JP2016519664A5 - - Google Patents

Info

Publication number

JP2016519664A5

JP2016519664A5 JP2016502561A JP2016502561A JP2016519664A5 JP 2016519664 A5 JP2016519664 A5 JP 2016519664A5 JP 2016502561 A JP2016502561 A JP 2016502561A JP 2016502561 A JP2016502561 A JP 2016502561A JP 2016519664 A5 JP2016519664 A5 JP 2016519664A5

Authority

JP

Japan

Prior art keywords

seq

bacterial

bacteria

clade

sequence

Prior art date

2014-03-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 230000001580 bacterial effect Effects 0.000 description 410
• 241000894006 Bacteria Species 0.000 description 394
• 239000000203 mixture Substances 0.000 description 383
• 238000000034 method Methods 0.000 description 168
• 210000004215 spore Anatomy 0.000 description 103
• 241000894007 species Species 0.000 description 92
• 108090000623 proteins and genes Proteins 0.000 description 83
• 239000003613 bile acid Substances 0.000 description 81
• 244000005700 microbiome Species 0.000 description 78
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 73
• 238000012163 sequencing technique Methods 0.000 description 71
• 238000011282 treatment Methods 0.000 description 69
• 210000001035 gastrointestinal tract Anatomy 0.000 description 68
• 230000001225 therapeutic effect Effects 0.000 description 64
• 230000000813 microbial effect Effects 0.000 description 60
• 239000000463 material Substances 0.000 description 56
• 239000000047 product Substances 0.000 description 55
• 201000010099 disease Diseases 0.000 description 53
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 48
• 230000006870 function Effects 0.000 description 47
• 230000001717 pathogenic effect Effects 0.000 description 47
• 230000002550 fecal effect Effects 0.000 description 45
• 244000052769 pathogen Species 0.000 description 43
• 241000282414 Homo sapiens Species 0.000 description 41
• 238000003012 network analysis Methods 0.000 description 41
• 241000588724 Escherichia coli Species 0.000 description 36
• 210000004027 cell Anatomy 0.000 description 36
• 230000036541 health Effects 0.000 description 36
• 239000000523 sample Substances 0.000 description 36
• 108020004465 16S ribosomal RNA Proteins 0.000 description 35
• 238000009472 formulation Methods 0.000 description 34
• 238000003752 polymerase chain reaction Methods 0.000 description 34
• 238000002360 preparation method Methods 0.000 description 34
• 239000002773 nucleotide Substances 0.000 description 33
• 125000003729 nucleotide group Chemical group 0.000 description 33
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 32
• 238000004519 manufacturing process Methods 0.000 description 32
• 230000037361 pathway Effects 0.000 description 32
• 210000004666 bacterial spore Anatomy 0.000 description 31
• 230000000694 effects Effects 0.000 description 31
• 241000699670 Mus sp. Species 0.000 description 30
• 230000003115 biocidal effect Effects 0.000 description 30
• 238000006243 chemical reaction Methods 0.000 description 30
• 150000004666 short chain fatty acids Chemical class 0.000 description 30
• 235000021391 short chain fatty acids Nutrition 0.000 description 29
• 230000009897 systematic effect Effects 0.000 description 29
• 241000736262 Microbiota Species 0.000 description 28
• 244000005709 gut microbiome Species 0.000 description 28
• 230000001965 increasing effect Effects 0.000 description 27
• 239000000126 substance Substances 0.000 description 27
• 244000005706 microflora Species 0.000 description 25
• 241000193163 Clostridioides difficile Species 0.000 description 24
• 235000013305 food Nutrition 0.000 description 24
• 230000012010 growth Effects 0.000 description 23
• 241000606125 Bacteroides Species 0.000 description 22
• FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 22
• 230000002503 metabolic effect Effects 0.000 description 22
• 150000007523 nucleic acids Chemical group 0.000 description 22
• 238000003860 storage Methods 0.000 description 22
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 21
• 108020004414 DNA Proteins 0.000 description 21
• 208000018522 Gastrointestinal disease Diseases 0.000 description 21
• 239000003242 anti bacterial agent Substances 0.000 description 21
• 230000000968 intestinal effect Effects 0.000 description 21
• 239000013615 primer Substances 0.000 description 21
• 208000008589 Obesity Diseases 0.000 description 20
• 239000003814 drug Substances 0.000 description 20
• 230000004060 metabolic process Effects 0.000 description 20
• 230000002829 reductive effect Effects 0.000 description 20
• -1 ursocholate Chemical compound 0.000 description 20
• 108010059993 Vancomycin Proteins 0.000 description 19
• 238000004458 analytical method Methods 0.000 description 19
• 235000020824 obesity Nutrition 0.000 description 19
• 238000012360 testing method Methods 0.000 description 19
• 208000001072 type 2 diabetes mellitus Diseases 0.000 description 19
• 229960003165 vancomycin Drugs 0.000 description 19
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 19
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 19
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
• 210000001072 colon Anatomy 0.000 description 18
• 235000019441 ethanol Nutrition 0.000 description 18
• 239000002609 medium Substances 0.000 description 18
• 229940088710 antibiotic agent Drugs 0.000 description 17
• 208000002551 irritable bowel syndrome Diseases 0.000 description 17
• 241001464894 Blautia producta Species 0.000 description 16
• 241000193403 Clostridium Species 0.000 description 16
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 16
• 241001531188 [Eubacterium] rectale Species 0.000 description 16
• 238000012512 characterization method Methods 0.000 description 16
• 238000001514 detection method Methods 0.000 description 16
• 102000004169 proteins and genes Human genes 0.000 description 16
• 239000000243 solution Substances 0.000 description 16
• 241000606124 Bacteroides fragilis Species 0.000 description 15
• 241001465754 Metazoa Species 0.000 description 15
• 238000013459 approach Methods 0.000 description 15
• KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 15
• 208000035475 disorder Diseases 0.000 description 15
• 229940079593 drug Drugs 0.000 description 15
• 239000000546 pharmaceutical excipient Substances 0.000 description 15
• 108090000790 Enzymes Proteins 0.000 description 14
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 14
• 230000015572 biosynthetic process Effects 0.000 description 14
• 208000029182 enterotoxemia Diseases 0.000 description 14
• 230000007613 environmental effect Effects 0.000 description 14
• 239000003925 fat Substances 0.000 description 14
• 235000019197 fats Nutrition 0.000 description 14
• 208000015181 infectious disease Diseases 0.000 description 14
• 230000007246 mechanism Effects 0.000 description 14
• 230000008569 process Effects 0.000 description 14
• 235000018102 proteins Nutrition 0.000 description 14
• 230000009467 reduction Effects 0.000 description 14
• 241000193462 [Clostridium] innocuum Species 0.000 description 13
• 230000002496 gastric effect Effects 0.000 description 13
• 244000005702 human microbiome Species 0.000 description 13
• 229910052500 inorganic mineral Inorganic materials 0.000 description 13
• 239000007788 liquid Substances 0.000 description 13
• 235000010755 mineral Nutrition 0.000 description 13
• 239000011707 mineral Substances 0.000 description 13
• 239000003921 oil Substances 0.000 description 13
• 235000019198 oils Nutrition 0.000 description 13
• 229910052717 sulfur Inorganic materials 0.000 description 13
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 12
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
• 241000282412 Homo Species 0.000 description 12
• 206010022489 Insulin Resistance Diseases 0.000 description 12
• 108091028043 Nucleic acid sequence Proteins 0.000 description 12
• 241000192031 Ruminococcus Species 0.000 description 12
• 230000002068 genetic effect Effects 0.000 description 12
• 239000008194 pharmaceutical composition Substances 0.000 description 12
• 238000000746 purification Methods 0.000 description 12
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
• 230000003321 amplification Effects 0.000 description 11
• 244000052616 bacterial pathogen Species 0.000 description 11
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 11
• 239000008103 glucose Substances 0.000 description 11
• 229960001031 glucose Drugs 0.000 description 11
• 210000000936 intestine Anatomy 0.000 description 11
• 238000003199 nucleic acid amplification method Methods 0.000 description 11
• 239000007787 solid Substances 0.000 description 11
• 210000002784 stomach Anatomy 0.000 description 11
• 229940088594 vitamin Drugs 0.000 description 11
• 229930003231 vitamin Natural products 0.000 description 11
• 235000013343 vitamin Nutrition 0.000 description 11
• 239000011782 vitamin Substances 0.000 description 11
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 10
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
• 206010009900 Colitis ulcerative Diseases 0.000 description 10
• 241000949098 Coprococcus comes Species 0.000 description 10
• 241000016537 Dorea longicatena Species 0.000 description 10
• 208000037487 Endotoxemia Diseases 0.000 description 10
• 102000004190 Enzymes Human genes 0.000 description 10
• 241000186588 Erysipelatoclostridium ramosum Species 0.000 description 10
• 206010061218 Inflammation Diseases 0.000 description 10
• 201000006704 Ulcerative Colitis Diseases 0.000 description 10
• 241000700605 Viruses Species 0.000 description 10
• 230000008901 benefit Effects 0.000 description 10
• 239000012620 biological material Substances 0.000 description 10
• 239000002775 capsule Substances 0.000 description 10
• 235000010980 cellulose Nutrition 0.000 description 10
• 229920002678 cellulose Polymers 0.000 description 10
• 239000001913 cellulose Substances 0.000 description 10
• 239000011162 core material Substances 0.000 description 10
• 230000007423 decrease Effects 0.000 description 10
• 229940088598 enzyme Drugs 0.000 description 10
• 230000014509 gene expression Effects 0.000 description 10
• 230000004054 inflammatory process Effects 0.000 description 10
• 108020004707 nucleic acids Proteins 0.000 description 10
• 102000039446 nucleic acids Human genes 0.000 description 10
• 229920001282 polysaccharide Polymers 0.000 description 10
• 239000005017 polysaccharide Substances 0.000 description 10
• 150000004804 polysaccharides Chemical class 0.000 description 10
• 230000002265 prevention Effects 0.000 description 10
• 210000002966 serum Anatomy 0.000 description 10
• 210000000813 small intestine Anatomy 0.000 description 10
• 239000002904 solvent Substances 0.000 description 10
• RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 9
• 206010017943 Gastrointestinal conditions Diseases 0.000 description 9
• 206010018429 Glucose tolerance impaired Diseases 0.000 description 9
• SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 description 9
• 241000699666 Mus <mouse, genus> Species 0.000 description 9
• 208000001280 Prediabetic State Diseases 0.000 description 9
• 229920002472 Starch Polymers 0.000 description 9
• 238000003556 assay Methods 0.000 description 9
• 210000000941 bile Anatomy 0.000 description 9
• 150000001720 carbohydrates Chemical class 0.000 description 9
• 235000014633 carbohydrates Nutrition 0.000 description 9
• BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 9
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
• 235000005911 diet Nutrition 0.000 description 9
• 208000010643 digestive system disease Diseases 0.000 description 9
• 239000002552 dosage form Substances 0.000 description 9
• 208000018685 gastrointestinal system disease Diseases 0.000 description 9
• SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 description 9
• 238000005259 measurement Methods 0.000 description 9
• 229920001542 oligosaccharide Polymers 0.000 description 9
• 201000009104 prediabetes syndrome Diseases 0.000 description 9
• 239000003826 tablet Substances 0.000 description 9
• BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 8
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 8
• 239000004380 Cholic acid Substances 0.000 description 8
• 241000193171 Clostridium butyricum Species 0.000 description 8
• 241000194033 Enterococcus Species 0.000 description 8
• 241000186394 Eubacterium Species 0.000 description 8
• 229920001202 Inulin Polymers 0.000 description 8
• 241000193157 Paraclostridium bifermentans Species 0.000 description 8
• 241001531197 [Eubacterium] hallii Species 0.000 description 8
• 229940121375 antifungal agent Drugs 0.000 description 8
• 238000004422 calculation algorithm Methods 0.000 description 8
• 239000003795 chemical substances by application Substances 0.000 description 8
• 235000019416 cholic acid Nutrition 0.000 description 8
• 229960002471 cholic acid Drugs 0.000 description 8
• 206010012601 diabetes mellitus Diseases 0.000 description 8
• 235000014113 dietary fatty acids Nutrition 0.000 description 8
• 239000007884 disintegrant Substances 0.000 description 8
• 239000002158 endotoxin Substances 0.000 description 8
• 229930195729 fatty acid Natural products 0.000 description 8
• 239000000194 fatty acid Substances 0.000 description 8
• 230000035784 germination Effects 0.000 description 8
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
• 230000003993 interaction Effects 0.000 description 8
• JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 8
• 229940029339 inulin Drugs 0.000 description 8
• 150000002632 lipids Chemical class 0.000 description 8
• 229920006008 lipopolysaccharide Polymers 0.000 description 8
• 230000002906 microbiologic effect Effects 0.000 description 8
• 238000007481 next generation sequencing Methods 0.000 description 8
• 235000013406 prebiotics Nutrition 0.000 description 8
• 108090000765 processed proteins & peptides Proteins 0.000 description 8
• LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 8
• 238000003753 real-time PCR Methods 0.000 description 8
• 238000007480 sanger sequencing Methods 0.000 description 8
• 235000019698 starch Nutrition 0.000 description 8
• 235000000346 sugar Nutrition 0.000 description 8
• 208000024891 symptom Diseases 0.000 description 8
• 210000001519 tissue Anatomy 0.000 description 8
• 206010012735 Diarrhoea Diseases 0.000 description 7
• 241000588921 Enterobacteriaceae Species 0.000 description 7
• 241000605980 Faecalibacterium prausnitzii Species 0.000 description 7
• 241000233866 Fungi Species 0.000 description 7
• 238000007476 Maximum Likelihood Methods 0.000 description 7
• 241001464870 [Ruminococcus] torques Species 0.000 description 7
• 229960003022 amoxicillin Drugs 0.000 description 7
• LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 7
• YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 description 7
• 239000003153 chemical reaction reagent Substances 0.000 description 7
• RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 7
• 239000000460 chlorine Substances 0.000 description 7
• 238000002052 colonoscopy Methods 0.000 description 7
• 150000001875 compounds Chemical class 0.000 description 7
• KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 7
• 229960003964 deoxycholic acid Drugs 0.000 description 7
• 150000004665 fatty acids Chemical class 0.000 description 7
• 238000000855 fermentation Methods 0.000 description 7
• 239000000796 flavoring agent Substances 0.000 description 7
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 7
• 238000010438 heat treatment Methods 0.000 description 7
• 230000005764 inhibitory process Effects 0.000 description 7
• 230000007774 longterm Effects 0.000 description 7
• LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 7
• 230000001681 protective effect Effects 0.000 description 7
• 210000003289 regulatory T cell Anatomy 0.000 description 7
• 235000002639 sodium chloride Nutrition 0.000 description 7
• 230000028070 sporulation Effects 0.000 description 7
• 239000008107 starch Substances 0.000 description 7
• 229940032147 starch Drugs 0.000 description 7
• 230000004083 survival effect Effects 0.000 description 7
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
• 108020004463 18S ribosomal RNA Proteins 0.000 description 6
• 241001135228 Bacteroides ovatus Species 0.000 description 6
• 241001148536 Bacteroides sp. Species 0.000 description 6
• 241000606215 Bacteroides vulgatus Species 0.000 description 6
• 241001262170 Collinsella aerofaciens Species 0.000 description 6
• 208000011231 Crohn disease Diseases 0.000 description 6
• 241000196324 Embryophyta Species 0.000 description 6
• 241000194032 Enterococcus faecalis Species 0.000 description 6
• 241000263843 Lachnospiraceae bacterium 1_1_57FAA Species 0.000 description 6
• 241000262538 Lachnospiraceae bacterium 1_4_56FAA Species 0.000 description 6
• 241000583542 Lachnospiraceae bacterium 8_1_57FAA Species 0.000 description 6
• 241000872831 Roseburia faecis Species 0.000 description 6
• 241000607142 Salmonella Species 0.000 description 6
• 241000763413 Shuttleworthia Species 0.000 description 6
• 241001147795 Tyzzerella nexilis Species 0.000 description 6
• 241000696045 [Clostridium] glycyrrhizinilyticum Species 0.000 description 6
• 210000000577 adipose tissue Anatomy 0.000 description 6
• 239000000872 buffer Substances 0.000 description 6
