JP2016519078A5 - - Google Patents
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- JP2016519078A5 JP2016519078A5 JP2016502796A JP2016502796A JP2016519078A5 JP 2016519078 A5 JP2016519078 A5 JP 2016519078A5 JP 2016502796 A JP2016502796 A JP 2016502796A JP 2016502796 A JP2016502796 A JP 2016502796A JP 2016519078 A5 JP2016519078 A5 JP 2016519078A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- ring
- compound according
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 105
- 125000000623 heterocyclic group Chemical group 0.000 claims 37
- 229910052739 hydrogen Inorganic materials 0.000 claims 27
- 239000001257 hydrogen Substances 0.000 claims 27
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 125000000547 substituted alkyl group Chemical group 0.000 claims 24
- 150000002431 hydrogen Chemical class 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 18
- 125000003107 substituted aryl group Chemical group 0.000 claims 17
- 125000004452 carbocyclyl group Chemical group 0.000 claims 14
- 125000005842 heteroatom Chemical group 0.000 claims 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims 10
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 10
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000002950 monocyclic group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 150000003573 thiols Chemical class 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 6
- -1 amino, substituted amino, carbonyl Chemical class 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 125000003367 polycyclic group Chemical group 0.000 claims 4
- 125000000475 sulfinyl group Chemical class [*:2]S([*:1])=O 0.000 claims 4
- 125000000472 sulfonyl group Chemical class *S(*)(=O)=O 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 102100025210 Histone-arginine methyltransferase CARM1 Human genes 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 108010030886 coactivator-associated arginine methyltransferase 1 Proteins 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 102000015735 Beta-catenin Human genes 0.000 claims 1
- 108060000903 Beta-catenin Proteins 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 101000904152 Homo sapiens Transcription factor E2F1 Proteins 0.000 claims 1
- 102100024026 Transcription factor E2F1 Human genes 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
- 0 CC(*1)NNNC1N Chemical compound CC(*1)NNNC1N 0.000 description 1
- RFRKXBHBPOTRTP-LJQANCHMSA-N Cc1n[o]c(C)c1-c1nc(-c2cc(OC[C@@H](CNC)O)ccc2Cl)nc(N(C2)Cc3c2cccn3)c1C Chemical compound Cc1n[o]c(C)c1-c1nc(-c2cc(OC[C@@H](CNC)O)ccc2Cl)nc(N(C2)Cc3c2cccn3)c1C RFRKXBHBPOTRTP-LJQANCHMSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794442P | 2013-03-15 | 2013-03-15 | |
| US61/794,442 | 2013-03-15 | ||
| US201461937333P | 2014-02-07 | 2014-02-07 | |
| US61/937,333 | 2014-02-07 | ||
| PCT/US2014/028463 WO2014144169A1 (en) | 2013-03-15 | 2014-03-14 | Carm1 inhibitors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018071070A Division JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016519078A JP2016519078A (ja) | 2016-06-30 |
| JP2016519078A5 true JP2016519078A5 (enExample) | 2017-02-02 |
Family
ID=50687649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502796A Pending JP2016519078A (ja) | 2013-03-15 | 2014-03-14 | Ｃａｒｍ１阻害剤およびその使用 |
| JP2018071070A Pending JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018071070A Pending JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9738651B2 (enExample) |
| EP (1) | EP2970219B1 (enExample) |
| JP (2) | JP2016519078A (enExample) |
| KR (1) | KR20160003647A (enExample) |
| CN (1) | CN105228997B (enExample) |
| AU (2) | AU2014227775B2 (enExample) |
| BR (1) | BR112015022787A2 (enExample) |
| CA (1) | CA2903813C (enExample) |
| EA (1) | EA201591532A1 (enExample) |
