|
US5571506A
(en)
|
1989-08-14 |
1996-11-05 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Aromatic oligomeric compounds useful as mimics of bioactive macromolecules
|
|
AU658134B2
(en)
|
1989-12-28 |
1995-04-06 |
Virginia Commonwealth University |
Sigma receptor ligands and the use thereof
|
|
US6004979A
(en)
|
1991-02-07 |
1999-12-21 |
Hoechst Marion Roussel |
Nitrogenous bicycles
|
|
JP3531944B2
(ja)
|
1991-02-07 |
2004-05-31 |
アベンティス・ファーマ・ソシエテ・アノニム |
新規のベンジル基で置換された窒素系二環式誘導体及びその製造方法
|
|
EP0519211A1
(de)
|
1991-05-17 |
1992-12-23 |
Hoechst Schering AgrEvo GmbH |
Substituierte 4-Aminopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
|
|
DE4208254A1
(de)
|
1992-03-14 |
1993-09-16 |
Hoechst Ag |
Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
|
|
AU3933493A
(en)
|
1992-04-24 |
1993-11-29 |
E.I. Du Pont De Nemours And Company |
Arthropodicidal and fungicidal aminopyrimidines
|
|
US5595756A
(en)
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
DE4437406A1
(de)
|
1994-10-19 |
1996-04-25 |
Hoechst Ag |
Chinoxaline, Verfahren zu ihrer Herstellung und ihre Verwendung
|
|
US5977117A
(en)
|
1996-01-05 |
1999-11-02 |
Texas Biotechnology Corporation |
Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
|
|
JP4495257B2
(ja)
|
1997-02-19 |
2010-06-30 |
バーレツクス ラボラトリーズ インコーポレーテツド |
Ｎｏｓ抑制剤としてのｎ−複素環誘導体
|
|
JPH10251255A
(ja)
|
1997-03-14 |
1998-09-22 |
Nissan Chem Ind Ltd |
アジン誘導体
|
|
AU742739B2
(en)
*
|
1997-05-28 |
2002-01-10 |
Aventis Pharmaceuticals Inc. |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56 lck tyrosine kinases
|
|
DE19801598C2
(de)
|
1998-01-17 |
2000-05-11 |
Aventis Res & Tech Gmbh & Co |
Katalytische Synthese von N-alkylierten Anilinen aus Olefinen und Anilinen
|
|
DE19836697A1
(de)
|
1998-08-13 |
2000-02-17 |
Hoechst Marion Roussel De Gmbh |
Substituierte 4-Amino-2-aryl-pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
|
|
JP2002534512A
(ja)
|
1999-01-15 |
2002-10-15 |
ノボ ノルディスク アクティーゼルスカブ |
非ペプチドｇｌｐ−１アゴニスト
|
|
JP2003511378A
(ja)
|
1999-10-07 |
2003-03-25 |
アムジエン・インコーポレーテツド |
トリアジン系キナーゼ阻害薬
|
|
GB9924092D0
(en)
|
1999-10-13 |
1999-12-15 |
Zeneca Ltd |
Pyrimidine derivatives
|
|
US6552016B1
(en)
|
1999-10-14 |
2003-04-22 |
Curis, Inc. |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
|
|
EP1255741A2
(en)
|
2000-02-01 |
2002-11-13 |
Cor Therapeutics, Inc. |
2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa
|
|
ES2254385T3
(es)
|
2000-02-29 |
2006-06-16 |
Millennium Pharmaceuticals, Inc. |
Benzamidas e inhibidores relacionados del factor xa.