• 229910052799 carbon Inorganic materials 0.000 description 6
• 230000036755 cellular response Effects 0.000 description 6
• 238000005119 centrifugation Methods 0.000 description 6
• 229960001091 chenodeoxycholic acid Drugs 0.000 description 6
• 239000011248 coating agent Substances 0.000 description 6
• 238000000576 coating method Methods 0.000 description 6
• 239000000356 contaminant Substances 0.000 description 6
• 238000010586 diagram Methods 0.000 description 6
• 230000037213 diet Effects 0.000 description 6
• 230000004151 fermentation Effects 0.000 description 6
• 235000003599 food sweetener Nutrition 0.000 description 6
• 235000009200 high fat diet Nutrition 0.000 description 6
• 235000015097 nutrients Nutrition 0.000 description 6
• 150000002482 oligosaccharides Chemical class 0.000 description 6
• 230000036961 partial effect Effects 0.000 description 6
• 239000000843 powder Substances 0.000 description 6
• 238000012545 processing Methods 0.000 description 6
• 238000011084 recovery Methods 0.000 description 6
• 230000011664 signaling Effects 0.000 description 6
• 239000003765 sweetening agent Substances 0.000 description 6
• XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 6
• 239000003053 toxin Substances 0.000 description 6
• 231100000765 toxin Toxicity 0.000 description 6
• 108700012359 toxins Proteins 0.000 description 6
• 230000007704 transition Effects 0.000 description 6
• 150000003722 vitamin derivatives Chemical class 0.000 description 6
• 241000131482 Bifidobacterium sp. Species 0.000 description 5
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
• 241000193155 Clostridium botulinum Species 0.000 description 5
• 241001147706 Clostridium sardiniense Species 0.000 description 5
• 241001531200 Dorea formicigenerans Species 0.000 description 5
• 241000792859 Enema Species 0.000 description 5
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 5
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 5
• 108010010803 Gelatin Proteins 0.000 description 5
• 241000186660 Lactobacillus Species 0.000 description 5
• 108010013563 Lipoprotein Lipase Proteins 0.000 description 5
• 102000043296 Lipoprotein lipases Human genes 0.000 description 5
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 5
• 241000202356 Ruminococcus lactaris Species 0.000 description 5
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 5
• 241001531273 [Eubacterium] eligens Species 0.000 description 5
• 150000001413 amino acids Chemical class 0.000 description 5
• 230000033228 biological regulation Effects 0.000 description 5
• 229940077731 carbohydrate nutrients Drugs 0.000 description 5
• 230000008859 change Effects 0.000 description 5
• 238000010276 construction Methods 0.000 description 5
• 238000009826 distribution Methods 0.000 description 5
• 239000007920 enema Substances 0.000 description 5
• 229940095399 enema Drugs 0.000 description 5
• 238000005516 engineering process Methods 0.000 description 5
• 230000002538 fungal effect Effects 0.000 description 5
• 239000000499 gel Substances 0.000 description 5
• 239000008273 gelatin Substances 0.000 description 5
• 229920000159 gelatin Polymers 0.000 description 5
• 235000019322 gelatine Nutrition 0.000 description 5
• 235000011852 gelatine desserts Nutrition 0.000 description 5
• 238000000338 in vitro Methods 0.000 description 5
• 238000001727 in vivo Methods 0.000 description 5
• 230000001939 inductive effect Effects 0.000 description 5
• 210000001630 jejunum Anatomy 0.000 description 5
• 230000007102 metabolic function Effects 0.000 description 5
• 230000000877 morphologic effect Effects 0.000 description 5
• 102000042567 non-coding RNA Human genes 0.000 description 5
• 239000008188 pellet Substances 0.000 description 5
• 239000006187 pill Substances 0.000 description 5
• 229920000642 polymer Polymers 0.000 description 5
• 238000002203 pretreatment Methods 0.000 description 5
• 230000035755 proliferation Effects 0.000 description 5
• 230000002441 reversible effect Effects 0.000 description 5
• 150000003839 salts Chemical class 0.000 description 5
• 239000000758 substrate Substances 0.000 description 5
• 239000000829 suppository Substances 0.000 description 5
• 239000000725 suspension Substances 0.000 description 5
• 238000003786 synthesis reaction Methods 0.000 description 5
• 238000012546 transfer Methods 0.000 description 5
• 241000589291 Acinetobacter Species 0.000 description 4
• 229920001817 Agar Polymers 0.000 description 4
• 241001135230 Alistipes putredinis Species 0.000 description 4
• 208000031729 Bacteremia Diseases 0.000 description 4
• 241000186000 Bifidobacterium Species 0.000 description 4
• 241001608472 Bifidobacterium longum Species 0.000 description 4
• 102100038495 Bile acid receptor Human genes 0.000 description 4
• 239000002028 Biomass Substances 0.000 description 4
• 241000605900 Butyrivibrio fibrisolvens Species 0.000 description 4
• 208000035473 Communicable disease Diseases 0.000 description 4
• 241000186249 Corynebacterium sp. Species 0.000 description 4
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 4
• 238000007399 DNA isolation Methods 0.000 description 4
• 241000186398 Eubacterium limosum Species 0.000 description 4
• 101710153349 Fibroblast growth factor 19 Proteins 0.000 description 4
• 102100031734 Fibroblast growth factor 19 Human genes 0.000 description 4
• 102100040133 Free fatty acid receptor 2 Human genes 0.000 description 4
• 241000605956 Fusobacterium mortiferum Species 0.000 description 4
• 241001185600 Gemmiger Species 0.000 description 4
• 101000603876 Homo sapiens Bile acid receptor Proteins 0.000 description 4
• 101000890668 Homo sapiens Free fatty acid receptor 2 Proteins 0.000 description 4
• 102000004877 Insulin Human genes 0.000 description 4
• 108090001061 Insulin Proteins 0.000 description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
• 241001177766 Lachnospiraceae bacterium 2_1_46FAA Species 0.000 description 4
• 241000263842 Lachnospiraceae bacterium 2_1_58FAA Species 0.000 description 4
• 241000482910 Lachnospiraceae bacterium 4_1_37FAA Species 0.000 description 4
• 241000263848 Lachnospiraceae bacterium 9_1_43BFAA Species 0.000 description 4
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• 241001135232 Odoribacter splanchnicus Species 0.000 description 4
• 241000191992 Peptostreptococcus Species 0.000 description 4
• 241001528479 Pseudoflavonifractor capillosus Species 0.000 description 4
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 4
• BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 4
• 229920002684 Sepharose Polymers 0.000 description 4
• 241000607768 Shigella Species 0.000 description 4
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
• 241000191940 Staphylococcus Species 0.000 description 4
• 241000191967 Staphylococcus aureus Species 0.000 description 4
• 229930006000 Sucrose Natural products 0.000 description 4
• 229930003268 Vitamin C Natural products 0.000 description 4
• 229930003427 Vitamin E Natural products 0.000 description 4
• 241000204291 [Bacteroides] coagulans Species 0.000 description 4
• 230000009471 action Effects 0.000 description 4
• 239000008272 agar Substances 0.000 description 4
• 229940023476 agar Drugs 0.000 description 4
• 235000010419 agar Nutrition 0.000 description 4
• 229940024606 amino acid Drugs 0.000 description 4
• 235000001014 amino acid Nutrition 0.000 description 4
• 239000003963 antioxidant agent Substances 0.000 description 4
• 235000006708 antioxidants Nutrition 0.000 description 4
• 235000013361 beverage Nutrition 0.000 description 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
• 230000001684 chronic effect Effects 0.000 description 4
• 206010009887 colitis Diseases 0.000 description 4
• 230000000112 colonic effect Effects 0.000 description 4
• 239000003086 colorant Substances 0.000 description 4
• 238000002648 combination therapy Methods 0.000 description 4
• 150000002016 disaccharides Chemical class 0.000 description 4
• 231100000249 enterotoxic Toxicity 0.000 description 4
• 230000002242 enterotoxic effect Effects 0.000 description 4
• 210000003608 fece Anatomy 0.000 description 4
• 238000005187 foaming Methods 0.000 description 4
• 235000013355 food flavoring agent Nutrition 0.000 description 4
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 4
• 230000003862 health status Effects 0.000 description 4
• 238000011534 incubation Methods 0.000 description 4
• 230000002757 inflammatory effect Effects 0.000 description 4
• 239000004615 ingredient Substances 0.000 description 4
• 229940125396 insulin Drugs 0.000 description 4
• 238000002955 isolation Methods 0.000 description 4
• 229940001447 lactate Drugs 0.000 description 4
• 210000002429 large intestine Anatomy 0.000 description 4
• 230000000670 limiting effect Effects 0.000 description 4
• 210000004185 liver Anatomy 0.000 description 4
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
• 239000003550 marker Substances 0.000 description 4
• 230000001404 mediated effect Effects 0.000 description 4
• 238000009629 microbiological culture Methods 0.000 description 4
• 150000002772 monosaccharides Chemical class 0.000 description 4
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 description 4
• 235000016709 nutrition Nutrition 0.000 description 4
• 239000000049 pigment Substances 0.000 description 4
• 239000003755 preservative agent Substances 0.000 description 4
• 102000004196 processed proteins & peptides Human genes 0.000 description 4
• RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 4
• 108700022487 rRNA Genes Proteins 0.000 description 4
• 210000000664 rectum Anatomy 0.000 description 4
• 230000000306 recurrent effect Effects 0.000 description 4
• 238000011160 research Methods 0.000 description 4
• 230000004044 response Effects 0.000 description 4
• 238000012552 review Methods 0.000 description 4
• 229910052711 selenium Inorganic materials 0.000 description 4
• 239000011669 selenium Substances 0.000 description 4
• 235000011649 selenium Nutrition 0.000 description 4
• 238000000926 separation method Methods 0.000 description 4
• 210000003491 skin Anatomy 0.000 description 4
• 239000005720 sucrose Substances 0.000 description 4
• 150000008163 sugars Chemical class 0.000 description 4
• 230000000153 supplemental effect Effects 0.000 description 4
• 239000004094 surface-active agent Substances 0.000 description 4
• 230000009885 systemic effect Effects 0.000 description 4
• RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 4
• 239000013598 vector Substances 0.000 description 4
• 235000019154 vitamin C Nutrition 0.000 description 4
• 239000011718 vitamin C Substances 0.000 description 4
• 235000019165 vitamin E Nutrition 0.000 description 4
• 239000011709 vitamin E Substances 0.000 description 4
• 229940046009 vitamin E Drugs 0.000 description 4
• 229940011671 vitamin b6 Drugs 0.000 description 4
• 150000003952 β-lactams Chemical class 0.000 description 4
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
• IGRCWJPBLWGNPX-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-(4-chlorophenyl)-n,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound C=1C=C(Cl)C=CC=1N(C)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl IGRCWJPBLWGNPX-UHFFFAOYSA-N 0.000 description 3
• 241001109646 Acetivibrio ethanolgignens Species 0.000 description 3
• 241000099223 Alistipes sp. Species 0.000 description 3
• 241000193457 Anaerocolumna aminovalerica Species 0.000 description 3
• 241000081343 Anaerosporobacter mobilis Species 0.000 description 3
• 241000193830 Bacillus <bacterium> Species 0.000 description 3
• 208000035143 Bacterial infection Diseases 0.000 description 3
• 241001135322 Bacteroides eggerthii Species 0.000 description 3
• 241001221145 Bacteroides pyogenes Species 0.000 description 3
• 241000606123 Bacteroides thetaiotaomicron Species 0.000 description 3
• 241000606219 Bacteroides uniformis Species 0.000 description 3
• 241000186018 Bifidobacterium adolescentis Species 0.000 description 3
• 241000589876 Campylobacter Species 0.000 description 3
• 108010000231 Choloylglycine hydrolase Proteins 0.000 description 3
• 241001656807 Clostridium haemolyticum Species 0.000 description 3
• 108010078777 Colistin Proteins 0.000 description 3
• AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 3
• 241001267419 Eubacterium sp. Species 0.000 description 3
• 241001531182 Eubacterium xylanophilum Species 0.000 description 3
• 241000206602 Eukaryota Species 0.000 description 3
• 241000192125 Firmicutes Species 0.000 description 3
• 102100025353 G-protein coupled bile acid receptor 1 Human genes 0.000 description 3
• 241000287828 Gallus gallus Species 0.000 description 3
• 241001223495 Gemmiger formicilis Species 0.000 description 3
• 229930182566 Gentamicin Natural products 0.000 description 3
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 3
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 description 3
• 101000857733 Homo sapiens G-protein coupled bile acid receptor 1 Proteins 0.000 description 3
• 101000843809 Homo sapiens Hydroxycarboxylic acid receptor 2 Proteins 0.000 description 3
• 102100030643 Hydroxycarboxylic acid receptor 2 Human genes 0.000 description 3
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
• 241000933069 Lachnoclostridium phytofermentans Species 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 3
• 229920000881 Modified starch Polymers 0.000 description 3
• 102000015728 Mucins Human genes 0.000 description 3
• 108010063954 Mucins Proteins 0.000 description 3
• 241000204031 Mycoplasma Species 0.000 description 3
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 3
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
• PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 3
• 241000206591 Peptococcus Species 0.000 description 3
• 241001394655 Roseburia inulinivorans Species 0.000 description 3
• 241000711837 Roseburia sp. Species 0.000 description 3
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
• 241000763410 Shuttleworthia satelles Species 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 241000194017 Streptococcus Species 0.000 description 3
• 241001580973 Subdoligranulum variabile Species 0.000 description 3
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
• 210000001744 T-lymphocyte Anatomy 0.000 description 3
• 241000167944 Tissierella praeacuta Species 0.000 description 3
• 102000002689 Toll-like receptor Human genes 0.000 description 3
• 108020000411 Toll-like receptor Proteins 0.000 description 3
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
• 241000514948 [Bacteroides] pectinophilus Species 0.000 description 3
• 241000186561 [Clostridium] clostridioforme Species 0.000 description 3
• 241000985249 [Clostridium] indolis Species 0.000 description 3
• 241001464867 [Ruminococcus] gnavus Species 0.000 description 3
• 238000010521 absorption reaction Methods 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 238000001042 affinity chromatography Methods 0.000 description 3
• 235000010443 alginic acid Nutrition 0.000 description 3
• 229920000615 alginic acid Polymers 0.000 description 3
• MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 3
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
• 229960000723 ampicillin Drugs 0.000 description 3
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 3
• 238000010171 animal model Methods 0.000 description 3
• 239000003429 antifungal agent Substances 0.000 description 3
• 239000004599 antimicrobial Substances 0.000 description 3
• 208000022362 bacterial infectious disease Diseases 0.000 description 3
• 229940009291 bifidobacterium longum Drugs 0.000 description 3
• 239000011230 binding agent Substances 0.000 description 3
• 229960002685 biotin Drugs 0.000 description 3
• 235000020958 biotin Nutrition 0.000 description 3
• 239000011616 biotin Substances 0.000 description 3
• 238000004364 calculation method Methods 0.000 description 3
• 239000007795 chemical reaction product Substances 0.000 description 3
• 235000013330 chicken meat Nutrition 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 239000012501 chromatography medium Substances 0.000 description 3
• 229960002227 clindamycin Drugs 0.000 description 3
• KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 3
• 229960003346 colistin Drugs 0.000 description 3
• 230000001332 colony forming effect Effects 0.000 description 3
• 239000002299 complementary DNA Substances 0.000 description 3
• 238000004590 computer program Methods 0.000 description 3
• 229920001577 copolymer Polymers 0.000 description 3
• 230000000875 corresponding effect Effects 0.000 description 3
• 239000002537 cosmetic Substances 0.000 description 3
• 238000005138 cryopreservation Methods 0.000 description 3
• 238000012258 culturing Methods 0.000 description 3
• 230000001472 cytotoxic effect Effects 0.000 description 3
• 238000009795 derivation Methods 0.000 description 3
• 230000000378 dietary effect Effects 0.000 description 3
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
• POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 3
• 229920001971 elastomer Polymers 0.000 description 3
• 230000008030 elimination Effects 0.000 description 3
• 238000003379 elimination reaction Methods 0.000 description 3
• 239000000839 emulsion Substances 0.000 description 3
• 238000009505 enteric coating Methods 0.000 description 3
