|
NL6815872A
(https=)
|
1967-11-22 |
1969-05-27 |
|
|
|
JPS5614663B2
(https=)
*
|
1971-08-21 |
1981-04-06 |
|
|
|
US4582833A
(en)
|
1984-04-16 |
1986-04-15 |
American Cyanamid Company |
2-(substituted-1-piperazinyl)[1,2,4]triazolo[1,5-a]pyrimidines
|
|
JPS6130554A
(ja)
|
1984-07-23 |
1986-02-12 |
Ono Pharmaceut Co Ltd |
プロスタグランジン類似化合物のある特定の立体配置を有する異性体及びそれらを有効成分として含有する治療剤
|
|
US4576943A
(en)
|
1984-10-09 |
1986-03-18 |
American Cyanamid Company |
Pyrazolo[1,5-a]pyrimidines
|
|
DE3608088C2
(de)
|
1986-03-07 |
1995-11-16 |
Schering Ag |
Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
|
|
IL87116A
(en)
|
1987-07-17 |
1993-03-15 |
Schering Ag |
9-halogen-(z)-prostaglandin derivatives and pharmaceutical compositions containing the same
|
|
US5308852A
(en)
|
1992-06-29 |
1994-05-03 |
Merck Frosst Canada, Inc. |
Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
|
|
US5631401A
(en)
|
1994-02-09 |
1997-05-20 |
Abbott Laboratories |
Inhibitors of protein farnesyltransferase and squalene synthase
|
|
US6506876B1
(en)
|
1994-10-11 |
2003-01-14 |
G.D. Searle & Co. |
LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
|
|
US5585492A
(en)
|
1994-10-11 |
1996-12-17 |
G. D. Searle & Co. |
LTA4 Hydrolase inhibitors
|
|
DK0880363T3
(da)
|
1996-02-13 |
2003-01-20 |
Searle & Co |
Kombinationer der omfatter en cyclooxygenase-2 hæmmer samt en leukotrien A4 hydrolasehæmmer, som har immunsuppressive virkninger
|
|
US5952349A
(en)
*
|
1996-07-10 |
1999-09-14 |
Schering Corporation |
Muscarinic antagonists for treating memory loss
|
|
WO1998006703A1
(en)
*
|
1996-08-14 |
1998-02-19 |
Warner-Lambert Company |
2-phenyl benzimidazole derivatives as mcp-1 antagonists
|
|
NO317155B1
(no)
|
1997-02-04 |
2004-08-30 |
Ono Pharmaceutical Co |
<omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater
|
|
JP4044967B2
(ja)
|
1997-02-10 |
2008-02-06 |
小野薬品工業株式会社 |
１１，１５−ｏ−ジアルキルプロスタグランジンｅ誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤
|
|
DE19743435A1
(de)
*
|
1997-10-01 |
1999-04-08 |
Merck Patent Gmbh |
Benzamidinderivate
|
|
US6309561B1
(en)
|
1997-12-24 |
2001-10-30 |
3M Innovative Properties Company |
Liquid crystal compounds having a chiral fluorinated terminal portion
|
|
DE69821987T2
(de)
|
1997-12-25 |
2004-12-16 |
Ono Pharmaceutical Co. Ltd. |
Omega-cycloalkyl-prostaglandin e2 derivate
|
|
US6380203B1
(en)
|
1998-01-14 |
2002-04-30 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
|
JP4087938B2
(ja)
|
1998-02-04 |
2008-05-21 |
高砂香料工業株式会社 |
ヒノキチオ−ル類の分岐サイクロデキストリン包接化合物からなる抗菌剤およびそれを含有する組成物
|
|
US6096745A
(en)
|
1998-03-25 |
2000-08-01 |
Bristol-Myers Squibb Co. |
Imidazolone anorectic agents: III. heteroaryl derivatives
|
|
GB9815880D0
(en)
|
1998-07-21 |
1998-09-16 |
Pfizer Ltd |
Heterocycles
|
|
US6235780B1
(en)
|
1998-07-21 |
2001-05-22 |
Ono Pharmaceutical Co., Ltd. |
ω-cycloalkyl-prostaglandin E1 derivatives
|
|
GB9919776D0
(en)
|
1998-08-31 |
1999-10-27 |
Zeneca Ltd |
Compoujnds
|
|
AR023659A1
(es)
|
1998-09-18 |
2002-09-04 |
Vertex Pharma |
Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
|
|
US6699873B1
(en)
|
1999-08-04 |
2004-03-02 |
Millennium Pharmaceuticals, Inc. |
Melanocortin-4 receptor binding compounds and methods of use thereof
|
|
US6924313B1
(en)
|
1999-09-23 |
