JP2009516697A5 - - Google Patents
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- Publication number
- JP2009516697A5 JP2009516697A5 JP2008541463A JP2008541463A JP2009516697A5 JP 2009516697 A5 JP2009516697 A5 JP 2009516697A5 JP 2008541463 A JP2008541463 A JP 2008541463A JP 2008541463 A JP2008541463 A JP 2008541463A JP 2009516697 A5 JP2009516697 A5 JP 2009516697A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- optionally substituted
- hydrogen
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- -1 3-methylaminocarbonylphenyl group Chemical group 0.000 claims 17
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010023774 Large cell lung cancer Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010989 colorectal carcinoma Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000006301 indolyl methyl group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000009546 lung large cell carcinoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- AHNHXHYLOGBUTC-UHFFFAOYSA-N n-methyl-2-[5-methyl-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-1-benzothiophene-4-carboxamide Chemical compound C=1C=2C(C(=O)NC)=CC=CC=2SC=1C(C(=CN=1)C)=NC=1NCCCN1CCN(C)CC1 AHNHXHYLOGBUTC-UHFFFAOYSA-N 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73809705P | 2005-11-18 | 2005-11-18 | |
| PCT/US2006/060911 WO2007092095A2 (en) | 2005-11-18 | 2006-11-15 | [4-(benzo [b] thi0phen-2-yl) pyrimidin-2yl] -amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009516697A JP2009516697A (ja) | 2009-04-23 |
| JP2009516697A5 true JP2009516697A5 (https=) | 2009-12-17 |
Family
ID=38345605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541463A Ceased JP2009516697A (ja) | 2005-11-18 | 2006-11-15 | 癌および炎症性疾患の治療のためのｉｋｋ−ベータ阻害剤としての［４−（ベンゾ［ｂ］チオフェン−２−イル）ピリミジン−２イル］アミン誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7547691B2 (https=) |
| EP (1) | EP1989200B1 (https=) |
| JP (1) | JP2009516697A (https=) |
| KR (1) | KR100990771B1 (https=) |
| CN (1) | CN101309918B (https=) |
| AR (1) | AR057911A1 (https=) |
| AT (1) | ATE437873T1 (https=) |
| AU (1) | AU2006337626B2 (https=) |
| BR (1) | BRPI0618245A2 (https=) |
| CA (1) | CA2629336A1 (https=) |
| CR (1) | CR9947A (https=) |
| DE (1) | DE602006008187D1 (https=) |
| DK (1) | DK1989200T3 (https=) |
| EA (1) | EA014426B1 (https=) |
| EC (1) | ECSP088456A (https=) |
| ES (1) | ES2329085T3 (https=) |
| IL (1) | IL190489A0 (https=) |
| MA (1) | MA30053B1 (https=) |
| NO (1) | NO20082594L (https=) |
| PE (1) | PE20070833A1 (https=) |
| PL (1) | PL1989200T3 (https=) |
| PT (1) | PT1989200E (https=) |
| SI (1) | SI1989200T1 (https=) |
| TN (1) | TNSN08227A1 (https=) |
| TW (1) | TW200800201A (https=) |
| WO (1) | WO2007092095A2 (https=) |
| ZA (1) | ZA200803940B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2007752T3 (pl) | 2006-03-31 | 2011-02-28 | Janssen Pharmaceutica Nv | Benzoimidazol-2-ilopirymidyny i pirazyny jako modulatory receptora histaminowego H4 |
| AU2007275221A1 (en) * | 2006-07-20 | 2008-01-24 | Allen J. Borchardt | Benzothiophene inhibitors of RHO kinase |
| DK2125794T3 (da) * | 2006-12-21 | 2011-01-24 | Lilly Co Eli | Imidazolidinonylaminopyrimidin-forbindelser til behandling af cancer |
| ES2349169T3 (es) * | 2006-12-21 | 2010-12-28 | ELI LILLY & COMPANY | Compuestos de imidazolidinonil aminopirimidina para el tratamiento del cáncer. |
| CN101679396B (zh) | 2007-05-16 | 2012-06-06 | 伊莱利利公司 | 三唑基氨基嘧啶化合物 |
| US8063035B2 (en) | 2007-05-16 | 2011-11-22 | Eli Lilly And Company | Triazolyl aminopyrimidine compounds |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| TWI498326B (zh) | 2008-06-30 | 2015-09-01 | Janssen Pharmaceutica Nv | 用於製備經取代之嘧啶衍生物之化合物 |
| KR101123178B1 (ko) * | 2009-04-09 | 2012-06-13 | (주)에스메디 | 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
| MX2012001974A (es) | 2009-08-19 | 2012-04-11 | Ambit Biosciences Corp | Compuestos de biarilo y metodos de uso de los mismos. |