| IL (1) | IL241370A0 (enExample) |
| MX (1) | MX2015012803A (enExample) |
| SG (1) | SG11201507070XA (enExample) |
| WO (1) | WO2014144169A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2753606T (pt) * | 2011-09-02 | 2017-10-02 | Purdue Pharma Lp | Pirimidinas como bloqueadoras dos canais de sódio |
| JP2016505002A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用 |
| WO2014100716A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| CA2894157A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| JP2016505000A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| MY199894A (en) | 2012-12-21 | 2023-11-27 | Epizyme Inc | Prmt5 inhibitors and uses thereof |
| US9394258B2 (en) | 2013-03-14 | 2016-07-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2014144659A1 (en) | 2013-03-14 | 2014-09-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| AU2014260433A1 (en) | 2013-03-14 | 2015-09-10 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
| SG11201506972PA (en) | 2013-03-14 | 2015-10-29 | Epizyme Inc | Arginine methyltransferase inhibitors and uses thereof |
| EP2970133B1 (en) | 2013-03-14 | 2018-10-24 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| EP2970136A1 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| KR20160003647A (ko) | 2013-03-15 | 2016-01-11 | 에피자임, 인코포레이티드 | Carm1 억제제 및 이의 용도 |
| EP2970266B1 (en) | 2013-03-15 | 2018-01-31 | Epizyme, Inc. | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| CA2953572A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| JP2017530959A (ja) * | 2014-09-17 | 2017-10-19 | エピザイム，インコーポレイティド | Ｃａｒｍ１阻害剤およびその使用 |
| WO2016044569A1 (en) * | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor |
| RS62639B1 (sr) | 2015-07-06 | 2021-12-31 | Alkermes Inc | Hetero-halo inhibitori histonskih deacetilaza |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| CA3039026A1 (en) * | 2016-09-07 | 2018-03-15 | The Regents Of The University Of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
| CA3042700A1 (en) | 2016-11-07 | 2018-05-11 | University Of Massachusetts | Therapeutic targets for facioscapulohumeral muscular dystrophy |
| JP6756925B2 (ja) | 2017-01-11 | 2020-09-16 | ロダン・セラピューティクス，インコーポレーテッド | ヒストンデアセチラーゼの二環式阻害剤 |
| WO2018140512A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| EP3573967A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused hetero-hetero bicyclic compounds and methods of use thereof |
| US11358959B2 (en) | 2017-01-26 | 2022-06-14 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
| CN110831933A (zh) | 2017-05-25 | 2020-02-21 | 亚瑞克西斯制药公司 | 喹唑啉衍生物作为突变kras、hras或nras的调节剂 |
| CA3063440A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Covalent inhibitors of kras |
| ES2914355T3 (es) | 2017-08-07 | 2022-06-09 | Alkermes Inc | Inhibidores bicíclicos de la histona desacetilasa |
| EP3829580A1 (en) * | 2018-08-01 | 2021-06-09 | Araxes Pharma LLC | Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer |
| CN112007032B (zh) * | 2020-09-16 | 2021-10-22 | 厦门大学 | 化合物在制备小分子抑制剂或治疗癌症的药物中的应用及小分子抑制剂和治疗癌症的药物 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB148830A (en) | 1918-12-04 | 1921-11-10 | Aegir Electrische Bordapp Und | Device for signalling liquid levels at a distance |
| GB1488330A (en) | 1973-12-19 | 1977-10-12 | Smith Kline French Lab | Dihydropyridazinones |
| US4011321A (en) | 1973-12-19 | 1977-03-08 | Smith Kline & French Laboratories Limited | Pharmaceutical compositions and methods of inhibiting β-adrenergic receptors |
| GB1464242A (en) | 1974-04-18 | 1977-02-09 | Smithkline Corp | Benzoyl benzofurans and compositions comprising them |
| US4001426A (en) | 1974-10-17 | 1977-01-04 | Smithkline Corporation | Substituted benzofurans and benzothiophenes |
| GB1548601A (en) | 1976-03-29 | 1979-07-18 | Smith Kline French Lab | Pyridazines |