2005-08-02 |
Pfizer Inc. |
Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
|
|
US6800651B2
(en)
|
2000-02-03 |
2004-10-05 |
Eli Lilly And Company |
Potentiators of glutamate receptors
|
|
US6451798B2
(en)
|
2000-02-22 |
2002-09-17 |
Cv Therapeutics, Inc. |
Substituted alkyl piperazine derivatives
|
|
US6552023B2
(en)
|
2000-02-22 |
2003-04-22 |
Cv Therapeutics, Inc. |
Aralkyl substituted piperazine compounds
|
|
JP2001354657A
(ja)
|
2000-06-09 |
2001-12-25 |
Sds Biotech:Kk |
置換ピペラジン誘導体及び農園芸用殺菌剤
|
|
US6875483B2
(en)
|
2000-07-06 |
2005-04-05 |
Fuji Photo Film Co., Ltd. |
Liquid crystal composition comprising liquid crystal molecules and alignment promoter
|
|
WO2002064211A1
(en)
|
2001-02-09 |
2002-08-22 |
Merck & Co., Inc. |
Thrombin inhibitors
|
|
CA2439415C
(en)
|
2001-03-02 |
2011-09-20 |
Merck Frosst Canada & Co. |
Cathepsin cysteine protease inhibitors
|
|
AUPR362001A0
(en)
|
2001-03-08 |
2001-04-05 |
Fujisawa Pharmaceutical Co., Ltd. |
New compound
|
|
FR2826011B1
(fr)
|
2001-06-14 |
2004-12-10 |
Oreal |
Nouveaux derives de la 7-oxo-dhea et utilisation cosmetique
|
|
SE0102616D0
(sv)
|
2001-07-25 |
2001-07-25 |
Astrazeneca Ab |
Novel compounds
|
|
BR0212512A
(pt)
|
2001-09-14 |
2004-10-26 |
Tularik Inc |
Composto, composição farmacêutica e métodos para tratar um distúrbio, condição ou doença, elevar os nìveis do colesterol hdl, reduzir os nìveis de triglicerìdeo, tratar diabete, diminuir a resistência à insulina ou diminuir a pressão arterial e modular a ppardelta
|
|
WO2003037271A2
(en)
|
2001-10-30 |
2003-05-08 |
Millennium Pharmaceuticals,Inc. |
Compounds, pharmaceutical compositions and methods of use therefor
|
|
DE60307308T2
(de)
*
|
2002-10-04 |
2006-12-28 |
Ucb S.A. |
4-aminopiperidin-derivate, verfahren zur herstellung und ihre verwendung als arzneimittel
|
|
WO2005027886A2
(en)
|
2003-09-17 |
2005-03-31 |
Decode Genetics Ehf. |
Methods of preventing or treating recurrence of myocardial infarction
|
|
CA2502359A1
(en)
|
2002-10-17 |
2004-04-29 |
Decode Genetics Ehf. |
Susceptibility gene for myocardial infarction
|
|
US7851486B2
(en)
|
2002-10-17 |
2010-12-14 |
Decode Genetics Ehf. |
Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
|
|
WO2004058683A2
(en)
|
2002-12-20 |
2004-07-15 |
Migenix Corp. |
Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto
|
|
EP1611902A4
(en)
|
2003-04-03 |
2006-04-12 |
Kyowa Hakko Kogyo Kk |
MEANS FOR THE PREVENTION AND / OR TREATMENT OF NEUROPATHIC PAIN
|
|
US7115642B2
(en)
|
2003-05-02 |
2006-10-03 |
Rigel Pharmaceuticals, Inc. |
Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
|
|
JP2005008581A
(ja)
|
2003-06-20 |
2005-01-13 |
Kissei Pharmaceut Co Ltd |
新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
|
|
ATE403654T1
(de)
|
2003-07-28 |
2008-08-15 |
Janssen Pharmaceutica Nv |
Benzimidazol-, benzothiazol- und benzoxazolderivate und deren verwendung als lta4h-modulatoren
|
|
WO2005033079A1
(ja)
|
2003-09-30 |
2005-04-14 |
Eisai Co., Ltd. |
ヘテロ環化合物を含有する新規な抗真菌剤
|
|
GB0326632D0
(en)
|
2003-11-14 |
2003-12-17 |
Jagotec Ag |
Dry powder formulations
|
|
DE10356579A1
(de)
|
2003-12-04 |
2005-07-07 |
Merck Patent Gmbh |
Aminderivate
|
|
SE0303480D0
(sv)
|
2003-12-19 |
2003-12-19 |
Biovitrum Ab |
Benzofuranes
|
|
DE602004032265D1
