JP2018529770A5 - - Google Patents
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- Publication number
- JP2018529770A5 JP2018529770A5 JP2018535238A JP2018535238A JP2018529770A5 JP 2018529770 A5 JP2018529770 A5 JP 2018529770A5 JP 2018535238 A JP2018535238 A JP 2018535238A JP 2018535238 A JP2018535238 A JP 2018535238A JP 2018529770 A5 JP2018529770 A5 JP 2018529770A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- indol
- pyrazol
- propanamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562232629P | 2015-09-25 | 2015-09-25 | |
| US62/232,629 | 2015-09-25 | ||
| PCT/EP2016/072616 WO2017050938A1 (en) | 2015-09-25 | 2016-09-22 | Compounds and methods for inhibiting jak |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529770A JP2018529770A (ja) | 2018-10-11 |
| JP2018529770A5 true JP2018529770A5 (https=) | 2020-01-23 |
| JP6767491B2 JP6767491B2 (ja) | 2020-10-14 |
Family
ID=56979589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535238A Active JP6767491B2 (ja) | 2015-09-25 | 2016-09-22 | Ｊａｋを阻害するための化合物及び方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US9714236B2 (https=) |
| EP (2) | EP4219482A1 (https=) |
| JP (1) | JP6767491B2 (https=) |
| KR (2) | KR20250035597A (https=) |
| CN (4) | CN111848586B (https=) |
| AR (1) | AR106138A1 (https=) |
| AU (1) | AU2016328764B2 (https=) |
| BR (1) | BR112018005833B1 (https=) |
| CA (1) | CA2995430C (https=) |
| DK (1) | DK3353168T3 (https=) |
| ES (1) | ES2956642T3 (https=) |
| MX (1) | MX375724B (https=) |
| PT (1) | PT3353168T (https=) |
| RU (1) | RU2760359C2 (https=) |
| TW (1) | TWI740843B (https=) |
| WO (1) | WO2017050938A1 (https=) |
| ZA (1) | ZA201800782B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018005833B1 (pt) * | 2015-09-25 | 2023-10-10 | Dizal (Jiangsu) Pharmaceutical Co., Limited | Composto, sal farmaceuticamente aceitável, composição farmacêutica e uso do composto |
| AU2017269335B2 (en) | 2016-05-26 | 2021-07-01 | Recurium Ip Holdings, Llc | EGFR inhibitor compounds |
| KR102585048B1 (ko) | 2017-01-17 | 2023-10-05 | 아스트라제네카 아베 | Jak1 선택적 억제제 |
| KR20190043437A (ko) | 2017-10-18 | 2019-04-26 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| SG11202100240RA (en) * | 2018-07-18 | 2021-02-25 | Astrazeneca Ab | A xinafoate salt of a jak inhibiting compound |
| CA3113732C (en) * | 2018-09-21 | 2023-07-11 | Shanghai Ennovabio Pharmaceuticals Co., Ltd. | Aromatic heterocyclic compound with kinase inhibitory activity |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| TWI910107B (zh) * | 2019-04-19 | 2026-01-01 | 大陸商迪哲（江蘇）醫藥股份有限公司 | Ｊａｋ１選擇性激酶抑制劑 |
| CN110627775B (zh) * | 2019-10-24 | 2026-01-30 | 特科罗生物科技(成都)有限公司 | 一种小分子化合物 |
| CN111961037B (zh) * | 2020-09-17 | 2021-09-21 | 嘉兴特科罗生物科技有限公司 | 一种作为jak激酶抑制剂的药物化合物 |
| JP7613778B2 (ja) * | 2020-11-26 | 2025-01-15 | 科輝智薬（深▲セン▼）新薬研究中心有限公司 | アミド化合物、医薬組成物およびその使用 |
| BR112023016986A2 (pt) * | 2021-02-26 | 2023-11-07 | Tyra Biosciences Inc | Compostos de aminopirimidina e métodos de seu uso |
| BR112023018286A2 (pt) * | 2021-03-11 | 2023-10-31 | Janssen Pharmaceutica Nv | Lorpucitinib para uso no tratamento de distúrbios mediados por jak |
| CN115260128B (zh) * | 2022-09-21 | 2022-12-09 | 苏州凯瑞医药科技有限公司 | 一种新型jak抑制剂关键中间体的制备方法 |
| WO2025230951A1 (en) * | 2024-04-29 | 2025-11-06 | Icahn School Of Medicine At Mount Sinai | Method of treating adenoid cystic carcinoma |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI372624B (en) * | 2004-03-30 | 2012-09-21 | Vertex Pharma | Azaindoles useful as inhibitors of jak and other protein kinases |