| US4728651A (en) | 1985-10-24 | 1988-03-01 | Hoechst-Roussel Pharmaceuticals Inc. | Antihypertensive thieno-isoxazoles and -pyrazoles |
| US5221675A (en) | 1989-12-15 | 1993-06-22 | Abbott Laboratories | Aza-spirocyclic compounds that enhance cholinergic neurotransmission |
| GB9325217D0 (en) * | 1993-12-09 | 1994-02-09 | Zeneca Ltd | Pyrimidine derivatives |
| ES2232137T3 (es) * | 1998-05-15 | 2005-05-16 | Astrazeneca Ab | Derivados de benzamida para el tratamiento de enfermedades mediadas por citoquinas. |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| CA2389034A1 (en) | 1999-10-27 | 2001-05-03 | Cor Therapeutics, Inc. | Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| DE10010067A1 (de) | 2000-03-02 | 2001-09-06 | Bayer Ag | Neue Imidazotriazinone und ihre Verwendung |
| HRP20030018A2 (en) | 2000-07-13 | 2003-04-30 | Lilly Co Eli | Beta3 adrenergic agonists |
| US6864267B2 (en) | 2001-07-16 | 2005-03-08 | Smithkline Beecham Corporation | Calcilytic compounds |
| CN1747949A (zh) * | 2002-12-20 | 2006-03-15 | 法马西亚公司 | 无环吡唑化合物 |
| EP1603884A4 (en) | 2003-02-28 | 2008-05-28 | Encysive Pharmaceuticals Inc | PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE AND NAPHTHALENE UROTENSIN II RECEPTOR ANTAGONISTS |
| US7408008B2 (en) | 2003-12-09 | 2008-08-05 | Janssen Pharmaceutica, N.V. | Method of producing highly functionalized 1,3-diamino-propan-2-ols from solid support |
| WO2006113458A1 (en) | 2005-04-15 | 2006-10-26 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of protein arginine methyl transferases |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| FR2904827B1 (fr) * | 2006-08-11 | 2008-09-19 | Sanofi Aventis Sa | Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii |
| WO2008032191A2 (en) | 2006-09-13 | 2008-03-20 | Astrazeneca Ab | Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators |
| US8338437B2 (en) | 2007-02-28 | 2012-12-25 | Methylgene Inc. | Amines as small molecule inhibitors |
| JP5539235B2 (ja) | 2008-02-29 | 2014-07-02 | エボテック・アーゲー | アミド化合物、組成物およびそれらの使用 |
| WO2010028179A1 (en) | 2008-09-03 | 2010-03-11 | Dr. Reddy's Laboratories Ltd. | Heterocyclic compounds as gata modulators |
| WO2010120994A2 (en) * | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ureidoaryl-and carbamoylaryl-morpholino- pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis |
| JP2013107824A (ja) | 2010-03-17 | 2013-06-06 | Dainippon Sumitomo Pharma Co Ltd | 新規単環ピリミジン誘導体 |
| US8962623B2 (en) | 2011-03-04 | 2015-02-24 | Locus Pharmaceuticals, Inc. | Aminopyrazine compounds |
| CN109053695A (zh) | 2011-04-15 | 2018-12-21 | 梅琳塔治疗公司 | 抗微生物化合物及制备和使用所述化合物的方法 |
| CN103841657B (zh) | 2012-11-21 | 2018-08-14 | 中兴通讯股份有限公司 | 一种本地ip访问连接的释放方法和mrn |
| MY199894A (en) | 2012-12-21 | 2023-11-27 | Epizyme Inc | Prmt5 inhibitors and uses thereof |
| WO2014100716A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| JP2016505000A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| JP2016505002A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用 |
| CA2894157A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| CA2894230A1 (en) * | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Methods of inhibiting prmt5 |
| TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Ｆｌａｐ調節劑 |
| WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970136A1 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
| US20160031839A1 (en) | 2013-03-14 | 2016-02-04 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970133B1 (en) | 2013-03-14 | 2018-10-24 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9394258B2 (en) | 2013-03-14 | 2016-07-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| AU2014260433A1 (en) | 2013-03-14 | 2015-09-10 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
