|
US5571506A
(en)
|
1989-08-14 |
1996-11-05 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Aromatic oligomeric compounds useful as mimics of bioactive macromolecules
|
|
CA2071897A1
(en)
|
1989-12-28 |
1991-06-29 |
Richard A. Glennon |
Sigma receptor ligands and the use thereof
|
|
US6004979A
(en)
|
1991-02-07 |
1999-12-21 |
Hoechst Marion Roussel |
Nitrogenous bicycles
|
|
ES2104862T3
(es)
|
1991-02-07 |
1997-10-16 |
Roussel Uclaf |
Derivados biciclicos nitrogenados, su procedimiento de preparacion, sus productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
|
|
EP0519211A1
(de)
|
1991-05-17 |
1992-12-23 |
Hoechst Schering AgrEvo GmbH |
Substituierte 4-Aminopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
|
|
DE4208254A1
(de)
|
1992-03-14 |
1993-09-16 |
Hoechst Ag |
Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
|
|
WO1993022291A1
(en)
|
1992-04-24 |
1993-11-11 |
E.I. Du Pont De Nemours And Company |
Arthropodicidal and fungicidal aminopyrimidines
|
|
US5595756A
(en)
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
DE4437406A1
(de)
|
1994-10-19 |
1996-04-25 |
Hoechst Ag |
Chinoxaline, Verfahren zu ihrer Herstellung und ihre Verwendung
|
|
US5977117A
(en)
|
1996-01-05 |
1999-11-02 |
Texas Biotechnology Corporation |
Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
|
|
GB2338957B
(en)
|
1997-02-19 |
2001-08-01 |
Berlex Lab |
N-heterocyclic derivatives as nos inhibitors
|
|
JPH10251255A
(ja)
|
1997-03-14 |
1998-09-22 |
Nissan Chem Ind Ltd |
アジン誘導体
|
|
SI0991628T1
(en)
*
|
1997-05-28 |
2005-06-30 |
Aventis Pharmaceuticals Inc |
QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR P56lck TYROSINE KINASES
|
|
DE19801598C2
(de)
|
1998-01-17 |
2000-05-11 |
Aventis Res & Tech Gmbh & Co |
Katalytische Synthese von N-alkylierten Anilinen aus Olefinen und Anilinen
|
|
DE19836697A1
(de)
|
1998-08-13 |
2000-02-17 |
Hoechst Marion Roussel De Gmbh |
Substituierte 4-Amino-2-aryl-pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
|
|
WO2000042026A1
(en)
|
1999-01-15 |
2000-07-20 |
Novo Nordisk A/S |
Non-peptide glp-1 agonists
|
|
MXPA02003436A
(es)
|
1999-10-07 |
2002-08-20 |
Amgen Inc |
Inhibidores de triazina cinasa.
|
|
GB9924092D0
(en)
|
1999-10-13 |
1999-12-15 |
Zeneca Ltd |
Pyrimidine derivatives
|
|
US6552016B1
(en)
|
1999-10-14 |
2003-04-22 |
Curis, Inc. |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
|
|
WO2001057021A2
(en)
|
2000-02-01 |
2001-08-09 |
Cor Therapeutics, Inc. |
2-[1H]-QUINOLONE AND 2-[1H]-QUINOXALONE INHIBITORS OF FACTOR Xa
|
|
WO2001064642A2
(en)
|
2000-02-29 |
2001-09-07 |
Cor Therapeutics, Inc. |
Benzamides and related inhibitors of factor xa
|
|
US6605615B2
(en)
|
2000-03-01 |
2003-08-12 |
Tularik Inc. |
Hydrazones and analogs as cholesterol lowering agents
|
|
DE10013318A1
(de)
|
2000-03-17 |
2001-09-20 |
Merck Patent Gmbh |
Formulierung enthaltend Chinoxalinderivate
|
|
US7498304B2
(en)
|
2000-06-16 |
2009-03-03 |
Curis, Inc. |
Angiogenesis-modulating compositions and uses
|
|
WO2002020500A2
(en)
*
|
2000-09-01 |
2002-03-14 |
Icos Corporation |
