JP2016503065A5 - - Google Patents
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- JP2016503065A5 JP2016503065A5 JP2015549784A JP2015549784A JP2016503065A5 JP 2016503065 A5 JP2016503065 A5 JP 2016503065A5 JP 2015549784 A JP2015549784 A JP 2015549784A JP 2015549784 A JP2015549784 A JP 2015549784A JP 2016503065 A5 JP2016503065 A5 JP 2016503065A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence shown
- tau
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 146
- 235000001014 amino acid Nutrition 0.000 claims 64
- 150000001413 amino acids Chemical class 0.000 claims 64
- 239000002773 nucleotide Substances 0.000 claims 60
- 125000003729 nucleotide group Chemical group 0.000 claims 60
- 102100040243 Microtubule-associated protein tau Human genes 0.000 claims 54
- 239000012634 fragment Substances 0.000 claims 54
- 108010026424 tau Proteins Proteins 0.000 claims 54
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000018737 Parkinson disease Diseases 0.000 claims 7
- 208000034799 Tauopathies Diseases 0.000 claims 7
- 230000000626 neurodegenerative effect Effects 0.000 claims 7
- 210000002682 neurofibrillary tangle Anatomy 0.000 claims 6
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000002339 Frontotemporal Lobar Degeneration Diseases 0.000 claims 3
- 210000000349 chromosome Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 102100034452 Alternative prion protein Human genes 0.000 claims 2
- 206010059245 Angiopathy Diseases 0.000 claims 2
- 208000004434 Calcinosis Diseases 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 208000011990 Corticobasal Degeneration Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 206010018341 Gliosis Diseases 0.000 claims 2
- 208000032382 Ischaemic stroke Diseases 0.000 claims 2
- 208000005314 Multi-Infarct Dementia Diseases 0.000 claims 2
- 208000001089 Multiple system atrophy Diseases 0.000 claims 2
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 2
- 208000014060 Niemann-Pick disease Diseases 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 108091000054 Prion Proteins 0.000 claims 2
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 claims 2
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 claims 2
- 201000004810 Vascular dementia Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 230000002308 calcification Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 208000017004 dementia pugilistica Diseases 0.000 claims 2
- 206010014599 encephalitis Diseases 0.000 claims 2
- 230000007387 gliosis Effects 0.000 claims 2
- 201000008319 inclusion body myositis Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000002161 motor neuron Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000750 progressive effect Effects 0.000 claims 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 2
- 235000004400 serine Nutrition 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 230000002739 subcortical effect Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 102000043676 human tau 40 Human genes 0.000 claims 1
- 108700043385 human tau 40 Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261745410P | 2012-12-21 | 2012-12-21 | |
| US61/745,410 | 2012-12-21 | ||
| PCT/US2013/076952 WO2014100600A2 (en) | 2012-12-21 | 2013-12-20 | Human anti-tau antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503065A JP2016503065A (ja) | 2016-02-01 |
| JP2016503065A5 true JP2016503065A5 (cg-RX-API-DMAC7.html) | 2016-09-01 |
| JP6284548B2 JP6284548B2 (ja) | 2018-02-28 |
Family
ID=49920689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549784A Expired - Fee Related JP6284548B2 (ja) | 2012-12-21 | 2013-12-20 | ヒト抗タウ抗体 |