• 239000002702 enteric coating Substances 0.000 description 3
• 229940032049 enterococcus faecalis Drugs 0.000 description 3
• 230000000688 enterotoxigenic effect Effects 0.000 description 3
• 230000002255 enzymatic effect Effects 0.000 description 3
• 210000003527 eukaryotic cell Anatomy 0.000 description 3
• 235000019634 flavors Nutrition 0.000 description 3
• 235000019152 folic acid Nutrition 0.000 description 3
• 239000011724 folic acid Substances 0.000 description 3
• 229960000304 folic acid Drugs 0.000 description 3
• 238000004108 freeze drying Methods 0.000 description 3
• 229960002518 gentamicin Drugs 0.000 description 3
• 230000014101 glucose homeostasis Effects 0.000 description 3
• 239000008187 granular material Substances 0.000 description 3
• 229920000591 gum Polymers 0.000 description 3
• 230000002440 hepatic effect Effects 0.000 description 3
• 238000009396 hybridization Methods 0.000 description 3
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
• 210000003405 ileum Anatomy 0.000 description 3
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
• 230000028993 immune response Effects 0.000 description 3
• 230000001976 improved effect Effects 0.000 description 3
• 230000006698 induction Effects 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 230000003870 intestinal permeability Effects 0.000 description 3
• 150000002500 ions Chemical class 0.000 description 3
• 229960000318 kanamycin Drugs 0.000 description 3
• 229930027917 kanamycin Natural products 0.000 description 3
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 3
• 229930182823 kanamycin A Natural products 0.000 description 3
• 229940039696 lactobacillus Drugs 0.000 description 3
• 210000005228 liver tissue Anatomy 0.000 description 3
• 244000144972 livestock Species 0.000 description 3
• 239000000314 lubricant Substances 0.000 description 3
• 238000004949 mass spectrometry Methods 0.000 description 3
• 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 3
• 235000012054 meals Nutrition 0.000 description 3
• 210000004379 membrane Anatomy 0.000 description 3
• 239000012528 membrane Substances 0.000 description 3
• KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 3
• 229960004963 mesalazine Drugs 0.000 description 3
• 208000030159 metabolic disease Diseases 0.000 description 3
• 239000002207 metabolite Substances 0.000 description 3
• 229920000609 methyl cellulose Polymers 0.000 description 3
• 235000010981 methylcellulose Nutrition 0.000 description 3
• 239000001923 methylcellulose Substances 0.000 description 3
• 229960003085 meticillin Drugs 0.000 description 3
• 229960000282 metronidazole Drugs 0.000 description 3
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 3
• 238000002156 mixing Methods 0.000 description 3
• 229940051875 mucins Drugs 0.000 description 3
• JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 description 3
• 229960003512 nicotinic acid Drugs 0.000 description 3
• 239000002245 particle Substances 0.000 description 3
• 229920001277 pectin Polymers 0.000 description 3
• 235000010987 pectin Nutrition 0.000 description 3
• 239000001814 pectin Substances 0.000 description 3
• 239000012071 phase Substances 0.000 description 3
• 239000002953 phosphate buffered saline Substances 0.000 description 3
• SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 3
• XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 3
• KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 description 3
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
• 239000006041 probiotic Substances 0.000 description 3
• 235000018291 probiotics Nutrition 0.000 description 3
• 238000003127 radioimmunoassay Methods 0.000 description 3
• 229960002477 riboflavin Drugs 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• 230000035945 sensitivity Effects 0.000 description 3
• 239000011734 sodium Substances 0.000 description 3
• 229910052708 sodium Inorganic materials 0.000 description 3
• 239000007858 starting material Substances 0.000 description 3
• 229960003080 taurine Drugs 0.000 description 3
• 238000002560 therapeutic procedure Methods 0.000 description 3
• 229960003495 thiamine Drugs 0.000 description 3
• 238000002054 transplantation Methods 0.000 description 3
• 150000003626 triacylglycerols Chemical class 0.000 description 3
• 229960001661 ursodiol Drugs 0.000 description 3
• 229920002554 vinyl polymer Polymers 0.000 description 3
• 235000019155 vitamin A Nutrition 0.000 description 3
• 239000011719 vitamin A Substances 0.000 description 3
• 229940045997 vitamin a Drugs 0.000 description 3
• 239000001993 wax Substances 0.000 description 3
• OQANPHBRHBJGNZ-FYJGNVAPSA-N (3e)-6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid Chemical compound C1=CC(=O)C(C(=O)O)=C\C1=N\NC1=CC=C(S(=O)(=O)NC=2N=CC=CC=2)C=C1 OQANPHBRHBJGNZ-FYJGNVAPSA-N 0.000 description 2
• WDLWHQDACQUCJR-ZAMMOSSLSA-N (6r,7r)-7-[[(2r)-2-azaniumyl-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(e)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)/C=C/C)C(O)=O)=CC=C(O)C=C1 WDLWHQDACQUCJR-ZAMMOSSLSA-N 0.000 description 2
• GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
• NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 2
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
• 102000014156 AMP-Activated Protein Kinases Human genes 0.000 description 2
• 108010011376 AMP-Activated Protein Kinases Proteins 0.000 description 2
• 241001116699 Acidaminococcus intestini Species 0.000 description 2
• 241000452716 Adlercreutzia equolifaciens Species 0.000 description 2
• VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 description 2
• 108091093088 Amplicon Proteins 0.000 description 2
• 241001505572 Anaerostipes caccae Species 0.000 description 2
• 102100025674 Angiopoietin-related protein 4 Human genes 0.000 description 2
• 241000203069 Archaea Species 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 241000217846 Bacteroides caccae Species 0.000 description 2
• 241001105998 Bacteroides dorei Species 0.000 description 2
• 241000605059 Bacteroidetes Species 0.000 description 2
• 241000260432 Barnesiella intestinihominis Species 0.000 description 2
• 241000123777 Blautia obeum Species 0.000 description 2
• 241000283690 Bos taurus Species 0.000 description 2
• 241000301580 Butyricicoccus pullicaecorum Species 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 241000606208 Campylobacter gracilis Species 0.000 description 2
• 241000282472 Canis lupus familiaris Species 0.000 description 2
• 241000283707 Capra Species 0.000 description 2
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
• 108010078791 Carrier Proteins Proteins 0.000 description 2
• 229930186147 Cephalosporin Natural products 0.000 description 2
• 241000606161 Chlamydia Species 0.000 description 2
• 206010008635 Cholestasis Diseases 0.000 description 2
• VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
• 241001147768 Clostridium argentinense Species 0.000 description 2
• 241000186542 Clostridium baratii Species 0.000 description 2
• 241000193455 Clostridium cadaveris Species 0.000 description 2
• 241000186571 Clostridium fallax Species 0.000 description 2
• 241001509499 Clostridium felsineum Species 0.000 description 2
• 241000193468 Clostridium perfringens Species 0.000 description 2
• 241000408944 Clostridium putrefaciens Species 0.000 description 2
• 241000193466 Clostridium septicum Species 0.000 description 2
• 241000193470 Clostridium sporogenes Species 0.000 description 2
• 241000186524 Clostridium subterminale Species 0.000 description 2
• 241000186528 Clostridium tertium Species 0.000 description 2
• ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
• 241001464948 Coprococcus Species 0.000 description 2
• 229920002261 Corn starch Polymers 0.000 description 2
• 241000353681 Corynebacterium appendicis Species 0.000 description 2
• 241000520076 Corynebacterium coyleae Species 0.000 description 2
• 241001517043 Corynebacterium genitalium Species 0.000 description 2
• 241001117273 Corynebacterium glaucum Species 0.000 description 2
• 241000024402 Corynebacterium imitans Species 0.000 description 2
• 241000577797 Corynebacterium mucifaciens Species 0.000 description 2
• 241000024400 Corynebacterium riegelii Species 0.000 description 2
• 241000334945 Corynebacterium sundsvallense Species 0.000 description 2
• 241000892281 Corynebacterium tuscaniense Species 0.000 description 2
• 241000586985 Corynebacterium ureicelerivorans Species 0.000 description 2
• 241000699800 Cricetinae Species 0.000 description 2
• SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
• 238000007400 DNA extraction Methods 0.000 description 2
• 238000001712 DNA sequencing Methods 0.000 description 2
• 241000605716 Desulfovibrio Species 0.000 description 2
• 241001535058 Dialister pneumosintes Species 0.000 description 2
• 102100020743 Dipeptidase 1 Human genes 0.000 description 2
• 208000027244 Dysbiosis Diseases 0.000 description 2
• 241000520130 Enterococcus durans Species 0.000 description 2
• 241000194029 Enterococcus hirae Species 0.000 description 2
• 241000588722 Escherichia Species 0.000 description 2
• 239000001856 Ethyl cellulose Substances 0.000 description 2
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
• 241001531190 Eubacterium ramulus Species 0.000 description 2
• 241001531192 Eubacterium ventriosum Species 0.000 description 2
• 241000282326 Felis catus Species 0.000 description 2
• 235000012571 Ficus glomerata Nutrition 0.000 description 2
• 244000153665 Ficus glomerata Species 0.000 description 2
• 241000192016 Finegoldia magna Species 0.000 description 2
• 241001134569 Flavonifractor plautii Species 0.000 description 2
• 229920002670 Fructan Polymers 0.000 description 2
• 229930091371 Fructose Natural products 0.000 description 2
• 239000005715 Fructose Substances 0.000 description 2
• 241001453172 Fusobacteria Species 0.000 description 2
• 241000605909 Fusobacterium Species 0.000 description 2
• 241000605986 Fusobacterium nucleatum Species 0.000 description 2
• 108091092584 GDNA Proteins 0.000 description 2
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 description 2
• 101800000224 Glucagon-like peptide 1 Proteins 0.000 description 2
• 102400000326 Glucagon-like peptide 2 Human genes 0.000 description 2
• 101800000221 Glucagon-like peptide 2 Proteins 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• 238000003794 Gram staining Methods 0.000 description 2
• 101000693076 Homo sapiens Angiopoietin-related protein 4 Proteins 0.000 description 2
• 101001125032 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 1 Proteins 0.000 description 2
• 101001125026 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 2 Proteins 0.000 description 2
• 101100518559 Homo sapiens OTUB1 gene Proteins 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
• 241000588748 Klebsiella Species 0.000 description 2
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
• 241001233594 Lachnobacterium bovis Species 0.000 description 2
• 241001134638 Lachnospira Species 0.000 description 2
• 241001534110 Lactarius <percoid fish> Species 0.000 description 2
• 244000199866 Lactobacillus casei Species 0.000 description 2
• 235000013958 Lactobacillus casei Nutrition 0.000 description 2
• 241001134654 Lactobacillus leichmannii Species 0.000 description 2
• 241000186604 Lactobacillus reuteri Species 0.000 description 2
• 241000186610 Lactobacillus sp. Species 0.000 description 2
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
• MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 2
• 206010027476 Metastases Diseases 0.000 description 2
• BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
• ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 2
• 101100001708 Mus musculus Angptl4 gene Proteins 0.000 description 2
• LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
• 102100029424 Nucleotide-binding oligomerization domain-containing protein 1 Human genes 0.000 description 2
• 102100029441 Nucleotide-binding oligomerization domain-containing protein 2 Human genes 0.000 description 2
• 101150115940 OTU1 gene Proteins 0.000 description 2
• 241000604373 Ovatus Species 0.000 description 2
• 238000012408 PCR amplification Methods 0.000 description 2
• 241001147789 Paeniclostridium ghonii Species 0.000 description 2
• 241000193465 Paeniclostridium sordellii Species 0.000 description 2
• 241000606210 Parabacteroides distasonis Species 0.000 description 2
• 241001494479 Pecora Species 0.000 description 2
• 241000286209 Phasianidae Species 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
• 241000257453 Pisaster ochraceus Species 0.000 description 2
• 241000606999 Plesiomonas shigelloides Species 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• 241000605860 Prevotella ruminicola Species 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• 108010058003 Proglucagon Proteins 0.000 description 2
• 102000035554 Proglucagon Human genes 0.000 description 2
• 240000005809 Prunus persica Species 0.000 description 2
• 235000006040 Prunus persica var persica Nutrition 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 241000283984 Rodentia Species 0.000 description 2
• 241000605947 Roseburia Species 0.000 description 2
• 241000605944 Roseburia cecicola Species 0.000 description 2
• 241000872832 Roseburia hominis Species 0.000 description 2
• 241000398180 Roseburia intestinalis Species 0.000 description 2
• 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 2
• 241000096243 Shuttleworthia sp. oral taxon G69 Species 0.000 description 2
• 241000193817 Staphylococcus pasteuri Species 0.000 description 2
• 241000194046 Streptococcus intermedius Species 0.000 description 2
• 241000193998 Streptococcus pneumoniae Species 0.000 description 2
• 241001505901 Streptococcus sp. 'group A' Species 0.000 description 2
• 241000193990 Streptococcus sp. 'group B' Species 0.000 description 2
• 241000282887 Suidae Species 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
• 241001135235 Tannerella forsythia Species 0.000 description 2
• 241001509489 Terrisporobacter glycolicus Species 0.000 description 2
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
• JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
• 229920001615 Tragacanth Polymers 0.000 description 2
• 102100040461 Ubiquitin thioesterase OTUB1 Human genes 0.000 description 2
• 241000607598 Vibrio Species 0.000 description 2
• 229930003779 Vitamin B12 Natural products 0.000 description 2
• 229930003316 Vitamin D Natural products 0.000 description 2
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
• 229930003448 Vitamin K Natural products 0.000 description 2
• PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 description 2
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
• 241001147801 [Clostridium] scindens Species 0.000 description 2
• 241001147717 [Clostridium] sphenoides Species 0.000 description 2
• 241000193450 [Clostridium] symbiosum Species 0.000 description 2
• 241000186397 [Eubacterium] tenue Species 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
• 230000001154 acute effect Effects 0.000 description 2
• 238000007792 addition Methods 0.000 description 2
• 210000001789 adipocyte Anatomy 0.000 description 2
• 150000001298 alcohols Chemical class 0.000 description 2
• 229940072056 alginate Drugs 0.000 description 2
• 210000004102 animal cell Anatomy 0.000 description 2
• 230000000843 anti-fungal effect Effects 0.000 description 2
• 238000009635 antibiotic susceptibility testing Methods 0.000 description 2
• 239000000427 antigen Substances 0.000 description 2
• 108091007433 antigens Proteins 0.000 description 2
• 102000036639 antigens Human genes 0.000 description 2
• 239000003443 antiviral agent Substances 0.000 description 2
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
• 230000009286 beneficial effect Effects 0.000 description 2
• 239000000440 bentonite Substances 0.000 description 2
• 229910000278 bentonite Inorganic materials 0.000 description 2
• 235000012216 bentonite Nutrition 0.000 description 2
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
• 239000003858 bile acid conjugate Substances 0.000 description 2
• 239000000090 biomarker Substances 0.000 description 2
• 230000037396 body weight Effects 0.000 description 2
• RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• PTOJXIKSKSASRB-UHFFFAOYSA-O candicine Chemical compound C[N+](C)(C)CCC1=CC=C(O)C=C1 PTOJXIKSKSASRB-UHFFFAOYSA-O 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• 229960005361 cefaclor Drugs 0.000 description 2
• QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 description 2
• 229960001139 cefazolin Drugs 0.000 description 2
• MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 2
• WZOZEZRFJCJXNZ-ZBFHGGJFSA-N cefoxitin Chemical compound N([C@]1(OC)C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)CC1=CC=CS1 WZOZEZRFJCJXNZ-ZBFHGGJFSA-N 0.000 description 2
• 229960002580 cefprozil Drugs 0.000 description 2
• 229960001668 cefuroxime Drugs 0.000 description 2
• JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 description 2
• 230000034303 cell budding Effects 0.000 description 2
• 229920002301 cellulose acetate Polymers 0.000 description 2
• 229940124587 cephalosporin Drugs 0.000 description 2
• 150000001780 cephalosporins Chemical class 0.000 description 2