Materials and methods to potentiate cancer treatment
|
|
US6610677B2
(en)
|
2000-09-15 |
2003-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6613776B2
(en)
|
2000-09-15 |
2003-09-02 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
WO2002022605A1
(en)
|
2000-09-15 |
2002-03-21 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6660731B2
(en)
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US7473691B2
(en)
|
2000-09-15 |
2009-01-06 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
ATE407132T1
(de)
|
2000-12-05 |
2008-09-15 |
Vertex Pharma |
Inhibitoren von c-jun n-terminalen kinasen (jnk) und anderen proteinkinasen
|
|
US6989385B2
(en)
|
2000-12-21 |
2006-01-24 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
JP2004521901A
(ja)
|
2001-02-02 |
2004-07-22 |
グラクソ グループ リミテッド |
Tgf阻害剤としてのピラゾール
|
|
MY130778A
(en)
|
2001-02-09 |
2007-07-31 |
Vertex Pharma |
Heterocyclic inhibitiors of erk2 and uses thereof
|
|
CA2441733A1
(en)
|
2001-03-29 |
2002-10-10 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
|
|
AU2002338642A1
(en)
|
2001-04-13 |
2002-10-28 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
|
|
EP1383771A1
(en)
|
2001-04-20 |
2004-01-28 |
Vertex Pharmaceuticals Incorporated |
9-deazaguanine derivatives as inhibitors of gsk-3
|
|
WO2002092573A2
(en)
|
2001-05-16 |
2002-11-21 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases
|
|
MXPA03010961A
(es)
|
2001-05-31 |
2004-02-27 |
Vertex Pharma |
Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
|
|
ES2274035T3
(es)
|
2001-06-01 |
2007-05-16 |
Vertex Pharmaceuticals Incorporated |
Compuestos de tiazol utiles como inhibidores de proteina quinasas.
|
|
CA2450769A1
(en)
|
2001-06-15 |
2002-12-27 |
Vertex Pharmaceuticals Incorporated |
5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors
|
|
ATE337312T1
(de)
|
2001-07-03 |
2006-09-15 |
Vertex Pharma |
Isoxazolyl-pyrimidines als inhibitoren von src- und lck-protein-kinasen
|
|
GB0119865D0
(en)
*
|
2001-08-14 |
2001-10-10 |
Cancer Res Campaign Tech |
DNA-PK inhibitors
|
|
ATE466581T1
(de)
|
2001-12-07 |
2010-05-15 |
Vertex Pharma |
Verbindungen auf pyrimidin-basis als gsk-3-hemmer
|
|
WO2003066629A2
(en)
|
2002-02-06 |
2003-08-14 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl compounds useful as inhibitors of gsk-3
|
|
US20030199525A1
(en)
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
|
US20030207873A1
(en)
|
2002-04-10 |
2003-11-06 |
Edmund Harrington |
Inhibitors of Src and other protein kinases
|
|
US7304061B2
(en)
|
2002-04-26 |
2007-12-04 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic inhibitors of ERK2 and uses thereof
|
|
RU2004135386A
(ru)
|
2002-05-06 |
2005-07-20 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Тиадиазолы или оксадиазолы и их применение в качестве ингибиторов протеинкиназы jak
|
|
JP2005528443A
(ja)
|
2002-05-30 |
2005-09-22 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Jakキナーゼおよびcdk2プロテインキナーゼのインヒビター
|
|
MY141867A
(en)
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
|
US7361665B2
(en)
|
