|
US4017500A
(en)
|
1973-07-16 |
1977-04-12 |
Schering Corporation |
Certain 8-amino-1,7-naphthyridines
|
|
DE2908324A1
(de)
|
1979-03-03 |
1980-09-18 |
Hoechst Ag |
Triazolsubstituierte hydratopasaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als pflanzenschutzmittel
|
|
US4792562A
(en)
|
1985-12-04 |
1988-12-20 |
Hoechst-Roussel Pharmaceuticals, Inc. |
N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
|
|
JPH0532662A
(ja)
|
1990-11-09 |
1993-02-09 |
Nissan Chem Ind Ltd |
置換ピラゾール誘導体および農園芸用殺菌剤
|
|
US5214038A
(en)
|
1991-04-15 |
1993-05-25 |
Hoechst-Roussel Pharmaceuticals Inc. |
1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
|
|
DE4120107A1
(de)
|
1991-06-14 |
1992-12-17 |
Schering Ag |
Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
|
|
TW343965B
(en)
|
1994-03-30 |
1998-11-01 |
Hoffmann La Roche |
Novel mono- and bicyclic DNA gyrase inhibitors
|
|
AU2381397A
(en)
|
1996-04-19 |
1997-11-12 |
Novo Nordisk A/S |
Modulators of molecules with phosphotyrosine recognition units
|
|
EP0887348A1
(en)
|
1997-06-25 |
1998-12-30 |
Boehringer Mannheim Italia S.p.A. |
Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them
|
|
JP3712529B2
(ja)
|
1998-04-24 |
2005-11-02 |
大鵬薬品工業株式会社 |
３，３−ジピリジルアクリル酸アミド誘導体又はその薬学的に許容される塩
|
|
ATE438880T1
(de)
|
1999-02-12 |
2009-08-15 |
Hoya Corp |
Brille und ihre herstellung
|
|
AU4692400A
(en)
*
|
1999-05-03 |
2000-11-17 |
Smithkline Beecham Corporation |
Cxcr-4 receptor antagonists - thrombopoietin mimetics
|
|
JP5278983B2
(ja)
|
1999-11-17 |
2013-09-04 |
塩野義製薬株式会社 |
アミド化合物の新規用途
|
|
GB9929988D0
(en)
|
1999-12-17 |
2000-02-09 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6608053B2
(en)
|
2000-04-27 |
2003-08-19 |
Yamanouchi Pharmaceutical Co., Ltd. |
Fused heteroaryl derivatives
|
|
AU5261001A
(en)
|
2000-04-27 |
2001-11-12 |
Imperial Cancer Research Technology Ltd |
Condensed heteroaryl derivatives
|
|
WO2002002551A1
(en)
|
2000-06-30 |
2002-01-10 |
Sugen, Inc. |
4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
|
|
JP2004512336A
(ja)
*
|
2000-09-15 |
2004-04-22 |
アノーメッド インコーポレイティド |
ケモカインレセプター結合複素環式化合物
|
|
JP2002255964A
(ja)
|
2000-10-24 |
2002-09-11 |
Sankyo Co Ltd |
イミダゾピリジン誘導体
|
|
WO2002034748A1
(fr)
|
2000-10-24 |
2002-05-02 |
Sankyo Company, Limited |
Derives d'imidazopyridine
|
|
US6905669B2
(en)
|
2001-04-24 |
2005-06-14 |
Supergen, Inc. |
Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
|
|
US7429593B2
(en)
|
2001-09-14 |
2008-09-30 |
Shionogi & Co., Ltd. |
Utilities of amide compounds
|
|
CA2476583C
(en)
|
2002-03-13 |
2011-07-05 |
Kristof Van Emelen |
Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
|
|
JP2003313126A
(ja)
|
2002-04-23 |
2003-11-06 |
Sankyo Co Ltd |
イミダゾピリジン誘導体を有効成分とする医薬
|
|
JP2004002826A
(ja)
|
2002-04-24 |
2004-01-08 |
Sankyo Co Ltd |
高分子イミダゾピリジン誘導体
|
|
JP4235726B2
(ja)
|
2002-11-19 |
2009-03-11 |
国立大学法人 奈良先端科学技術大学院大学 |
大きな二光子吸収特性を示すアセチレン結合により連結されたビス（イミダゾリルポルフィリン金属錯体）を構成単位とするポルフィリン連鎖体及びその製造方法
|
|
AU2003900608A0
(en)
|
2003-02-11 |
2003-02-27 |
Fujisawa Pharmaceutical Co., Ltd. |
Hdac inhibitor
|
|
CA2557541C
(en)
|
2004-02-26 |
2014-12-16 |
Aska Pharmaceutical Co., Ltd. |
Pyrimidine derivatives
|
|
DE602005020280D1
(de)
|
2004-06-01 |
2010-05-12 |
Hoffmann La Roche |
3-amino-1-arylpropyl-indole als monoamin-wiederaufnahmehemmer
|
|
CA2581489A1
(en)
|
2004-10-06 |
2006-04-13 |
Recepticon Aps |
Use of compounds for the prevention of drug-induced cell toxicity
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
JP2008530136A
(ja)
*
|
2005-02-14 |
