|
JPH085859B2
(ja)
|
1986-07-01 |
1996-01-24 |
日本バイエルアグロケム株式会社 |
新規アルキレンジアミン類
|
|
US5204482A
(en)
|
1988-07-28 |
1993-04-20 |
Hoffman-Laroche Inc. |
Compounds for treating and preventing cognitive diseases and depression and methods of making same
|
|
EP0352581A3
(de)
|
1988-07-28 |
1990-07-04 |
F. Hoffmann-La Roche Ag |
Aethylendiaminmonoamid-Derivate
|
|
AU3993795A
(en)
|
1994-12-02 |
1996-06-19 |
Fujisawa Pharmaceutical Co., Ltd. |
Peptide compounds for prevention and/or treatment of no-mediated diseases
|
|
SE9902765D0
(sv)
|
1999-07-21 |
1999-07-21 |
Astra Pharma Prod |
Novel compounds
|
|
CN1331326A
(zh)
*
|
2000-06-30 |
2002-01-16 |
上海博德基因开发有限公司 |
一种新的多肽——人精氨酸甲基转移酶(hrmt)32.12和编码这种多肽的多核苷酸
|
|
US20020090627A1
(en)
|
2000-10-05 |
2002-07-11 |
Rachel Meyers |
27419, a novel human arginine-N-methyl transferase and uses thereof
|
|
DE10149370A1
(de)
|
2001-10-06 |
2003-04-10 |
Merck Patent Gmbh |
Pyrazolderivate
|
|
ES2306859T3
(es)
|
2002-03-13 |
2008-11-16 |
Janssen Pharmaceutica Nv |
Derivados de sulfonil como nuevos inhibidores de histona deacetilasa.
|
|
GB0219961D0
(en)
|
2002-08-28 |
2002-10-02 |
Pfizer Ltd |
Oxytocin inhibitors
|
|
EP1571146A4
(en)
|
2002-12-10 |
2010-09-01 |
Ono Pharmaceutical Co |
NITROGENIC HETEROCYCLIC COMPOUNDS AND THEIR MEDICAL USE
|
|
US7135575B2
(en)
|
2003-03-03 |
2006-11-14 |
Array Biopharma, Inc. |
P38 inhibitors and methods of use thereof
|
|
DE10315572A1
(de)
|
2003-04-05 |
2004-10-14 |
Merck Patent Gmbh |
Substituierte Pyrazole
|
|
GB0309637D0
(en)
|
2003-04-28 |
2003-06-04 |
Cancer Rec Tech Ltd |
Pyrazole compounds
|
|
WO2004098634A2
(en)
|
2003-04-30 |
2004-11-18 |
Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health |
Protein arginine n-methyltransferase 2 (prmt-2)
|
|
US20050032794A1
(en)
|
2003-08-05 |
2005-02-10 |
Padia Janak K. |
Diamine derivatives of quinone and uses thereof
|
|
DE102004008807A1
(de)
|
2004-02-20 |
2005-09-08 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
KR101166342B1
(ko)
|
2004-03-15 |
2012-07-18 |
얀센 파마슈티카 엔.브이. |
아편계 약물 수용체 조절자로서의 신규의 화합물
|
|
CA2577937C
(en)
|
2004-08-26 |
2010-12-21 |
Pfizer Inc. |
Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
|
|
DE602004023766D1
(de)
|
2004-08-31 |
2009-12-03 |
Univ North Carolina |
Dot1-histon-methyltransferasen als ziel zur identifizierung von therapeutika gegen leukämie
|
|
WO2006033995A2
(en)
|
2004-09-16 |
2006-03-30 |
Valeant Research And Development |
Thiazolidin-4-ones having anti-hepatitis b activity
|
|
EP1802600A1
(en)
|
2004-10-13 |
2007-07-04 |
Bayer HealthCare AG |
Substituted 4-benzyloxy-phenylmethylamide derivatives as cold menthol receptor-1 (cmr-1) antagonits for the treatment of urological disorders
|
|
US9550990B2
(en)
|
2004-12-10 |
2017-01-24 |
Ionis Pharmaceuticals, Inc. |
Regulation of epigenetic control of gene expression
|
|
US20070060589A1
(en)
|
2004-12-21 |
2007-03-15 |
Purandare Ashok V |
Inhibitors of protein arginine methyl transferases
|
|
EP1845973B1
(en)
|
2005-01-21 |
2015-08-12 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
|
US20060235037A1
(en)
*
|
2005-04-15 |
2006-10-19 |
Purandare Ashok V |
Heterocyclic inhibitors of protein arginine methyl transferases
|
|
US8063071B2
(en)
|
2007-10-31 |
2011-11-22 |
GlaxoSmithKline, LLC |
Chemical compounds
|
|
MX2008001778A
(es)
|
2005-08-19 |
2008-04-07 |
Aventis Pharma Inc |
Combinacion de un agente hipnotico y un compuesto de bis arilo y heteroarilo sustituido y aplicacion terapeutica de la misma.