2002-07-09 |
2008-04-22 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
|
|
AU2003262642B2
(en)
|
2002-08-14 |
2010-06-17 |
Vertex Pharmaceuticals Incorporated |
Protein kinase inhibitors and uses thereof
|
|
US7419984B2
(en)
|
2002-10-17 |
2008-09-02 |
Cell Therapeutics, Inc. |
Pyrimidines and uses thereof
|
|
AU2003286876A1
(en)
|
2002-11-01 |
2004-06-07 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of jak and other protein kinases
|
|
US7259161B2
(en)
|
2002-11-04 |
2007-08-21 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of JAK and other protein kinases
|
|
DE60326646D1
(de)
|
2002-12-18 |
2009-04-23 |
Vertex Pharma |
Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen
|
|
US7144911B2
(en)
|
2002-12-31 |
2006-12-05 |
Deciphera Pharmaceuticals Llc |
Anti-inflammatory medicaments
|
|
JP2006518381A
(ja)
|
2003-02-07 |
2006-08-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼのインヒビターとして有用なヘテロアリール置換ピロール
|
|
US7456190B2
(en)
|
2003-03-13 |
2008-11-25 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as protein kinase inhibitors
|
|
WO2004085418A2
(en)
|
2003-03-24 |
2004-10-07 |
Luitpold Pharmaceuticals, Inc. |
Xanthones, thioxanthones and acridinones as dna-pk inhibitors
|
|
CA2523125A1
(en)
|
2003-03-25 |
2004-10-14 |
Vertex Pharmaceuticals Incorporated |
Thiazoles useful as inhibitors of protein kinases
|
|
US6875781B2
(en)
|
2003-04-04 |
2005-04-05 |
Cell Therapeutics, Inc. |
Pyridines and uses thereof
|
|
US7189724B2
(en)
|
2003-04-15 |
2007-03-13 |
Valeant Research And Development |
Quinoxaline derivatives having antiviral activity
|
|
US8084457B2
(en)
|
2003-09-15 |
2011-12-27 |
Lead Discovery Center Gmbh |
Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
|
|
CA2547080A1
(en)
|
2003-12-02 |
2005-07-28 |
Vertex Pharmaceuticals, Inc. |
Heterocyclic protein kinase inhibitors and uses thereof
|
|
US7592340B2
(en)
|
2003-12-04 |
2009-09-22 |
Vertex Pharmaceuticals Incorporated |
Quinoxalines useful as inhibitors of protein kinases
|
|
TW200533357A
(en)
|
2004-01-08 |
2005-10-16 |
Millennium Pharm Inc |
2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
|
|
CA2559652C
(en)
|
2004-03-15 |
2017-02-14 |
Sunesis Pharmaceuticals, Inc. |
Methods of using sns-595 in treating cancer
|
|
GB0405985D0
(en)
|
2004-03-17 |
2004-04-21 |
Novartis Forschungsstiftung |
Kinase
|
|
AU2005245877B2
(en)
|
2004-05-14 |
2010-06-03 |
Vertex Pharmaceuticals, Incorporated |
Prodrugs of pyrrolylpyrimidine ERK protein kinase inhibitors
|
|
JP4449580B2
(ja)
|
2004-05-31 |
2010-04-14 |
宇部興産株式会社 |
4−アラルキルアミノピリミジン誘導体及び抗菌剤
|
|
PL1756084T3
(pl)
|
2004-06-04 |
2009-06-30 |
Arena Pharm Inc |
Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie zaburzeń z metabolizmem związanych
|
|
CN101039933B
(zh)
|
2004-09-17 |
2012-06-06 |
沃泰克斯药物股份有限公司 |
可用作蛋白激酶抑制剂的二氨基三唑化合物
|
|
EP2402323A3
(en)
|
2004-10-13 |
2012-05-30 |
PTC Therapeutics, Inc. |
Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases
|
|
MX2007004480A
(es)
|
2004-10-15 |
2007-05-08 |
Astrazeneca Ab |
Quinoxalinas como inhibidores b raf.