|
|
US6605615B2
(en)
|
2000-03-01 |
2003-08-12 |
Tularik Inc. |
Hydrazones and analogs as cholesterol lowering agents
|
|
DE10013318A1
(de)
|
2000-03-17 |
2001-09-20 |
Merck Patent Gmbh |
Formulierung enthaltend Chinoxalinderivate
|
|
US7498304B2
(en)
|
2000-06-16 |
2009-03-03 |
Curis, Inc. |
Angiogenesis-modulating compositions and uses
|
|
EP1351946A2
(en)
|
2000-09-01 |
2003-10-15 |
Icos Corporation |
Materials and methods to potentiate cancer treatment
|
|
US6660731B2
(en)
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6613776B2
(en)
|
2000-09-15 |
2003-09-02 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US7473691B2
(en)
|
2000-09-15 |
2009-01-06 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
ES2266258T3
(es)
|
2000-09-15 |
2007-03-01 |
Vertex Pharmaceuticals Incorporated |
Compuestos de pirazol utiles como inhibidores de proteina cinasas.
|
|
US6610677B2
(en)
|
2000-09-15 |
2003-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US20020111353A1
(en)
|
2000-12-05 |
2002-08-15 |
Mark Ledeboer |
Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
|
|
EP1345925B1
(en)
|
2000-12-21 |
2006-05-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
JP2004521901A
(ja)
|
2001-02-02 |
2004-07-22 |
グラクソ グループ リミテッド |
Ｔｇｆ阻害剤としてのピラゾール
|
|
MY130778A
(en)
|
2001-02-09 |
2007-07-31 |
Vertex Pharma |
Heterocyclic inhibitiors of erk2 and uses thereof
|
|
ES2292753T4
(es)
|
2001-03-29 |
2009-02-16 |
Vertex Pharmaceuticals Incorporated |
Inhibidores de quinasas n-terminales c-jun (jnk) y otras proteina quinasas.
|
|
JP2004535381A
(ja)
|
2001-04-13 |
2004-11-25 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ｃ−ＪｕｎＮ末端キナーゼ（ＪＮＫ）および他のプロテインキナーゼのインヒビター
|
|
US20030096813A1
(en)
|
2001-04-20 |
2003-05-22 |
Jingrong Cao |
Compositions useful as inhibitors of GSK-3
|
|
AU2002308748A1
(en)
|
2001-05-16 |
2002-11-25 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases
|
|
MXPA03010961A
(es)
|
2001-05-31 |
2004-02-27 |
Vertex Pharma |
Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
|
|
CA2446756C
(en)
|
2001-06-01 |
2011-03-08 |
Vertex Pharmaceuticals Incorporated |
Thiazole compounds useful as inhibitors of protein kinase
|
|
DE60232510D1
(de)
|
2001-06-15 |
2009-07-16 |
Vertex Pharma |
5-(2-aminopyrimidin-4-yl)benzisoxazole als proteinkinasehemmer
|
|
US6689778B2
(en)
|
2001-07-03 |
2004-02-10 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of Src and Lck protein kinases
|
|
GB0119865D0
(en)
*
|
2001-08-14 |
2001-10-10 |
Cancer Res Campaign Tech |
DNA-PK inhibitors
|
|
CA2469316A1
(en)
|
2001-12-07 |
2003-06-19 |
Vertex Pharmaceuticals, Inc. |
Pyrimidine-based compounds useful as gsk-3 inhibitors
|
|
RU2004126671A
(ru)
|
2002-02-06 |
2005-04-10 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Гетероарилсоединения, полезные в качестве ингибиторов gsk-3
|
|
US20030199525A1
(en)
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
|
US20030207873A1
(en)
|
2002-04-10 |
2003-11-06 |
Edmund Harrington |
Inhibitors of Src and other protein kinases
|
|
AU2003237121A1
(en)
|
2002-04-26 |
2003-11-10 |
Vertex Pharmaceuticals Incorporated |
Pyrrole derivatives as inhibitors of erk2 and uses thereof
|
|
US7271179B2
(en)
|
2002-05-06 |
