MX366972B - Metodos y composiciones para caracterizar imagenes medicas en forma objetiva. - Google Patents

Metodos y composiciones para caracterizar imagenes medicas en forma objetiva.

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Publication number
MX366972B
MX366972B MX2014003621A MX2014003621A MX366972B MX 366972 B MX366972 B MX 366972B MX 2014003621 A MX2014003621 A MX 2014003621A MX 2014003621 A MX2014003621 A MX 2014003621A MX 366972 B MX366972 B MX 366972B
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MX
Mexico
Prior art keywords
compositions
methods
patient
objectively characterizing
medical images
Prior art date
Application number
MX2014003621A
Other languages
English (en)
Other versions
MX2014003621A (es
Inventor
Starosolski Zbigniew
Original Assignee
Ananth Annapragada
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Publication date
Application filed by Ananth Annapragada filed Critical Ananth Annapragada
Publication of MX2014003621A publication Critical patent/MX2014003621A/es
Publication of MX366972B publication Critical patent/MX366972B/es

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    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5247—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
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    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
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    • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
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    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
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    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
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    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
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    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
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    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computerised tomographs
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    • G06T2207/30004—Biomedical image processing
    • G06T2207/30016—Brain

Abstract

Se proporcionan métodos y composiciones para caracterizar objetivamente una lesión patológica en un paciente. El método comprende: introducir en el paciente un agente potenciador de contraste; someter al paciente a formación de imágenes por resonancia magnética para obtener una imagen; y aplicar una función de autocorrelación 3-D a un subdominio de interés de la imagen para obtener por lo menos un espectro de autocorrelación 3-D. El método además puede comprender comparar el o los espectros de autocorrelación 3-D con un espectro de autocorrelación 3-D preexistente que es característico para la lesión patológica. En un ejemplo, los métodos y composiciones pueden ser útiles para identificar y caracterizar objetivamente depósitos de placas amiloideas característicos de la enfermedad de Alzheimer.
MX2014003621A 2012-01-20 2013-01-20 Metodos y composiciones para caracterizar imagenes medicas en forma objetiva. MX366972B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261589165P 2012-01-20 2012-01-20
PCT/US2013/022336 WO2013110013A1 (en) 2012-01-20 2013-01-20 Methods and compositions for objectively characterizing medical images

Publications (2)

Publication Number Publication Date
MX2014003621A MX2014003621A (es) 2014-08-22
MX366972B true MX366972B (es) 2019-08-01

Family

ID=48797775

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MX2014003621A MX366972B (es) 2012-01-20 2013-01-20 Metodos y composiciones para caracterizar imagenes medicas en forma objetiva.

Country Status (12)

Country Link
US (1) US10130326B2 (es)
EP (1) EP2756459B1 (es)
JP (1) JP6130401B2 (es)
KR (1) KR102064398B1 (es)
CN (1) CN104081416B (es)
AU (1) AU2013209437B2 (es)
BR (1) BR112014010879A2 (es)
CA (1) CA2848994A1 (es)
ES (1) ES2855165T3 (es)
HK (1) HK1202176A1 (es)
MX (1) MX366972B (es)
WO (1) WO2013110013A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012139080A2 (en) 2011-04-06 2012-10-11 Board Of Regents Of The University Of Texas System Lipid-based nanoparticles
EP2756459B1 (en) 2012-01-20 2020-12-09 Ananth Annapragada Methods and compositions for objectively characterizing medical images
US9744251B2 (en) 2014-10-08 2017-08-29 Texas Children's Hospital MRI imaging of amyloid plaque using liposomes
US20200281500A1 (en) * 2017-09-19 2020-09-10 University Of Cincinnati Systems and Methods for Detecting Small Physiological or Pathological Changes Using High Resolution Magnetic Resonance Imaging
CN108961210B (zh) * 2018-05-24 2021-08-31 上海集成电路研发中心有限公司 一种判断图像是否经过算法处理的方法

