JP2016509594A5 - - Google Patents
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- JP2016509594A5 JP2016509594A5 JP2015551761A JP2015551761A JP2016509594A5 JP 2016509594 A5 JP2016509594 A5 JP 2016509594A5 JP 2015551761 A JP2015551761 A JP 2015551761A JP 2015551761 A JP2015551761 A JP 2015551761A JP 2016509594 A5 JP2016509594 A5 JP 2016509594A5
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- Prior art keywords
- alkyl
- group
- compound according
- pharmaceutically acceptable
- formula
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- -1 amino, hydroxy Chemical group 0.000 claims 6
- 239000003242 anti bacterial agent Substances 0.000 claims 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- UUGRTBCTVUNWTN-DLRIENLKSA-N (2s,3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1,5-dihydroxy-4-oxopyridin-2-yl)methoxyimino]acetyl]amino]-2-methyl-4-oxoazetidine-1-sulfonic acid Chemical compound O=C1N(S(O)(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCC1=CC(=O)C(O)=CN1O UUGRTBCTVUNWTN-DLRIENLKSA-N 0.000 claims 2
- QUKGLNCXGVWCJX-UHFFFAOYSA-N 1,3,4-thiadiazol-2-amine Chemical compound NC1=NN=CS1 QUKGLNCXGVWCJX-UHFFFAOYSA-N 0.000 claims 2
- OMAFFHIGWTVZOH-UHFFFAOYSA-N 1-methyltetrazole Chemical compound CN1C=NN=N1 OMAFFHIGWTVZOH-UHFFFAOYSA-N 0.000 claims 2
- WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- TYMABNNERDVXID-DLYFRVTGSA-N Panipenem Chemical compound C([C@@H]1[C@H](C(N1C=1C(O)=O)=O)[C@H](O)C)C=1S[C@H]1CCN(C(C)=N)C1 TYMABNNERDVXID-DLYFRVTGSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 claims 2
- KLFSEZJCLYBFKQ-WXYNYTDUSA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1,5-dihydroxy-4-oxopyridin-2-yl)methoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCC1=CC(=O)C(O)=CN1O KLFSEZJCLYBFKQ-WXYNYTDUSA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 239000000043 antiallergic agent Substances 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 claims 2
- 229960003644 aztreonam Drugs 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- MRMBZHPJVKCOMA-YJFSRANCSA-N biapenem Chemical compound C1N2C=NC=[N+]2CC1SC([C@@H]1C)=C(C([O-])=O)N2[C@H]1[C@@H]([C@H](O)C)C2=O MRMBZHPJVKCOMA-YJFSRANCSA-N 0.000 claims 2
- 229960003169 biapenem Drugs 0.000 claims 2
- ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 claims 2
- 229960000484 ceftazidime Drugs 0.000 claims 2
- AVAACINZEOAHHE-VFZPANTDSA-N doripenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](CNS(N)(=O)=O)C1 AVAACINZEOAHHE-VFZPANTDSA-N 0.000 claims 2
- 229960000895 doripenem Drugs 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229960002182 imipenem Drugs 0.000 claims 2
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 claims 2
- 229960002260 meropenem Drugs 0.000 claims 2
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 claims 2
- 229950011346 panipenem Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 2
- VAMSVIZLXJOLHZ-QWFSEIHXSA-N tigemonam Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(=N/OCC(O)=O)\C1=CSC(N)=N1 VAMSVIZLXJOLHZ-QWFSEIHXSA-N 0.000 claims 2
- 229950010206 tigemonam Drugs 0.000 claims 2
- 229940124586 β-lactam antibiotics Drugs 0.000 claims 2
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 1
- RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical compound NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 claims 1
- MCTWTZJPVLRJOU-UHFFFAOYSA-N 1-methyl-1H-imidazole Chemical compound CN1C=CN=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 claims 1
- JWAWEQBUZOGIBZ-UHFFFAOYSA-N 1-methyltriazole Chemical compound CN1C=CN=N1 JWAWEQBUZOGIBZ-UHFFFAOYSA-N 0.000 claims 1
- XJLITJHUQRBWPN-UHFFFAOYSA-N 2-acetamidoacetic acid;4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide Chemical compound CC(=O)NCC(O)=O.C1=CC(C(=N)N)=CC=C1NN=NC1=CC=C(C(N)=N)C=C1 XJLITJHUQRBWPN-UHFFFAOYSA-N 0.000 claims 1
- ULRPISSMEBPJLN-UHFFFAOYSA-N 2h-tetrazol-5-amine Chemical compound NC1=NN=NN1 ULRPISSMEBPJLN-UHFFFAOYSA-N 0.000 claims 1
- QRZMXADUXZADTF-UHFFFAOYSA-N 4-aminoimidazole Chemical compound NC1=CNC=N1 QRZMXADUXZADTF-UHFFFAOYSA-N 0.000 claims 1
- KLSJWNVTNUYHDU-UHFFFAOYSA-N Amitrole Chemical compound NC1=NC=NN1 KLSJWNVTNUYHDU-UHFFFAOYSA-N 0.000 claims 1
- JUZNIMUFDBIJCM-ANEDZVCMSA-N Invanz Chemical compound O=C([C@H]1NC[C@H](C1)SC=1[C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)NC1=CC=CC(C(O)=O)=C1 JUZNIMUFDBIJCM-ANEDZVCMSA-N 0.000 claims 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical group CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 229950003476 aminothiazole Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229960002770 ertapenem Drugs 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229960003194 meglumine Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
- 0 CCOC(OC(C)OC(c1c2OB3*=C(CSC)N[C@]3Cc2ccc1)=O)=O Chemical compound CCOC(OC(C)OC(c1c2OB3*=C(CSC)N[C@]3Cc2ccc1)=O)=O 0.000 description 2
- VELHQRMGDOGMPM-UHFFFAOYSA-N CC(C)(C)C(OCOC(c(cccc1CC2NC(CSC)=O)c1OB2O)=O)=O Chemical compound CC(C)(C)C(OCOC(c(cccc1CC2NC(CSC)=O)c1OB2O)=O)=O VELHQRMGDOGMPM-UHFFFAOYSA-N 0.000 description 1
- WUQGISQYFIRBLU-ZDUSSCGKSA-N CC(C)OC(OCOC(c(cccc1C[C@@H]2NC(CSC)=O)c1OB2O)=O)=O Chemical compound CC(C)OC(OCOC(c(cccc1C[C@@H]2NC(CSC)=O)c1OB2O)=O)=O WUQGISQYFIRBLU-ZDUSSCGKSA-N 0.000 description 1
- IEYYFPPOBKZHPG-HNNXBMFYSA-N CCC(CC)C(OCOC(c(cccc1C[C@@H]2NC(CSC)=O)c1OB2O)=O)=O Chemical compound CCC(CC)C(OCOC(c(cccc1C[C@@H]2NC(CSC)=O)c1OB2O)=O)=O IEYYFPPOBKZHPG-HNNXBMFYSA-N 0.000 description 1
- JLXAZUMNJODWBO-ZDUSSCGKSA-N CCCC(OCOC(c(cccc1C[C@@H]2NC(CSC)=O)c1OB2O)=O)=O Chemical compound CCCC(OCOC(c(cccc1C[C@@H]2NC(CSC)=O)c1OB2O)=O)=O JLXAZUMNJODWBO-ZDUSSCGKSA-N 0.000 description 1
- GNWXQXUVACQZAY-VIFPVBQESA-N COB([C@H](Cc1ccc2)N/C(/c3nnc(N)[o]3)=[O]\C)Oc1c2C(O)=O Chemical compound COB([C@H](Cc1ccc2)N/C(/c3nnc(N)[o]3)=[O]\C)Oc1c2C(O)=O GNWXQXUVACQZAY-VIFPVBQESA-N 0.000 description 1
- QTNJTYOSJMJPKB-ZETCQYMHSA-N Nc1nnc(C(N[C@H]2Cc3cccc(C(O)=O)c3OB2O)=O)[s]1 Chemical compound Nc1nnc(C(N[C@H]2Cc3cccc(C(O)=O)c3OB2O)=O)[s]1 QTNJTYOSJMJPKB-ZETCQYMHSA-N 0.000 description 1
- ZZZBWSAVQFPOLP-LBPRGKRZSA-N OB([C@H](Cc1ccc2)NC(c3cc(F)cnc3)=O)Oc1c2C(O)=O Chemical compound OB([C@H](Cc1ccc2)NC(c3cc(F)cnc3)=O)Oc1c2C(O)=O ZZZBWSAVQFPOLP-LBPRGKRZSA-N 0.000 description 1
- OMCMDOYTIDGOJK-LBPRGKRZSA-N OB([C@H](Cc1ccc2)NC(c3cccnc3)=O)Oc1c2C(O)=O Chemical compound OB([C@H](Cc1ccc2)NC(c3cccnc3)=O)Oc1c2C(O)=O OMCMDOYTIDGOJK-LBPRGKRZSA-N 0.000 description 1
