|
JPS4995971A
(OSRAM)
|
1973-01-27 |
1974-09-11 |
|
|
|
DE2448869A1
(de)
|
1973-10-19 |
1975-09-04 |
Mcneilab Inc |
4-oxo-2-imidazolidinylidenharnstoffe, verfahren zu ihrer herstellung und arzneimittel
|
|
US4025517A
(en)
|
1975-06-23 |
1977-05-24 |
Mcneil Laboratories, Incorporated |
4-Oxo-2-hexahydropyrimidinylidene ureas
|
|
JPS554305A
(en)
*
|
1978-06-13 |
1980-01-12 |
Nippon Zoki Pharmaceut Co Ltd |
Remedy for disease caused by stress and its preparation
|
|
US4864028A
(en)
*
|
1983-09-14 |
1989-09-05 |
Alcon Laboratories, Inc. |
Spiro-tricyclicaromatic succinimide derivatives
|
|
US5070100A
(en)
|
1983-09-14 |
1991-12-03 |
Alcon Laboratories, Inc. |
Spiro-tricyclicaromatic succinimide derivatives
|
|
GB2189698A
(en)
|
1986-04-30 |
1987-11-04 |
Haessle Ab |
Coated omeprazole tablets
|
|
GB2189699A
(en)
|
1986-04-30 |
1987-11-04 |
Haessle Ab |
Coated acid-labile medicaments
|
|
CH677886A5
(OSRAM)
|
1989-06-26 |
1991-07-15 |
Hans Georg Prof Dr Weder |
|
|
US5387742A
(en)
|
1990-06-15 |
1995-02-07 |
Scios Nova Inc. |
Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease
|
|
DK0568575T4
(da)
|
1991-01-21 |
2010-12-20 |
Elan Pharm Inc |
Test og model for Alzheimers sygdom
|
|
DK0620849T3
(da)
|
1992-01-07 |
2003-10-20 |
Elan Pharm Inc |
Transgene dyremodeller for Alzheimer's sygdom
|
|
US5604102A
(en)
|
1992-04-15 |
1997-02-18 |
Athena Neurosciences, Inc. |
Methods of screening for β-amyloid peptide production inhibitors
|
|
DE69426571T2
(de)
|
1993-10-27 |
2001-08-09 |
Elan Pharm Inc |
TRANSGENE TIERE, DIE APP Allele mit der schwedischen Mutation beherbergen
|
|
US5877399A
(en)
|
1994-01-27 |
1999-03-02 |
Johns Hopkins University |
Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
|
|
ES2094688B1
(es)
|
1994-08-08 |
1997-08-01 |
Cusi Lab |
Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
|
|
FR2730932B1
(fr)
|
1995-02-27 |
1997-04-04 |
Oreal |
Nanoemulsion transparente a base de lipides amphiphiles non-ioniques fluides et utilisation en cosmetique ou en dermopharmacie
|
|
US5744346A
(en)
|
1995-06-07 |
1998-04-28 |
Athena Neurosciences, Inc. |
β-secretase
|
|
EP0871720A2
(en)
|
1995-06-07 |
1998-10-21 |
Athena Neurosciences, Inc. |
Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition
|
|
FR2742676B1
(fr)
|
1995-12-21 |
1998-02-06 |
Oreal |
Nanoemulsion transparente a base de tensioactifs silicones et utilisation en cosmetique ou en dermopharmacie
|
|
FR2755854B1
(fr)
|
1996-11-15 |
1998-12-24 |
Oreal |
Nanoemulsion a base de lipides amphiphiles non-ioniques et cationiques et utilisations
|
|
FR2760970B1
(fr)
|
1997-03-18 |
2000-03-10 |
Oreal |
Nanoemulsions a base de lipides amphiphiles non-ioniques et de silicones aminees et utilisations
|
|
AU5002399A
(en)
|
1998-07-17 |
2000-02-07 |
National Broach And Machine Company |
Full form roll finishing technique
|
|
CA2343004A1
(en)
|
1998-09-24 |
2000-03-30 |
Pharmacia & Upjohn Company |
Alzheimer's disease secretase
|
|
FR2787027B1
(fr)
|
1998-12-14 |
2001-01-12 |
Oreal |
Nanoemulsion a base d'esters gras de sucre ou d'ethers gras de sucre et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
|
FR2787026B1
(fr)
|
1998-12-14 |
2001-01-12 |
Oreal |
Nanoemulsion a base d'esters mixtes d'acide gras ou d'alcool gras, d'acide carboxylique et de glyceryle, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
|
FR2787325B1
(fr)
|
1998-12-17 |
2001-01-26 |
Oreal |