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204085A (en) 1985-01-08 1993-04-20 Mallinckrodt Medical, Inc. Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents
US4893082A (en) * 1989-02-13 1990-01-09 Letcher Iii John H Noise suppression in magnetic resonance imaging
ZA952485B (en) 1994-03-28 1995-12-15 Nycomed Imaging As Liposomes
US6071532A (en) 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
US6067465A (en) * 1997-11-26 2000-05-23 General Electric Company System and method for detecting and tracking reference position changes with linear phase shift in magnetic resonance imaging
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
DE60017787T2 (de) 1999-11-30 2006-01-05 ARIZONA BOARD OF REGENTS, on behalf of THE UNIVERSITY OF ARIZONA, Tucson Strahlung-sensitive liposomen
US6463315B1 (en) * 2000-01-26 2002-10-08 The Board Of Trustees Of The Leland Stanford Junior University Analysis of cerebral white matter for prognosis and diagnosis of neurological disorders
US7029655B2 (en) 2000-10-04 2006-04-18 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US6821504B2 (en) * 2001-05-23 2004-11-23 New York University Detection of alzheimer's amyloid by magnetic resonance imaging
US20070021345A1 (en) * 2003-06-30 2007-01-25 Ehud Gazit Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
JP2005519129A (ja) 2002-03-05 2005-06-30 クリーブランド ステート ユニバーシティー エアロゾル薬物送達のための凝集粒子
ES2368907T3 (es) * 2002-04-19 2011-11-23 The Governing Council Of The University Of Toronto Procedimientos y composiciones inmunológicas para el tratamiento de la enfermedad de alzheimer.
US20060120580A1 (en) * 2002-09-04 2006-06-08 Sherif Makram-Ebeid Characterizing, surfaces in medical imaging
WO2004096120A2 (en) 2003-05-01 2004-11-11 Nst Neurosurvival Technologies Ltd. Compounds that selectively bind to membranes of apoptotic cells
US7208174B2 (en) 2003-12-18 2007-04-24 Hoffmann-La Roche Inc. Liposome compositions
WO2005077263A2 (en) * 2004-02-06 2005-08-25 Wake Forest University Health Services Non-invasive imaging for determining global tissue characteristics
US20100031378A1 (en) * 2008-08-04 2010-02-04 Edwards Joel A Novel gene disruptions, compositions and methods relating thereto
US7713517B2 (en) 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US8357351B2 (en) 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
BRPI0512932A (pt) * 2004-07-02 2008-04-15 Univ Pittsburgh compostos e métodos de identificação e de diagnóstico de paciente como prodrÈmico para doença associada com a deposição amilóide
WO2006014260A2 (en) * 2004-07-06 2006-02-09 Mayo Foundation For Medical Education And Research Magnetic resonance imaging of amyloid plaque
DE602005025659D1 (es) 2004-09-23 2011-02-10 Guerbet Sa
WO2006120195A1 (en) * 2005-05-12 2006-11-16 Bracco Imaging S.P.A. Method for coding pixels or voxels of a digital image and a method for processing digital images
WO2007048019A2 (en) 2005-10-20 2007-04-26 The Penn State Research Foundation Delivery system for diagnostic and therapeutic agents
EP1780672A1 (en) * 2005-10-25 2007-05-02 Bracco Imaging, S.P.A. Method of registering images, algorithm for carrying out the method of registering images, a program for registering images using the said algorithm and a method of treating biomedical images to reduce imaging artefacts caused by object movement
US20090123047A1 (en) 2007-03-21 2009-05-14 Yfantis Spyros A Method and system for characterizing prostate images
EP1982733A1 (en) * 2007-04-17 2008-10-22 Bayer Schering Pharma Aktiengesellschaft Use of a contrast agent for magnetic resonance imaging of endoleaks
AU2008278605A1 (en) 2007-07-26 2009-01-29 Nanoscan Imaging, Llc Methods for imaging using improved nanoparticulate contrast agents
WO2009073236A1 (en) 2007-12-05 2009-06-11 Marval Biosciences, Inc. Nano-scale contrast agents and methods of use
US8192721B2 (en) * 2007-12-13 2012-06-05 Verrow Pharmaceuticals, Inc. Compositions useful for reducing toxicity associated with gadolinium-based contrast agents
CN102037004A (zh) 2008-01-08 2011-04-27 生物种属学股份公司 使用寡糖基转移酶的多肽的糖缀合
ITMI20081052A1 (it) 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
AU2009257279A1 (en) 2008-06-13 2009-12-17 Marval Biosciences, Inc. Imaging of atherosclerotic plaques using liposomal imaging agents
US20110208064A1 (en) 2008-07-31 2011-08-25 Ran Chongzhao Curcumin Derivatives for Amyloid-Beta Plaque Imaging
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
US20120003159A1 (en) 2009-03-19 2012-01-05 Board Of Regents Of The University Of Texas System Compositions and methods for enhancing contrast in imaging
JP5665040B2 (ja) * 2009-09-10 2015-02-04 学校法人上智学院 変位計測方法及び装置、並びに、超音波診断装置
ES2620177T3 (es) * 2009-10-15 2017-06-27 Guerbet Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas
US8679009B2 (en) * 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
ES2526124T3 (es) 2010-06-16 2015-01-07 Cymabay Therapeutics, Inc. Agonistas del receptor GPR120 y sus usos
US8658614B2 (en) * 2010-08-13 2014-02-25 The University of Texas Health Science Center Aptamer-containing compositions and methods for targeting E-selectin
EP2680822B1 (en) 2011-03-02 2022-02-23 Sensulin, LLC Vesicle compositions
WO2012139080A2 (en) 2011-04-06 2012-10-11 Board Of Regents Of The University Of Texas System Lipid-based nanoparticles
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
EP2756459B1 (en) 2012-01-20 2020-12-09 Ananth Annapragada Methods and compositions for objectively characterizing medical images
US9377472B2 (en) 2012-04-30 2016-06-28 Amoneta Diagnostics Biological complex specific for Alzheimer's disease detection in vitro and use thereof
EP2968264A4 (en) 2013-03-14 2016-11-02 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
US9744251B2 (en) 2014-10-08 2017-08-29 Texas Children's Hospital MRI imaging of amyloid plaque using liposomes

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