KR20160003647A - Carm1 억제제 및 이의 용도 - Google Patents

Carm1 억제제 및 이의 용도 Download PDF

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KR20160003647A
KR20160003647A KR1020157029125A KR20157029125A KR20160003647A KR 20160003647 A KR20160003647 A KR 20160003647A KR 1020157029125 A KR1020157029125 A KR 1020157029125A KR 20157029125 A KR20157029125 A KR 20157029125A KR 20160003647 A KR20160003647 A KR 20160003647A
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South Korea
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optionally substituted
certain embodiments
hydrogen
ring
alkyl
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Korean (ko)
Inventor
리처드 치스워스
오스카 미구엘 모라데이
기드온 샤피로
레이 진
로버트 이. 버바인
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에피자임, 인코포레이티드
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D498/04—Ortho-condensed systems
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    • C07D498/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020157029125A 2013-03-15 2014-03-14 Carm1 억제제 및 이의 용도 Withdrawn KR20160003647A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361794442P 2013-03-15 2013-03-15
US61/794,442 2013-03-15
US201461937333P 2014-02-07 2014-02-07
US61/937,333 2014-02-07
PCT/US2014/028463 WO2014144169A1 (en) 2013-03-15 2014-03-14 Carm1 inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
KR20160003647A true KR20160003647A (ko) 2016-01-11

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KR1020157029125A Withdrawn KR20160003647A (ko) 2013-03-15 2014-03-14 Carm1 억제제 및 이의 용도

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US (6) US9738651B2 (enExample)
EP (1) EP2970219B1 (enExample)
JP (2) JP2016519078A (enExample)
KR (1) KR20160003647A (enExample)
CN (1) CN105228997B (enExample)
AU (2) AU2014227775B2 (enExample)
BR (1) BR112015022787A2 (enExample)
CA (1) CA2903813C (enExample)
EA (1) EA201591532A1 (enExample)
IL (1) IL241370A0 (enExample)
MX (1) MX2015012803A (enExample)
SG (1) SG11201507070XA (enExample)
WO (1) WO2014144169A1 (enExample)

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JP2016514164A (ja) 2013-03-14 2016-05-19 エピザイム，インコーポレイティド アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用
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WO2014144169A1 (en) * 2013-03-15 2014-09-18 Epizyme, Inc. Carm1 inhibitors and uses thereof
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AU2014227775A1 (en) 2015-09-10
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US20170320883A1 (en) 2017-11-09
EA201591532A1 (ru) 2016-03-31
US20210155631A1 (en) 2021-05-27
EP2970219A1 (en) 2016-01-20
EP2970219B1 (en) 2019-02-27
WO2014144169A1 (en) 2014-09-18
US20230416263A1 (en) 2023-12-28
CA2903813A1 (en) 2014-09-18
CN105228997B (zh) 2018-03-27
US11834455B2 (en) 2023-12-05
BR112015022787A2 (pt) 2017-11-07
US20230279020A9 (en) 2023-09-07
CA2903813C (en) 2023-08-29
US10118931B2 (en) 2018-11-06
US20190135819A1 (en) 2019-05-09
US9856267B2 (en) 2018-01-02
US9738651B2 (en) 2017-08-22
JP2018118994A (ja) 2018-08-02
AU2014227775B2 (en) 2018-05-31
US10633389B2 (en) 2020-04-28
CN105228997A (zh) 2016-01-06
JP2016519078A (ja) 2016-06-30
MX2015012803A (es) 2016-08-19
US20180282343A1 (en) 2018-10-04
US20160039834A1 (en) 2016-02-11
AU2018211214A1 (en) 2018-08-23
HK1219947A1 (en) 2017-04-21

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