AR068498A1 - Compuestos de oxadiazol para inhibicion de biosintesis de leucotrienos - Google Patents

Compuestos de oxadiazol para inhibicion de biosintesis de leucotrienos

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Publication number
AR068498A1
AR068498A1 ARP080104086A ARP080104086A AR068498A1 AR 068498 A1 AR068498 A1 AR 068498A1 AR P080104086 A ARP080104086 A AR P080104086A AR P080104086 A ARP080104086 A AR P080104086A AR 068498 A1 AR068498 A1 AR 068498A1
Authority
AR
Argentina
Prior art keywords
salt
leucotriens
biosynthesis
inhibition
oxadiazol
Prior art date
Application number
ARP080104086A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR068498A1 publication Critical patent/AR068498A1/es

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

Los compuestos son inhibidores de 5-LO y son utiles para tratamiento de afecciones tales como asma, rinitis alérgica, EPOC, y aterosclerosis. Reivindicacion1: Una sal de (-) 4-(4-fluorofenil)-7-[({5-[1-hidroxi-1-(trifluorometil)propil]-1,3,4-oxadiazol-2-il}amino)metil]-2H-cromen-2-ona seleccionada del grupo constituido por una sal de ácido p-toluensulfonico, y una sal de ácido bencensulfonico. Reivindicacion 5: Sal de ácido p-toluensulfonico cristalina de (-) 4-(4-fluorofenil)-7-[({5-[1-hidroxi-1-(trifluorometil)propil]-1,3,4-oxadiazol-2-il}amino)metil]-2H-cromen-2-ona caracterizada por tener un patron XRPD obtenido usando radiacion de CuKalfa conteniendo al menos un espaciamiento d seleccionado de 17,77, 8,90 y 5,17.
ARP080104086A 2007-09-27 2008-09-19 Compuestos de oxadiazol para inhibicion de biosintesis de leucotrienos AR068498A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99552507P 2007-09-27 2007-09-27

Publications (1)

Publication Number Publication Date
AR068498A1 true AR068498A1 (es) 2009-11-18

Family

ID=40139104

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080104086A AR068498A1 (es) 2007-09-27 2008-09-19 Compuestos de oxadiazol para inhibicion de biosintesis de leucotrienos

Country Status (10)

Country Link
US (1) US7915298B2 (es)
EP (1) EP2203446A1 (es)
JP (1) JP2010540518A (es)
AR (1) AR068498A1 (es)
AU (1) AU2008305683A1 (es)
CA (1) CA2700797A1 (es)
CL (1) CL2008002857A1 (es)
PE (1) PE20091028A1 (es)
TW (1) TW200920359A (es)
WO (1) WO2009042098A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014249168B2 (en) * 2013-03-12 2018-07-12 Celltaxis, Llc Methods of inhibiting leukotriene A4 hydrolase
BR112015022226A2 (pt) 2013-03-14 2017-07-18 Celtaxsys Inc inibidores de leucotrieno a4 hidrolase
JP7386815B2 (ja) 2018-05-31 2023-11-27 セルタクシー、エルエルシー 呼吸器疾患患者の肺増悪を軽減する方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424320A (en) * 1993-06-23 1995-06-13 Merck Frosst Canada, Inc. Heteroaryl coumarins as inhibitors of leukotriene biosynthesis
CA2527769A1 (en) * 2003-06-11 2004-12-16 Merck Frosst Canada Ltd. 7- (1, 3-thiazol-2-yl)thio!-coumarin derivatives and their use as leukotriene biosynthesis inhibitors
AR055041A1 (es) * 2005-03-23 2007-08-01 Merck Frosst Canada Ltd Tiadiazoles y oxadiazoles como inhibidores de la sintesis de leucotrienos. composiciones farmaceuticas.
CA2602916C (en) * 2005-03-24 2010-06-01 Soleno Textiles Techniques Inc. Electrically conductive non-woven fabric
EP1934205A4 (en) * 2005-10-05 2010-06-02 Merck Frosst Canada Ltd SUBSTITUTED QUINOLINES AS INHIBITORS OF LEUCOTRIENE BIOSYNTHESIS

Also Published As

Publication number Publication date
US7915298B2 (en) 2011-03-29
AU2008305683A1 (en) 2009-04-02
PE20091028A1 (es) 2009-08-09
TW200920359A (en) 2009-05-16
EP2203446A1 (en) 2010-07-07
CA2700797A1 (en) 2009-04-02
AU2008305683A8 (en) 2010-04-15
WO2009042098A1 (en) 2009-04-02
CL2008002857A1 (es) 2009-05-22
US20090088477A1 (en) 2009-04-02
JP2010540518A (ja) 2010-12-24

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