CN105228997B - Carm1抑制剂及其用途 - Google Patents

Carm1抑制剂及其用途 Download PDF

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Publication number
CN105228997B
CN105228997B CN201480020614.4A CN201480020614A CN105228997B CN 105228997 B CN105228997 B CN 105228997B CN 201480020614 A CN201480020614 A CN 201480020614A CN 105228997 B CN105228997 B CN 105228997B
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optionally substituted
certain embodiments
alkyl
compound
hydrogen
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CN105228997A (zh
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理查德·切兹沃思
奥斯卡·米格尔·莫拉代
吉迪恩·夏皮罗
雷·金
罗伯特·E·巴比尼
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Epizyme Inc
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Epizyme Inc
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    • C07D487/10—Spiro-condensed systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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CN201480020614.4A 2013-03-15 2014-03-14 Carm1抑制剂及其用途 Expired - Fee Related CN105228997B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361794442P 2013-03-15 2013-03-15
US61/794,442 2013-03-15
US201461937333P 2014-02-07 2014-02-07
US61/937,333 2014-02-07
PCT/US2014/028463 WO2014144169A1 (en) 2013-03-15 2014-03-14 Carm1 inhibitors and uses thereof

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CN105228997A CN105228997A (zh) 2016-01-06
CN105228997B true CN105228997B (zh) 2018-03-27

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US (6) US9738651B2 (enExample)
EP (1) EP2970219B1 (enExample)
JP (2) JP2016519078A (enExample)
KR (1) KR20160003647A (enExample)
CN (1) CN105228997B (enExample)
AU (2) AU2014227775B2 (enExample)
BR (1) BR112015022787A2 (enExample)
CA (1) CA2903813C (enExample)
EA (1) EA201591532A1 (enExample)
IL (1) IL241370A0 (enExample)
MX (1) MX2015012803A (enExample)
SG (1) SG11201507070XA (enExample)
WO (1) WO2014144169A1 (enExample)

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WO2014144169A1 (en) * 2013-03-15 2014-09-18 Epizyme, Inc. Carm1 inhibitors and uses thereof
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TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
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WO2016044604A1 (en) * 2014-09-17 2016-03-24 Epizyme, Inc. Carm1 inhibitors and uses thereof
HUE057041T2 (hu) 2015-07-06 2022-04-28 Alkermes Inc Hiszton deacetiláz hetero-halogén gátlói
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
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US11160823B2 (en) 2016-11-07 2021-11-02 University Of Massachusetts Therapeutic targets for facioscapulohumeral muscular dystrophy
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EP3573971A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
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