2007-09-18 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of JAK protein kinase
|
|
AU2003231880A1
(en)
|
2002-05-30 |
2003-12-19 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of jak and cdk2 protein kinases
|
|
MY141867A
(en)
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
|
EP1554269A1
(en)
|
2002-07-09 |
2005-07-20 |
Vertex Pharmaceuticals Incorporated |
Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities
|
|
CA2495386C
(en)
|
2002-08-14 |
2011-06-21 |
Vertex Pharmaceuticals Incorporated |
Protein kinase inhibitors and uses thereof
|
|
US7419984B2
(en)
|
2002-10-17 |
2008-09-02 |
Cell Therapeutics, Inc. |
Pyrimidines and uses thereof
|
|
EP2172460A1
(en)
|
2002-11-01 |
2010-04-07 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of JAK and other protein kinases
|
|
US7259161B2
(en)
|
2002-11-04 |
2007-08-21 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of JAK and other protein kinases
|
|
ATE425160T1
(de)
|
2002-12-18 |
2009-03-15 |
Vertex Pharma |
Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen
|
|
US7144911B2
(en)
|
2002-12-31 |
2006-12-05 |
Deciphera Pharmaceuticals Llc |
Anti-inflammatory medicaments
|
|
AU2004212421B2
(en)
|
2003-02-07 |
2009-08-20 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl substituted pyrolls useful as inhibitors of protein kinases
|
|
US7456190B2
(en)
|
2003-03-13 |
2008-11-25 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as protein kinase inhibitors
|
|
WO2004085418A2
(en)
|
2003-03-24 |
2004-10-07 |
Luitpold Pharmaceuticals, Inc. |
Xanthones, thioxanthones and acridinones as dna-pk inhibitors
|
|
WO2004087698A2
(en)
|
2003-03-25 |
2004-10-14 |
Vertex Pharmaceuticals Incorporated |
Thiazoles useful as inhibitors of protein kinases
|
|
US6875781B2
(en)
|
2003-04-04 |
2005-04-05 |
Cell Therapeutics, Inc. |
Pyridines and uses thereof
|
|
US7189724B2
(en)
|
2003-04-15 |
2007-03-13 |
Valeant Research And Development |
Quinoxaline derivatives having antiviral activity
|
|
EP1678147B1
(en)
|
2003-09-15 |
2012-08-08 |
Lead Discovery Center GmbH |
Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
|
|
AU2004313928A1
(en)
|
2003-12-02 |
2005-07-28 |
Vertex Pharmaceuticals, Inc. |
Heterocyclic protein kinase inhibitors and uses thereof
|
|
US7592340B2
(en)
|
2003-12-04 |
2009-09-22 |
Vertex Pharmaceuticals Incorporated |
Quinoxalines useful as inhibitors of protein kinases
|
|
TW200533357A
(en)
|
2004-01-08 |
2005-10-16 |
Millennium Pharm Inc |
2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
|
|
DE602005018333D1
(de)
|
2004-03-15 |
2010-01-28 |
Sunesis Pharmaceuticals Inc |
Sns-595 und anwendungsverfahren
|
|
GB0405985D0
(en)
|
2004-03-17 |
2004-04-21 |
Novartis Forschungsstiftung |
Kinase
|
|
RU2006144448A
(ru)
|
2004-05-14 |
2008-06-20 |
Вертекс Фармасьютикалз |
Пролекарства пирролилпиримидиновых ингибиторов протеинкиназы erk
|
|
JP4449580B2
(ja)
|
2004-05-31 |
2010-04-14 |
宇部興産株式会社 |
４−アラルキルアミノピリミジン誘導体及び抗菌剤
|
|
HRP20090093T3
(en)
|
2004-06-04 |
2009-03-31 |
Arena Pharmaceuticals Inc. |
Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
|
|
MX2007003154A
(es)
|
2004-09-17 |
2007-05-15 |
Vertex Pharma |
Compuestos de diaminotriazol de utilidad como inhibidores de proteina quinasa.