- OQGUPXPWULVSPM-NSHDSACASA-N OB([C@H](Cc1ccc2)NC(c3cncnc3)=O)Oc1c2C(O)=O Chemical compound OB([C@H](Cc1ccc2)NC(c3cncnc3)=O)Oc1c2C(O)=O OQGUPXPWULVSPM-NSHDSACASA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361749210P | 2013-01-04 | 2013-01-04 | |
| US61/749,210 | 2013-01-04 | ||
| US201361780828P | 2013-03-13 | 2013-03-13 | |
| US61/780,828 | 2013-03-13 | ||
| PCT/US2014/010106 WO2014107535A1 (en) | 2013-01-04 | 2014-01-02 | Boronic acid derivatives and therapeutic uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016509594A JP2016509594A (ja) | 2016-03-31 |
| JP2016509594A5 true JP2016509594A5 (enExample) | 2017-02-09 |
Family
ID=51061421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551761A Pending JP2016509594A (ja) | 2013-01-04 | 2014-01-02 | ボロン酸誘導体及びその治療的使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9642869B2 (enExample) |
| EP (1) | EP2941246A4 (enExample) |
| JP (1) | JP2016509594A (enExample) |
| KR (1) | KR20150103269A (enExample) |
| CN (1) | CN104994844A (enExample) |
| AU (1) | AU2014204045B2 (enExample) |
| BR (1) | BR112015016001A2 (enExample) |
| CA (1) | CA2894891A1 (enExample) |
| EA (1) | EA201591003A1 (enExample) |
| MX (1) | MX2015008628A (enExample) |
| TW (1) | TW201431866A (enExample) |
| WO (1) | WO2014107535A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3412676T3 (pl) | 2010-08-10 | 2021-04-06 | Melinta Therapeutics, Inc. | Cykliczne pochodne estrowe kwasu boronowego, sposób otrzymywania oraz ich zastosowania terapeutyczne |
| WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| US9642896B1 (en) | 2011-11-14 | 2017-05-09 | Yale University | Compositions and methods for modulating coagulation |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| PL2928898T3 (pl) | 2012-12-07 | 2021-10-25 | VenatoRx Pharmaceuticals, Inc. | Inhibitory beta-laktamaz |
| EP2941246A4 (en) | 2013-01-04 | 2016-12-21 | Rempex Pharmaceuticals Inc | BORONIC ACID DERIVATIVES AND THEIR THERAPEUTIC USES |
| KR20150103270A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| ES2730013T3 (es) | 2013-01-10 | 2019-11-07 | Venatorx Pharmaceuticals Inc | Inhibidores de betalactamasa |
| US9944658B2 (en) | 2013-03-14 | 2018-04-17 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| US9687497B1 (en) | 2014-05-05 | 2017-06-27 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| EP3140310B1 (en) | 2014-05-05 | 2019-08-07 | Rempex Pharmaceuticals, Inc. | Synthesis of boronate salts and uses thereof |
| AU2015264418A1 (en) * | 2014-05-19 | 2016-11-10 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| ES2874579T3 (es) | 2014-06-11 | 2021-11-05 | Venatorx Pharmaceuticals Inc | Inhibidores de betalactamasa |
| US10206937B2 (en) | 2014-07-01 | 2019-02-19 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| WO2016165019A1 (en) * | 2015-04-14 | 2016-10-20 | B-Organic Films Corp. | Antiviral and antibacteria agents based on quaternary ammonium compound complexed with boric acid and its derivatives |
| CN108472284A (zh) * | 2015-09-11 | 2018-08-31 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
| WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CN105801610B (zh) * | 2016-04-19 | 2018-05-18 | 武汉维舜医药科技有限公司 | 新型广谱β-内酰胺酶抑制剂 |
| WO2017190043A1 (en) * | 2016-04-29 | 2017-11-02 | University Of Kansas | Cephalosporin-type compounds |
| MY196909A (en) | 2016-06-30 | 2023-05-09 | Qpex Biopharma Inc | Boronic acid derivatives and therapeutic uses thereof |
| US10889600B2 (en) | 2016-08-04 | 2021-01-12 | VenatoRx Pharmaceuticals, Inc. | Boron-containing compounds |
| JOP20190188A1 (ar) * | 2017-02-01 | 2019-08-01 | Rempex Pharmaceuticals Inc | جهاز وعملية تدفق مستمرة لإنتاج مشتق حمض بورونيك |
| PL3592362T3 (pl) | 2017-03-06 | 2025-06-23 | VenatoRx Pharmaceuticals, Inc. | Postacie stałe i kompozycje skojarzone zawierające inhibitor beta-laktamaz i ich zastosowania |
| EP3630782A4 (en) * | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| US11267826B2 (en) | 2017-05-26 | 2022-03-08 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| JP7511469B2 (ja) | 2017-09-27 | 2024-07-05 | イノザイム ファーマ， インコーポレイテッド | 組換えエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ（ｎｐｐ１）を使用して心血管機能を改善し、心血管疾患を処置するための方法。 |
| EP3694864B1 (en) | 2017-10-11 | 2025-03-05 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis thereof |
| AU2019256351B2 (en) | 2018-04-20 | 2024-02-29 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| CN118638140A (zh) | 2018-04-27 | 2024-09-13 | 住友制药株式会社 | 氧代取代化合物 |
| EP3802551A4 (en) | 2018-05-25 | 2022-03-02 | Venatorx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| EP3886798B1 (en) * | 2018-11-29 | 2026-01-28 | Venatorx Pharmaceuticals, Inc. | Combination compositions comprising a beta-lactamase inhibitor and uses thereof |
| AU2020256179A1 (en) * | 2019-04-02 | 2021-11-18 | VenatoRx Pharmaceuticals, Inc. | Solid forms of an orally-delivered beta-lactamase inhibitor and uses thereof |
| WO2021079984A1 (ja) | 2019-10-25 | 2021-04-29 | 大日本住友製薬株式会社 | 新規置換縮環型化合物 |
| US12552815B2 (en) | 2020-05-05 | 2026-02-17 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof |
| WO2022187362A1 (en) * | 2021-03-02 | 2022-09-09 | Case Western Reserve University | Β-lactamase inhibitors and uses thereof |
| CN113150022B (zh) * | 2021-04-23 | 2022-12-06 | 四川大学 | 3-取代五元环状硼酸酯衍生物及其药物组合物和制药用途 |
| WO2025119216A1 (zh) * | 2023-12-04 | 2025-06-12 | 珠海联邦制药股份有限公司 | 硼酸类β-内酰胺酶抑制剂及其制备方法和应用 |
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2014
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- 2014-01-02 US US14/146,671 patent/US9642869B2/en not_active Expired - Fee Related
- 2014-01-02 EA EA201591003A patent/EA201591003A1/ru unknown
- 2014-01-02 AU AU2014204045A patent/AU2014204045B2/en not_active Expired - Fee Related
- 2014-01-02 WO PCT/US2014/010106 patent/WO2014107535A1/en not_active Ceased
- 2014-01-02 JP JP2015551761A patent/JP2016509594A/ja active Pending
- 2014-01-02 KR KR1020157021053A patent/KR20150103269A/ko not_active Withdrawn
- 2014-01-02 BR BR112015016001A patent/BR112015016001A2/pt not_active IP Right Cessation
- 2014-01-02 CA CA2894891A patent/CA2894891A1/en not_active Abandoned
- 2014-01-02 CN CN201480003981.3A patent/CN104994844A/zh active Pending
- 2014-01-02 MX MX2015008628A patent/MX2015008628A/es unknown
- 2014-01-03 TW TW103100234A patent/TW201431866A/zh unknown