(de)
|
2003-12-30 |
2011-05-26 |
3M Innovative Properties Co |
Herstellungsverfahren von medizinischen zusammensetzungen
|
|
DE602005015682D1
(de)
|
2004-02-04 |
2009-09-10 |
Neurosearch As |
Dimere azacyclische verbindungen und deren verwendung
|
|
WO2006033795A2
(en)
|
2004-09-17 |
2006-03-30 |
Wyeth |
Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth
|
|
EP1863476B1
(en)
|
2005-03-16 |
2016-02-03 |
MEDA Pharma GmbH & Co. KG |
The combination of anticholinergics and leukotriene receptor antagonists for the treatment of respiratory diseases
|
|
CA2603122A1
(en)
|
2005-03-31 |
2006-10-05 |
Janssen Pharmaceutica N.V. |
Phenyl and pyridyl lta4h modulators
|
|
JP2008540395A
(ja)
|
2005-05-03 |
2008-11-20 |
ファイザー・インク |
アミドレソルシノール化合物
|
|
CA2610671A1
(en)
|
2005-05-31 |
2006-12-07 |
Astrazeneca Ab |
Novel mchr1 antagonists and their use for the treatment of mchr1 mediated conditions and disorders
|
|
GB0514018D0
(en)
|
2005-07-07 |
2005-08-17 |
Ionix Pharmaceuticals Ltd |
Chemical compounds
|
|
JP5133889B2
(ja)
*
|
2005-09-21 |
2013-01-30 |
デコード ジェネティクス イーエイチエフ |
炎症治療のためのビアリール基置換複素環ｌｔａ４ｈ阻害剤
|
|
CN1947717B
(zh)
|
2005-10-14 |
2012-09-26 |
卓敏 |
选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用
|
|
DE102005049954A1
(de)
|
2005-10-19 |
2007-05-31 |
Sanofi-Aventis Deutschland Gmbh |
Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
|
|
WO2007079003A2
(en)
*
|
2005-12-29 |
2007-07-12 |
Bayer Schering Pharma Aktiengesellschaft |
Amide inhibitors of leukotriene a4 hydrolase
|
|
LT1976828T
(lt)
*
|
2005-12-29 |
2017-04-25 |
Celtaxsys, Inc. |
Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
|
|
CN101379060B
(zh)
|
2006-02-10 |
2012-05-23 |
转化技术制药公司 |
作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法
|
|
EP2058309A4
(en)
|
2006-08-04 |
2010-12-22 |
Takeda Pharmaceutical |
CONDENSED HETEROCYCLIC COMPOUND
|
|
AU2007312389B2
(en)
*
|
2006-10-19 |
2012-02-23 |
F. Hoffmann-La Roche Ag |
Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
|
|
JP5219465B2
(ja)
*
|
2006-11-10 |
2013-06-26 |
大塚製薬株式会社 |
医薬
|
|
SI2121636T1
(sl)
|
2006-12-14 |
2017-06-30 |
Janssen Pharmaceutica N.V. |
Postopek za pripravo derivatov piperazinila in diazepanil benzamida
|
|
FR2911138B1
(fr)
|
2007-01-05 |
2009-02-20 |
Sanofi Aventis Sa |
Nouveaux derives de n, n'-2,4-dianilinopyrimidines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
|
|
FR2911139A1
(fr)
|
2007-01-05 |
2008-07-11 |
Sanofi Aventis Sa |
Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
|
|
FR2911140B1
(fr)
|
2007-01-05 |
2009-02-20 |
Sanofi Aventis Sa |
Nouveaux derives de 2-anilino 4-heteroaryle pyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
|
|
CA2691662A1
(en)
|
2007-07-02 |
2009-01-08 |
F. Hoffmann-La Roche Ag |
Imidazole derivatives as ccr2 receptor antagonists
|
|
JP5341084B2
(ja)
|
2007-08-03 |
2013-11-13 |
エフ．ホフマン−ラ ロシュ アーゲー |
Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
|
|
AR068498A1
(es)
|
2007-09-27 |
2009-11-18 |
Merck & Co Inc |
Compuestos de oxadiazol para inhibicion de biosintesis de leucotrienos
|
|
US7902181B2
(en)
|
2007-12-12 |
2011-03-08 |
Astrazeneca Ab |
Compounds 010
|
|
MX2010009416A
(es)
|
2008-02-26 |
2010-09-24 |
Novartis Ag |
Compuestos heterociclicos como inhibidores de cxcr2.