|
|
EP1815206B1
(en)
|
2004-10-13 |
2016-04-06 |
PTC Therapeutics, Inc. |
Compounds for nonsense suppression, and methods for their use
|
|
JP2008516939A
(ja)
|
2004-10-15 |
2008-05-22 |
アストラゼネカ アクチボラグ |
化学化合物
|
|
GT200500284A
(es)
|
2004-10-15 |
2006-03-27 |
Aventis Pharma Inc |
Pirimidinas como antagonistas del receptor de prostaglandina d2
|
|
US20060166936A1
(en)
|
2004-10-29 |
2006-07-27 |
Hayley Binch |
Diaminotriazole compounds useful as inhibitors of protein kinases
|
|
US7517870B2
(en)
|
2004-12-03 |
2009-04-14 |
Fondazione Telethon |
Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
|
|
AU2005316599A1
(en)
|
2004-12-14 |
2006-06-22 |
Vertex Pharmaceuticals Incorporated |
Pyrimidine inhibitors of ERK protein kinase and uses therof
|
|
EP1833820A1
(en)
|
2004-12-23 |
2007-09-19 |
Vertex Pharmaceuticals Incorporated |
Selective inhibitors of erk protein kinase and uses therof
|
|
MX2007009388A
(es)
|
2005-02-04 |
2007-09-25 |
Senomyx Inc |
Compuestos que comprenden porciones heteroarilo unidas y su uso como modificadores del sabor unami, saborizantes y mejoradores del sabor para composiciones comestibles.
|
|
EP1865775A1
(en)
|
2005-04-06 |
2007-12-19 |
Irm, Llc |
Diarylamine-containing compounds and compositions, and their use as modulators of steroid hormone nuclear receptors
|
|
AR053358A1
(es)
|
2005-04-15 |
2007-05-02 |
Cancer Rec Tech Ltd |
Inhibidores de adn - pk
|
|
JP2008542219A
(ja)
|
2005-05-25 |
2008-11-27 |
インゲニウム ファーマシューティカルズ ジーエムビーエイチ |
疼痛処置法
|
|
WO2006138418A2
(en)
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
JP2007008045A
(ja)
|
2005-06-30 |
2007-01-18 |
Mitsui Chemicals Inc |
光記録媒体および１ｈ−キノキサリン−２−オン誘導体
|
|
WO2007014250A2
(en)
|
2005-07-26 |
2007-02-01 |
Vertex Pharmaceuticals Incorporated |
Abl kinase inhibition
|
|
GB0520657D0
(en)
|
2005-10-11 |
2005-11-16 |
Ludwig Inst Cancer Res |
Pharmaceutical compounds
|
|
US20070219192A1
(en)
|
2005-11-02 |
2007-09-20 |
Xiangping Qian |
Certain chemical entities, compositions, and methods
|
|
WO2007056163A2
(en)
|
2005-11-03 |
2007-05-18 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as kinase inhibitors
|
|
US20070179125A1
(en)
|
2005-11-16 |
2007-08-02 |
Damien Fraysse |
Aminopyrimidines useful as kinase inhibitors
|
|
WO2007082899A1
(en)
|
2006-01-17 |
2007-07-26 |
Vib Vzw |
Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
UY30118A1
(es)
|
2006-01-31 |
2007-06-29 |
Tanabe Seiyaku Co |
Compueto amina trisustituido
|
|
WO2007109783A2
(en)
|
2006-03-23 |
2007-09-27 |
Janssen Pharmaceutica, N.V. |
Substituted pyrimidine kinase inhibitors
|
|
US20080280891A1
(en)
|
2006-06-27 |
2008-11-13 |
Locus Pharmaceuticals, Inc. |
Anti-cancer agents and uses thereof
|
|
WO2008008852A2
(en)
|
2006-07-11 |
2008-01-17 |
Emory University |
Cxcr4 antagonists including heteroatoms for the treatment of medical disorders
|
|
TW200811134A
(en)
|
2006-07-12 |
2008-03-01 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
EP2044056B1
(en)
|
2006-07-14 |
2012-08-22 |
Novartis AG |
Pyrimidine derivatives as alk-5 inhibitors
|
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US7635683B2
(en)
|
2006-08-04 |
2009-12-22 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl tripeptide hepatitis C virus inhibitors
|
|
EP2061764B1
(en)
|
2006-08-22 |
2014-07-02 |
Technion Research & Development Foundation LTD. |
Heterocyclic derivatives binding to the peripheral-type benzodiazepine receptor (pbr)
|
|
EP1903038A1
(de)
|
2006-09-07 |
2008-03-26 |
Bayer Schering Pharma Aktiengesellschaft |
N-(1-Hetaryl-piperidin-4-yl)-(het)arylamide als EP2-Rezeptor Modulatoren
|
|
US7875603B2
(en)
|
2006-09-21 |
2011-01-25 |
Nova Southeastern University |
Specific inhibitors for vascular endothelial growth factor receptors
|
|
MX2009003456A
(es)
|
2006-10-02 |
2009-04-14 |
Irm Llc |
Compuestos y composiciones como inhibidores de proteina cinasa.