Nanoemulsion a base d'esters gras de sorbitan oxyethylenes ou non oxyethylenes, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
|
FR2787326B1
(fr)
|
1998-12-17 |
2001-01-26 |
Oreal |
Nanoemulsion a base d'esters gras de glycerol, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
|
FR2787728B1
(fr)
|
1998-12-23 |
2001-01-26 |
Oreal |
Nanoemulsion a base d'esters gras d'acide phosphorique, et ses utilisations dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique
|
|
FR2787703B1
(fr)
|
1998-12-29 |
2001-01-26 |
Oreal |
Nanoemulsion a base d'ethers gras ethoxyles ou d'esters gras ethoxyles, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
|
FR2788007B1
(fr)
|
1999-01-05 |
2001-02-09 |
Oreal |
Nanoemulsion a base de copolymeres blocs d'oxyde d'ethylene et d'oxyde de propylene, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
|
FR2788449B1
(fr)
|
1999-01-14 |
2001-02-16 |
Oreal |
Nanoemulsion a base de citrates d'alkylether, et ses utilisations dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique
|
|
FR2789076B1
(fr)
|
1999-02-02 |
2001-03-02 |
Synthelabo |
Derives de alpha-azacyclomethyl quinoleine, leur preparation et leur application en therapeutique
|
|
US7161962B1
(en)
|
1999-05-27 |
2007-01-09 |
Nuera Communications, Inc. |
Method and apparatus for coding modem signals for transmission over voice networks
|
|
FR2811564B1
(fr)
|
2000-07-13 |
2002-12-27 |
Oreal |
Nanoemulsion contenant des polymeres non ioniques, et ses utilisations notamment dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique
|
|
AU2002241823A1
(en)
|
2001-01-11 |
2002-07-24 |
Eastman Chemical Company |
Cyclodextrin sulfonates, guest inclusion complexes, methods of making the same and related materials
|
|
FR2819427B1
(fr)
|
2001-01-18 |
2003-04-11 |
Oreal |
Nanoemulsion translucide, son procede de fabrication et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
|
JP2006512401A
(ja)
|
2001-06-05 |
2006-04-13 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
ナノエマルジョンワクチン
|
|
US7476393B2
(en)
|
2002-11-29 |
2009-01-13 |
L'oreal |
Process for the preparation of a cationic nanoemulsion, and cosmetic composition
|
|
JP4448134B2
(ja)
|
2003-08-08 |
2010-04-07 |
シェーリング コーポレイション |
ベンズアミド置換基を有する環状アミンbase−1阻害剤
|
|
AR045219A1
(es)
|
2003-08-08 |
2005-10-19 |
Pharmacopeia Inc |
Aminas ciclicas inhibidoras de base - 1 que poseen un sustiuyente heterociclico
|
|
US7592348B2
(en)
|
2003-12-15 |
2009-09-22 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
|
US7763609B2
(en)
|
2003-12-15 |
2010-07-27 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
|
NZ547462A
(en)
|
2003-12-15 |
2010-06-25 |
Schering Corp |
Heterocyclic aspartyl protease inhibitors
|
|
US7468402B2
(en)
|
2004-03-17 |
2008-12-23 |
Baker Hughes Incorporated |
Polymeric nanoemulsion as drag reducer for multiphase flow
|
|
EP1743170A2
(en)
|
2004-04-02 |
2007-01-17 |
Merck & Co., Inc. |
Methods for detecting substances which bind to the amyloid precursor protein or beta amyloid fragments, and binding compounds
|
|
US7618978B2
(en)
|
2004-04-22 |
2009-11-17 |
Eli Lilly And Company |
Amides as BACE inhibitors
|
|
IL162288A0
(en)
|
2004-06-01 |
2005-11-20 |
Future Products Man S A |
Compositions and methods for treating neurodegenerative disorders
|
|
ES2321853T3
(es)
|
2004-06-16 |
2009-06-12 |
Wyeth |
Difenilimidazopiridina e -imidazol aminas como inhibidores de b-secretasa".
