JP2016520637A5 - - Google Patents

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Publication number
JP2016520637A5
JP2016520637A5 JP2016517275A JP2016517275A JP2016520637A5 JP 2016520637 A5 JP2016520637 A5 JP 2016520637A5 JP 2016517275 A JP2016517275 A JP 2016517275A JP 2016517275 A JP2016517275 A JP 2016517275A JP 2016520637 A5 JP2016520637 A5 JP 2016520637A5
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JP
Japan
Prior art keywords
methyl
methoxy
imidazol
trifluoroethoxy
phenyl
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JP2016517275A
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English (en)
Japanese (ja)
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JP6368777B2 (ja
JP2016520637A (ja
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Priority claimed from PCT/EP2014/061503 external-priority patent/WO2014195323A1/en
Publication of JP2016520637A publication Critical patent/JP2016520637A/ja
Publication of JP2016520637A5 publication Critical patent/JP2016520637A5/ja
Application granted granted Critical
Publication of JP6368777B2 publication Critical patent/JP6368777B2/ja
Expired - Fee Related legal-status Critical Current
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JP2016517275A 2013-06-04 2014-06-03 ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用 Expired - Fee Related JP6368777B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1350685-2 2013-06-04
SE1350685 2013-06-04
PCT/EP2014/061503 WO2014195323A1 (en) 2013-06-04 2014-06-03 Pyrimidine compounds and their use as gamma secretase modulators

Publications (3)

Publication Number Publication Date
JP2016520637A JP2016520637A (ja) 2016-07-14
JP2016520637A5 true JP2016520637A5 (https=) 2017-06-01
JP6368777B2 JP6368777B2 (ja) 2018-08-01

Family

ID=50877325

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016517275A Expired - Fee Related JP6368777B2 (ja) 2013-06-04 2014-06-03 ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用

Country Status (9)

Country Link
US (1) US9439904B2 (https=)
EP (1) EP3004079B1 (https=)
JP (1) JP6368777B2 (https=)
CN (1) CN105263923B (https=)
DK (1) DK3004079T3 (https=)
ES (1) ES2665421T3 (https=)
NO (1) NO3004079T3 (https=)
PL (1) PL3004079T3 (https=)
WO (1) WO2014195323A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3481829B1 (en) * 2016-07-08 2021-04-07 H. Hoffnabb-La Roche Ag Fused pyrimidine derivatives
CN108191776A (zh) * 2018-01-22 2018-06-22 无锡富泽药业有限公司 一种尿嘧啶的绿色生产工艺
WO2020247707A1 (en) * 2019-06-05 2020-12-10 Chunyu Wang SYSTEMS AND METHOD FOR INHIBITING γ-SECRETASE PRODUCTION OF AMYLOID-β PEPTIDES
US12297244B2 (en) 2019-06-05 2025-05-13 Rensselaer Polytechnic Institute Systems and methods for inhibiting γ-secretase production of amyloid-β peptides
CN110372603A (zh) * 2019-06-24 2019-10-25 南京普锐达医药科技有限公司 一种2-氯-5-氟-6-乙基嘧啶的合成方法
CN113149977A (zh) 2020-01-22 2021-07-23 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
CA3214360A1 (en) 2021-03-23 2022-09-29 Halia Therapeutics, Inc. Pyrimidine derivatives useful as lrrk2 kinase inhibitors

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WO2000025780A1 (en) * 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
ITMI20030312A1 (it) 2003-02-21 2004-08-22 Chiesi Farma Spa Derivati di acidi 2-fenil-2-alchil-acetici per il trattamento della malattia di alzheimer.
US20080153817A1 (en) 2003-08-07 2008-06-26 Dirk Beher Treatment for Alzheimer's Disease and Related Conditions
DE602004023762D1 (de) 2003-12-03 2009-12-03 Merck Sharp & Dohme Für die behandlung von alzheimer-krankheit und ähnlichen leiden geeignete 1-alkyl-3-thiosubstituierte indol-2-alkinsäuren
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CN103626742B (zh) * 2005-11-01 2017-04-26 塔格根公司 激酶的联-芳基间-嘧啶抑制剂
WO2007125364A1 (en) 2006-04-26 2007-11-08 Merck Sharp & Dohme Limited Piperidines and related compounds for treatment of alzheimer’s disease
KR20090018963A (ko) 2006-05-19 2009-02-24 에자이 알앤드디 매니지먼트 가부시키가이샤 우레아계 신나미드 유도체
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
JP2010518080A (ja) 2007-02-08 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション 治療薬
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BR112012017310A2 (pt) 2010-01-15 2016-04-19 Janssen Pharmaceuticals Inc derivados de triazol substituídos como moduladores de gama secretase
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TW201206946A (en) 2010-07-15 2012-02-16 Bristol Myers Squibb Co Compounds for the reduction of beta-amyloid production

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