JP2016513681A - ロイコトリエンａ４加水分解酵素の阻害剤 - Google Patents

ロイコトリエンａ４加水分解酵素の阻害剤 Download PDF

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JP2016513681A
JP2016513681A JP2016502333A JP2016502333A JP2016513681A JP 2016513681 A JP2016513681 A JP 2016513681A JP 2016502333 A JP2016502333 A JP 2016502333A JP 2016502333 A JP2016502333 A JP 2016502333A JP 2016513681 A JP2016513681 A JP 2016513681A
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ギルフォード，ウィリアム
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セルタクシス，インコーポレイテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
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  • Cardiology (AREA)
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JP2016502333A 2013-03-14 2014-03-14 ロイコトリエンａ４加水分解酵素の阻害剤 Pending JP2016513681A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361781181P 2013-03-14 2013-03-14
US61/781,181 2013-03-14
PCT/US2014/027097 WO2014152229A2 (en) 2013-03-14 2014-03-14 Inhibitors of leukotriene a4 hydrolase

Publications (2)

Publication Number Publication Date
JP2016513681A true JP2016513681A (ja) 2016-05-16
JP2016513681A5 JP2016513681A5 (https=) 2017-04-13

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JP2016502333A Pending JP2016513681A (ja) 2013-03-14 2014-03-14 ロイコトリエンａ４加水分解酵素の阻害剤

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US (2) US9856249B2 (https=)
EP (1) EP2968264A4 (https=)
JP (1) JP2016513681A (https=)
KR (1) KR20150127245A (https=)
AU (2) AU2014240042C1 (https=)
BR (1) BR112015022226A2 (https=)
CA (1) CA2906035A1 (https=)
MX (1) MX2015011677A (https=)
RU (1) RU2696559C2 (https=)
WO (1) WO2014152229A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2017131156A1 (ja) * 2016-01-29 2018-11-22 東レ株式会社 環状アミン誘導体及びその医薬用途
JP2020511409A (ja) * 2016-12-09 2020-04-16 セルタクシス，インコーポレイテッド ロイコトリエンａ４ヒドロラーゼの阻害剤

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WO2007079078A1 (en) 2005-12-29 2007-07-12 Bayer Schering Pharma Aktiengesellschaft Diamine derivatives as inhibitors of leukotriene a4 hydrolase
KR102035187B1 (ko) 2011-04-06 2019-11-08 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 지질-기반 나노입자들
MX366972B (es) 2012-01-20 2019-08-01 Ananth Annapragada Metodos y composiciones para caracterizar imagenes medicas en forma objetiva.
ES2864862T3 (es) 2013-03-12 2021-10-14 Celltaxis Llc Métodos de inhibición de la leucotrieno A4 hidrolasa
MX2015011677A (es) * 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
RU2678196C2 (ru) 2013-03-14 2019-01-24 Селтакссис, Инк. Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы
WO2014152536A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
AU2015330824A1 (en) * 2014-10-08 2017-05-25 Ananth Annapragada MRI imaging of amyloid plaque using liposomes
AU2017371353B2 (en) 2016-12-09 2022-02-03 Celltaxis, Llc Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
EP3801559B1 (en) 2018-05-31 2025-01-01 Celltaxis, LLC Method of reducing pulmonary exacerbations in respiratory disease patients
MX2023001725A (es) 2020-08-14 2023-02-22 Novartis Ag Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmaceuticos de los mismos.

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JP2000516611A (ja) * 1996-08-14 2000-12-12 ワーナー―ランバート・コンパニー Ｍｃｐ―１アンタゴニストとしての２―フェニルベンズイミダゾール誘導体
WO2007079078A1 (en) * 2005-12-29 2007-07-12 Bayer Schering Pharma Aktiengesellschaft Diamine derivatives as inhibitors of leukotriene a4 hydrolase
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