|
|
ES2332659T3
(es)
|
2004-06-16 |
2010-02-10 |
Wyeth |
Derivados de amino-5,5-difenilimidazolona para la inhibicion de beta-secretasa.
|
|
DE602005025363D1
(de)
|
2004-07-22 |
2011-01-27 |
Schering Corp |
Substituierte amide als inhibitoren der beta-sekretase
|
|
AR050184A1
(es)
|
2004-07-28 |
2006-10-04 |
Schering Corp |
Inhibidores macrociclicos de beta-secretasa
|
|
PE20060692A1
(es)
|
2004-09-21 |
2006-07-19 |
Lilly Co Eli |
Inhibidores bace
|
|
EP1851208A1
(en)
|
2005-01-13 |
2007-11-07 |
Novartis AG |
Macrocyclic compounds useful as bace inhibitors
|
|
GB0500683D0
(en)
|
2005-01-13 |
2005-02-23 |
Novartis Ag |
Organic compounds
|
|
US7759354B2
(en)
|
2005-06-14 |
2010-07-20 |
Schering Corporation |
Bicyclic guanidine derivatives as asparyl protease inhibitors, compositions, and uses thereof
|
|
WO2006138230A2
(en)
|
2005-06-14 |
2006-12-28 |
Schering Corporation |
The preparation and use of protease inhibitors
|
|
CA2609582A1
(en)
|
2005-06-14 |
2006-12-28 |
Schering Corporation |
Aspartyl protease inhibitors
|
|
ES2436795T3
(es)
|
2005-06-14 |
2014-01-07 |
Merck Sharp & Dohme Corp. |
Inhibidores heterocíclicos de aspartil proteasa, preparación y uso de los mismos
|
|
KR20080025079A
(ko)
|
2005-06-14 |
2008-03-19 |
쉐링 코포레이션 |
아스파르틸 프로테아제 억제제
|
|
DE602006018456D1
(de)
|
2005-06-14 |
2011-01-05 |
Schering Corp |
Herstellung und verwendung von verbindungen als aspartylproteasehemmer
|
|
CN101193892A
(zh)
|
2005-06-14 |
2008-06-04 |
先灵公司 |
大环杂环天冬氨酰基蛋白酶抑制剂
|
|
AU2006266167A1
(en)
*
|
2005-06-30 |
2007-01-11 |
Wyeth |
Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
|
|
TW200738683A
(en)
|
2005-06-30 |
2007-10-16 |
Wyeth Corp |
Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
|
|
TW200730523A
(en)
*
|
2005-07-29 |
2007-08-16 |
Wyeth Corp |
Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
|
|
WO2007038271A1
(en)
|
2005-09-26 |
2007-04-05 |
Wyeth |
Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace)
|
|
US7763606B2
(en)
|
2005-10-27 |
2010-07-27 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
|
US7560451B2
(en)
|
2005-10-31 |
2009-07-14 |
Schering Corporation |
Aspartyl protease inhibitors
|
|
WO2007058601A1
(en)
*
|
2005-11-21 |
2007-05-24 |
Astrazeneca Ab |
Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer’s disease, neurodegeneration and dementia
|
|
GB0602951D0
(en)
|
2006-02-14 |
2006-03-29 |
Novartis Ag |
Organic Compounds
|
|
CN101460480A
(zh)
|
2006-04-05 |
2009-06-17 |
阿斯利康(瑞典)有限公司 |
2-氨基嘧啶-4-酮类化合物及其用于治疗或预防Aβ相关病理的用途
|
|
GB0611064D0
(en)
|
2006-06-05 |
2006-07-12 |
Novartis Ag |
Organic compounds
|
|
EP2644600B1
(en)
|
2006-06-12 |
2017-01-11 |
Merck Sharp & Dohme Corp. |
Heterocyclic aspartyl protease inhibitors
|
|
TW200815443A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds I
|
|
TW200815447A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds IV
|
|
TW200808796A
(en)
|
2006-06-14 |
2008-02-16 |
Astrazeneca Ab |
New compounds III
|
|
TW200815449A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds II
|
|
TW200815349A
(en)
|
2006-06-22 |
2008-04-01 |
Astrazeneca Ab |
New compounds
|
|
MX2009000710A
(es)
|
2006-07-20 |
2009-01-30 |
Novartis Ag |
Compuestos macrociclicos utiles como inhibidores de bace.
