JP2016520637A5 - - Google Patents
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- Publication number
- JP2016520637A5 JP2016520637A5 JP2016517275A JP2016517275A JP2016520637A5 JP 2016520637 A5 JP2016520637 A5 JP 2016520637A5 JP 2016517275 A JP2016517275 A JP 2016517275A JP 2016517275 A JP2016517275 A JP 2016517275A JP 2016520637 A5 JP2016520637 A5 JP 2016520637A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- methoxy
- imidazol
- trifluoroethoxy
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc(nc1)c[n]1-c(c(OC)c1)ccc1Nc1nc(C(*)O*)c(*)c(*)n1 Chemical compound Cc(nc1)c[n]1-c(c(OC)c1)ccc1Nc1nc(C(*)O*)c(*)c(*)n1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1350685 | 2013-06-04 | ||
| SE1350685-2 | 2013-06-04 | ||
| PCT/EP2014/061503 WO2014195323A1 (en) | 2013-06-04 | 2014-06-03 | Pyrimidine compounds and their use as gamma secretase modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520637A JP2016520637A (ja) | 2016-07-14 |
| JP2016520637A5 true JP2016520637A5 (https=) | 2017-06-01 |
| JP6368777B2 JP6368777B2 (ja) | 2018-08-01 |
Family
ID=50877325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517275A Expired - Fee Related JP6368777B2 (ja) | 2013-06-04 | 2014-06-03 | ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9439904B2 (https=) |
| EP (1) | EP3004079B1 (https=) |
| JP (1) | JP6368777B2 (https=) |
| CN (1) | CN105263923B (https=) |
| DK (1) | DK3004079T3 (https=) |
| ES (1) | ES2665421T3 (https=) |
| NO (1) | NO3004079T3 (https=) |
| PL (1) | PL3004079T3 (https=) |
| WO (1) | WO2014195323A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018007331A1 (en) * | 2016-07-08 | 2018-01-11 | F. Hoffmann-La Roche Ag | Fused pyrimidine derivatives |
| CN108191776A (zh) * | 2018-01-22 | 2018-06-22 | 无锡富泽药业有限公司 | 一种尿嘧啶的绿色生产工艺 |
| WO2020247707A1 (en) * | 2019-06-05 | 2020-12-10 | Chunyu Wang | SYSTEMS AND METHOD FOR INHIBITING γ-SECRETASE PRODUCTION OF AMYLOID-β PEPTIDES |
| US12297244B2 (en) | 2019-06-05 | 2025-05-13 | Rensselaer Polytechnic Institute | Systems and methods for inhibiting γ-secretase production of amyloid-β peptides |
| CN110372603A (zh) * | 2019-06-24 | 2019-10-25 | 南京普锐达医药科技有限公司 | 一种2-氯-5-氟-6-乙基嘧啶的合成方法 |
| CN113149977A (zh) | 2020-01-22 | 2021-07-23 | 苏州爱科百发生物医药技术有限公司 | 一类呼吸道合胞病毒抑制剂的合成与用途 |
| JP2024512024A (ja) | 2021-03-23 | 2024-03-18 | ハリア・セラピューティクス・インコーポレイテッド | Ｌｒｒｋ２キナーゼ阻害剤として有用なピリミジン誘導体 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000025780A1 (en) * | 1998-10-29 | 2000-05-11 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus that are inhibitors of impdh enzyme |
| ITMI20030312A1 (it) | 2003-02-21 | 2004-08-22 | Chiesi Farma Spa | Derivati di acidi 2-fenil-2-alchil-acetici per il trattamento della malattia di alzheimer. |
| AU2004262970B2 (en) | 2003-08-07 | 2010-03-18 | Merck Sharp & Dohme Limited | Treatment for Alzheimer's disease and related conditions |
| JP2007513128A (ja) | 2003-12-03 | 2007-05-24 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病および関連状態の治療に有用な１−アルキル−３−チオ置換インドール−２−アルキン酸 |
| RU2361872C2 (ru) | 2004-05-26 | 2009-07-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Циннамидное соединение |
| JP5191391B2 (ja) * | 2005-11-01 | 2013-05-08 | ターゲジェン インコーポレーティッド | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| WO2007125364A1 (en) | 2006-04-26 | 2007-11-08 | Merck Sharp & Dohme Limited | Piperidines and related compounds for treatment of alzheimer’s disease |
| JPWO2007135969A1 (ja) | 2006-05-19 | 2009-10-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウレア系−シンナミド誘導体 |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| JP2010518080A (ja) | 2007-02-08 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | 治療薬 |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| US8252803B2 (en) | 2007-02-12 | 2012-08-28 | Merck Sharp & Dohme Corp. | Piperidine derivatives |
| EP2166854A4 (en) | 2007-06-13 | 2012-05-16 | Merck Sharp & Dohme | TRIAZONE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER AND RELATED SUFFERINGS |
| CA2695543A1 (en) | 2007-08-06 | 2009-02-12 | Schering Corporation | Gamma secretase modulators |
| WO2009087127A1 (en) | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| JP5328816B2 (ja) * | 2008-02-22 | 2013-10-30 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβの調節薬 |
| WO2010040661A1 (en) * | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| MX2011004680A (es) * | 2008-11-06 | 2011-05-25 | Astrazeneca Ab | Moduladores de beta amiloide. |
| AU2009312856A1 (en) | 2008-11-10 | 2010-05-14 | F. Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| UY32622A (es) | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
| ES2519565T3 (es) | 2009-07-15 | 2014-11-07 | Janssen Pharmaceuticals Inc. | Derivados de triazol e imidazol sustituidos como moduladores de gamma secretasa |
| TWI468402B (zh) | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β－類澱粉生成之化合物 |
| EP2523949B1 (en) | 2010-01-15 | 2014-08-20 | Janssen Pharmaceuticals Inc. | Novel substituted triazole derivatives as gamma secretase modulators |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| TW201206946A (en) | 2010-07-15 | 2012-02-16 | Bristol Myers Squibb Co | Compounds for the reduction of beta-amyloid production |
-
2014
- 2014-06-03 NO NO14727562A patent/NO3004079T3/no unknown
- 2014-06-03 DK DK14727562.2T patent/DK3004079T3/en active
- 2014-06-03 JP JP2016517275A patent/JP6368777B2/ja not_active Expired - Fee Related
- 2014-06-03 PL PL14727562T patent/PL3004079T3/pl unknown
- 2014-06-03 ES ES14727562.2T patent/ES2665421T3/es active Active
- 2014-06-03 EP EP14727562.2A patent/EP3004079B1/en active Active
- 2014-06-03 CN CN201480032083.0A patent/CN105263923B/zh not_active Expired - Fee Related
- 2014-06-03 US US14/895,528 patent/US9439904B2/en not_active Expired - Fee Related
- 2014-06-03 WO PCT/EP2014/061503 patent/WO2014195323A1/en not_active Ceased
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