|
|
GT200500284A
(es)
|
2004-10-15 |
2006-03-27 |
Aventis Pharma Inc |
Pirimidinas como antagonistas del receptor de prostaglandina d2
|
|
WO2006050249A1
(en)
|
2004-10-29 |
2006-05-11 |
Vertex Pharmaceuticals Incorporated |
Diaminotriazole compounds useful as inhibitors of protein kinases
|
|
US7517870B2
(en)
|
2004-12-03 |
2009-04-14 |
Fondazione Telethon |
Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
|
|
JP2008523103A
(ja)
|
2004-12-14 |
2008-07-03 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Erkプロテインキナーゼのピリミジンインヒビターおよびその使用
|
|
WO2006071644A1
(en)
|
2004-12-23 |
2006-07-06 |
Vertex Pharmaceuticals Incorporated |
Selective inhibitors of erk protein kinases and uses therof
|
|
JP4734346B2
(ja)
|
2005-02-04 |
2011-07-27 |
セノミックス インコーポレイテッド |
連結ヘテロアリール部分を含む化合物、ならびに食用組成物のための新規なうまみフレーバー改変剤、味物質および味覚増強剤としての使用
|
|
RU2007140733A
(ru)
|
2005-04-06 |
2009-05-20 |
Айрм Ллк (Bm) |
Диариламинсодержащие соединения и композиции, и их применение в качестве модуляторов ядерных рецепторов стероидного гормона
|
|
AR053358A1
(es)
|
2005-04-15 |
2007-05-02 |
Cancer Rec Tech Ltd |
Inhibidores de adn - pk
|
|
WO2006125616A2
(en)
|
2005-05-25 |
2006-11-30 |
Ingenium Pharmaceuticals Ag |
Pyrimidine-based cdk inhibitors for treating pain
|
|
WO2006138418A2
(en)
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
JP2007008045A
(ja)
|
2005-06-30 |
2007-01-18 |
Mitsui Chemicals Inc |
光記録媒体および1h−キノキサリン−2−オン誘導体
|
|
CA2616517A1
(en)
|
2005-07-26 |
2007-02-01 |
Vertex Pharmaceuticals Incorporated |
Abl kinase inhibition
|
|
GB0520657D0
(en)
|
2005-10-11 |
2005-11-16 |
Ludwig Inst Cancer Res |
Pharmaceutical compounds
|
|
JP2009514875A
(ja)
|
2005-11-02 |
2009-04-09 |
サイトキネティクス・インコーポレーテッド |
化学物質、組成物、および方法
|
|
MX2008005814A
(es)
|
2005-11-03 |
2008-10-15 |
Vertex Pharma |
Aminopirimidinas utiles como inhibidores de cinasa.
|
|
US20070179125A1
(en)
|
2005-11-16 |
2007-08-02 |
Damien Fraysse |
Aminopyrimidines useful as kinase inhibitors
|
|
WO2007082899A1
(en)
|
2006-01-17 |
2007-07-26 |
Vib Vzw |
Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
UY30118A1
(es)
|
2006-01-31 |
2007-06-29 |
Tanabe Seiyaku Co |
Compueto amina trisustituido
|
|
US8013153B2
(en)
|
2006-03-23 |
2011-09-06 |
Janssen Pharmaceutica, N.V. |
Substituted pyrimidine kinase inhibitors
|
|
US20080280891A1
(en)
|
2006-06-27 |
2008-11-13 |
Locus Pharmaceuticals, Inc. |
Anti-cancer agents and uses thereof
|
|
WO2008008852A2
(en)
|
2006-07-11 |
2008-01-17 |
Emory University |
Cxcr4 antagonists including heteroatoms for the treatment of medical disorders
|
|
TW200811134A
(en)
|
2006-07-12 |
2008-03-01 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
PL2044056T3
(pl)
|
2006-07-14 |
2013-01-31 |
Novartis Ag |
Pochodne pirymidyny jako inhibitory ALK-5
|
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US7635683B2
(en)
|
2006-08-04 |
2009-12-22 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl tripeptide hepatitis C virus inhibitors
|
|
WO2008023357A1
(en)
|
2006-08-22 |
2008-02-28 |
Technion Research And Development Foundation Ltd. |
Heterocyclic derivatives binding to the peripheral-type benzodiazepine receptor (pbr)
|
|
EP1903038A1
(de)
|
2006-09-07 |
2008-03-26 |
Bayer Schering Pharma Aktiengesellschaft |
N-(1-Hetaryl-piperidin-4-yl)-(het)arylamide als EP2-Rezeptor Modulatoren
|
|
US7875603B2
(en)
|
2006-09-21 |
2011-01-25 |
Nova Southeastern University |
Specific inhibitors for vascular endothelial growth factor receptors
|
|
CN103739595A
(zh)
|
2006-10-02 |