• 238000001311 chemical methods and process Methods 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 235000012000 cholesterol Nutrition 0.000 description 2
• 229910052804 chromium Inorganic materials 0.000 description 2
• 239000011651 chromium Substances 0.000 description 2
• MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
• AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 2
• 235000017471 coenzyme Q10 Nutrition 0.000 description 2
• ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
• 230000005757 colony formation Effects 0.000 description 2
• 230000000052 comparative effect Effects 0.000 description 2
• 230000000295 complement effect Effects 0.000 description 2
• 238000011109 contamination Methods 0.000 description 2
• 229910052802 copper Inorganic materials 0.000 description 2
• 239000010949 copper Substances 0.000 description 2
• 239000008120 corn starch Substances 0.000 description 2
• RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
• 231100000433 cytotoxic Toxicity 0.000 description 2
• 230000002354 daily effect Effects 0.000 description 2
• 230000006378 damage Effects 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• WHBIGIKBNXZKFE-UHFFFAOYSA-N delavirdine Chemical compound CC(C)NC1=CC=CN=C1N1CCN(C(=O)C=2NC3=CC=C(NS(C)(=O)=O)C=C3C=2)CC1 WHBIGIKBNXZKFE-UHFFFAOYSA-N 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 238000005906 dihydroxylation reaction Methods 0.000 description 2
• 239000003085 diluting agent Substances 0.000 description 2
• 238000010790 dilution Methods 0.000 description 2
• 239000012895 dilution Substances 0.000 description 2
• 230000006806 disease prevention Effects 0.000 description 2
• 208000037765 diseases and disorders Diseases 0.000 description 2
• 239000006185 dispersion Substances 0.000 description 2
• 235000020669 docosahexaenoic acid Nutrition 0.000 description 2
• NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
• UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
• 239000003651 drinking water Substances 0.000 description 2
• 235000020188 drinking water Nutrition 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 238000001035 drying Methods 0.000 description 2
• 230000007140 dysbiosis Effects 0.000 description 2
• 235000013399 edible fruits Nutrition 0.000 description 2
• 235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
• 230000002708 enhancing effect Effects 0.000 description 2
• 229960003276 erythromycin Drugs 0.000 description 2
• 235000020774 essential nutrients Nutrition 0.000 description 2
• 235000019325 ethyl cellulose Nutrition 0.000 description 2
• 229920001249 ethyl cellulose Polymers 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 230000002349 favourable effect Effects 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 description 2
• 229960004413 flucytosine Drugs 0.000 description 2
• 230000004907 flux Effects 0.000 description 2
• 235000021588 free fatty acids Nutrition 0.000 description 2
• 229960002737 fructose Drugs 0.000 description 2
• 229940068517 fruit extracts Drugs 0.000 description 2
• 235000021255 galacto-oligosaccharides Nutrition 0.000 description 2
• 150000003271 galactooligosaccharides Chemical class 0.000 description 2
• 210000004051 gastric juice Anatomy 0.000 description 2
• 238000001502 gel electrophoresis Methods 0.000 description 2
• 239000007903 gelatin capsule Substances 0.000 description 2
• 238000012252 genetic analysis Methods 0.000 description 2
• 238000003205 genotyping method Methods 0.000 description 2
• TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 description 2
• 230000004110 gluconeogenesis Effects 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• KEMQGTRYUADPNZ-UHFFFAOYSA-N heptadecanoic acid Chemical compound CCCCCCCCCCCCCCCCC(O)=O KEMQGTRYUADPNZ-UHFFFAOYSA-N 0.000 description 2
• IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
• 230000013632 homeostatic process Effects 0.000 description 2
• 210000005260 human cell Anatomy 0.000 description 2
• 239000001257 hydrogen Substances 0.000 description 2
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 2
• 230000036039 immunity Effects 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 230000002458 infectious effect Effects 0.000 description 2
• 208000027866 inflammatory disease Diseases 0.000 description 2
• 210000005027 intestinal barrier Anatomy 0.000 description 2
• 230000007358 intestinal barrier function Effects 0.000 description 2
• 210000002490 intestinal epithelial cell Anatomy 0.000 description 2
• 230000006799 invasive growth in response to glucose limitation Effects 0.000 description 2
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
• NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 2
• 229910052742 iron Inorganic materials 0.000 description 2
• BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 2
• 229940017800 lactobacillus casei Drugs 0.000 description 2
• 229940001882 lactobacillus reuteri Drugs 0.000 description 2
• JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 2
• 229960000511 lactulose Drugs 0.000 description 2
• PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 2
• 208000019423 liver disease Diseases 0.000 description 2
• 230000004807 localization Effects 0.000 description 2
• 239000007937 lozenge Substances 0.000 description 2
• 239000008176 lyophilized powder Substances 0.000 description 2
• 235000021073 macronutrients Nutrition 0.000 description 2
• 239000011777 magnesium Substances 0.000 description 2
• 229910052749 magnesium Inorganic materials 0.000 description 2
• 235000019359 magnesium stearate Nutrition 0.000 description 2
• WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 2
• 150000003272 mannan oligosaccharides Chemical class 0.000 description 2
• 239000000155 melt Substances 0.000 description 2
• DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 description 2
• 230000037323 metabolic rate Effects 0.000 description 2
• 230000009401 metastasis Effects 0.000 description 2
• 239000011785 micronutrient Substances 0.000 description 2
• 235000013369 micronutrients Nutrition 0.000 description 2
• 230000005012 migration Effects 0.000 description 2
• 238000013508 migration Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 238000012986 modification Methods 0.000 description 2
• 229910052750 molybdenum Inorganic materials 0.000 description 2
• 239000011733 molybdenum Substances 0.000 description 2
• 238000010172 mouse model Methods 0.000 description 2
• 210000000214 mouth Anatomy 0.000 description 2
• 210000004877 mucosa Anatomy 0.000 description 2
• NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 description 2
• 235000001968 nicotinic acid Nutrition 0.000 description 2
• 239000011664 nicotinic acid Substances 0.000 description 2
• DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
• 229910052757 nitrogen Inorganic materials 0.000 description 2
• 235000015816 nutrient absorption Nutrition 0.000 description 2
• 238000013116 obese mouse model Methods 0.000 description 2
• 244000039328 opportunistic pathogen Species 0.000 description 2
• 230000003204 osmotic effect Effects 0.000 description 2
• 230000003647 oxidation Effects 0.000 description 2
• 238000007254 oxidation reaction Methods 0.000 description 2
• SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 2
• 244000045947 parasite Species 0.000 description 2
• 230000035699 permeability Effects 0.000 description 2
• 229910052698 phosphorus Inorganic materials 0.000 description 2
• 239000011574 phosphorus Substances 0.000 description 2
• 229920001223 polyethylene glycol Polymers 0.000 description 2
• 229920005862 polyol Polymers 0.000 description 2
• 150000003077 polyols Chemical class 0.000 description 2
• 229920001184 polypeptide Polymers 0.000 description 2
• 239000011591 potassium Substances 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 229920001592 potato starch Polymers 0.000 description 2
• 244000062645 predators Species 0.000 description 2
• QAQREVBBADEHPA-IEXPHMLFSA-N propionyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QAQREVBBADEHPA-IEXPHMLFSA-N 0.000 description 2
• 235000008160 pyridoxine Nutrition 0.000 description 2
• 239000011677 pyridoxine Substances 0.000 description 2
• 150000003254 radicals Chemical class 0.000 description 2
• 239000003642 reactive oxygen metabolite Substances 0.000 description 2
• 235000019192 riboflavin Nutrition 0.000 description 2
• 239000002151 riboflavin Substances 0.000 description 2
• 210000003705 ribosome Anatomy 0.000 description 2
• 230000024053 secondary metabolic process Effects 0.000 description 2
• 239000006152 selective media Substances 0.000 description 2
• 238000013207 serial dilution Methods 0.000 description 2
• 235000017557 sodium bicarbonate Nutrition 0.000 description 2
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
• 229920003109 sodium starch glycolate Polymers 0.000 description 2
• 239000008109 sodium starch glycolate Substances 0.000 description 2
• 229940079832 sodium starch glycolate Drugs 0.000 description 2
• 235000021055 solid food Nutrition 0.000 description 2
• 238000000527 sonication Methods 0.000 description 2
• 235000011496 sports drink Nutrition 0.000 description 2
• 238000001694 spray drying Methods 0.000 description 2
• 239000003381 stabilizer Substances 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• 239000013589 supplement Substances 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 2
• 208000011580 syndromic disease Diseases 0.000 description 2
• 238000004885 tandem mass spectrometry Methods 0.000 description 2
• ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
• 239000011721 thiamine Substances 0.000 description 2
• 235000019157 thiamine Nutrition 0.000 description 2
• KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 2
• 230000000699 topical effect Effects 0.000 description 2
• 230000001988 toxicity Effects 0.000 description 2
• 231100000419 toxicity Toxicity 0.000 description 2
• KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 2
• 238000013518 transcription Methods 0.000 description 2
• 230000035897 transcription Effects 0.000 description 2
• 230000001052 transient effect Effects 0.000 description 2
• ARCGXLSVLAOJQL-UHFFFAOYSA-N trimellitic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C(C(O)=O)=C1 ARCGXLSVLAOJQL-UHFFFAOYSA-N 0.000 description 2
• 230000001228 trophic effect Effects 0.000 description 2
• 238000011144 upstream manufacturing Methods 0.000 description 2
• 210000001215 vagina Anatomy 0.000 description 2
• 235000019163 vitamin B12 Nutrition 0.000 description 2
• 239000011715 vitamin B12 Substances 0.000 description 2
• 235000019158 vitamin B6 Nutrition 0.000 description 2
• 239000011726 vitamin B6 Substances 0.000 description 2
• 235000019166 vitamin D Nutrition 0.000 description 2
• 239000011710 vitamin D Substances 0.000 description 2
• 150000003710 vitamin D derivatives Chemical class 0.000 description 2
• 235000019168 vitamin K Nutrition 0.000 description 2
• 239000011712 vitamin K Substances 0.000 description 2
• 150000003721 vitamin K derivatives Chemical class 0.000 description 2
• 229940046008 vitamin d Drugs 0.000 description 2
• 229940046010 vitamin k Drugs 0.000 description 2
• 238000012070 whole genome sequencing analysis Methods 0.000 description 2
• 229920001221 xylan Polymers 0.000 description 2
• 150000004823 xylans Chemical class 0.000 description 2
• 239000011701 zinc Substances 0.000 description 2
• 229910052725 zinc Inorganic materials 0.000 description 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
• BITHHVVYSMSWAG-KTKRTIGZSA-N (11Z)-icos-11-enoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCC(O)=O BITHHVVYSMSWAG-KTKRTIGZSA-N 0.000 description 1
• XSXIVVZCUAHUJO-HZJYTTRNSA-N (11Z,14Z)-icosadienoic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-HZJYTTRNSA-N 0.000 description 1
• GEHPRJRWZDWFBJ-FOCLMDBBSA-N (2E)-2-heptadecenoic acid Chemical compound CCCCCCCCCCCCCC\C=C\C(O)=O GEHPRJRWZDWFBJ-FOCLMDBBSA-N 0.000 description 1
• LGHXTTIAZFVCCU-SSVNFBSYSA-N (2E,4E,6E,8E)-octadeca-2,4,6,8-tetraenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O LGHXTTIAZFVCCU-SSVNFBSYSA-N 0.000 description 1
• BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 description 1
• 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 description 1
• OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
• JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 description 1
• SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
• FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
• JSRREMIKIHJGAA-JTQLQIEISA-N (6s)-2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-10-hydroxy-n,6-dimethyl-1,9-dioxo-6,7-dihydropyrazino[5,6]pyrrolo[1,3-b]pyridazine-4-carboxamide Chemical compound N1([C@@H](C)CN(C2=O)CC)C2=C(O)C(C2=O)=C1C(C(=O)NC)=NN2CC1=CC=C(F)C(Cl)=C1 JSRREMIKIHJGAA-JTQLQIEISA-N 0.000 description 1
• YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
• 229930182837 (R)-adrenaline Natural products 0.000 description 1
• GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
• ATNNLHXCRAAGJS-QZQOTICOSA-N (e)-docos-2-enoic acid Chemical compound CCCCCCCCCCCCCCCCCCC\C=C\C(O)=O ATNNLHXCRAAGJS-QZQOTICOSA-N 0.000 description 1
• NCCJWSXETVVUHK-ZYSAIPPVSA-N (z)-7-[(2r)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid;(5r,6s)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1r)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical compound C1C(SCC\N=C/N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21.CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O NCCJWSXETVVUHK-ZYSAIPPVSA-N 0.000 description 1
• AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 description 1
• JLGKQTAYUIMGRK-UHFFFAOYSA-N 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C2=CC=CC(Cl)=C2SC=1)CN1C=NC=C1 JLGKQTAYUIMGRK-UHFFFAOYSA-N 0.000 description 1
• FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
• SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
• BHNQPLPANNDEGL-UHFFFAOYSA-N 2-(4-octylphenoxy)ethanol Chemical compound CCCCCCCCC1=CC=C(OCCO)C=C1 BHNQPLPANNDEGL-UHFFFAOYSA-N 0.000 description 1
• NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
• VLEIUWBSEKKKFX-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid Chemical compound OCC(N)(CO)CO.OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O VLEIUWBSEKKKFX-UHFFFAOYSA-N 0.000 description 1
• TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 1
• ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
• WLAMNBDJUVNPJU-UHFFFAOYSA-M 2-methylbutyrate Chemical compound CCC(C)C([O-])=O WLAMNBDJUVNPJU-UHFFFAOYSA-M 0.000 description 1
• GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
• GUPXYSSGJWIURR-UHFFFAOYSA-N 3-octoxypropane-1,2-diol Chemical compound CCCCCCCCOCC(O)CO GUPXYSSGJWIURR-UHFFFAOYSA-N 0.000 description 1
• 101710172561 3alpha-hydroxysteroid dehydrogenase Proteins 0.000 description 1
• ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
• ACRRANHJMOPYFZ-UHFFFAOYSA-N 6-methyl-2,2-dioxooxathiazinan-4-one Chemical compound CC1CC(=O)NS(=O)(=O)O1 ACRRANHJMOPYFZ-UHFFFAOYSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• 244000215068 Acacia senegal Species 0.000 description 1
• WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
• 108030002957 Acetate CoA-transferases Proteins 0.000 description 1
• 241000204396 Acetonema Species 0.000 description 1
• 241000604450 Acidaminococcus fermentans Species 0.000 description 1
• 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
• 241000607528 Aeromonas hydrophila Species 0.000 description 1
• 241001531272 Agathobaculum desmolans Species 0.000 description 1
• 241001147780 Alicyclobacillus Species 0.000 description 1
• 241001580959 Alistipes finegoldii Species 0.000 description 1
• 241000030713 Alistipes onderdonkii Species 0.000 description 1
• 241000030716 Alistipes shahii Species 0.000 description 1
• 241000197729 Alkaliphilus Species 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 239000005995 Aluminium silicate Substances 0.000 description 1
• 241000147157 Ammonifex Species 0.000 description 1
• 241001147782 Amphibacillus Species 0.000 description 1
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
• 241000079561 Anaerofustis Species 0.000 description 1
• 241001227086 Anaerostipes Species 0.000 description 1
• 241001584951 Anaerostipes hadrus Species 0.000 description 1
• 241001013579 Anaerotruncus Species 0.000 description 1
• 241000428313 Anaerotruncus colihominis Species 0.000 description 1
• 235000007119 Ananas comosus Nutrition 0.000 description 1
• 244000099147 Ananas comosus Species 0.000 description 1
• 108010064760 Anidulafungin Proteins 0.000 description 1
• 241001626813 Anoxybacillus Species 0.000 description 1
• 108700042778 Antimicrobial Peptides Proteins 0.000 description 1
• 102000044503 Antimicrobial Peptides Human genes 0.000 description 1
• 241001147785 Asaccharospora irregularis Species 0.000 description 1
• 108010011485 Aspartame Proteins 0.000 description 1
• JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
• 241000258957 Asteroidea Species 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• AXRYRYVKAWYZBR-UHFFFAOYSA-N Atazanavir Natural products C=1C=C(C=2N=CC=CC=2)C=CC=1CN(NC(=O)C(NC(=O)OC)C(C)(C)C)CC(O)C(NC(=O)C(NC(=O)OC)C(C)(C)C)CC1=CC=CC=C1 AXRYRYVKAWYZBR-UHFFFAOYSA-N 0.000 description 1
• 108010019625 Atazanavir Sulfate Proteins 0.000 description 1
