie |
| WO2004056806A1 (en) | 2002-12-19 | 2004-07-08 | Pfizer Inc. | 2-(1h-indazol-6-ylamino)-benzamide compounds as protein kinases inhibitors useful for the treatment of ophtalmic diseases |
| JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| KR20060006954A (ko) | 2003-04-30 | 2006-01-20 | 디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 | 단백질 티로신 포스파타제-１ｂ 억제제로서의 페닐 치환된카르복실산 |
| EP1836182A2 (en) | 2004-11-18 | 2007-09-26 | The Institutes for Pharmaceutical Discovery, LLC | Heterocyclylbiphenyl derivates as protein tyrosine phosphatase inhibitors |
| CN101115724A (zh) * | 2005-02-08 | 2008-01-30 | 默克公司 | 关卡激酶抑制剂 |
| EP2205085A1 (en) | 2007-09-25 | 2010-07-14 | Merck Sharp & Dohme Corp. | 2-aryl or heteroaryl indole derivatives |
| WO2009076404A1 (en) | 2007-12-10 | 2009-06-18 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
| AR070398A1 (es) | 2008-02-22 | 2010-03-31 | Gruenenthal Chemie | Derivados sustituidos de indol |
| JO3265B1 (ar) | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| JP5852958B2 (ja) | 2009-07-14 | 2016-02-03 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Ｐａｒｐ阻害剤としての３−オキソ−２，３−ジヒドロ−１ｈ−イソインドール−４−カルボキサミド |
| JP5879273B2 (ja) | 2010-03-01 | 2016-03-08 | ジーティーエックス・インコーポレイテッド | 癌を処置するための化合物 |
| US20130310379A1 (en) | 2010-11-19 | 2013-11-21 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| PT2661433T (pt) * | 2011-01-04 | 2017-10-24 | Novartis Ag | Compostos de indole ou seus análogos úteis para o tratamento da degeneração macular relacionada com a idade (amd) |
| EA027113B1 (ru) * | 2012-05-04 | 2017-06-30 | Новартис Аг | Регуляторы пути комплемента и их применение |
| EA201590053A1 (ru) * | 2012-06-20 | 2015-08-31 | Новартис Аг | Модуляторы пути системы комплемента и их применение |
| JO3425B1 (ar) | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
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2014
- 2014-07-13 JO JOP/2014/0224A patent/JO3425B1/ar active
- 2014-07-14 PL PL14744744T patent/PL3022192T3/pl unknown
- 2014-07-14 CA CA2917839A patent/CA2917839C/en active Active
- 2014-07-14 UA UAA201600266A patent/UA117371C2/uk unknown
- 2014-07-14 PE PE2016000651A patent/PE20161066A1/es active IP Right Grant
- 2014-07-14 EP EP14744744.5A patent/EP3022192B1/en active Active
- 2014-07-14 US US14/904,694 patent/US9682968B2/en active Active
- 2014-07-14 AU AU2014290298A patent/AU2014290298B2/en active Active
- 2014-07-14 KR KR1020167003321A patent/KR102242742B1/ko active Active
- 2014-07-14 JP JP2016527011A patent/JP6378761B2/ja active Active
- 2014-07-14 EP EP17191470.8A patent/EP3299365A1/en not_active Withdrawn
- 2014-07-14 HU HUE14744744A patent/HUE037510T2/hu unknown
- 2014-07-14 EA EA201690223A patent/EA031030B1/ru not_active IP Right Cessation
- 2014-07-14 TN TN2016000017A patent/TN2016000017A1/en unknown
- 2014-07-14 MY MYPI2020004691A patent/MY196427A/en unknown
- 2014-07-14 CN CN201480050471.1A patent/CN105579444B/zh active Active
- 2014-07-14 ES ES14744744T patent/ES2655855T4/es active Active
- 2014-07-14 RS RS20171318A patent/RS56721B1/sr unknown
- 2014-07-14 MY MYPI2016700023A patent/MY187454A/en unknown
- 2014-07-14 CU CU2016000006A patent/CU24397B1/es unknown
- 2014-07-14 MX MX2016000662A patent/MX351291B/es active IP Right Grant
- 2014-07-14 HR HRP20172000TT patent/HRP20172000T1/hr unknown
- 2014-07-14 SG SG11201600086PA patent/SG11201600086PA/en unknown
- 2014-07-14 BR BR112016000909-6A patent/BR112016000909B1/pt active IP Right Grant
- 2014-07-14 WO PCT/US2014/046515 patent/WO2015009616A1/en not_active Ceased
- 2014-07-14 DK DK14744744.5T patent/DK3022192T3/en active
- 2014-07-14 SI SI201430522T patent/SI3022192T1/en unknown
- 2014-07-14 PT PT147447445T patent/PT3022192T/pt unknown
- 2014-07-14 AP AP2016008992A patent/AP2016008992A0/xx unknown
- 2014-07-14 LT LTEP14744744.5T patent/LT3022192T/lt unknown
- 2014-07-14 TW TW103124190A patent/TWI641600B/zh active
- 2014-07-15 UY UY35663A patent/UY35663A/es active IP Right Grant
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2016
- 2016-01-10 IL IL243540A patent/IL243540B/en active IP Right Grant
- 2016-01-11 PH PH12016500072A patent/PH12016500072A1/en unknown
- 2016-01-12 CL CL2016000060A patent/CL2016000060A1/es unknown
- 2016-01-14 SV SV2016005137A patent/SV2016005137A/es unknown
- 2016-01-14 GT GT201600007A patent/GT201600007A/es unknown
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2017
- 2017-06-19 US US15/626,981 patent/US10093663B2/en active Active
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2018
- 2018-01-08 CY CY20181100019T patent/CY1119767T1/el unknown
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2019
- 2019-08-11 IL IL268623A patent/IL268623B/en active IP Right Grant
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2024
- 2024-09-30 NO NO2024042C patent/NO2024042I1/no unknown
- 2024-10-01 FR FR24C1036C patent/FR24C1036I2/fr active Active
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