|
|
FR2928070A1
(fr)
|
2008-02-27 |
2009-09-04 |
Sumitomo Chemical Co |
Composition agricole, utilisation d'un compose pour sa production et procede pour matriser ou prevenir les maladies des plantes.
|
|
US20100029657A1
(en)
|
2008-02-29 |
2010-02-04 |
Wyeth |
Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof
|
|
MY157597A
(en)
|
2008-04-11 |
2016-06-30 |
Janssen Pharmaceutica Nv |
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
|
|
EP2110374A1
(en)
|
2008-04-18 |
2009-10-21 |
Merck Sante |
Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
|
|
WO2010011912A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Trpv4 antagonists
|
|
NZ590774A
(en)
|
2008-08-07 |
2012-09-28 |
Pulmagen Therapeutics Inflammation Ltd |
Substantially pure 5R enantiomers of pioglitazone and rosiglitazone for treating inflammatory respiratory diseases
|
|
CA2757979A1
(en)
|
2009-04-09 |
2010-10-14 |
Alkermes Pharma Ireland Limited |
Controlled-release clozapine compositions
|
|
CN102030700B
(zh)
|
2009-09-30 |
2016-06-01 |
中国医学科学院药物研究所 |
苯甲酰胺基羧酸类化合物及其制法和药物用途
|
|
US8846655B2
(en)
*
|
2009-10-30 |
2014-09-30 |
Janssen Pharmaceutica, Nv |
4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
|
|
US8802694B2
(en)
|
2009-12-07 |
2014-08-12 |
Targacept, Inc. |
3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands
|
|
JP2013047189A
(ja)
|
2009-12-25 |
2013-03-07 |
Kyorin Pharmaceutical Co Ltd |
新規パラバン酸誘導体及びそれらを有効成分とする医薬
|
|
PE20130774A1
(es)
*
|
2010-07-29 |
2013-06-26 |
Rigel Pharmaceuticals Inc |
Compuestos heterociclicos activadores de ampk y metodos para emplearlos
|
|
US8609669B2
(en)
|
2010-11-16 |
2013-12-17 |
Abbvie Inc. |
Potassium channel modulators
|
|
CN103415513B
(zh)
|
2011-03-14 |
2016-01-20 |
勃林格殷格翰国际有限公司 |
白三烯产物的苯并二氧杂环己烷抑制剂
|
|
CA2829993A1
(en)
|
2011-03-15 |
2012-09-20 |
Rib-X Pharmaceuticals, Inc. |
Antimicrobial agents
|
|
BR112013026313A8
(pt)
|
2011-04-12 |
2018-01-30 |
Moerae Matrix Inc |
composições e métodos para prevenir ou tratar doenças, condições ou processos caracterizados por proliferação anormal de fibroblastos e depósito de matriz extracelular
|
|
US8748624B2
(en)
|
2011-05-23 |
2014-06-10 |
Janssen Pharmaceutica Nv |
Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists
|
|
CN103159742B
(zh)
*
|
2011-12-16 |
2015-08-12 |
北京韩美药品有限公司 |
5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
|
|
US9006235B2
(en)
|
2012-03-06 |
2015-04-14 |
Bristol-Myers Squibb Company |
Inhibitors of human immunodeficiency virus replication
|
|
WO2013142369A1
(en)
|
2012-03-23 |
2013-09-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of pulmonary hypertension with leukotriene inhibitors
|
|
AU2014249168B2
(en)
|
2013-03-12 |
2018-07-12 |
Celltaxis, Llc |
Methods of inhibiting leukotriene A4 hydrolase
|
|
BR112015022864A8
(pt)
|
2013-03-14 |
2019-11-26 |
Celtaxsys Inc |
composto, composição farmacêutica e uso dos mesmos
|
|
CA2906035A1
(en)
|
2013-03-14 |
2014-09-25 |
Celtaxsys, Inc. |
Inhibitors of leukotriene a4 hydrolase
|
|
WO2014152536A2
(en)
|
2013-03-14 |
2014-09-25 |
Celtaxsys, Inc. |
Inhibitors of leukotriene a4 hydrolase
|