• 241000193755 Bacillus cereus Species 0.000 description 1
• 108010077805 Bacterial Proteins Proteins 0.000 description 1
• 208000034309 Bacterial disease carrier Diseases 0.000 description 1
• 241000168635 Bacteroides barnesiae Species 0.000 description 1
• 241001220439 Bacteroides coprocola Species 0.000 description 1
• 241000545821 Bacteroides coprophilus Species 0.000 description 1
• 241000514947 Bacteroides galacturonicus Species 0.000 description 1
• 241001195773 Bacteroides massiliensis Species 0.000 description 1
• 241001220441 Bacteroides plebeius Species 0.000 description 1
• 241000204294 Bacteroides stercoris Species 0.000 description 1
• 235000021357 Behenic acid Nutrition 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• 241001430332 Bifidobacteriaceae Species 0.000 description 1
• 241000042873 Bifidobacterium scardovii Species 0.000 description 1
• 241001468229 Bifidobacterium thermophilum Species 0.000 description 1
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
• 208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
• 241001202853 Blautia Species 0.000 description 1
• 241000588807 Bordetella Species 0.000 description 1
• ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
• 241000589968 Borrelia Species 0.000 description 1
• 241000167854 Bourreria succulenta Species 0.000 description 1
• 241000555281 Brevibacillus Species 0.000 description 1
• 241000589562 Brucella Species 0.000 description 1
• 241001453380 Burkholderia Species 0.000 description 1
• 239000012619 Butyl Sepharose® Substances 0.000 description 1
• 241000193174 Butyrivibrio crossotus Species 0.000 description 1
• 108050007083 Butyryl-CoA:acetate CoA-transferases Proteins 0.000 description 1
• KAWOEDMUUFFXAM-UHFFFAOYSA-N CC1(C)CCCC2(C)C(C)C(C=O)=CCC21 Polymers CC1(C)CCCC2(C)C(C)C(C=O)=CCC21 KAWOEDMUUFFXAM-UHFFFAOYSA-N 0.000 description 1
• QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 241000589874 Campylobacter fetus Species 0.000 description 1
• 241000589875 Campylobacter jejuni Species 0.000 description 1
• 241000606177 Campylobacter ureolyticus Species 0.000 description 1
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
• 206010007134 Candida infections Diseases 0.000 description 1
• 102100037403 Carbohydrate-responsive element-binding protein Human genes 0.000 description 1
• 101710101477 Carbohydrate-responsive element-binding protein Proteins 0.000 description 1
• 108010020326 Caspofungin Proteins 0.000 description 1
• 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
• 235000013912 Ceratonia siliqua Nutrition 0.000 description 1
• 240000008886 Ceratonia siliqua Species 0.000 description 1
• GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
• 229920001661 Chitosan Polymers 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
• 108010077544 Chromatin Proteins 0.000 description 1
• VWFCHDSQECPREK-LURJTMIESA-N Cidofovir Chemical compound NC=1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1 VWFCHDSQECPREK-LURJTMIESA-N 0.000 description 1
• 102000004162 Claudin-1 Human genes 0.000 description 1
• 108090000600 Claudin-1 Proteins 0.000 description 1
• HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 description 1
• 208000037384 Clostridium Infections Diseases 0.000 description 1
• 241001509496 Clostridium celatum Species 0.000 description 1
• 241000206044 Clostridium chauvoei Species 0.000 description 1
• 241000193167 Clostridium cochlearium Species 0.000 description 1
• 206010009657 Clostridium difficile colitis Diseases 0.000 description 1
• 206010054236 Clostridium difficile infection Diseases 0.000 description 1
• 241000186565 Clostridium malenominatum Species 0.000 description 1
• 241000186581 Clostridium novyi Species 0.000 description 1
• 241001147791 Clostridium paraputrificum Species 0.000 description 1
• 241001656793 Clostridium sartagoforme Species 0.000 description 1
• 241000193464 Clostridium sp. Species 0.000 description 1
• 241000193449 Clostridium tetani Species 0.000 description 1
• 241001330547 Collinsella intestinalis Species 0.000 description 1
• 241001330548 Collinsella stercoris Species 0.000 description 1
• 241000801626 Collinsella tanakaei Species 0.000 description 1
• 206010009944 Colon cancer Diseases 0.000 description 1
• 108020004394 Complementary RNA Proteins 0.000 description 1
• 241000220677 Coprococcus catus Species 0.000 description 1
• 241000186216 Corynebacterium Species 0.000 description 1
• 241001445332 Coxiella <snail> Species 0.000 description 1
• 206010011409 Cross infection Diseases 0.000 description 1
• 241000186427 Cutibacterium acnes Species 0.000 description 1
• 229920000858 Cyclodextrin Polymers 0.000 description 1
• 229930105110 Cyclosporin A Natural products 0.000 description 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
• 108010036949 Cyclosporine Proteins 0.000 description 1
• 101710200331 Cytochrome b-245 chaperone 1 Proteins 0.000 description 1
• 102100037186 Cytochrome b-245 chaperone 1 Human genes 0.000 description 1
• 101710119396 Cytochrome b-245 chaperone 1 homolog Proteins 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• SRBFZHDQGSBBOR-SOOFDHNKSA-N D-ribopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@@H]1O SRBFZHDQGSBBOR-SOOFDHNKSA-N 0.000 description 1
• 102000053602 DNA Human genes 0.000 description 1
• 238000013382 DNA quantification Methods 0.000 description 1
• 238000012270 DNA recombination Methods 0.000 description 1
• 102100036504 Dehydrogenase/reductase SDR family member 9 Human genes 0.000 description 1
• 241001313301 Dendrosporobacter Species 0.000 description 1
• 241001509319 Desulfitobacterium Species 0.000 description 1
• 241001338026 Desulfosporosinus Species 0.000 description 1
• 241000186541 Desulfotomaculum Species 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• 208000002249 Diabetes Complications Diseases 0.000 description 1
• 206010012655 Diabetic complications Diseases 0.000 description 1
• 238000009007 Diagnostic Kit Methods 0.000 description 1
• BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 description 1
• IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 1
• XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 1
• 240000005717 Dioscorea alata Species 0.000 description 1
• 235000002723 Dioscorea alata Nutrition 0.000 description 1
• 235000002727 Dioscorea praehensilis Nutrition 0.000 description 1
• 235000002726 Dioscorea rotundata Nutrition 0.000 description 1
• 108010016626 Dipeptides Proteins 0.000 description 1
• 235000021294 Docosapentaenoic acid Nutrition 0.000 description 1
• 241001143779 Dorea Species 0.000 description 1
• 206010059866 Drug resistance Diseases 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 108010049047 Echinocandins Proteins 0.000 description 1
• XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 description 1
• 241000605314 Ehrlichia Species 0.000 description 1
• XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 description 1
• 108010032976 Enfuvirtide Proteins 0.000 description 1
• 241000588914 Enterobacter Species 0.000 description 1
• 241000283073 Equus caballus Species 0.000 description 1
• 241001125671 Eretmochelys imbricata Species 0.000 description 1
• 241001058146 Erium Species 0.000 description 1
• 241001505295 Eros Species 0.000 description 1
• 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 description 1
• 241001646719 Escherichia coli O157:H7 Species 0.000 description 1
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
• JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
• 239000005977 Ethylene Substances 0.000 description 1
• 241000143590 Eubacterium ruminantium Species 0.000 description 1
• 241000986808 Eubacterium sp. oral clone GI038 Species 0.000 description 1
• 244000004281 Eucalyptus maculata Species 0.000 description 1
• 229920003134 Eudragit® polymer Polymers 0.000 description 1
• 241001608234 Faecalibacterium Species 0.000 description 1
• 241000186589 Faecalicatena orotica Species 0.000 description 1
• 241001531275 Faecalitalea cylindroides Species 0.000 description 1
• 206010016654 Fibrosis Diseases 0.000 description 1
• 229920001917 Ficoll Polymers 0.000 description 1
• 241000178967 Filifactor Species 0.000 description 1
• 241001147710 Filifactor villosus Species 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• 240000009088 Fragaria x ananassa Species 0.000 description 1
• 241000589601 Francisella Species 0.000 description 1
• 108020000949 Fungal DNA Proteins 0.000 description 1
• 241001303074 Fusobacterium naviforme Species 0.000 description 1
• 241000605978 Fusobacterium russii Species 0.000 description 1
• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
• 229920000926 Galactomannan Polymers 0.000 description 1
• 229920002148 Gellan gum Polymers 0.000 description 1
• 241000626621 Geobacillus Species 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 108010015031 Glycochenodeoxycholic Acid Proteins 0.000 description 1
• 229920002527 Glycogen Polymers 0.000 description 1
• AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 239000004378 Glycyrrhizin Substances 0.000 description 1
• UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 1
• 229920002907 Guar gum Polymers 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 229920000569 Gum karaya Polymers 0.000 description 1
• 101100500479 Hafnia alvei eaeA gene Proteins 0.000 description 1
• 241000144305 Halobacteroides Species 0.000 description 1
• 229930195098 Hamycin Natural products 0.000 description 1
• 241000193159 Hathewaya histolytica Species 0.000 description 1
• 241000186568 Hathewaya limosa Species 0.000 description 1
• 241000590002 Helicobacter pylori Species 0.000 description 1
• 241001134726 Heliobacillus Species 0.000 description 1
• 241000207155 Heliobacterium Species 0.000 description 1
• 241001628319 Heliophilum Species 0.000 description 1
• 241001326442 Heliorestis Species 0.000 description 1
• 229920002488 Hemicellulose Polymers 0.000 description 1
• 102000001554 Hemoglobins Human genes 0.000 description 1
• 108010054147 Hemoglobins Proteins 0.000 description 1
• QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 1
• 241000238631 Hexapoda Species 0.000 description 1
• 108090000353 Histone deacetylase Proteins 0.000 description 1
• 102000003964 Histone deacetylase Human genes 0.000 description 1
• 102100038720 Histone deacetylase 9 Human genes 0.000 description 1
• 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 description 1
• 101000886868 Homo sapiens Gastric inhibitory polypeptide Proteins 0.000 description 1
• 101001032092 Homo sapiens Histone deacetylase 9 Proteins 0.000 description 1
• 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 description 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• 241001529428 Hydrogenoanaerobacterium saccharovorans Species 0.000 description 1
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
• 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
• 208000015580 Increased body weight Diseases 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 108091023242 Internal transcribed spacer Proteins 0.000 description 1
• 241000037075 Intestinibacter bartlettii Species 0.000 description 1
• JUZNIMUFDBIJCM-ANEDZVCMSA-N Invanz Chemical compound O=C([C@H]1NC[C@H](C1)SC=1[C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)NC1=CC=CC(C(O)=O)=C1 JUZNIMUFDBIJCM-ANEDZVCMSA-N 0.000 description 1
• LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
• UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
• 206010023126 Jaundice Diseases 0.000 description 1
• KJHKTHWMRKYKJE-SUGCFTRWSA-N Kaletra Chemical compound N1([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=2C=CC=CC=2)NC(=O)COC=2C(=CC=CC=2C)C)CC=2C=CC=CC=2)CCCNC1=O KJHKTHWMRKYKJE-SUGCFTRWSA-N 0.000 description 1
• 241000588747 Klebsiella pneumoniae Species 0.000 description 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
• 241000122535 Lachnoanaerobaculum Species 0.000 description 1
• 241001134640 Lachnospira multipara Species 0.000 description 1
• 241000186605 Lactobacillus paracasei Species 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 239000004166 Lanolin Substances 0.000 description 1
• 239000005639 Lauric acid Substances 0.000 description 1
• 241000589248 Legionella Species 0.000 description 1
• 208000007764 Legionnaires' Disease Diseases 0.000 description 1
• 241000589902 Leptospira Species 0.000 description 1
• 235000021353 Lignoceric acid Nutrition 0.000 description 1
• CQXMAMUUWHYSIY-UHFFFAOYSA-N Lignoceric acid Natural products CCCCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 CQXMAMUUWHYSIY-UHFFFAOYSA-N 0.000 description 1
• OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
• 108090001030 Lipoproteins Proteins 0.000 description 1
• 102000004895 Lipoproteins Human genes 0.000 description 1
• 241000186781 Listeria Species 0.000 description 1
• 241000186779 Listeria monocytogenes Species 0.000 description 1
• 229920000161 Locust bean gum Polymers 0.000 description 1
• 244000241838 Lycium barbarum Species 0.000 description 1
• 235000015459 Lycium barbarum Nutrition 0.000 description 1
• 235000015468 Lycium chinense Nutrition 0.000 description 1
• UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
• JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
• 208000016604 Lyme disease Diseases 0.000 description 1
• 229940124528 MK-2048 Drugs 0.000 description 1
• 229920002774 Maltodextrin Polymers 0.000 description 1
• 239000005913 Maltodextrin Substances 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• 240000003183 Manihot esculenta Species 0.000 description 1
• 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
• 229920000057 Mannan Polymers 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 1
• 208000001145 Metabolic Syndrome Diseases 0.000 description 1
• CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
• 108010021062 Micafungin Proteins 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 241001529936 Murinae Species 0.000 description 1
• 101000693095 Mus musculus Angiopoietin-related protein 4 Proteins 0.000 description 1
• 101000878182 Mus musculus Fibroblast growth factor 15 Proteins 0.000 description 1
• 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
• 241000186359 Mycobacterium Species 0.000 description 1
• 235000021360 Myristic acid Nutrition 0.000 description 1
• TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
• OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Chemical group CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
• MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Chemical group CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
• DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 1
• 241000588653 Neisseria Species 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
• 206010073310 Occupational exposures Diseases 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 241000984031 Orientia Species 0.000 description 1
• BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
• 208000012868 Overgrowth Diseases 0.000 description 1
• 201000002451 Overnutrition Diseases 0.000 description 1
• 239000004100 Oxytetracycline Substances 0.000 description 1
• 235000021314 Palmitic acid Nutrition 0.000 description 1
• 235000021319 Palmitoleic acid Nutrition 0.000 description 1
• 241000204306 Parabacteroides merdae Species 0.000 description 1
• UOZODPSAJZTQNH-UHFFFAOYSA-N Paromomycin II Natural products NC1C(O)C(O)C(CN)OC1OC1C(O)C(OC2C(C(N)CC(N)C2O)OC2C(C(O)C(O)C(CO)O2)N)OC1CO UOZODPSAJZTQNH-UHFFFAOYSA-N 0.000 description 1
• JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 229930195708 Penicillin V Natural products 0.000 description 1
• ZYFVNVRFVHJEIU-UHFFFAOYSA-N PicoGreen Chemical compound CN(C)CCCN(CCCN(C)C)C1=CC(=CC2=[N+](C3=CC=CC=C3S2)C)C2=CC=CC=C2N1C1=CC=CC=C1 ZYFVNVRFVHJEIU-UHFFFAOYSA-N 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• AZJUJOFIHHNCSV-KCQAQPDRSA-N Polygodial Polymers C[C@@]1([C@H](C(C=O)=CC2)C=O)[C@@H]2C(C)(C)CCC1 AZJUJOFIHHNCSV-KCQAQPDRSA-N 0.000 description 1
• 229920001213 Polysorbate 20 Polymers 0.000 description 1
• 239000004372 Polyvinyl alcohol Substances 0.000 description 1
• 241001135239 Porphyromonas levii Species 0.000 description 1
• 241001135241 Porphyromonas macacae Species 0.000 description 1
• 208000012654 Primary biliary cholangitis Diseases 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
• 241000169380 Propionispora Species 0.000 description 1
• 241001494501 Prosopis <angiosperm> Species 0.000 description 1
• 235000001560 Prosopis chilensis Nutrition 0.000 description 1
• 235000014460 Prosopis juliflora var juliflora Nutrition 0.000 description 1
• 235000009827 Prunus armeniaca Nutrition 0.000 description 1
• 244000018633 Prunus armeniaca Species 0.000 description 1
• 241000589516 Pseudomonas Species 0.000 description 1
• 241000220324 Pyrus Species 0.000 description 1
• LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
• 238000003559 RNA-seq method Methods 0.000 description 1
• MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
• 241000084225 Raoultella sp. Species 0.000 description 1
• 102100037886 Regenerating islet-derived protein 3-gamma Human genes 0.000 description 1
• 101710086144 Regenerating islet-derived protein 3-gamma Proteins 0.000 description 1
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