|
|
WO2007091393A1
(ja)
|
2006-02-07 |
2007-08-16 |
Taisho Pharmaceutical Co., Ltd. |
10a-アザライド化合物
|
|
US20090306201A1
(en)
|
2006-06-23 |
2009-12-10 |
University Of Medicine And Dentistry Of New Jersey |
Selective inhibitors for transferases
|
|
WO2008001076A1
(en)
|
2006-06-26 |
2008-01-03 |
Ucb Pharma S.A. |
Fused thiazole derivatives as kinase inhibitors
|
|
US20090253673A1
(en)
|
2006-07-12 |
2009-10-08 |
Min Ge |
Substituted Pyrazoles as Ghrelin Receptor Antagonists
|
|
JP2010503656A
(ja)
|
2006-09-13 |
2010-02-04 |
アストラゼネカ アクチボラグ |
スピロ−オキサゾリジノン化合物と代謝共役型グルタミン酸受容体ポテンシエーターとしてのその使用
|
|
US8648096B2
(en)
|
2006-09-15 |
2014-02-11 |
Celgene Corporation |
N-methylaminomethyl isoindole compounds and compositions comprising and methods of using the same
|
|
US8338437B2
(en)
|
2007-02-28 |
2012-12-25 |
Methylgene Inc. |
Amines as small molecule inhibitors
|
|
US20080312298A1
(en)
|
2007-04-11 |
2008-12-18 |
Kenneth William Foreman |
Methods for Identification of Modulators of Carm1 Methyl Transferase Activity
|
|
WO2008137834A2
(en)
|
2007-05-04 |
2008-11-13 |
Osi Pharmaceuticals, Inc. |
Crystal structure of smyd3 protein
|
|
WO2009006577A2
(en)
|
2007-07-03 |
2009-01-08 |
The Regents Of The University Of Michigan |
Compositions and methods for inhibiting ezh2
|
|
US8133904B2
(en)
|
2007-09-07 |
2012-03-13 |
Jenrin Discovery, Inc. |
Cannabinoid receptor antagonists/inverse agonists useful for treating obesity
|
|
WO2009084695A1
(ja)
|
2007-12-28 |
2009-07-09 |
Carna Biosciences Inc. |
2-アミノキナゾリン誘導体
|
|
JP2009179616A
(ja)
|
2008-01-31 |
2009-08-13 |
Kowa Co |
3−ナフチルピラゾール化合物
|
|
WO2009110985A2
(en)
|
2008-02-29 |
2009-09-11 |
Renovis, Inc. |
Amide compounds, compositions and uses thereof
|
|
WO2009126537A1
(en)
|
2008-04-07 |
2009-10-15 |
Syndax Pharmaceuticals, Inc. |
Administration of an inhibitor of hdac and an hmt inhibitor
|
|
JP5764822B2
(ja)
|
2008-08-27 |
2015-08-19 |
オンコセラピー・サイエンス株式会社 |
がんの治療および診断の標的遺伝子としてのprmt1
|
|
TWI607996B
(zh)
|
2008-09-24 |
2017-12-11 |
巴地斯顏料化工廠 |
控制無脊椎害蟲之吡唑化合物
|
|
US8323918B2
(en)
|
2008-12-12 |
2012-12-04 |
University Of South Carolina |
Chloroacetamidine based inhibitors and activity based probes for the protein arginine methytransferases
|
|
US20130345268A1
(en)
|
2009-02-13 |
2013-12-26 |
The Trustees Of Dartmouth College |
Methods and Compositions for the Treatment of RAS Associated Disorders
|
|
WO2010094009A2
(en)
|
2009-02-13 |
2010-08-19 |
Children's Hospital Medical Center |
Methods and compositions for the treatment of ras associated disorders
|
|
EP2221053A1
(de)
|
2009-02-20 |
2010-08-25 |
Albert-Ludwigs-Universität Freiburg |
Pharmazeutische Zusammensetzung enthaltend Hemmstoffe der Proteinmethyltransferase I und deren Verwendung zur Behandlung von Tumorerkrankungen
|
|
RU2011141121A
(ru)
*
|
2009-03-11 |
2013-04-20 |
Окленд Юнисервисиз Лимитед |
Пролекарственные формы ингибиторов киназ и их применение в терапии
|
|
IN2012DN00352A
(enExample)
|
2009-06-16 |
2015-08-21 |