|
|
DE102006050512A1
(de)
|
2006-10-26 |
2008-04-30 |
Bayer Healthcare Ag |
Substituierte heterocyclische Verbindungen und ihre Verwendung
|
|
MX2009004807A
(es)
|
2006-11-02 |
2009-06-15 |
Vertex Pharma |
Aminopiridinas y aminopirimidinas utiles como inhibidores de proteina cinasa.
|
|
CN101679371A
(zh)
|
2006-12-04 |
2010-03-24 |
艾美罗股份公司 |
作为腺苷受体拮抗剂的取代的嘧啶
|
|
JP2010513567A
(ja)
|
2006-12-19 |
2010-04-30 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼの阻害剤として有用なアミノピリミジン
|
|
AU2007341997A1
(en)
|
2006-12-28 |
2008-07-10 |
Ambrx, Inc. |
Phenazine and quinoxaline substituted amino acids and polypeptides
|
|
ES2702362T3
(es)
|
2007-01-31 |
2019-02-28 |
Ym Biosciences Australia Pty |
Compuestos a base de tiopirimidina y usos de los mismos
|
|
WO2008106202A1
(en)
|
2007-02-27 |
2008-09-04 |
Housey Gerard M |
Theramutein modulators
|
|
WO2008112642A1
(en)
|
2007-03-09 |
2008-09-18 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as inhibitors of protein kinases
|
|
WO2008112646A1
(en)
|
2007-03-09 |
2008-09-18 |
Vertex Pharmaceuticals Incorporated |
Aminopyridines useful as inhibitors of protein kinases
|
|
ATE526328T1
(de)
|
2007-03-09 |
2011-10-15 |
Vertex Pharma |
Als inhibitoren von proteinkinasen geeignete aminopyrimidine
|
|
CN101675041A
(zh)
|
2007-03-20 |
2010-03-17 |
沃泰克斯药物股份有限公司 |
用作激酶抑制剂的氨基嘧啶类化合物
|
|
DE102007015169A1
(de)
|
2007-03-27 |
2008-10-02 |
Universität des Saarlandes Campus Saarbrücken |
17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
|
|
CA2683785A1
(en)
|
2007-04-13 |
2008-10-23 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as kinase inhibitors
|
|
US7910587B2
(en)
|
2007-04-26 |
2011-03-22 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl dipeptide hepatitis C virus inhibitors
|
|
MX2009011811A
(es)
|
2007-05-02 |
2010-01-14 |
Vertex Pharma |
Aminopirimidinas utiles como inhibidores de cinasa.
|
|
MX2009011812A
(es)
|
2007-05-02 |
2010-01-14 |
Vertex Pharma |
Aminopirimidinas utiles como inhibidores de cinasa.