2014-04-23 |
Irm责任有限公司 |
作为蛋白激酶抑制剂的化合物和组合物
|
|
DE102006050512A1
(de)
|
2006-10-26 |
2008-04-30 |
Bayer Healthcare Ag |
Substituierte heterocyclische Verbindungen und ihre Verwendung
|
|
CA2668429A1
(en)
|
2006-11-02 |
2008-05-15 |
Vertex Pharmaceuticals Incorporated |
Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases
|
|
JP2010511727A
(ja)
|
2006-12-04 |
2010-04-15 |
ニューロクライン バイオサイエンシーズ,インコーポレイテッド |
アデノシン受容体アンタゴニストとしての置換ピリミジン
|
|
ES2347721T3
(es)
|
2006-12-19 |
2010-11-03 |
Vertex Pharmaceuticals, Inc. |
Aminopirimidinas utiles como inhibidores de proteina quinasas.
|
|
US20100098630A1
(en)
|
2006-12-28 |
2010-04-22 |
Ambrx, Inc. |
Phenazine and Quinoxaline Substituted Amino Acids and Polypeptides
|
|
PT2114900T
(pt)
|
2007-01-31 |
2019-01-17 |
Ym Biosciences Australia Pty |
Compostos à base de tiopirimidina e as suas utilizações
|
|
WO2008106202A1
(en)
|
2007-02-27 |
2008-09-04 |
Housey Gerard M |
Theramutein modulators
|
|
AU2008226457B2
(en)
|
2007-03-09 |
2014-03-20 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as inhibitors of protein kinases
|
|
EP2137183B1
(en)
|
2007-03-09 |
2011-09-28 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as inhibitors of protein kinases
|
|
EP2134709A1
(en)
|
2007-03-09 |
2009-12-23 |
Vertex Pharmaceuticals, Inc. |
Aminopyridines useful as inhibitors of protein kinases
|
|
WO2008115973A2
(en)
|
2007-03-20 |
2008-09-25 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as kinase inhibitors
|
|
DE102007015169A1
(de)
|
2007-03-27 |
2008-10-02 |
Universität des Saarlandes Campus Saarbrücken |
17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
|
|
NZ580343A
(en)
|
2007-04-13 |
2012-03-30 |
Vertex Pharma |
Aminopyrimidines useful as kinase inhibitors
|
|
US7910587B2
(en)
|
2007-04-26 |
2011-03-22 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl dipeptide hepatitis C virus inhibitors
|
|
JP5389785B2
(ja)
|
2007-05-02 |
2014-01-15 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
キナーゼ阻害剤として有用なチアゾールおよびピラゾール
|
|
MX2009011811A
(es)
|
2007-05-02 |
2010-01-14 |
Vertex Pharma |
Aminopirimidinas utiles como inhibidores de cinasa.
|
|
CA2694381A1
(en)
|
2007-05-02 |
2008-11-13 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as kinase inhibitors
|
|
PE20090288A1
(es)
|
2007-05-10 |
2009-04-03 |
Smithkline Beecham Corp |
Derivados de quinoxalina como inhibidores de la pi3 quinasa
|
|
WO2008144253A1
(en)
|
2007-05-14 |
2008-11-27 |
Irm Llc |
Protein kinase inhibitors and methods for using thereof
|
|
EP2164842A2
(en)
|
2007-05-24 |
2010-03-24 |
Vertex Pharmaceuticals Incorporated |
Thiazoles and pyrazoles useful as kinase inhibitors
|
|
EP2167464B1
(en)
|
2007-05-25 |
2014-12-03 |
AbbVie Deutschland GmbH & Co KG |
Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mglu2 receptor)
|
|
EP2170274A1
(en)
|
2007-07-02 |
2010-04-07 |
Technion Research and Development Foundation, Ltd. |
Compositions, articles and methods comprising tspo ligands for preventing or reducing tobacco-associated damage
|
|
US20100130597A1
(en)
|
2007-07-06 |
2010-05-27 |
The United State Of America, As Represented By The Secretary Of The Dept Of Health And Human Service |
Dna-pkcs modulates energy regulation and brain function
|
|
UY31232A1
(es)
|
2007-07-19 |
2009-03-02 |
|
Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
|
|
MX2010001240A
(es)
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2007-08-01 |
2010-04-30 |
Kumiai Chemical Industry Co |
Derivado de oxopirazina y herbicida.