2008-08-07 |
ミイカナ セラピューティクス インコーポレイテッド |
ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物
|
|
SG171690A1
(en)
|
2005-03-22 |
2011-06-29 |
Harvard College |
Treatment of protein degradation disorders
|
|
JP2008545660A
(ja)
|
2005-05-20 |
2008-12-18 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼ阻害剤として有用なピロロピリジン化合物
|
|
TW200716545A
(en)
|
2005-06-10 |
2007-05-01 |
Sigma Tau Ind Farmaceuti |
Indole derivatives having anti-tumor activity
|
|
WO2007050348A2
(en)
|
2005-10-21 |
2007-05-03 |
Merck & Co., Inc. |
Potassium channel inhibitors
|
|
WO2007084667A2
(en)
|
2006-01-19 |
2007-07-26 |
Osi Pharmaceutical, Inc. |
Fused heterobicyclic kinase inhibitors
|
|
WO2007085540A1
(en)
|
2006-01-27 |
2007-08-02 |
Glaxo Group Limited |
1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
|
|
AU2007243466B2
(en)
|
2006-04-26 |
2012-01-19 |
F. Hoffmann-La Roche Ag |
Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
|
|
KR20090021155A
(ko)
|
2006-04-26 |
2009-02-27 |
에프. 호프만-라 로슈 아게 |
Ｐｉ3ｋ 억제제로서의 피리미딘 유도체
|
|
KR20090031898A
(ko)
|
2006-07-13 |
2009-03-30 |
교와 핫꼬 기린 가부시키가이샤 |
펜타디엔아미드 유도체
|
|
WO2008033746A2
(en)
|
2006-09-11 |
2008-03-20 |
Curis, Inc. |
Tyrosine kinase inhibitors containing a zinc binding moiety
|
|
CA2667826C
(en)
*
|
2006-10-28 |
2013-10-08 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
CA2670223A1
(en)
|
2006-11-22 |
2008-05-29 |
Karus Therapeutics Limited |
Depsipeptides and their therapeutic use
|
|
CN101663276A
(zh)
|
2007-01-31 |
2010-03-03 |
沃泰克斯药物股份有限公司 |
用作激酶抑制剂的2-氨基吡啶衍生物
|
|
EP2121613A2
(en)
|
2007-01-31 |
2009-11-25 |
Vertex Pharmaceuticals, Inc. |
2-aminopyridine derivatives useful as kinase inhibitors
|
|
CN101679220A
(zh)
|
2007-04-09 |
2010-03-24 |
梅特希尔基因公司 |
组蛋白脱乙酰酶抑制剂
|
|
EP2151236A4
(en)
|
2007-04-26 |
2013-01-16 |
Japan Science & Tech Agency |
G-PROTEIN-CONJUGATED RECEPTOR AGONIST
|
|
WO2008137270A1
(en)
|
2007-05-04 |
2008-11-13 |
H. Lundbeck A/S |
Methods of diagnosing and monitoring of npy y5 based disorders
|
|
EP2154965A4
(en)
|
2007-05-29 |
2011-08-17 |
Glaxosmithkline Llc |
NAPHTHYRIDINE DERIVATIVES AS P13 KINASE INHIBITORS
|
|
GB0710528D0
(en)
|
2007-06-01 |
2007-07-11 |
Glaxo Group Ltd |
Novel compounds
|
|
WO2009063240A1
(en)
|
2007-11-16 |
2009-05-22 |
Arrow Therapeutics Limited |
2,4-diaminopyrimidine derivatives useful as inhibitors of aurora kinase
|
|
US20110288070A1
(en)
|
2008-05-05 |
2011-11-24 |
ROGERS Kathryn |
Methods for treating cognitive disorders using inhibitors of histone deacetylase
|
|
JP2011529932A
(ja)
|
2008-08-05 |
2011-12-15 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
置換ナフチリジン及び医薬としてのその使用
|
|
WO2010037765A2
(en)
|
2008-10-03 |
2010-04-08 |
Merck Serono S.A. |
4-morpholino-pyrido[3,2-d]pyrimidines
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
CA2750086C
(en)
*
|
2009-01-28 |
2018-01-02 |
Karus Therapeutics Limited |
Scriptaid isosteres and their use in therapy
|
|
JP5838157B2
(ja)
*
|
2009-07-22 |
2015-12-24 |
ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ |
Ｈｄａｃ阻害剤およびそれを用いる治療法
|
|
NZ597983A
(en)
|
2009-08-20 |
2014-05-30 |
Karus Therapeutics Ltd |
Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
|
|
GB201007347D0
(en)
|
2010-04-30 |
2010-06-16 |
Karus Therapeutics Ltd |
Compounds
|
|
CA2812855C
(en)
|
2010-10-08 |
2017-12-19 |
Vib Vzw |
Hdac inhibitors to treat charcot-marie-tooth disease
|
|
EA026134B1
(ru)
|
2010-12-16 |
2017-03-31 |
Ф. Хоффманн-Ля Рош Аг |
Трициклические ингибиторы pi3k и способы их применения
|
|
USRE47009E1
(en)
*