Bikam Pharmaceuticals Inc |
|
|
WO2011011366A2
(en)
|
2009-07-20 |
2011-01-27 |
Constellation Pharmaceuticals |
Agents for stimulating activity of methyl modifying enzymes and methods of use thereof
|
|
WO2011079236A1
(en)
|
2009-12-22 |
2011-06-30 |
The Ohio State University Research Foundation |
Compositions and methods for cancer detection and treatment
|
|
WO2011082098A1
(en)
|
2009-12-30 |
2011-07-07 |
The Rockefeller University |
Lysine and arginine methyltransferase inhibitors for treating cancer
|
|
WO2011096210A1
(en)
|
2010-02-03 |
2011-08-11 |
Oncotherapy Science, Inc. |
Prmt1 and prmt6 for target genes of cancer therapy and diagnosis
|
|
EP2531598A4
(en)
|
2010-02-03 |
2013-05-22 |
Oncotherapy Science Inc |
WHSC1 AND WHSC1L1 FOR TARGET GENES TO CANCER THERAPY AND DIAGNOSIS
|
|
US20110251216A1
(en)
|
2010-02-19 |
2011-10-13 |
The Regents Of The University Of Michigan |
Compositions and methods for inhibiting ezh2
|
|
MX2012012966A
(es)
|
2010-05-07 |
2013-01-22 |
Glaxosmithkline Llc |
Indoles.
|
|
WO2012005805A1
(en)
|
2010-05-07 |
2012-01-12 |
Glaxosmithkline Llc |
Azaindazoles
|
|
BR112013005806B1
(pt)
|
2010-09-10 |
2022-05-10 |
Epizyme, Inc |
Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
|
|
WO2012060760A1
(en)
|
2010-11-05 |
2012-05-10 |
Fujirebio Diagnostics Ab |
Molecular marker for cancer
|
|
WO2012068589A2
(en)
|
2010-11-19 |
2012-05-24 |
Constellation Pharmaceuticals |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
EP2646020B1
(en)
|
2010-12-01 |
2016-09-21 |
Glaxosmithkline LLC |
Indoles
|
|
US9394310B2
(en)
|
2010-12-03 |
2016-07-19 |
Epizyme, Inc. |
Carbocycle-substituted purine and 7-deazapurine compounds
|
|
EP2646454B1
(en)
|
2010-12-03 |
2015-07-08 |
Epizyme, Inc. |
7-deazapurine modulators of histone methyltransferase, and methods of use thereof
|
|
AU2011341441A1
(en)
|
2010-12-03 |
2013-06-20 |
Epizyme, Inc. |
Modulators of histone methyltransferase, and methods of use thereof
|
|
CN103391939B
(zh)
|
2010-12-03 |
2016-03-09 |
Epizyme股份有限公司 |
作为表观遗传酶调节剂的经取代的嘌呤和7-氮杂嘌呤化合物
|
|
WO2012118812A2
(en)
|
2011-02-28 |
2012-09-07 |
Epizyme, Inc. |
Substituted 6,5-fused bicyclic heteroaryl compounds
|
|
JO3363B1
(ar)
|
2011-04-13 |
2019-03-13 |
Epizyme Inc |
مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
|
|
TW201733984A
(zh)
|
2011-04-13 |
2017-10-01 |
雅酶股份有限公司 |
經取代之苯化合物
|
|
CA2873984A1
(en)
|
2012-05-23 |
2013-11-28 |
Stemergie Biotechnology Sa |
Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof
|
|
UY34997A
(es)
|
2012-08-30 |
2014-03-31 |
Nihon Nohyaku Co Ltd |
Agente de control de endoparásitos y método para usarlo
|
|
CN106963760A
(zh)
|
2012-08-30 |
2017-07-21 |
国立大学法人东京大学 |
体内寄生虫防治剂在制备防治体内寄生虫的药物中的用途
|
|
JP2016505002A
(ja)
|
2012-12-21 |
2016-02-18 |
エピザイム,インコーポレイティド |
ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するprmt5阻害剤およびその使用
|
|
WO2014100764A2
(en)
|
2012-12-21 |
2014-06-26 |
Epizyme, Inc. |
Methods of inhibiting prmt5
|
|
US10118918B2
(en)
|
2012-12-21 |