| CN102858764B (zh) | 2010-04-27 | 2014-08-20 | 和记黄埔医药（上海）有限公司 | 嘧啶基吲哚化合物 |
| WO2013058824A1 (en) | 2011-04-07 | 2013-04-25 | Cornell University | Monomers capable of dimerizing in an aqueous solution, and methods of using same |
| US9245773B2 (en) | 2011-09-02 | 2016-01-26 | Taiwan Semiconductor Manufacturing Company, Ltd. | Semiconductor device packaging methods and structures thereof |
| CN103159742B (zh) * | 2011-12-16 | 2015-08-12 | 北京韩美药品有限公司 | 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用 |
| WO2013119895A1 (en) * | 2012-02-08 | 2013-08-15 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| CN105085434B (zh) * | 2014-05-09 | 2018-02-09 | 上海特化医药科技有限公司 | 硫乙拉嗪或其中间体的制备方法 |
| WO2017076888A1 (en) * | 2015-11-03 | 2017-05-11 | Janssen Pharmaceutica Nv | 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same |
| PT3494119T (pt) | 2016-07-29 | 2024-12-10 | Pgi Drug Discovery Llc | Compostos e composições e seus usos |
| MA45795A (fr) | 2016-07-29 | 2019-06-05 | Sunovion Pharmaceuticals Inc | Composés et compositions, et utilisations associées |
| WO2018140599A1 (en) * | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| US10745385B2 (en) | 2017-05-25 | 2020-08-18 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| CA3070993C (en) | 2017-08-02 | 2025-05-20 | Sunovion Pharmaceuticals Inc. | ISOCHROMANE COMPOUNDS AND THEIR USES |
| MX2021000887A (es) | 2018-08-01 | 2021-03-31 | Araxes Pharma Llc | Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer. |
| EP3938045A1 (en) | 2019-03-14 | 2022-01-19 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3752589A (en) * | 1988-05-16 | 1989-12-12 | Georgia State University Research Foundation, Inc. | Nucleic acid interacting unfused heteropolycyclic compounds |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| EP1831207B1 (en) | 2004-12-17 | 2012-11-14 | Amgen Inc. | Aminopyrimidine compounds as plk inhibitors |
-
2006
- 2006-10-23 TW TW095139053A patent/TW200800201A/zh unknown
- 2006-11-15 PT PT06850430T patent/PT1989200E/pt unknown
- 2006-11-15 KR KR1020087011830A patent/KR100990771B1/ko not_active Expired - Fee Related
- 2006-11-15 CA CA002629336A patent/CA2629336A1/en not_active Abandoned
- 2006-11-15 SI SI200630446T patent/SI1989200T1/sl unknown
- 2006-11-15 PL PL06850430T patent/PL1989200T3/pl unknown
- 2006-11-15 DK DK06850430T patent/DK1989200T3/da active
- 2006-11-15 CN CN2006800428126A patent/CN101309918B/zh not_active Expired - Fee Related
- 2006-11-15 ES ES06850430T patent/ES2329085T3/es active Active
- 2006-11-15 WO PCT/US2006/060911 patent/WO2007092095A2/en not_active Ceased
- 2006-11-15 JP JP2008541463A patent/JP2009516697A/ja not_active Ceased
- 2006-11-15 PE PE2006001456A patent/PE20070833A1/es not_active Application Discontinuation
- 2006-11-15 DE DE602006008187T patent/DE602006008187D1/de active Active
- 2006-11-15 EP EP06850430A patent/EP1989200B1/en active Active
- 2006-11-15 BR BRPI0618245-3A patent/BRPI0618245A2/pt not_active IP Right Cessation
- 2006-11-15 AU AU2006337626A patent/AU2006337626B2/en not_active Ceased
- 2006-11-15 EA EA200801362A patent/EA014426B1/ru not_active IP Right Cessation
- 2006-11-15 US US12/093,024 patent/US7547691B2/en not_active Expired - Fee Related
- 2006-11-15 AT AT06850430T patent/ATE437873T1/de active
- 2006-11-17 AR ARP060105065A patent/AR057911A1/es unknown
-
2008
- 2008-03-27 IL IL190489A patent/IL190489A0/en unknown
- 2008-04-29 CR CR9947A patent/CR9947A/es not_active Application Discontinuation
- 2008-05-08 ZA ZA200803940A patent/ZA200803940B/xx unknown
- 2008-05-16 EC EC2008008456A patent/ECSP088456A/es unknown
- 2008-05-16 TN TNP2008000227A patent/TNSN08227A1/en unknown
- 2008-06-10 NO NO20082594A patent/NO20082594L/no not_active Application Discontinuation
- 2008-06-13 MA MA31035A patent/MA30053B1/fr unknown
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