|
2011-02-01 |
2018-08-28 |
The Children's Hospital Of Philadelphia |
HDAC inhibitors and therapeutic methods using the same
|
|
EP2508510A1
(en)
|
2011-04-06 |
2012-10-10 |
Ikerchem, S.L. |
Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
|
|
EP2734500A4
(en)
|
2011-07-20 |
2015-04-08 |
Gen Hospital Corp |
SELECTIVE HISTONDEACETYLASE-6 INHIBITORS FOR THE TREATMENT OF BONE DISORDERS
|
|
WO2013052110A1
(en)
|
2011-10-03 |
2013-04-11 |
The Trustees Of Columbia University In The City Of New York |
Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1
|
|
PH12014500724A1
(en)
|
2011-10-04 |
2014-05-19 |
Institute For Hepatitis And Virus Res |
Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication
|
|
WO2013062344A1
(en)
*
|
2011-10-28 |
2013-05-02 |
Chong Kun Dang Pharmaceutical Corp. |
Hydroxamate derivatives for hdac inhibitor, and the pharmaceutical composition comprising thereof
|
|
ES2661510T3
(es)
|
2011-12-15 |
2018-04-02 |
Novartis Ag |
Uso de inhibidores de la actividad o función de PI3K
|
|
KR101415742B1
(ko)
|
2011-12-21 |
2014-07-04 |
영남대학교 산학협력단 |
6―아미노피리딘―3―올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물
|
|
GB201204125D0
(en)
|
2012-03-08 |
2012-04-25 |
Karus Therapeutics Ltd |
Compounds
|
|
WO2014032019A2
(en)
|
2012-08-23 |
2014-02-27 |
Georgetown University |
Compounds and methods of use thereof for treating tumors
|
|
US9676765B2
(en)
|
2012-11-07 |
2017-06-13 |
Karus Therapeutics Limited |
Histone deacetylase inhibitors and their use in therapy
|
|
HK1214159A1
(zh)
|
2012-11-08 |
2016-07-22 |
Rhizen Pharmaceuticals S.A. |
含有PDE4抑制剂和PI3δ或双重PI3δ-γ激酶抑制剂的药物组合物
|
|
US9169214B2
(en)
|
2012-12-21 |
2015-10-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
|
|
CA2903481A1
(en)
*
|
2013-03-13 |
2014-10-09 |
The University Of North Carolina At Chapel Hill |
Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
|
|
US20160052926A1
(en)
|
2013-03-15 |
2016-02-25 |
Hutchison Medipharma Limited |
Novel pyrimidine and pyridine compounds and usage thereof
|
|
WO2014153280A1
(en)
|
2013-03-22 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
|
|
SI2994465T1
(sl)
|
2013-05-10 |
2018-10-30 |
Karus Therapeutics Limited |
Novi inhibitorji histon deacetilaze
|
|
ES2818933T3
(es)
|
2013-10-10 |
2021-04-14 |
Acetylon Pharmaceuticals Inc |
Inhibidores de la HDAC en combinación con los inhibidores de la pi3k, para el tratamiento del linfoma no Hodgkin
|
|
GB201402431D0
(en)
|
2014-02-12 |
2014-03-26 |
Karus Therapeutics Ltd |
Compounds
|
|
EP3187497A4
(en)
|
2014-08-26 |
2018-02-07 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
GB201419228D0
(en)
|
2014-10-29 |
2014-12-10 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201419264D0
(en)
|
2014-10-29 |
2014-12-10 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201514756D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compound and method of use
|
|
GB201609786D0
(en)
|
2016-06-03 |
2016-07-20 |
Karus Therapeutics Ltd |
Compounds and method of use
|
|
WO2017222952A1
(en)
|
2016-06-23 |
2017-12-28 |
Merck Sharp & Dohme Corp. |
3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
|
|
WO2017222950A1
(en)
|
2016-06-23 |
2017-12-28 |
Merck Sharp & Dohme Corp. |
3-heterocyclyl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
|
|
EP3475275B1
(en)
|
2016-06-23 |
2024-04-10 |
Merck Sharp & Dohme LLC |
3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
|
|
GB201803361D0
(en)
|
2018-03-01 |
2018-04-18 |
Karus Therapeutics Ltd |
Histone deacetylase inhibitors
|