JP2016519124A5 - - Google Patents

Info

Publication number

JP2016519124A5

JP2016519124A5 JP2016511042A JP2016511042A JP2016519124A5 JP 2016519124 A5 JP2016519124 A5 JP 2016519124A5 JP 2016511042 A JP2016511042 A JP 2016511042A JP 2016511042 A JP2016511042 A JP 2016511042A JP 2016519124 A5 JP2016519124 A5 JP 2016519124A5

Authority

JP

Japan

Prior art keywords

formulation

concentration

seq

antibody

antigen

Prior art date

2014-04-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000009472 formulation Methods 0.000 claims 32
• 239000000203 mixture Substances 0.000 claims 32
• 239000000427 antigen Substances 0.000 claims 8
• 102000036639 antigens Human genes 0.000 claims 8
• 108091007433 antigens Proteins 0.000 claims 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 239000012634 fragment Substances 0.000 claims 6
• 239000007853 buffer solution Substances 0.000 claims 5
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 4
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 4
• 229930195725 Mannitol Natural products 0.000 claims 4
• 239000007983 Tris buffer Substances 0.000 claims 4
• 239000000594 mannitol Substances 0.000 claims 4
• 235000010355 mannitol Nutrition 0.000 claims 4
• 239000008363 phosphate buffer Substances 0.000 claims 4
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 4
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
• 229920000053 polysorbate 80 Polymers 0.000 claims 4
• 229940068968 polysorbate 80 Drugs 0.000 claims 4
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 4
• 229930006000 Sucrose Natural products 0.000 claims 3
• 239000002736 nonionic surfactant Substances 0.000 claims 3
• 239000005720 sucrose Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 102000004388 Interleukin-4 Human genes 0.000 claims 2
• 108090000978 Interleukin-4 Proteins 0.000 claims 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 229920000136 polysorbate Polymers 0.000 claims 2
• 229950008882 polysorbate Drugs 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 101100152731 Arabidopsis thaliana TH2 gene Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 239000000872 buffer Substances 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000000600 disaccharide group Chemical group 0.000 claims 1
• 150000002016 disaccharides Chemical class 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000000185 sucrose group Chemical group 0.000 claims 1
• 239000012905 visible particle Substances 0.000 claims 1