|
|
CA2685876A1
(en)
|
2007-05-02 |
2008-11-13 |
Vertex Pharmaceuticals Incorporated |
Thiazoles and pyrazoles useful as kinase inhibitors
|
|
PE20090288A1
(es)
|
2007-05-10 |
2009-04-03 |
Smithkline Beecham Corp |
Derivados de quinoxalina como inhibidores de la pi3 quinasa
|
|
WO2008144253A1
(en)
|
2007-05-14 |
2008-11-27 |
Irm Llc |
Protein kinase inhibitors and methods for using thereof
|
|
CN101687852A
(zh)
|
2007-05-24 |
2010-03-31 |
沃泰克斯药物股份有限公司 |
可用作激酶抑制剂的噻唑类和吡唑类化合物
|
|
US9242933B2
(en)
|
2007-05-25 |
2016-01-26 |
AbbVie Deutschland GmbH & Co. KG |
Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mGlu2 receptor)
|
|
EP2170274A1
(en)
|
2007-07-02 |
2010-04-07 |
Technion Research and Development Foundation, Ltd. |
Compositions, articles and methods comprising tspo ligands for preventing or reducing tobacco-associated damage
|
|
US20100130597A1
(en)
|
2007-07-06 |
2010-05-27 |
The United State Of America, As Represented By The Secretary Of The Dept Of Health And Human Service |
Dna-pkcs modulates energy regulation and brain function
|
|
UY31232A1
(es)
|
2007-07-19 |
2009-03-02 |
|
Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
|
|
MX2010001240A
(es)
|
2007-08-01 |
2010-04-30 |
Kumiai Chemical Industry Co |
Derivado de oxopirazina y herbicida.
|
|
EP2190466A4
(en)
|
2007-08-10 |
2011-12-21 |
Burnham Inst Medical Research |
Tissue-specific alkaline phosphatase (TNAP) activators and their use
|
|
DE102007044032A1
(de)
|
2007-09-14 |
2009-03-19 |
Bayer Healthcare Ag |
Substituierte heterocyclische Verbindungen und ihre Verwendung
|
|
WO2009047359A1
(en)
|
2007-10-12 |
2009-04-16 |
Ingenium Pharmaceuticals Gmbh |
Inhibitors of protein kinases
|
|
WO2009061761A2
(en)
|
2007-11-06 |
2009-05-14 |
E. I. Du Pont De Nemours And Company |
Fungicidal heterocyclic amines
|
|
EP2231624A4
(en)
|
2007-12-21 |
2011-07-06 |
Progenics Pharm Inc |
TRIAZINE AND CORRESPONDING COMPOUNDS WITH ANTIVIRAL EFFECT, COMPOSITIONS AND METHOD THEREFOR
|
|
US8562945B2
(en)
|
2008-01-09 |
2013-10-22 |
Molecular Insight Pharmaceuticals, Inc. |
Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
|
|
CA2714743C
(en)
|
2008-02-19 |
2017-01-17 |
Janssen Pharmaceutica N.V. |
Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase
|
|
US20110009421A1
(en)
|
2008-02-27 |
2011-01-13 |
Takeda Pharmaceutical Company Limited |
Compound having 6-membered aromatic ring
|
|
AU2009221327B2
(en)
|
2008-03-05 |
2014-03-27 |
Merck Patent Gmbh |
Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
CA2725316A1
(en)
|
2008-06-02 |
2009-12-10 |
Banyu Pharmaceutical Co., Ltd. |
Novel isoxazole derivative
|
|
BRPI0915064B8
(pt)
|
2008-06-16 |
2021-05-25 |
Merck Patent Gmbh |
derivados de quinoxalinadiona, seus usos, e medicamentos
|
|
EP2138488A1
(en)
|
2008-06-26 |
2009-12-30 |
sanofi-aventis |
4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
|
|
AU2009274011B2
(en)
|
2008-07-23 |
2014-12-18 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyridine kinase inhibitors
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
US8697685B2
(en)
|
2008-11-20 |
2014-04-15 |
Glaxosmithkline Llc |
Chemical compounds
|
|
BRPI0924084B1
(pt)
|
2008-12-19 |