| WO2014144659A1 (en) | 2013-03-14 | 2014-09-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| SG11201506972PA (en) | 2013-03-14 | 2015-10-29 | Epizyme Inc | Arginine methyltransferase inhibitors and uses thereof |
| EP2970134B1 (en) | 2013-03-14 | 2018-02-28 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| KR20160003647A (ko) * | 2013-03-15 | 2016-01-11 | 에피자임, 인코포레이티드 | Carm1 억제제 및 이의 용도 |
| EP2970266B1 (en) | 2013-03-15 | 2018-01-31 | Epizyme, Inc. | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| US9346802B2 (en) | 2013-03-15 | 2016-05-24 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
| US20170198006A1 (en) | 2014-06-25 | 2017-07-13 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP3160466A4 (en) | 2014-06-25 | 2017-12-27 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| CA2953572A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US20170283400A1 (en) | 2014-09-17 | 2017-10-05 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US20170280720A1 (en) | 2014-09-17 | 2017-10-05 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| PE20170905A1 (es) | 2014-09-17 | 2017-07-12 | Genentech Inc | Pirrolobenzodiazepinas y conjugados de anticuerpo-disulfuro de las mismas |
| JP2017530959A (ja) * | 2014-09-17 | 2017-10-19 | エピザイム，インコーポレイティド | Ｃａｒｍ１阻害剤およびその使用 |
| WO2016044569A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor |
| WO2016044641A2 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| WO2016044650A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| US20170291905A1 (en) | 2014-09-17 | 2017-10-12 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2016044576A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Salts, co-crystals, amorphous forms, and crystalline forms of an arginine methyltransferase inhibitor |
| WO2017136699A1 (en) | 2016-02-05 | 2017-08-10 | Epizyme, Inc | Arginine methyltransferase inhibitors and uses thereof |
| CN109715790A (zh) | 2016-07-25 | 2019-05-03 | 埃皮兹姆公司 | Crebbp相关的癌症疗法 |
| US20190083482A1 (en) | 2017-09-18 | 2019-03-21 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
-
2014
- 2014-03-14 KR KR1020157029125A patent/KR20160003647A/ko not_active Withdrawn
- 2014-03-14 JP JP2016502796A patent/JP2016519078A/ja active Pending
- 2014-03-14 WO PCT/US2014/028463 patent/WO2014144169A1/en not_active Ceased
- 2014-03-14 EP EP14723190.6A patent/EP2970219B1/en active Active
- 2014-03-14 CN CN201480020614.4A patent/CN105228997B/zh active Active
- 2014-03-14 SG SG11201507070XA patent/SG11201507070XA/en unknown
- 2014-03-14 CA CA2903813A patent/CA2903813C/en active Active
- 2014-03-14 MX MX2015012803A patent/MX2015012803A/es unknown
- 2014-03-14 BR BR112015022787A patent/BR112015022787A2/pt not_active IP Right Cessation
- 2014-03-14 EA EA201591532A patent/EA201591532A1/ru unknown
- 2014-03-14 AU AU2014227775A patent/AU2014227775B2/en not_active Ceased
- 2014-03-14 US US14/775,766 patent/US9738651B2/en not_active Expired - Fee Related
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2015
- 2015-09-09 IL IL241370A patent/IL241370A0/en active IP Right Grant
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2017
- 2017-07-13 US US15/648,701 patent/US9856267B2/en active Active
- 2017-12-08 US US15/835,758 patent/US10118931B2/en active Active
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2018
- 2018-04-02 JP JP2018071070A patent/JP2018118994A/ja active Pending
- 2018-07-31 AU AU2018211214A patent/AU2018211214A1/en not_active Abandoned
- 2018-10-02 US US16/149,519 patent/US10633389B2/en active Active
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2020
- 2020-03-18 US US16/822,478 patent/US11834455B2/en active Active
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2022
- 2022-11-23 US US18/058,549 patent/US20230416263A1/en not_active Abandoned
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