• 241000606701 Rickettsia Species 0.000 description 1
• AWGBZRVEGDNLDZ-UHFFFAOYSA-N Rimocidin Natural products C1C(C(C(O)C2)C(O)=O)OC2(O)CC(O)CCCC(=O)CC(O)C(CC)C(=O)OC(CCC)CC=CC=CC=CC=CC1OC1OC(C)C(O)C(N)C1O AWGBZRVEGDNLDZ-UHFFFAOYSA-N 0.000 description 1
• AWGBZRVEGDNLDZ-JCUCCFEFSA-N Rimocidine Chemical compound O([C@H]1/C=C/C=C/C=C/C=C/C[C@H](OC(=O)[C@@H](CC)[C@H](O)CC(=O)CCC[C@H](O)C[C@@]2(O)O[C@H]([C@@H]([C@@H](O)C2)C(O)=O)C1)CCC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O AWGBZRVEGDNLDZ-JCUCCFEFSA-N 0.000 description 1
• NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 description 1
• 240000007651 Rubus glaucus Species 0.000 description 1
• 241000482911 Ruminococcaceae bacterium D16 Species 0.000 description 1
• 241000192029 Ruminococcus albus Species 0.000 description 1
• 241000123753 Ruminococcus bromii Species 0.000 description 1
• 241000192026 Ruminococcus flavefaciens Species 0.000 description 1
• 241000607149 Salmonella sp. Species 0.000 description 1
• 241000192023 Sarcina Species 0.000 description 1
• 241000245026 Scoliopus bigelovii Species 0.000 description 1
• 238000012300 Sequence Analysis Methods 0.000 description 1
• 229920001800 Shellac Polymers 0.000 description 1
• 108010017898 Shiga Toxins Proteins 0.000 description 1
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
• 229920002125 Sokalan® Polymers 0.000 description 1
• 241001446760 Sporobacterium Species 0.000 description 1
• 241000605066 Sporohalobacter Species 0.000 description 1
• 241000204117 Sporolactobacillus Species 0.000 description 1
• 241000204388 Sporomusa Species 0.000 description 1
• 241000186547 Sporosarcina Species 0.000 description 1
• 241000969788 Sporotomaculum Species 0.000 description 1
• UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 1
• 241000191963 Staphylococcus epidermidis Species 0.000 description 1
• 241000192086 Staphylococcus warneri Species 0.000 description 1
• XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• 241000934878 Sterculia Species 0.000 description 1
• 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 description 1
• 102100026839 Sterol regulatory element-binding protein 1 Human genes 0.000 description 1
• 244000228451 Stevia rebaudiana Species 0.000 description 1
• 235000006092 Stevia rebaudiana Nutrition 0.000 description 1
• UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
• 241001134658 Streptococcus mitis Species 0.000 description 1
• 201000005010 Streptococcus pneumonia Diseases 0.000 description 1
• 241001136694 Subdoligranulum Species 0.000 description 1
• 241001648295 Succinivibrio Species 0.000 description 1
• 239000004376 Sucralose Substances 0.000 description 1
• 241000207198 Symbiobacterium Species 0.000 description 1
• 241000498538 Syntrophobotulus Species 0.000 description 1
• 241000606017 Syntrophomonas Species 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• 244000269722 Thea sinensis Species 0.000 description 1
• 241000186339 Thermoanaerobacter Species 0.000 description 1
• 241000035670 Thermosinus Species 0.000 description 1
• FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
• 102000000591 Tight Junction Proteins Human genes 0.000 description 1
• 108010002321 Tight Junction Proteins Proteins 0.000 description 1
• ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
• SUJUHGSWHZTSEU-UHFFFAOYSA-N Tipranavir Natural products C1C(O)=C(C(CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)C(=O)OC1(CCC)CCC1=CC=CC=C1 SUJUHGSWHZTSEU-UHFFFAOYSA-N 0.000 description 1
• 108010060804 Toll-Like Receptor 4 Proteins 0.000 description 1
• 102000008233 Toll-Like Receptor 4 Human genes 0.000 description 1
• 102000008228 Toll-like receptor 2 Human genes 0.000 description 1
• 108010060888 Toll-like receptor 2 Proteins 0.000 description 1
• 102000008234 Toll-like receptor 5 Human genes 0.000 description 1
• 108010060812 Toll-like receptor 5 Proteins 0.000 description 1
• 241000223996 Toxoplasma Species 0.000 description 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
• 241000589886 Treponema Species 0.000 description 1
• 241000219793 Trifolium Species 0.000 description 1
• 239000007983 Tris buffer Substances 0.000 description 1
• 239000013504 Triton X-100 Substances 0.000 description 1
• 229920004890 Triton X-100 Polymers 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
• 208000025865 Ulcer Diseases 0.000 description 1
• WPVFJKSGQUFQAP-GKAPJAKFSA-N Valcyte Chemical compound N1C(N)=NC(=O)C2=C1N(COC(CO)COC(=O)[C@@H](N)C(C)C)C=N2 WPVFJKSGQUFQAP-GKAPJAKFSA-N 0.000 description 1
• 235000009499 Vanilla fragrans Nutrition 0.000 description 1
• 244000263375 Vanilla tahitensis Species 0.000 description 1
• 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
• 241000607626 Vibrio cholerae Species 0.000 description 1
• 241000607272 Vibrio parahaemolyticus Species 0.000 description 1
• 241000607265 Vibrio vulnificus Species 0.000 description 1
• 241000282840 Vicugna vicugna Species 0.000 description 1
• OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 description 1
• 229930003451 Vitamin B1 Natural products 0.000 description 1
• 229930003471 Vitamin B2 Natural products 0.000 description 1
• 229930003537 Vitamin B3 Natural products 0.000 description 1
• 229930003761 Vitamin B9 Natural products 0.000 description 1
• 241000607734 Yersinia <bacteria> Species 0.000 description 1
• 241000607447 Yersinia enterocolitica Species 0.000 description 1
• JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 description 1
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
• UGXQOOQUZRUVSS-ZZXKWVIFSA-N [5-[3,5-dihydroxy-2-(1,3,4-trihydroxy-5-oxopentan-2-yl)oxyoxan-4-yl]oxy-3,4-dihydroxyoxolan-2-yl]methyl (e)-3-(4-hydroxyphenyl)prop-2-enoate Chemical compound OC1C(OC(CO)C(O)C(O)C=O)OCC(O)C1OC1C(O)C(O)C(COC(=O)\C=C\C=2C=CC(O)=CC=2)O1 UGXQOOQUZRUVSS-ZZXKWVIFSA-N 0.000 description 1
• 241000985257 [Clostridium] cocleatum Species 0.000 description 1
• 241000186569 [Clostridium] leptum Species 0.000 description 1
• 241000193460 [Clostridium] piliforme Species 0.000 description 1
• 241001147796 [Clostridium] spiroforme Species 0.000 description 1
• 241001531189 [Eubacterium] siraeum Species 0.000 description 1
• MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 description 1
• 229960004748 abacavir Drugs 0.000 description 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• 235000010358 acesulfame potassium Nutrition 0.000 description 1
• 239000000619 acesulfame-K Substances 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• 229960004150 aciclovir Drugs 0.000 description 1
• 238000010306 acid treatment Methods 0.000 description 1
• 150000007513 acids Chemical group 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000008186 active pharmaceutical agent Substances 0.000 description 1
• 125000002015 acyclic group Chemical group 0.000 description 1
• 108091005764 adaptor proteins Proteins 0.000 description 1
• 102000035181 adaptor proteins Human genes 0.000 description 1
• 229960001997 adefovir Drugs 0.000 description 1
• WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 230000004931 aggregating effect Effects 0.000 description 1
• 239000000556 agonist Substances 0.000 description 1
• UHIXWHUVLCAJQL-MPBGBICISA-N albaconazole Chemical compound C([C@@](O)([C@H](N1C(C2=CC=C(Cl)C=C2N=C1)=O)C)C=1C(=CC(F)=CC=1)F)N1C=NC=N1 UHIXWHUVLCAJQL-MPBGBICISA-N 0.000 description 1
• 229950006816 albaconazole Drugs 0.000 description 1
• 235000013334 alcoholic beverage Nutrition 0.000 description 1
• 230000001476 alcoholic effect Effects 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 150000001335 aliphatic alkanes Chemical class 0.000 description 1
• JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
• OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
• JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 description 1
• 229940087168 alpha tocopherol Drugs 0.000 description 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
• 102000018568 alpha-Defensin Human genes 0.000 description 1
• 108050007802 alpha-defensin Proteins 0.000 description 1
• DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
• 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• 229960004821 amikacin Drugs 0.000 description 1
• LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 1
• 239000002647 aminoglycoside antibiotic agent Substances 0.000 description 1
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
• 229960003942 amphotericin b Drugs 0.000 description 1
• 229960001830 amprenavir Drugs 0.000 description 1
• YMARZQAQMVYCKC-OEMFJLHTSA-N amprenavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 YMARZQAQMVYCKC-OEMFJLHTSA-N 0.000 description 1
• 239000012491 analyte Substances 0.000 description 1
• JHVAMHSQVVQIOT-MFAJLEFUSA-N anidulafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@@H](C)O)[C@H](O)[C@@H](O)C=2C=CC(O)=CC=2)[C@@H](C)O)=O)C=C1 JHVAMHSQVVQIOT-MFAJLEFUSA-N 0.000 description 1
• 229960003348 anidulafungin Drugs 0.000 description 1
• 239000010617 anise oil Substances 0.000 description 1
• 230000002528 anti-freeze Effects 0.000 description 1
• 230000001387 anti-histamine Effects 0.000 description 1
• 230000002590 anti-leukotriene effect Effects 0.000 description 1
• 239000000739 antihistaminic agent Substances 0.000 description 1
• 230000003078 antioxidant effect Effects 0.000 description 1
• 239000003096 antiparasitic agent Substances 0.000 description 1
• 229940125687 antiparasitic agent Drugs 0.000 description 1
• XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical compound O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 description 1
• 229950006334 apramycin Drugs 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
• 229920000617 arabinoxylan Polymers 0.000 description 1
• MKKYBZZTJQGVCD-XTCKQBCOSA-N arbekacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)CC[C@H]1N MKKYBZZTJQGVCD-XTCKQBCOSA-N 0.000 description 1
• 229960005397 arbekacin Drugs 0.000 description 1
• 210000001815 ascending colon Anatomy 0.000 description 1
• 229940072107 ascorbate Drugs 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 239000000605 aspartame Substances 0.000 description 1
• 235000010357 aspartame Nutrition 0.000 description 1
• 229960003438 aspartame Drugs 0.000 description 1
• 238000003149 assay kit Methods 0.000 description 1
• 235000013793 astaxanthin Nutrition 0.000 description 1
• 239000001168 astaxanthin Substances 0.000 description 1
• MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
• 229940022405 astaxanthin Drugs 0.000 description 1
• 239000000305 astragalus gummifer gum Substances 0.000 description 1
• AXRYRYVKAWYZBR-GASGPIRDSA-N atazanavir Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)[C@@H](O)CN(CC=1C=CC(=CC=1)C=1N=CC=CC=1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C1=CC=CC=C1 AXRYRYVKAWYZBR-GASGPIRDSA-N 0.000 description 1
• 229960003277 atazanavir Drugs 0.000 description 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
• 230000003190 augmentative effect Effects 0.000 description 1
• 229940098164 augmentin Drugs 0.000 description 1
• QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 description 1
• 230000006472 autoimmune response Effects 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• UMEAURNTRYCPNR-UHFFFAOYSA-N azane;iron(2+) Chemical compound N.[Fe+2] UMEAURNTRYCPNR-UHFFFAOYSA-N 0.000 description 1
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
• 229960002170 azathioprine Drugs 0.000 description 1
• 238000013398 bayesian method Methods 0.000 description 1
• 235000013871 bee wax Nutrition 0.000 description 1
• 235000013405 beer Nutrition 0.000 description 1
• 239000012166 beeswax Substances 0.000 description 1
• 230000006399 behavior Effects 0.000 description 1
• 229940116226 behenic acid Drugs 0.000 description 1
• 229960004365 benzoic acid Drugs 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• 235000013734 beta-carotene Nutrition 0.000 description 1
• 239000011648 beta-carotene Substances 0.000 description 1
• TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
• 102000012265 beta-defensin Human genes 0.000 description 1
• 108050002883 beta-defensin Proteins 0.000 description 1
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
• 229960002747 betacarotene Drugs 0.000 description 1
• 239000003833 bile salt Substances 0.000 description 1
• 229940093761 bile salts Drugs 0.000 description 1
• 238000010876 biochemical test Methods 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 239000012472 biological sample Substances 0.000 description 1
• 230000005540 biological transmission Effects 0.000 description 1
• 230000036983 biotransformation Effects 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 229910052796 boron Inorganic materials 0.000 description 1
• 235000012467 brownies Nutrition 0.000 description 1
• 239000006172 buffering agent Substances 0.000 description 1
• 230000003139 buffering effect Effects 0.000 description 1
• 229960002962 butenafine Drugs 0.000 description 1
• ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 description 1
• CRFNGMNYKDXRTN-CITAKDKDSA-N butyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CRFNGMNYKDXRTN-CITAKDKDSA-N 0.000 description 1
• 229960001948 caffeine Drugs 0.000 description 1
• VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
• NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
• 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 235000011148 calcium chloride Nutrition 0.000 description 1
• 159000000007 calcium salts Chemical class 0.000 description 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
• 235000013539 calcium stearate Nutrition 0.000 description 1
• 239000008116 calcium stearate Substances 0.000 description 1
• 235000019577 caloric intake Nutrition 0.000 description 1
• 229940041514 candida albicans extract Drugs 0.000 description 1
• 201000003984 candidiasis Diseases 0.000 description 1
• 229930003827 cannabinoid Natural products 0.000 description 1
• 239000003557 cannabinoid Substances 0.000 description 1
• 239000007894 caplet Substances 0.000 description 1
• KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
• 108010068385 carbapenemase Proteins 0.000 description 1
• 229960003669 carbenicillin Drugs 0.000 description 1
• FPPNZSSZRUTDAP-UWFZAAFLSA-N carbenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C(O)=O)C1=CC=CC=C1 FPPNZSSZRUTDAP-UWFZAAFLSA-N 0.000 description 1
• 150000001721 carbon Chemical group 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 229910002092 carbon dioxide Inorganic materials 0.000 description 1
• 239000007833 carbon precursor Substances 0.000 description 1
• 235000014171 carbonated beverage Nutrition 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 239000004203 carnauba wax Substances 0.000 description 1
• 235000013869 carnauba wax Nutrition 0.000 description 1
• 235000021466 carotenoid Nutrition 0.000 description 1
• 150000001747 carotenoids Chemical class 0.000 description 1
• 235000010418 carrageenan Nutrition 0.000 description 1
• 229920001525 carrageenan Polymers 0.000 description 1
• 239000000679 carrageenan Substances 0.000 description 1
• 229940113118 carrageenan Drugs 0.000 description 1
• JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 description 1
• 229960003034 caspofungin Drugs 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 210000004534 cecum Anatomy 0.000 description 1
• 229960000603 cefalotin Drugs 0.000 description 1
• 229960003012 cefamandole Drugs 0.000 description 1
• OLVCFLKTBJRLHI-AXAPSJFSSA-N cefamandole Chemical compound CN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)[C@H](O)C=3C=CC=CC=3)[C@H]2SC1 OLVCFLKTBJRLHI-AXAPSJFSSA-N 0.000 description 1
• 229960002129 cefixime Drugs 0.000 description 1
• OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 description 1
• 229960002682 cefoxitin Drugs 0.000 description 1
• 229960000484 ceftazidime Drugs 0.000 description 1
• ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 description 1
• VOAZJEPQLGBXGO-SDAWRPRTSA-N ceftobiprole Chemical compound S1C(N)=NC(C(=N\O)\C(=O)N[C@@H]2C(N3C(=C(\C=C/4C(N([C@H]5CNCC5)CC\4)=O)CS[C@@H]32)C(O)=O)=O)=N1 VOAZJEPQLGBXGO-SDAWRPRTSA-N 0.000 description 1
• 239000008004 cell lysis buffer Substances 0.000 description 1
• 230000010001 cellular homeostasis Effects 0.000 description 1
• 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
• VUFGUVLLDPOSBC-XRZFDKQNSA-M cephalothin sodium Chemical compound [Na+].N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C([O-])=O)C(=O)CC1=CC=CS1 VUFGUVLLDPOSBC-XRZFDKQNSA-M 0.000 description 1
• 235000013339 cereals Nutrition 0.000 description 1
• 239000003638 chemical reducing agent Substances 0.000 description 1
• 229940009025 chenodeoxycholate Drugs 0.000 description 1
• 235000019693 cherries Nutrition 0.000 description 1
• 229940045110 chitosan Drugs 0.000 description 1
• 150000001805 chlorine compounds Chemical class 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 229940099352 cholate Drugs 0.000 description 1
• 231100000359 cholestasis Toxicity 0.000 description 1
• 230000007870 cholestasis Effects 0.000 description 1
• 125000003716 cholic acid group Chemical group 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• 239000000812 cholinergic antagonist Substances 0.000 description 1
• 210000003483 chromatin Anatomy 0.000 description 1