2018-11-06 |
Epizyme, Inc. |
PRMT5 inhibitors and uses thereof
|
|
US9908887B2
(en)
|
2012-12-21 |
2018-03-06 |
Epizyme, Inc. |
PRMT5 inhibitors and uses thereof
|
|
US9604930B2
(en)
|
2012-12-21 |
2017-03-28 |
Epizyme, Inc. |
Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
|
|
US9365555B2
(en)
|
2012-12-21 |
2016-06-14 |
Epizyme, Inc. |
PRMT5 inhibitors and uses thereof
|
|
US9120757B2
(en)
|
2013-03-14 |
2015-09-01 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
JP2016514164A
(ja)
|
2013-03-14 |
2016-05-19 |
エピザイム,インコーポレイティド |
アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用
|
|
EP3363434A1
(en)
|
2013-03-14 |
2018-08-22 |
Epizyme Inc |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2014153172A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
US9133189B2
(en)
|
2013-03-14 |
2015-09-15 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
EP2970135B1
(en)
|
2013-03-14 |
2018-07-18 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
CA2903394C
(en)
*
|
2013-03-14 |
2021-08-31 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
EP2970181B1
(en)
|
2013-03-14 |
2017-06-07 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US20160039767A1
(en)
|
2013-03-14 |
2016-02-11 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
US9394258B2
(en)
|
2013-03-14 |
2016-07-19 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2014144169A1
(en)
|
2013-03-15 |
2014-09-18 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
US9346802B2
(en)
|
2013-03-15 |
2016-05-24 |
Epizyme, Inc. |
CARM1 inhibitors and uses thereof
|
|
EP2970266B1
(en)
|
2013-03-15 |
2018-01-31 |
Epizyme, Inc. |
1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
|
|
WO2015200680A2
(en)
|
2014-06-25 |
2015-12-30 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
EP3160466A4
(en)
|
2014-06-25 |
2017-12-27 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
AU2015301196A1
(en)
|
2014-08-04 |
2017-01-12 |
Epizyme, Inc. |
PRMT5 inhibitors and uses thereof
|
|
US20170280720A1
(en)
|
2014-09-17 |
2017-10-05 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2016044576A1
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Salts, co-crystals, amorphous forms, and crystalline forms of an arginine methyltransferase inhibitor
|
|
WO2016044604A1
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
US20170283400A1
(en)
|
2014-09-17 |
2017-10-05 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2016044641A2
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
US20170298073A1
(en)
|
2014-09-17 |
2017-10-19 |
Epizyme, Inc |
Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor
|
|
WO2016044626A1
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2016044650A1
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
WO2017136699A1
(en)
|
2016-02-05 |
2017-08-10 |
Epizyme, Inc |
Arginine methyltransferase inhibitors and uses thereof
|
|
US20190083482A1
(en)
|
2017-09-18 |
2019-03-21 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|