2021-12-21 |
Vertex Pharmaceuticals Incorporated |
Derivados de pirazina e composição farmacêutica que os compreende
|
|
JP2012517448A
(ja)
|
2009-02-11 |
2012-08-02 |
リアクション バイオロジー コープ． |
選択的キナーゼ阻害剤
|
|
JP2010111702A
(ja)
|
2009-02-16 |
2010-05-20 |
Tetsuya Nishio |
複素環化合物、その製造法および用途
|
|
US8906914B2
(en)
|
2009-08-18 |
2014-12-09 |
Janssen Pharmaceutica Nv |
Ethylene diamine modulators of fatty acid hydrolase
|
|
AR077999A1
(es)
|
2009-09-02 |
2011-10-05 |
Vifor Int Ag |
Antagonistas de pirimidin y triazin-hepcidina
|
|
EP2947073B1
(en)
|
2009-10-22 |
2019-04-03 |
Fibrotech Therapeutics Pty Ltd |
Fused ring analogues of anti-fibrotic agents
|
|
ES2360333B1
(es)
|
2009-10-29 |
2012-05-04 |
Consejo Superior De Investigaciones Cientificas (Csic) (70%) |
Derivados de bis (aralquil) amino y sistemas (hetero) aromaticos de seis miembros y su uso en el tratamiento de patologias neurodegenerativas, incluida la enfermedad de alzheimer
|
|
JPWO2011052756A1
(ja)
|
2009-10-30 |
2013-03-21 |
持田製薬株式会社 |
新規３−ヒドロキシ−５−アリールイソキサゾール誘導体
|
|
PH12012501456A1
(en)
|
2009-12-25 |
2012-10-29 |
Mochida Pharm Co Ltd |
Novel 3-hydroxy -5- arylisothiazole derivative
|
|
UY33213A
(es)
|
2010-02-18 |
2011-09-30 |
Almirall Sa |
Derivados de pirazol como inhibidores de jak
|
|
MX2012010557A
(es)
|
2010-03-16 |
2012-10-05 |
Merck Patent Gmbh |
Morfolinilquinazolinas.
|
|
TWI516264B
(zh)
|
2010-05-06 |
2016-01-11 |
臺北醫學大學 |
芳香醯喹啉化合物
|
|
JP2011246389A
(ja)
*
|
2010-05-26 |
2011-12-08 |
Oncotherapy Science Ltd |
Ｔｔｋ阻害作用を有する縮環ピラゾール誘導体
|
|
DE102010025786A1
(de)
|
2010-07-01 |
2012-01-05 |
Merck Patent Gmbh |
Pyrazolochinoline
|
|
DE102010035744A1
(de)
|
2010-08-28 |
2012-03-01 |
Merck Patent Gmbh |
Imidazolonylchinoline
|
|
WO2012129562A2
(en)
|
2011-03-24 |
2012-09-27 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
GB201114051D0
(en)
|
2011-08-15 |
2011-09-28 |
Domainex Ltd |
Compounds and their uses
|
|
CN107245056A
(zh)
|
2011-08-26 |
2017-10-13 |
润新生物公司 |
化学实体、组合物及方法
|
|
EP2755657B1
(en)
|
2011-09-14 |
2017-11-29 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
US9249110B2
(en)
|
2011-09-21 |
2016-02-02 |
Neupharma, Inc. |
Substituted quinoxalines as B-raf kinase inhibitors
|
|
WO2013049701A1
(en)
|
2011-09-30 |
2013-04-04 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
DE102011118830A1
(de)
|
2011-11-18 |
2013-05-23 |
Merck Patent Gmbh |
Morpholinylbenzotriazine
|
|
GB201120993D0
(en)
|
2011-12-06 |
2012-01-18 |
Imp Innovations Ltd |
Novel compounds and their use in therapy
|
|
EP2806874B1
(en)
|
2012-01-25 |
2017-11-15 |
Neupharma, Inc. |
Quinoxaline-oxy-phenyl derivatives as kinase inhibitors
|
|
SI3459942T1
(sl)
|
2012-04-24 |
2021-05-31 |
Vertex Pharmaceuticals Incorporated |
Inhibitorji DNA-PK
|
|
US9725421B2
(en)
|
2012-11-12 |
2017-08-08 |
Neupharma, Inc. |
Substituted quinoxalines as B-raf kinase inhibitors
|
|
HUE041544T2
(hu)
|
2013-03-12 |
2019-05-28 |
Vertex Pharma |
DNS-PK inhibitorok
|
|
PT3424920T
(pt)
|
2013-10-17 |
2020-07-07 |
Vertex Pharma |
Co-cristais de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propan-2-il)quinolina-4-carboxamida e derivados deuterados dos mesmos como inibidores de adn-pk
|