• 229960003749 ciclopirox Drugs 0.000 description 1
• SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 description 1
• 229960001265 ciclosporin Drugs 0.000 description 1
• 229960000724 cidofovir Drugs 0.000 description 1
• 239000010630 cinnamon oil Substances 0.000 description 1
• 229960003405 ciprofloxacin Drugs 0.000 description 1
• 230000004087 circulation Effects 0.000 description 1
• 230000007882 cirrhosis Effects 0.000 description 1
• 208000019425 cirrhosis of liver Diseases 0.000 description 1
• SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 description 1
• APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 description 1
• 229940010007 cobalamins Drugs 0.000 description 1
• 150000001867 cobalamins Chemical class 0.000 description 1
• 229940110767 coenzyme Q10 Drugs 0.000 description 1
• 210000004922 colonic epithelial cell Anatomy 0.000 description 1
• 238000007398 colorimetric assay Methods 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 239000003184 complementary RNA Substances 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 238000013329 compounding Methods 0.000 description 1
• 238000007906 compression Methods 0.000 description 1
• 230000006835 compression Effects 0.000 description 1
• 238000000205 computational method Methods 0.000 description 1
• 235000009508 confectionery Nutrition 0.000 description 1
• 238000012790 confirmation Methods 0.000 description 1
• 238000004825 constant-volume calorimetry Methods 0.000 description 1
• 238000010411 cooking Methods 0.000 description 1
• 239000008162 cooking oil Substances 0.000 description 1
• 235000014510 cooky Nutrition 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 238000012937 correction Methods 0.000 description 1
• 230000002596 correlated effect Effects 0.000 description 1
• 239000003246 corticosteroid Substances 0.000 description 1
• 229960001334 corticosteroids Drugs 0.000 description 1
• 235000012495 crackers Nutrition 0.000 description 1
• 229960000265 cromoglicic acid Drugs 0.000 description 1
• 238000012136 culture method Methods 0.000 description 1
• 235000000639 cyanocobalamin Nutrition 0.000 description 1
• 239000011666 cyanocobalamin Substances 0.000 description 1
• 229960002104 cyanocobalamin Drugs 0.000 description 1
• 125000004122 cyclic group Chemical group 0.000 description 1
• 229960002433 cysteine Drugs 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 201000003146 cystitis Diseases 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 238000004163 cytometry Methods 0.000 description 1
• 239000000824 cytostatic agent Substances 0.000 description 1
• 230000001085 cytostatic effect Effects 0.000 description 1
• 229960005107 darunavir Drugs 0.000 description 1
• CJBJHOAVZSMMDJ-HEXNFIEUSA-N darunavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)C1=CC=CC=C1 CJBJHOAVZSMMDJ-HEXNFIEUSA-N 0.000 description 1
• 239000000850 decongestant Substances 0.000 description 1
• 229940124581 decongestants Drugs 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 229960005319 delavirdine Drugs 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 238000004925 denaturation Methods 0.000 description 1
• 230000036425 denaturation Effects 0.000 description 1
• 238000000432 density-gradient centrifugation Methods 0.000 description 1
• 210000001731 descending colon Anatomy 0.000 description 1
• 238000011026 diafiltration Methods 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 229960001585 dicloxacillin Drugs 0.000 description 1
• YFAGHNZHGGCZAX-JKIFEVAISA-N dicloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(Cl)C=CC=C1Cl YFAGHNZHGGCZAX-JKIFEVAISA-N 0.000 description 1
• 229960002656 didanosine Drugs 0.000 description 1
• 238000001085 differential centrifugation Methods 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• 238000009792 diffusion process Methods 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical compound CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
• 208000016097 disease of metabolism Diseases 0.000 description 1
• VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 229940090949 docosahexaenoic acid Drugs 0.000 description 1
• KFEVDPWXEVUUMW-UHFFFAOYSA-N docosanoic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 KFEVDPWXEVUUMW-UHFFFAOYSA-N 0.000 description 1
• 229960000735 docosanol Drugs 0.000 description 1
• MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
• 229940043264 dodecyl sulfate Drugs 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 229960003722 doxycycline Drugs 0.000 description 1
• 210000001198 duodenum Anatomy 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 101150107911 eae gene Proteins 0.000 description 1
• XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 description 1
• 229960003804 efavirenz Drugs 0.000 description 1
• 230000001729 effect on metabolism Effects 0.000 description 1
• 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
• IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 description 1
• 229940108623 eicosenoic acid Drugs 0.000 description 1
• BITHHVVYSMSWAG-UHFFFAOYSA-N eicosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCC(O)=O BITHHVVYSMSWAG-UHFFFAOYSA-N 0.000 description 1
• 238000010894 electron beam technology Methods 0.000 description 1
• 239000012149 elution buffer Substances 0.000 description 1
• 229960000366 emtricitabine Drugs 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 238000004146 energy storage Methods 0.000 description 1
• PEASPLKKXBYDKL-FXEVSJAOSA-N enfuvirtide Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(C)=O)[C@@H](C)O)[C@@H](C)CC)C1=CN=CN1 PEASPLKKXBYDKL-FXEVSJAOSA-N 0.000 description 1
• 229960002062 enfuvirtide Drugs 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 210000003158 enteroendocrine cell Anatomy 0.000 description 1
• 230000000369 enteropathogenic effect Effects 0.000 description 1
• 238000006911 enzymatic reaction Methods 0.000 description 1
• 201000010063 epididymitis Diseases 0.000 description 1
• 238000006345 epimerization reaction Methods 0.000 description 1
• 229960005139 epinephrine Drugs 0.000 description 1
• 230000004890 epithelial barrier function Effects 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 229960002770 ertapenem Drugs 0.000 description 1
• 210000003238 esophagus Anatomy 0.000 description 1
• 150000002170 ethers Chemical class 0.000 description 1
• SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000029142 excretion Effects 0.000 description 1
• 210000000887 face Anatomy 0.000 description 1
• 229960004396 famciclovir Drugs 0.000 description 1
• GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 description 1
• 150000002191 fatty alcohols Chemical class 0.000 description 1
• 239000000835 fiber Substances 0.000 description 1
• 239000002657 fibrous material Substances 0.000 description 1
• 239000000945 filler Substances 0.000 description 1
• 239000012467 final product Substances 0.000 description 1
• 210000003495 flagella Anatomy 0.000 description 1
• 229930003935 flavonoid Natural products 0.000 description 1
• 150000002215 flavonoids Chemical class 0.000 description 1
• 235000017173 flavonoids Nutrition 0.000 description 1
• 238000000684 flow cytometry Methods 0.000 description 1
• 229960004884 fluconazole Drugs 0.000 description 1
• RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 125000001153 fluoro group Chemical group F* 0.000 description 1
• 229940124307 fluoroquinolone Drugs 0.000 description 1
• 235000012041 food component Nutrition 0.000 description 1
• 230000037406 food intake Effects 0.000 description 1
• 235000012631 food intake Nutrition 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 230000008014 freezing Effects 0.000 description 1
• 238000007710 freezing Methods 0.000 description 1
• 235000015203 fruit juice Nutrition 0.000 description 1
• 244000053095 fungal pathogen Species 0.000 description 1
• 239000000417 fungicide Substances 0.000 description 1
• 229930182830 galactose Natural products 0.000 description 1
• 210000000232 gallbladder Anatomy 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 238000004817 gas chromatography Methods 0.000 description 1
• 238000001030 gas--liquid chromatography Methods 0.000 description 1
• 230000030135 gastric motility Effects 0.000 description 1
• 235000010492 gellan gum Nutrition 0.000 description 1
• 239000000216 gellan gum Substances 0.000 description 1
• 208000004104 gestational diabetes Diseases 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 239000003862 glucocorticoid Substances 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• 125000005456 glyceride group Chemical group 0.000 description 1
• GHCZAUBVMUEKKP-GYPHWSFCSA-N glycochenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)CC1 GHCZAUBVMUEKKP-GYPHWSFCSA-N 0.000 description 1
• 229940096919 glycogen Drugs 0.000 description 1
• 230000002414 glycolytic effect Effects 0.000 description 1
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
• LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
• 229960004949 glycyrrhizic acid Drugs 0.000 description 1
• UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
• 235000019410 glycyrrhizin Nutrition 0.000 description 1
• LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
• 230000036449 good health Effects 0.000 description 1
• 238000000227 grinding Methods 0.000 description 1
• 229960002867 griseofulvin Drugs 0.000 description 1
• DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 239000001963 growth medium Substances 0.000 description 1
• 235000010417 guar gum Nutrition 0.000 description 1
• 239000000665 guar gum Substances 0.000 description 1
• 229960002154 guar gum Drugs 0.000 description 1
• 229950006942 hamycin Drugs 0.000 description 1
• 238000003306 harvesting Methods 0.000 description 1
• 229940037467 helicobacter pylori Drugs 0.000 description 1
• 244000000013 helminth Species 0.000 description 1
• BTIJJDXEELBZFS-UHFFFAOYSA-K hemin Chemical compound [Cl-].[Fe+3].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 BTIJJDXEELBZFS-UHFFFAOYSA-K 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 210000003494 hepatocyte Anatomy 0.000 description 1
• 229940025878 hesperidin Drugs 0.000 description 1
• QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 1
• VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 description 1
• 150000002402 hexoses Chemical class 0.000 description 1
• 231100000086 high toxicity Toxicity 0.000 description 1
• 210000003630 histaminocyte Anatomy 0.000 description 1
• 239000012456 homogeneous solution Substances 0.000 description 1
• 230000007366 host health Effects 0.000 description 1
• 230000007412 host metabolism Effects 0.000 description 1
• 102000047000 human FGF19 Human genes 0.000 description 1
• 150000002431 hydrogen Chemical class 0.000 description 1
• 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
• 239000012616 hydrophobic interaction chromatography medium Substances 0.000 description 1
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
• 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
• 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
• 201000001421 hyperglycemia Diseases 0.000 description 1
• 235000015243 ice cream Nutrition 0.000 description 1
• 229960004716 idoxuridine Drugs 0.000 description 1
• 230000002519 immonomodulatory effect Effects 0.000 description 1
• 230000005934 immune activation Effects 0.000 description 1
• 230000003832 immune regulation Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000001506 immunosuppresive effect Effects 0.000 description 1
• 229960003444 immunosuppressant agent Drugs 0.000 description 1
• 239000003018 immunosuppressive agent Substances 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 238000005462 in vivo assay Methods 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 229960001936 indinavir Drugs 0.000 description 1
• CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 210000005026 intestinal epithelial barrier Anatomy 0.000 description 1
• 210000004347 intestinal mucosa Anatomy 0.000 description 1
• 230000001134 intestinotrophic effect Effects 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 230000010189 intracellular transport Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 229960004903 invert sugar Drugs 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 239000002563 ionic surfactant Substances 0.000 description 1
• 230000005865 ionizing radiation Effects 0.000 description 1
• SMEROWZSTRWXGI-WFVDQZAMSA-N isolithocholic acid Chemical compound C([C@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-WFVDQZAMSA-N 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• 238000011901 isothermal amplification Methods 0.000 description 1
• GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
• 229960004130 itraconazole Drugs 0.000 description 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
• 235000010494 karaya gum Nutrition 0.000 description 1
• 239000000231 karaya gum Substances 0.000 description 1
• 229940039371 karaya gum Drugs 0.000 description 1
• 150000002576 ketones Chemical class 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 229960001627 lamivudine Drugs 0.000 description 1
• JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 description 1
• 235000019388 lanolin Nutrition 0.000 description 1
• 229940039717 lanolin Drugs 0.000 description 1
• 229930013686 lignan Natural products 0.000 description 1
• 235000009408 lignans Nutrition 0.000 description 1
• 150000005692 lignans Chemical class 0.000 description 1
• 238000012417 linear regression Methods 0.000 description 1
• 235000020778 linoleic acid Nutrition 0.000 description 1
• OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
• 229960004488 linolenic acid Drugs 0.000 description 1
• KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
• 230000037356 lipid metabolism Effects 0.000 description 1
• 230000004130 lipolysis Effects 0.000 description 1
• 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
• 238000009630 liquid culture Methods 0.000 description 1
• 230000003908 liver function Effects 0.000 description 1
• 208000018191 liver inflammation Diseases 0.000 description 1
• 235000010420 locust bean gum Nutrition 0.000 description 1
• 239000000711 locust bean gum Substances 0.000 description 1
• 229960004525 lopinavir Drugs 0.000 description 1
• 235000004213 low-fat Nutrition 0.000 description 1
• 229960005375 lutein Drugs 0.000 description 1
• 235000012680 lutein Nutrition 0.000 description 1
• 239000001656 lutein Substances 0.000 description 1
• KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
• ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
• 229960004999 lycopene Drugs 0.000 description 1
• 235000012661 lycopene Nutrition 0.000 description 1
• 239000001751 lycopene Substances 0.000 description 1
• OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
• 239000006166 lysate Substances 0.000 description 1
• 239000012139 lysis buffer Substances 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 description 1
• 239000002370 magnesium bicarbonate Substances 0.000 description 1
• 229910000022 magnesium bicarbonate Inorganic materials 0.000 description 1
• 235000014824 magnesium bicarbonate Nutrition 0.000 description 1
• ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
• 239000001095 magnesium carbonate Substances 0.000 description 1
• 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
• 235000019341 magnesium sulphate Nutrition 0.000 description 1
• 229940035034 maltodextrin Drugs 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• GSNHKUDZZFZSJB-QYOOZWMWSA-N maraviroc Chemical compound CC(C)C1=NN=C(C)N1[C@@H]1C[C@H](N2CC[C@H](NC(=O)C3CCC(F)(F)CC3)C=3C=CC=CC=3)CC[C@H]2C1 GSNHKUDZZFZSJB-QYOOZWMWSA-N 0.000 description 1
• 229960004710 maraviroc Drugs 0.000 description 1
• 235000013310 margarine Nutrition 0.000 description 1
• 239000003264 margarine Substances 0.000 description 1
• 238000001819 mass spectrum Methods 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• 239000012092 media component Substances 0.000 description 1
• 239000013028 medium composition Substances 0.000 description 1
• 239000011676 menaquinone-4 Substances 0.000 description 1
• 239000011700 menaquinone-7 Substances 0.000 description 1
• 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
• 229960001428 mercaptopurine Drugs 0.000 description 1
• 229960002260 meropenem Drugs 0.000 description 1
• DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 230000037353 metabolic pathway Effects 0.000 description 1
• 229960000485 methotrexate Drugs 0.000 description 1
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
• 229960002159 micafungin Drugs 0.000 description 1
• KOOAFHGJVIVFMZ-WZPXRXMFSA-M micafungin sodium Chemical compound [Na+].C1=CC(OCCCCC)=CC=C1C1=CC(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@H](O)CC(N)=O)[C@H](O)[C@@H](O)C=2C=C(OS([O-])(=O)=O)C(O)=CC=2)[C@@H](C)O)=O)=NO1 KOOAFHGJVIVFMZ-WZPXRXMFSA-M 0.000 description 1
• 239000000693 micelle Substances 0.000 description 1
• 238000001471 micro-filtration Methods 0.000 description 1
• 238000013048 microbiological method Methods 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 229960004023 minocycline Drugs 0.000 description 1
• 235000019426 modified starch Nutrition 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1