|
|
CN101484431A
(zh)
|
2006-07-20 |
2009-07-15 |
诺瓦提斯公司 |
大环内酰胺
|
|
BRPI0719336A2
(pt)
|
2006-11-23 |
2014-02-04 |
Novartis Ag |
Derivados de 2-hidróxi-1,3-diaminopropano
|
|
CA2672293A1
(en)
|
2006-12-12 |
2008-06-19 |
Schering Corporation |
Aspartyl protease inhibitors
|
|
JP2010512390A
(ja)
|
2006-12-12 |
2010-04-22 |
シェーリング コーポレイション |
三環式系を含むアスパルチルプロテアーゼ阻害剤
|
|
TW200831091A
(en)
*
|
2006-12-20 |
2008-08-01 |
Astrazeneca Ab |
New compounds
|
|
EP2134342B1
(en)
|
2007-03-12 |
2013-01-30 |
Merck Sharp & Dohme Corp. |
Monocyclic anilide spirolactam cgrp receptor antagonists
|
|
CL2008000784A1
(es)
|
2007-03-20 |
2008-05-30 |
Wyeth Corp |
Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co
|
|
TW200902499A
(en)
|
2007-05-15 |
2009-01-16 |
Astrazeneca Ab |
New compounds
|
|
US20090041201A1
(en)
|
2007-08-06 |
2009-02-12 |
Carestream Health, Inc. |
Alignment apparatus for imaging system
|
|
EP2190833A1
(en)
|
2007-08-23 |
2010-06-02 |
Novartis Ag |
Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors
|
|
US20090062361A1
(en)
|
2007-08-30 |
2009-03-05 |
Allergan, Inc. |
Therapeutic hydantoins
|
|
TWI431004B
(zh)
|
2008-05-02 |
2014-03-21 |
Lilly Co Eli |
Bace抑制劑
|
|
JP2011527311A
(ja)
|
2008-07-10 |
2011-10-27 |
ノバルティス アーゲー |
Bace阻害薬として有用なアミノベンジル置換環状スルホン誘導体
|
|
EP2360155A4
(en)
|
2008-10-22 |
2012-06-20 |
Shionogi & Co |
2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT
|
|
AP2011005707A0
(en)
|
2008-11-11 |
2011-06-30 |
Cspc Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd |
Inclusion complexes of pinocembrin with cyclodextrin or its derivatives.
|
|
AR077277A1
(es)
|
2009-07-09 |
2011-08-17 |
Lilly Co Eli |
Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer
|
|
WO2011044187A1
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
UA108363C2
(uk)
|
2009-10-08 |
2015-04-27 |
|
Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
|
|
DK2605655T3
(en)
|
2010-08-19 |
2019-02-04 |
Buck Institute For Age Res |
METHODS OF TREATING SMALL COGNITIVE DISABILITY (MCI) AND RELATED DISORDERS
|
|
US20120165346A1
(en)
|
2010-12-22 |
2012-06-28 |
Astrazeneca Ab |
Compounds and their use as BACE inhibitors
|
|
US8415483B2
(en)
|
2010-12-22 |
2013-04-09 |
Astrazeneca Ab |
Compounds and their use as BACE inhibitors
|
|
US8877744B2
(en)
|
2011-04-04 |
2014-11-04 |
Hoffmann-La Roche Inc. |
1,4-Oxazepines as BACE1 and/or BACE2 inhibitors
|
|
CN104995176B
(zh)
|
2013-02-12 |
2019-02-22 |
巴克老龄化研究所 |
调节bace所介导的app加工的乙内酰脲
|
|
KR20180090778A
(ko)
*
|
2015-08-27 |
2018-08-13 |
난트뉴로, 엘엘씨 |
App-선택적 bace 억제를 위한 조성물 및 그의 용도
|