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WO2009042294A2
(en)
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2007-08-10 |
2009-04-02 |
Burnham Institute For Medical Research |
Tissue-nonspecific alkaline phosphatase (tnap) activators and uses thereof
|
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DE102007044032A1
(de)
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2007-09-14 |
2009-03-19 |
Bayer Healthcare Ag |
Substituierte heterocyclische Verbindungen und ihre Verwendung
|
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ATE510827T1
(de)
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2007-10-12 |
2011-06-15 |
Ingenium Pharmaceuticals Gmbh |
Inhibitoren von proteinkinasen
|
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AU2008324833A1
(en)
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2007-11-06 |
2009-05-14 |
E. I. Du Pont De Nemours And Company |
Fungicidal heterocyclic amines
|
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WO2009091388A2
(en)
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2007-12-21 |
2009-07-23 |
Progenics Pharmaceuticals, Inc. |
Triazines and related compounds having antiviral activity, compositions and methods thereof
|
|
US8562945B2
(en)
|
2008-01-09 |
2013-10-22 |
Molecular Insight Pharmaceuticals, Inc. |
Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
|
|
EP2254415B1
(en)
|
2008-02-19 |
2013-01-23 |
Janssen Pharmaceutica, N.V. |
Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase
|
|
WO2009107391A1
(ja)
|
2008-02-27 |
2009-09-03 |
武田薬品工業株式会社 |
6員芳香環含有化合物
|
|
EP2247580B1
(en)
|
2008-03-05 |
2015-07-08 |
Merck Patent GmbH |
Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
CA2725316A1
(en)
|
2008-06-02 |
2009-12-10 |
Banyu Pharmaceutical Co., Ltd. |
Novel isoxazole derivative
|
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HRP20131069T1
(hr)
|
2008-06-16 |
2013-12-20 |
Merck Patent Gmbh |
Derivati kinoksalindiona
|
|
EP2138488A1
(en)
|
2008-06-26 |
2009-12-30 |
sanofi-aventis |
4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
|
|
ES2402087T3
(es)
|
2008-07-23 |
2013-04-26 |
Vertex Pharmaceuticals Incorporated |
Inhibidores de la pirazolopiridina quinasa
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
AR074199A1
(es)
|
2008-11-20 |
2010-12-29 |
Glaxosmithkline Llc |
Compuesto de 6-(4-pirimidinil)-1h-indazol, composiciones farmaceuticas que lo comprenden y su uso para preparar un medicamento util para el tratamiento o disminucion de la gravedad del cancer.
