JP2010511721A5 - - Google Patents
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- Publication number
- JP2010511721A5 JP2010511721A5 JP2009540401A JP2009540401A JP2010511721A5 JP 2010511721 A5 JP2010511721 A5 JP 2010511721A5 JP 2009540401 A JP2009540401 A JP 2009540401A JP 2009540401 A JP2009540401 A JP 2009540401A JP 2010511721 A5 JP2010511721 A5 JP 2010511721A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- compound
- heteroaryl
- alkyl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87304106P | 2006-12-05 | 2006-12-05 | |
| PCT/US2007/086220 WO2008070599A1 (en) | 2006-12-05 | 2007-12-03 | Indazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010511721A JP2010511721A (ja) | 2010-04-15 |
| JP2010511721A5 true JP2010511721A5 (OSRAM) | 2011-01-27 |
Family
ID=39492604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540401A Withdrawn JP2010511721A (ja) | 2006-12-05 | 2007-12-03 | インダゾール化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7825261B2 (OSRAM) |
| EP (1) | EP2091329A4 (OSRAM) |
| JP (1) | JP2010511721A (OSRAM) |
| KR (1) | KR20090127867A (OSRAM) |
| CN (1) | CN101616587A (OSRAM) |
| AU (1) | AU2007329480A1 (OSRAM) |
| CA (1) | CA2671543A1 (OSRAM) |
| TW (1) | TWI433672B (OSRAM) |
| WO (1) | WO2008070599A1 (OSRAM) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010059658A1 (en) * | 2008-11-20 | 2010-05-27 | Glaxosmithkline Llc | Chemical compounds |
| DE102009049662A1 (de) | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
| JP5543980B2 (ja) | 2009-12-18 | 2014-07-09 | 田辺三菱製薬株式会社 | 新規抗血小板薬 |
| CA2786314A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| WO2014187744A1 (de) | 2013-05-23 | 2014-11-27 | Bayer Pharma Aktiengesellschaft | Pharmazeutische zusammensetzung und deren verwendung sowie anwendungsregime dieser pharmazeutischen zusammensetzung zur bedarfsweisen („on-demand") kontrazeption |
| JP2016523809A (ja) | 2013-07-09 | 2016-08-12 | 武田薬品工業株式会社 | 複素環化合物 |
| KR101713303B1 (ko) | 2015-12-24 | 2017-03-07 | 강원대학교산학협력단 | 2ｈ-인다졸 유도체의 제조방법 |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| CR20230030A (es) | 2018-02-27 | 2023-03-10 | Incyte Corp | Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b (divisional 2020-0441) |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| MX2020012376A (es) | 2018-05-18 | 2021-03-09 | Incyte Corp | Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b. |
| MX2021000116A (es) | 2018-07-05 | 2021-03-29 | Incyte Corp | Derivados de pirazina fusionados como inhibidores de a2a/a2b. |
| LT3860998T (lt) | 2018-10-05 | 2024-06-25 | Annapurna Bio Inc. | Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| MX2022003986A (es) * | 2019-10-01 | 2022-07-19 | Memorial Sloan Kettering Cancer Center | Inhibidores de moléculas pequeñas de proteínas id. |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| TW202241889A (zh) | 2020-12-23 | 2022-11-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| AU2022388555A1 (en) | 2021-11-09 | 2024-05-02 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU11299A (sh) * | 1996-09-04 | 2001-07-10 | Pfizer Inc. | Derivati indazola |
| AU779073B2 (en) * | 1998-12-23 | 2005-01-06 | Nps Allelix Corp. | Indole and indolizidine derivatives for the treatment of migraine |
| US7141581B2 (en) * | 1999-07-02 | 2006-11-28 | Agouron Pharmaceuticals, Inc. | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use |
| AU2002334355A1 (en) * | 2001-09-06 | 2003-03-18 | Prochon Biotech Ltd. | Protein tyrosine kinase inhibitors |
| WO2004052280A2 (en) * | 2002-12-10 | 2004-06-24 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
| WO2004089366A1 (en) * | 2003-04-10 | 2004-10-21 | Pfizer Japan, Inc. | Bicyclic compounds as nr2b receptor antagonists |
| RU2379292C2 (ru) * | 2003-04-18 | 2010-01-20 | Мемори Фармасьютиклз Корпорейшн | Производные пиразола в качестве ингибиторов фосфодиэстеразы 4 |
| EP1755394A4 (en) | 2004-04-16 | 2009-08-05 | Smithkline Beecham Corp | METHOD OF TREATING CANCER |
| JP2008516964A (ja) * | 2004-10-15 | 2008-05-22 | メモリー ファーマシューティカルス コーポレーション | ホスホジエステラーゼ４阻害剤としてのピラゾール誘導体 |
| JP2008525453A (ja) * | 2004-12-27 | 2008-07-17 | アルコン，インコーポレイティド | 緑内障と、ｒｈｏキナーゼを媒介とした他の疾患および症状を治療するためのアミノピラジン・アナログ |
| JP5116687B2 (ja) * | 2005-11-02 | 2013-01-09 | バイエル・ファルマ・アクチェンゲゼルシャフト | がんおよび他の過剰増殖性疾患の処置のためのピロロ［２，１−ｆ］［１，２，４］トリアジン−４−イルアミンＩＧＦ−１Ｒキナーゼ阻害剤 |
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2007
- 2007-12-03 KR KR1020097014013A patent/KR20090127867A/ko not_active Withdrawn
- 2007-12-03 CN CN200780045197A patent/CN101616587A/zh active Pending
- 2007-12-03 AU AU2007329480A patent/AU2007329480A1/en not_active Abandoned
- 2007-12-03 EP EP07865081A patent/EP2091329A4/en not_active Withdrawn
- 2007-12-03 JP JP2009540401A patent/JP2010511721A/ja not_active Withdrawn
- 2007-12-03 US US11/949,070 patent/US7825261B2/en not_active Expired - Fee Related
- 2007-12-03 WO PCT/US2007/086220 patent/WO2008070599A1/en not_active Ceased
- 2007-12-03 CA CA002671543A patent/CA2671543A1/en not_active Abandoned
- 2007-12-04 TW TW096146086A patent/TWI433672B/zh not_active IP Right Cessation