| GB0500492D0 (en) * | 2005-01-11 | 2005-02-16 | Cyclacel Ltd | Compound |
| WO2007049041A1 (en) | 2005-10-28 | 2007-05-03 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| KR20080110998A (ko) * | 2006-01-30 | 2008-12-22 | 엑셀리시스, 인코포레이티드 | Ｊａｋ２ 조절자로서 ４아릴２아미노피리미딘 또는 4아릴２아미노알킬피리미딘 및 이들을 포함하는 약제학적 조성물 |
| BRPI0720264B1 (pt) * | 2006-12-08 | 2022-03-03 | Novartis Ag | Compostos e composições como inibidores de proteína cinase |
| KR101705158B1 (ko) * | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Ｅｇｆｒ 억제제 및 질환 치료방법 |
| JP5775070B2 (ja) | 2009-05-22 | 2015-09-09 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | ヤヌスキナーゼ阻害剤としてのピラゾール−４−イル−ピロロ［２，３−ｄ］ピリミジンおよびピロール−３−イル−ピロロ［２，３−ｄ］ピリミジンのＮ−（ヘテロ）アリール−ピロリジン誘導体 |
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| EP2611793A1 (en) * | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | 2-cycloquinazoline derivatives and methods of use thereof |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| AU2011328237A1 (en) * | 2010-11-09 | 2013-05-23 | Cellzome Limited | Pyridine compounds and aza analogues thereof as TYK2 inhibitors |
| CA2818542A1 (en) * | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| US20140045908A1 (en) * | 2011-02-25 | 2014-02-13 | Synta Pharmaceuticals Corp. | Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers |
| MY165963A (en) * | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| EP3459565A1 (en) | 2012-03-29 | 2019-03-27 | The Trustees of Columbia University in the City of New York | Methods for treating hair loss disorders |
| BR112018005833B1 (pt) * | 2015-09-25 | 2023-10-10 | Dizal (Jiangsu) Pharmaceutical Co., Limited | Composto, sal farmaceuticamente aceitável, composição farmacêutica e uso do composto |
-
2016
- 2016-09-22 BR BR112018005833-5A patent/BR112018005833B1/pt active IP Right Grant
- 2016-09-22 CN CN202010626114.2A patent/CN111848586B/zh active Active
- 2016-09-22 AU AU2016328764A patent/AU2016328764B2/en active Active
- 2016-09-22 CN CN201680055491.7A patent/CN108368091B/zh active Active
- 2016-09-22 CA CA2995430A patent/CA2995430C/en active Active
- 2016-09-22 WO PCT/EP2016/072616 patent/WO2017050938A1/en not_active Ceased
- 2016-09-22 CN CN202010629290.1A patent/CN111606893B/zh active Active
- 2016-09-22 CN CN202010629286.5A patent/CN111646980B/zh active Active
- 2016-09-22 EP EP23150992.8A patent/EP4219482A1/en active Pending
- 2016-09-22 US US15/272,554 patent/US9714236B2/en active Active
- 2016-09-22 ES ES16770031T patent/ES2956642T3/es active Active
- 2016-09-22 DK DK16770031.9T patent/DK3353168T3/da active
- 2016-09-22 PT PT167700319T patent/PT3353168T/pt unknown
- 2016-09-22 MX MX2018003590A patent/MX375724B/es active IP Right Grant
- 2016-09-22 KR KR1020257006096A patent/KR20250035597A/ko active Pending
- 2016-09-22 RU RU2018112993A patent/RU2760359C2/ru active
- 2016-09-22 KR KR1020187008186A patent/KR102774784B1/ko active Active
- 2016-09-22 JP JP2018535238A patent/JP6767491B2/ja active Active
- 2016-09-22 EP EP16770031.9A patent/EP3353168B1/en active Active
- 2016-09-23 TW TW105130891A patent/TWI740843B/zh active
- 2016-09-23 AR ARP160102919A patent/AR106138A1/es active IP Right Grant
-
2017
- 2017-05-22 US US15/601,324 patent/US10167276B2/en active Active
-
2018
- 2018-02-06 ZA ZA2018/00782A patent/ZA201800782B/en unknown
- 2018-11-20 US US16/196,038 patent/US10654835B2/en active Active
-
2020
- 2020-04-28 US US16/860,169 patent/US11247983B2/en active Active
-
2021
- 2021-12-28 US US17/563,913 patent/US12319670B2/en active Active
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