JP2016519078A5 - - Google Patents
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- JP2016519078A5 JP2016519078A5 JP2016502796A JP2016502796A JP2016519078A5 JP 2016519078 A5 JP2016519078 A5 JP 2016519078A5 JP 2016502796 A JP2016502796 A JP 2016502796A JP 2016502796 A JP2016502796 A JP 2016502796A JP 2016519078 A5 JP2016519078 A5 JP 2016519078A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- ring
- compound according
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CC(*1)NNNC1N Chemical compound CC(*1)NNNC1N 0.000 description 1
- RFRKXBHBPOTRTP-LJQANCHMSA-N Cc1n[o]c(C)c1-c1nc(-c2cc(OC[C@@H](CNC)O)ccc2Cl)nc(N(C2)Cc3c2cccn3)c1C Chemical compound Cc1n[o]c(C)c1-c1nc(-c2cc(OC[C@@H](CNC)O)ccc2Cl)nc(N(C2)Cc3c2cccn3)c1C RFRKXBHBPOTRTP-LJQANCHMSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794442P | 2013-03-15 | 2013-03-15 | |
| US61/794,442 | 2013-03-15 | ||
| US201461937333P | 2014-02-07 | 2014-02-07 | |
| US61/937,333 | 2014-02-07 | ||
| PCT/US2014/028463 WO2014144169A1 (en) | 2013-03-15 | 2014-03-14 | Carm1 inhibitors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018071070A Division JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016519078A JP2016519078A (ja) | 2016-06-30 |
| JP2016519078A5 true JP2016519078A5 (enExample) | 2017-02-02 |
Family
ID=50687649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502796A Pending JP2016519078A (ja) | 2013-03-15 | 2014-03-14 | Ｃａｒｍ１阻害剤およびその使用 |
| JP2018071070A Pending JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018071070A Pending JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9738651B2 (enExample) |
| EP (1) | EP2970219B1 (enExample) |
| JP (2) | JP2016519078A (enExample) |
| KR (1) | KR20160003647A (enExample) |
| CN (1) | CN105228997B (enExample) |
| AU (2) | AU2014227775B2 (enExample) |
| BR (1) | BR112015022787A2 (enExample) |
| CA (1) | CA2903813C (enExample) |
| EA (1) | EA201591532A1 (enExample) |
| IL (1) | IL241370A0 (enExample) |
| MX (1) | MX2015012803A (enExample) |
| SG (1) | SG11201507070XA (enExample) |
| WO (1) | WO2014144169A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9163008B2 (en) * | 2011-09-02 | 2015-10-20 | Purdue Pharma, L.P. | Pyrimidines as sodium channel blockers |
| US9365555B2 (en) | 2012-12-21 | 2016-06-14 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP2016505002A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用 |
| US10118918B2 (en) | 2012-12-21 | 2018-11-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| US9604930B2 (en) | 2012-12-21 | 2017-03-28 | Epizyme, Inc. | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof |
| CA2903394C (en) | 2013-03-14 | 2021-08-31 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9394258B2 (en) | 2013-03-14 | 2016-07-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970181B1 (en) | 2013-03-14 | 2017-06-07 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| JP2016514164A (ja) | 2013-03-14 | 2016-05-19 | エピザイム，インコーポレイティド | アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用 |
| EP2970135B1 (en) | 2013-03-14 | 2018-07-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9133189B2 (en) | 2013-03-14 | 2015-09-15 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2014153172A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| WO2014144169A1 (en) * | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| EP2970266B1 (en) | 2013-03-15 | 2018-01-31 | Epizyme, Inc. | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| AU2015301196A1 (en) | 2014-08-04 | 2017-01-12 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| US20170298073A1 (en) * | 2014-09-17 | 2017-10-19 | Epizyme, Inc | Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor |
| WO2016044604A1 (en) * | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| HUE057041T2 (hu) | 2015-07-06 | 2022-04-28 | Alkermes Inc | Hiszton deacetiláz hetero-halogén gátlói |
| WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| EP3510029B1 (en) * | 2016-09-07 | 2025-11-05 | The Regents of The University of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
| US11160823B2 (en) | 2016-11-07 | 2021-11-02 | University Of Massachusetts | Therapeutic targets for facioscapulohumeral muscular dystrophy |
| HRP20220223T1 (hr) | 2017-01-11 | 2022-04-29 | Alkermes, Inc. | Biciklički inhibitori histon deacetilaze |
| EP3573971A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| JP7327802B2 (ja) | 2017-01-26 | 2023-08-16 | アラクセス ファーマ エルエルシー | 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法 |
| WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| CN110869358A (zh) | 2017-05-25 | 2020-03-06 | 亚瑞克西斯制药公司 | Kras的共价抑制剂 |
| US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
| BR112021001709A2 (pt) * | 2018-08-01 | 2021-05-04 | Araxes Pharma Llc | compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer |
| CN112007032B (zh) * | 2020-09-16 | 2021-10-22 | 厦门大学 | 化合物在制备小分子抑制剂或治疗癌症的药物中的应用及小分子抑制剂和治疗癌症的药物 |
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| GB1464242A (en) | 1974-04-18 | 1977-02-09 | Smithkline Corp | Benzoyl benzofurans and compositions comprising them |
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| US9604930B2 (en) | 2012-12-21 | 2017-03-28 | Epizyme, Inc. | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof |
| US9365555B2 (en) | 2012-12-21 | 2016-06-14 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
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| JP2016505002A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用 |
| US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Ｆｌａｐ調節劑 |
| US9394258B2 (en) | 2013-03-14 | 2016-07-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP3363434A1 (en) | 2013-03-14 | 2018-08-22 | Epizyme Inc | Arginine methyltransferase inhibitors and uses thereof |
| WO2014153172A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| JP2016514164A (ja) | 2013-03-14 | 2016-05-19 | エピザイム，インコーポレイティド | アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用 |
| US20160039767A1 (en) | 2013-03-14 | 2016-02-11 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9133189B2 (en) | 2013-03-14 | 2015-09-15 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970181B1 (en) | 2013-03-14 | 2017-06-07 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| CA2903394C (en) | 2013-03-14 | 2021-08-31 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970135B1 (en) | 2013-03-14 | 2018-07-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9346802B2 (en) | 2013-03-15 | 2016-05-24 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
| WO2014144169A1 (en) | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| EP2970266B1 (en) | 2013-03-15 | 2018-01-31 | Epizyme, Inc. | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| EP3160466A4 (en) | 2014-06-25 | 2017-12-27 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2015200680A2 (en) | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| AU2015301196A1 (en) | 2014-08-04 | 2017-01-12 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2016044650A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| US20170283400A1 (en) | 2014-09-17 | 2017-10-05 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2016044576A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Salts, co-crystals, amorphous forms, and crystalline forms of an arginine methyltransferase inhibitor |
| US20170280720A1 (en) | 2014-09-17 | 2017-10-05 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| JP2017533887A (ja) | 2014-09-17 | 2017-11-16 | ジェネンテック， インコーポレイテッド | ピロロベンゾジアゼピン類及びその抗体ジスルフィドコンジュゲート |
| WO2016044626A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2016044641A2 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| US20170298073A1 (en) | 2014-09-17 | 2017-10-19 | Epizyme, Inc | Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor |
| WO2016044604A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| WO2017136699A1 (en) | 2016-02-05 | 2017-08-10 | Epizyme, Inc | Arginine methyltransferase inhibitors and uses thereof |
| JP2019524740A (ja) | 2016-07-25 | 2019-09-05 | エピザイム インコーポレイテッド | Ｃｒｅｂｂｐ関連癌の治療法 |
| US20190083482A1 (en) | 2017-09-18 | 2019-03-21 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
-
2014
- 2014-03-14 WO PCT/US2014/028463 patent/WO2014144169A1/en not_active Ceased
- 2014-03-14 AU AU2014227775A patent/AU2014227775B2/en not_active Ceased
- 2014-03-14 CN CN201480020614.4A patent/CN105228997B/zh not_active Expired - Fee Related
- 2014-03-14 EP EP14723190.6A patent/EP2970219B1/en active Active
- 2014-03-14 BR BR112015022787A patent/BR112015022787A2/pt not_active IP Right Cessation
- 2014-03-14 MX MX2015012803A patent/MX2015012803A/es unknown
- 2014-03-14 SG SG11201507070XA patent/SG11201507070XA/en unknown
- 2014-03-14 US US14/775,766 patent/US9738651B2/en not_active Expired - Fee Related
- 2014-03-14 EA EA201591532A patent/EA201591532A1/ru unknown
- 2014-03-14 CA CA2903813A patent/CA2903813C/en active Active
- 2014-03-14 KR KR1020157029125A patent/KR20160003647A/ko not_active Withdrawn
- 2014-03-14 JP JP2016502796A patent/JP2016519078A/ja active Pending
-
2015
- 2015-09-09 IL IL241370A patent/IL241370A0/en active IP Right Grant
-
2017
- 2017-07-13 US US15/648,701 patent/US9856267B2/en not_active Expired - Fee Related
- 2017-12-08 US US15/835,758 patent/US10118931B2/en active Active
-
2018
- 2018-04-02 JP JP2018071070A patent/JP2018118994A/ja active Pending
- 2018-07-31 AU AU2018211214A patent/AU2018211214A1/en not_active Abandoned
- 2018-10-02 US US16/149,519 patent/US10633389B2/en active Active
-
2020
- 2020-03-18 US US16/822,478 patent/US11834455B2/en active Active
-
2022
- 2022-11-23 US US18/058,549 patent/US20230416263A1/en not_active Abandoned
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