|
|
ES2921576T3
(es)
|
2008-12-19 |
2022-08-29 |
Vertex Pharma |
Compuestos útiles como inhibidores de la quinasa ATR
|
|
WO2010093808A1
(en)
|
2009-02-11 |
2010-08-19 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
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JP2010111702A
(ja)
|
2009-02-16 |
2010-05-20 |
Tetsuya Nishio |
複素環化合物、その製造法および用途
|
|
US8906914B2
(en)
|
2009-08-18 |
2014-12-09 |
Janssen Pharmaceutica Nv |
Ethylene diamine modulators of fatty acid hydrolase
|
|
AR077999A1
(es)
|
2009-09-02 |
2011-10-05 |
Vifor Int Ag |
Antagonistas de pirimidin y triazin-hepcidina
|
|
CN102574843B
(zh)
|
2009-10-22 |
2015-06-17 |
法博太科制药有限公司 |
抗纤维化剂的稠环类似物
|
|
ES2360333B1
(es)
|
2009-10-29 |
2012-05-04 |
Consejo Superior De Investigaciones Cientificas (Csic) (70%) |
Derivados de bis (aralquil) amino y sistemas (hetero) aromaticos de seis miembros y su uso en el tratamiento de patologias neurodegenerativas, incluida la enfermedad de alzheimer
|
|
AU2010312365A1
(en)
|
2009-10-30 |
2012-06-07 |
Mochida Pharmaceutical Co.,Ltd. |
Novel 3-hydroxy-5-arylisoxazole derivative
|
|
CN104710381A
(zh)
|
2009-12-25 |
2015-06-17 |
持田制药株式会社 |
新的3-羟基-5-芳基异噻唑衍生物
|
|
UY33213A
(es)
|
2010-02-18 |
2011-09-30 |
Almirall Sa |
Derivados de pirazol como inhibidores de jak
|
|
BR112012022868A2
(pt)
|
2010-03-16 |
2018-06-05 |
Merck Patent Gmbh |
morfolinilquinazolinas
|
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TWI516264B
(zh)
|
2010-05-06 |
2016-01-11 |
臺北醫學大學 |
芳香醯喹啉化合物
|
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JP2011246389A
(ja)
*
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2010-05-26 |
2011-12-08 |
Oncotherapy Science Ltd |
Ttk阻害作用を有する縮環ピラゾール誘導体
|
|
DE102010025786A1
(de)
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2010-07-01 |
2012-01-05 |
Merck Patent Gmbh |
Pyrazolochinoline
|
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DE102010035744A1
(de)
|
2010-08-28 |
2012-03-01 |
Merck Patent Gmbh |
Imidazolonylchinoline
|
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US9464065B2
(en)
|
2011-03-24 |
2016-10-11 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
GB201114051D0
(en)
|
2011-08-15 |
2011-09-28 |
Domainex Ltd |
Compounds and their uses
|
|
ES2725790T3
(es)
|
2011-08-26 |
2019-09-27 |
Neupharma Inc |
Algunas entidades químicas, composiciones, y métodos
|
|
CN115403531A
(zh)
|
2011-09-14 |
2022-11-29 |
润新生物公司 |
作为激酶抑制剂的化学实体、组合物及方法
|
|
US9249110B2
(en)
|
2011-09-21 |
2016-02-02 |
Neupharma, Inc. |
Substituted quinoxalines as B-raf kinase inhibitors
|
|
US9249111B2
(en)
|
2011-09-30 |
2016-02-02 |
Neupharma, Inc. |
Substituted quinoxalines as B-RAF kinase inhibitors
|
|
DE102011118830A1
(de)
|
2011-11-18 |
2013-05-23 |
Merck Patent Gmbh |
Morpholinylbenzotriazine
|
|
GB201120993D0
(en)
|
2011-12-06 |
2012-01-18 |
Imp Innovations Ltd |
Novel compounds and their use in therapy
|
|
EP2806874B1
(en)
|
2012-01-25 |
2017-11-15 |
Neupharma, Inc. |
Quinoxaline-oxy-phenyl derivatives as kinase inhibitors
|
|
MX371331B
(es)
|
2012-04-24 |
2020-01-27 |
Vertex Pharma |
Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico(adn-pk).
|
|
WO2014075077A1
(en)
|
2012-11-12 |
2014-05-15 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
ME03336B
(me)
|
2013-03-12 |
2019-10-20 |
Vertex Pharma |
Inhibitori dnk-pk
|
|
JP6408569B2
(ja)
|
2013-10-17 |
2018-10-17 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Dna−pk阻害剤としての(s)−n−メチル−8−(1−((2’−メチル−[4,5’−ビピリミジン]−6−イル)アミノ)プロパン−2−イル)キノリン−4−カルボキサミドおよびその重水素化誘導体の共結晶
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