AU2014227775B2 - CARM1 inhibitors and uses thereof - Google Patents

CARM1 inhibitors and uses thereof Download PDF

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Publication number
AU2014227775B2
AU2014227775B2 AU2014227775A AU2014227775A AU2014227775B2 AU 2014227775 B2 AU2014227775 B2 AU 2014227775B2 AU 2014227775 A AU2014227775 A AU 2014227775A AU 2014227775 A AU2014227775 A AU 2014227775A AU 2014227775 B2 AU2014227775 B2 AU 2014227775B2
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Australia
Prior art keywords
certain embodiments
optionally substituted
hydrogen
alkyl
ring
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AU2014227775A1 (en
Inventor
Robert E. Babine
Richard Chesworth
Lei Jin
Oscar Miguel Moradei
Gideon Shapiro
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Epizyme Inc
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Epizyme Inc
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Priority to AU2018211214A priority Critical patent/AU2018211214A1/en
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2014227775A 2013-03-15 2014-03-14 CARM1 inhibitors and uses thereof Ceased AU2014227775B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018211214A AU2018211214A1 (en) 2013-03-15 2018-07-31 Carm1 inhibitors and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361794442P 2013-03-15 2013-03-15
US61/794,442 2013-03-15
US201461937333P 2014-02-07 2014-02-07
US61/937,333 2014-02-07
PCT/US2014/028463 WO2014144169A1 (en) 2013-03-15 2014-03-14 Carm1 inhibitors and uses thereof

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AU2018211214A Division AU2018211214A1 (en) 2013-03-15 2018-07-31 Carm1 inhibitors and uses thereof

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AU2014227775A1 AU2014227775A1 (en) 2015-09-10
AU2014227775B2 true AU2014227775B2 (en) 2018-05-31

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AU2014227775A Ceased AU2014227775B2 (en) 2013-03-15 2014-03-14 CARM1 inhibitors and uses thereof
AU2018211214A Abandoned AU2018211214A1 (en) 2013-03-15 2018-07-31 Carm1 inhibitors and uses thereof

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US (6) US9738651B2 (enExample)
EP (1) EP2970219B1 (enExample)
JP (2) JP2016519078A (enExample)
KR (1) KR20160003647A (enExample)
CN (1) CN105228997B (enExample)
AU (2) AU2014227775B2 (enExample)
BR (1) BR112015022787A2 (enExample)
CA (1) CA2903813C (enExample)
EA (1) EA201591532A1 (enExample)
IL (1) IL241370A0 (enExample)
MX (1) MX2015012803A (enExample)
SG (1) SG11201507070XA (enExample)
WO (1) WO2014144169A1 (enExample)

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AU2014260433A1 (en) 2013-03-14 2015-09-10 Epizyme, Inc. Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
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EP2970133B1 (en) 2013-03-14 2018-10-24 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
EP2970136A1 (en) 2013-03-14 2016-01-20 Epizyme, Inc. Arginine methyl transferase inhibtors and uses thereof
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
KR20160003647A (ko) 2013-03-15 2016-01-11 에피자임, 인코포레이티드 Carm1 억제제 및 이의 용도
EP2970266B1 (en) 2013-03-15 2018-01-31 Epizyme, Inc. 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
CA2953572A1 (en) 2014-08-04 2016-02-11 Epizyme, Inc. Prmt5 inhibitors and uses thereof
JP2017530959A (ja) * 2014-09-17 2017-10-19 エピザイム，インコーポレイティド Ｃａｒｍ１阻害剤およびその使用
WO2016044569A1 (en) * 2014-09-17 2016-03-24 Epizyme, Inc. Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor
RS62639B1 (sr) 2015-07-06 2021-12-31 Alkermes Inc Hetero-halo inhibitori histonskih deacetilaza
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CA3039026A1 (en) * 2016-09-07 2018-03-15 The Regents Of The University Of California Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition
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JP6756925B2 (ja) 2017-01-11 2020-09-16 ロダン・セラピューティクス，インコーポレーテッド ヒストンデアセチラーゼの二環式阻害剤
WO2018140512A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
EP3573967A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused hetero-hetero bicyclic compounds and methods of use thereof
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