• 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
• 235000019799 monosodium phosphate Nutrition 0.000 description 1
• 230000004899 motility Effects 0.000 description 1
• 235000012459 muffins Nutrition 0.000 description 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
• 229950006780 n-acetylglucosamine Drugs 0.000 description 1
• 229960003255 natamycin Drugs 0.000 description 1
• 239000004311 natamycin Substances 0.000 description 1
• 235000010298 natamycin Nutrition 0.000 description 1
• NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 description 1
• 230000017074 necrotic cell death Effects 0.000 description 1
• 229960000884 nelfinavir Drugs 0.000 description 1
• QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 description 1
• ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 210000000653 nervous system Anatomy 0.000 description 1
• ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 description 1
• 238000006386 neutralization reaction Methods 0.000 description 1
• 229960000689 nevirapine Drugs 0.000 description 1
• 229910052759 nickel Inorganic materials 0.000 description 1
• 229960003966 nicotinamide Drugs 0.000 description 1
• 235000005152 nicotinamide Nutrition 0.000 description 1
• 239000011570 nicotinamide Substances 0.000 description 1
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
• BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 description 1
• 239000012457 nonaqueous media Substances 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 239000006916 nutrient agar Substances 0.000 description 1
• 229960000988 nystatin Drugs 0.000 description 1
• VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
• 231100000675 occupational exposure Toxicity 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 238000006384 oligomerization reaction Methods 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 238000003305 oral gavage Methods 0.000 description 1
• 238000007410 oral glucose tolerance test Methods 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 230000001151 other effect Effects 0.000 description 1
• 235000020823 overnutrition Nutrition 0.000 description 1
• 229960003483 oxiconazole Drugs 0.000 description 1
• QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 description 1
• 238000010525 oxidative degradation reaction Methods 0.000 description 1
• 239000001301 oxygen Substances 0.000 description 1
• 229910052760 oxygen Inorganic materials 0.000 description 1
• 229960000625 oxytetracycline Drugs 0.000 description 1
• IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
• 235000019366 oxytetracycline Nutrition 0.000 description 1
• 239000003002 pH adjusting agent Substances 0.000 description 1
• 238000004806 packaging method and process Methods 0.000 description 1
• 229940055726 pantothenic acid Drugs 0.000 description 1
• 235000019161 pantothenic acid Nutrition 0.000 description 1
• 239000011713 pantothenic acid Substances 0.000 description 1
• 229960001914 paromomycin Drugs 0.000 description 1
• UOZODPSAJZTQNH-LSWIJEOBSA-N paromomycin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO UOZODPSAJZTQNH-LSWIJEOBSA-N 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000007918 pathogenicity Effects 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 102000007863 pattern recognition receptors Human genes 0.000 description 1
• 108010089193 pattern recognition receptors Proteins 0.000 description 1
• 235000021017 pears Nutrition 0.000 description 1
• 229960001179 penciclovir Drugs 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 229940056367 penicillin v Drugs 0.000 description 1
• PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
• 235000019477 peppermint oil Nutrition 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
• GVKCHTBDSMQENH-UHFFFAOYSA-L phloxine B Chemical compound [Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 GVKCHTBDSMQENH-UHFFFAOYSA-L 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 235000019175 phylloquinone Nutrition 0.000 description 1
• 239000011772 phylloquinone Substances 0.000 description 1
• MBWXNTAXLNYFJB-LKUDQCMESA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-LKUDQCMESA-N 0.000 description 1
• 238000000053 physical method Methods 0.000 description 1
• 230000008288 physiological mechanism Effects 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 229960001898 phytomenadione Drugs 0.000 description 1
• 230000036470 plasma concentration Effects 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1
• 235000021018 plums Nutrition 0.000 description 1
• 238000005498 polishing Methods 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920002401 polyacrylamide Polymers 0.000 description 1
• 150000004291 polyenes Chemical class 0.000 description 1
• FPGPDEPMWUWLOV-UHFFFAOYSA-N polygodial Natural products CC1(C)CCCC2(C)C(C=O)C(=CC(O)C12)C=O FPGPDEPMWUWLOV-UHFFFAOYSA-N 0.000 description 1
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
• 150000008442 polyphenolic compounds Chemical class 0.000 description 1
• 235000013824 polyphenols Nutrition 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
• 229920002451 polyvinyl alcohol Polymers 0.000 description 1
• 230000005195 poor health Effects 0.000 description 1
• 229960001589 posaconazole Drugs 0.000 description 1
• RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 description 1
• ABVRVIZBZKUTMK-JSYANWSFSA-M potassium clavulanate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 ABVRVIZBZKUTMK-JSYANWSFSA-M 0.000 description 1
• 159000000001 potassium salts Chemical class 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
• 229960004618 prednisone Drugs 0.000 description 1
• GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 208000037920 primary disease Diseases 0.000 description 1
• 239000002987 primer (paints) Substances 0.000 description 1
• 230000000529 probiotic effect Effects 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 229940055019 propionibacterium acne Drugs 0.000 description 1
• 230000004853 protein function Effects 0.000 description 1
• 230000005180 public health Effects 0.000 description 1
• 239000012264 purified product Substances 0.000 description 1
• 229960003581 pyridoxal Drugs 0.000 description 1
• 235000008164 pyridoxal Nutrition 0.000 description 1
• 239000011674 pyridoxal Substances 0.000 description 1
• ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
• 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
• 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
• 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
• 229940076788 pyruvate Drugs 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 238000004445 quantitative analysis Methods 0.000 description 1
• LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
• 230000005855 radiation Effects 0.000 description 1
• MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
• 229960004742 raltegravir Drugs 0.000 description 1
• CZFFBEXEKNGXKS-UHFFFAOYSA-N raltegravir Chemical compound O1C(C)=NN=C1C(=O)NC(C)(C)C1=NC(C(=O)NCC=2C=CC(F)=CC=2)=C(O)C(=O)N1C CZFFBEXEKNGXKS-UHFFFAOYSA-N 0.000 description 1
• 235000021013 raspberries Nutrition 0.000 description 1
• 238000011552 rat model Methods 0.000 description 1
• 239000002994 raw material Substances 0.000 description 1
• 230000036647 reaction Effects 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 235000021487 ready-to-eat food Nutrition 0.000 description 1
• 230000008707 rearrangement Effects 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1
• 238000006479 redox reaction Methods 0.000 description 1
• 235000018770 reduced food intake Nutrition 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 230000010076 replication Effects 0.000 description 1
• 210000002345 respiratory system Anatomy 0.000 description 1
• 230000000284 resting effect Effects 0.000 description 1
• 238000010839 reverse transcription Methods 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 206010039083 rhinitis Diseases 0.000 description 1
• 229930184609 rhodostreptomycin Natural products 0.000 description 1
• 108020004418 ribosomal RNA Proteins 0.000 description 1
• 239000004170 rice bran wax Substances 0.000 description 1
• 235000019384 rice bran wax Nutrition 0.000 description 1
• 229960002814 rilpivirine Drugs 0.000 description 1
• YIBOMRUWOWDFLG-ONEGZZNKSA-N rilpivirine Chemical compound CC1=CC(\C=C\C#N)=CC(C)=C1NC1=CC=NC(NC=2C=CC(=CC=2)C#N)=N1 YIBOMRUWOWDFLG-ONEGZZNKSA-N 0.000 description 1
• 229960000311 ritonavir Drugs 0.000 description 1
• NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
• 235000019204 saccharin Nutrition 0.000 description 1
• 229940081974 saccharin Drugs 0.000 description 1
• 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 238000005070 sampling Methods 0.000 description 1
• 229960001852 saquinavir Drugs 0.000 description 1
• QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
• 230000036186 satiety Effects 0.000 description 1
• 235000019627 satiety Nutrition 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 229940091258 selenium supplement Drugs 0.000 description 1
• 230000001953 sensory effect Effects 0.000 description 1
• 229960005429 sertaconazole Drugs 0.000 description 1
• 230000001568 sexual effect Effects 0.000 description 1
• 239000004208 shellac Substances 0.000 description 1
• 229940113147 shellac Drugs 0.000 description 1
• 235000013874 shellac Nutrition 0.000 description 1
• ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 210000001599 sigmoid colon Anatomy 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 229910052710 silicon Inorganic materials 0.000 description 1
• 239000010703 silicon Substances 0.000 description 1
• 235000021309 simple sugar Nutrition 0.000 description 1
• 238000004088 simulation Methods 0.000 description 1
• 235000009561 snack bars Nutrition 0.000 description 1
• 235000011888 snacks Nutrition 0.000 description 1
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
• 239000004299 sodium benzoate Substances 0.000 description 1
• 235000010234 sodium benzoate Nutrition 0.000 description 1
• MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
• 239000012064 sodium phosphate buffer Substances 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• RMLUKZWYIKEASN-UHFFFAOYSA-M sodium;2-amino-9-(2-hydroxyethoxymethyl)purin-6-olate Chemical compound [Na+].O=C1[N-]C(N)=NC2=C1N=CN2COCCO RMLUKZWYIKEASN-UHFFFAOYSA-M 0.000 description 1
• 239000002689 soil Substances 0.000 description 1
• 239000007909 solid dosage form Substances 0.000 description 1
• 239000002910 solid waste Substances 0.000 description 1
• 239000000600 sorbitol Substances 0.000 description 1
• 229960002920 sorbitol Drugs 0.000 description 1
• 125000006850 spacer group Chemical group 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 230000004763 spore germination Effects 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 235000000891 standard diet Nutrition 0.000 description 1
• 229960001203 stavudine Drugs 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 210000000130 stem cell Anatomy 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 229940013618 stevioside Drugs 0.000 description 1
• OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
• 235000019202 steviosides Nutrition 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 235000021012 strawberries Nutrition 0.000 description 1
• 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 238000000859 sublimation Methods 0.000 description 1
• 230000008022 sublimation Effects 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
• 235000019408 sucralose Nutrition 0.000 description 1
• BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
• 150000005846 sugar alcohols Chemical class 0.000 description 1
• 229960002607 sulconazole Drugs 0.000 description 1
• 229960001940 sulfasalazine Drugs 0.000 description 1
• NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 230000001839 systemic circulation Effects 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 229960001367 tartaric acid Drugs 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 239000006068 taste-masking agent Substances 0.000 description 1
• BHTRKEVKTKCXOH-BJLOMENOSA-N taurochenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-BJLOMENOSA-N 0.000 description 1
• WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 description 1
• 229960004556 tenofovir Drugs 0.000 description 1
• VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 1
• 229960000580 terconazole Drugs 0.000 description 1
• IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
• QZZGJDVWLFXDLK-UHFFFAOYSA-N tetracosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(O)=O QZZGJDVWLFXDLK-UHFFFAOYSA-N 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 229940072172 tetracycline antibiotic Drugs 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
• 229960000278 theophylline Drugs 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 238000007669 thermal treatment Methods 0.000 description 1
• DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
• 239000010409 thin film Substances 0.000 description 1
• 238000004809 thin layer chromatography Methods 0.000 description 1
• 229910052718 tin Inorganic materials 0.000 description 1
• 239000011135 tin Substances 0.000 description 1
• 229960000838 tipranavir Drugs 0.000 description 1
• NZPXPXAGXYTROM-FYBSXPHGSA-N tipranavir Chemical compound C([C@@]1(CCC)OC(O)=C([C@H](CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)C(=O)C1)CC1=CC=CC=C1 NZPXPXAGXYTROM-FYBSXPHGSA-N 0.000 description 1
• 229960000707 tobramycin Drugs 0.000 description 1
• NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
• 229960000984 tocofersolan Drugs 0.000 description 1
• AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
• 229960004880 tolnaftate Drugs 0.000 description 1
• FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 230000007888 toxin activity Effects 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
• 210000003384 transverse colon Anatomy 0.000 description 1
• 150000003852 triazoles Chemical class 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• 150000004043 trisaccharides Chemical class 0.000 description 1
• 210000003812 trophozoite Anatomy 0.000 description 1
• 231100000397 ulcer Toxicity 0.000 description 1
• 229960002703 undecylenic acid Drugs 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 230000002485 urinary effect Effects 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 229940014499 ursodeoxycholate Drugs 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 229940070710 valerate Drugs 0.000 description 1
• NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
• 229960002149 valganciclovir Drugs 0.000 description 1
• 229910052720 vanadium Inorganic materials 0.000 description 1
• GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
• 230000009105 vegetative growth Effects 0.000 description 1
• 239000003981 vehicle Substances 0.000 description 1
• 230000035899 viability Effects 0.000 description 1
• 229940118696 vibrio cholerae Drugs 0.000 description 1
• 229960003636 vidarabine Drugs 0.000 description 1
• 229940117958 vinyl acetate Drugs 0.000 description 1
• 229920006163 vinyl copolymer Polymers 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1
• 230000001018 virulence Effects 0.000 description 1
• 235000010374 vitamin B1 Nutrition 0.000 description 1
• 239000011691 vitamin B1 Substances 0.000 description 1
• 235000019164 vitamin B2 Nutrition 0.000 description 1
• 239000011716 vitamin B2 Substances 0.000 description 1
• 235000019160 vitamin B3 Nutrition 0.000 description 1
• 239000011708 vitamin B3 Substances 0.000 description 1
• 235000021470 vitamin B5 (pantothenic acid) Nutrition 0.000 description 1
• 235000021467 vitamin B7(Biotin) Nutrition 0.000 description 1
• 235000019159 vitamin B9 Nutrition 0.000 description 1
• 239000011727 vitamin B9 Substances 0.000 description 1
• 235000019143 vitamin K2 Nutrition 0.000 description 1
• 239000011728 vitamin K2 Substances 0.000 description 1
• 235000012711 vitamin K3 Nutrition 0.000 description 1
• 239000011652 vitamin K3 Substances 0.000 description 1
• 229940041603 vitamin k 3 Drugs 0.000 description 1
• 235000019195 vitamin supplement Nutrition 0.000 description 1
• 229960004740 voriconazole Drugs 0.000 description 1
• BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 230000004584 weight gain Effects 0.000 description 1
• 235000019786 weight gain Nutrition 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 208000016261 weight loss Diseases 0.000 description 1
• 229940100445 wheat starch Drugs 0.000 description 1
• 239000009637 wintergreen oil Substances 0.000 description 1
• 239000002023 wood Substances 0.000 description 1
• FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
• 239000012138 yeast extract Substances 0.000 description 1
• 229940098232 yersinia enterocolitica Drugs 0.000 description 1
• 235000013618 yogurt Nutrition 0.000 description 1
• 235000010930 zeaxanthin Nutrition 0.000 description 1
• 239000001775 zeaxanthin Substances 0.000 description 1
• 229940043269 zeaxanthin Drugs 0.000 description 1
• XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
• 239000002076 α-tocopherol Substances 0.000 description 1
• 235000004835 α-tocopherol Nutrition 0.000 description 1
• OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1