Country Status (27)
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2627672T (pt) | 2010-10-11 | 2018-11-16 | Univ Zuerich | Anticorpos anti-tau humanos |
| KR20200013072A (ko) | 2012-07-03 | 2020-02-05 | 워싱턴 유니버시티 | Tau에 대한 항체 |
| US12024568B2 (en) | 2012-09-13 | 2024-07-02 | Cornell University | Treatment of brain cancers using central nervous system mediated gene transfer of monoclonal antibodies |
| CN105121465B (zh) | 2013-03-13 | 2020-09-08 | 普罗塞纳生物科技公司 | Tau免疫疗法 |
| WO2015035190A1 (en) * | 2013-09-05 | 2015-03-12 | Cornell University | Gene therapy for alzheimer's and other neurodegenerative diseases and conditions |
| ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| AU2015279089B2 (en) * | 2014-06-26 | 2021-01-28 | Janssen Vaccines & Prevention B.V. | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| DE102014013571A1 (de) | 2014-09-18 | 2016-03-24 | Aj Roboscreen Gmbh | Monoklonaler Antikörper gegen humanes TAU-Protein |
| WO2016079597A1 (en) | 2014-11-19 | 2016-05-26 | Axon Neuroscience Se | Humanized tau antibodies in alzheimer's disease |
| EP3261670A4 (en) | 2015-02-24 | 2018-08-01 | Rpeptide, LLC | Anti-tau antibodies |
| TWI669314B (zh) | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對ｔａｕ之抗體及其用途 |
| CA3258972A1 (en) | 2015-06-05 | 2025-04-17 | Ac Immune Sa | TAU ANTIBODIES AND METHODS OF USING THEM |
| CN107849105B (zh) | 2015-07-06 | 2021-09-17 | Ucb生物制药有限责任公司 | Tau结合抗体 |
| WO2017005734A1 (en) | 2015-07-06 | 2017-01-12 | Ucb Biopharma Sprl | Tau-binding antibodies |
| WO2017157961A1 (en) | 2016-03-14 | 2017-09-21 | Biogen International Neuroscience Gmbh | Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins |
| IL262726B2 (en) * | 2016-05-02 | 2024-07-01 | Prothena Biosciences Ltd | Antibodies recognizing tau |
| FI3452507T3 (fi) | 2016-05-02 | 2022-12-15 | Tau-immuunihoito | |
| WO2017191561A1 (en) * | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| KR20190021311A (ko) | 2016-06-07 | 2019-03-05 | 바이오겐 인터내셔널 뉴로사이언스 게엠베하 | 알츠하이머병의 치료 방법 |
| US20190330318A1 (en) | 2016-07-25 | 2019-10-31 | Biogen Ma Inc. | Anti-hspa5 (grp78) antibodies and uses thereof |
| US10988529B2 (en) | 2016-08-09 | 2021-04-27 | Eli Lilly And Company | Combination therapy |
| WO2018106781A1 (en) | 2016-12-07 | 2018-06-14 | Genentech, Inc | Anti-tau antibodies and methods of use |
| JP2020511937A (ja) * | 2016-12-07 | 2020-04-23 | ジェネンテック， インコーポレイテッド | 抗ｔａｕ抗体及び使用方法 |
| EP3562840A1 (en) | 2016-12-16 | 2019-11-06 | Biogen MA Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| CN110520440A (zh) | 2017-02-17 | 2019-11-29 | 戴纳立制药公司 | 抗τ抗体及其使用方法 |
| JP2018139530A (ja) | 2017-02-27 | 2018-09-13 | 帝人ファーマ株式会社 | 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤 |
| SG11201908326YA (en) | 2017-03-28 | 2019-10-30 | Genentech Inc | Methods of treating neurodegenerative diseases |
| EP3602046A1 (en) * | 2017-03-28 | 2020-02-05 | Janssen Vaccines & Prevention B.V. | Methods for detection of tau protein aggregation modulating compounds |
| IL270375B2 (en) | 2017-05-02 | 2024-12-01 | Prothena Biosciences Ltd | Antibodies recognizing tau |
| TWI853617B (zh) | 2017-10-16 | 2024-08-21 | 日商衛材R&D企管股份有限公司 | 抗tau抗體及其用途 |
| US11629183B2 (en) | 2017-12-29 | 2023-04-18 | University Of Florida Research Foundation, Inc. | Monoclonal antibodies targeting microtubule-binding domain of tau protein and methods of detecting tau protein in vivo |
| BR112020018193A2 (pt) * | 2018-03-05 | 2021-02-02 | Janssen Pharmaceutica Nv | ensaios para detectar neurodegeneração |
| WO2019175735A1 (en) * | 2018-03-11 | 2019-09-19 | Koorosh Shahpasand | Conformation-independent antibodies against neurotoxic tau proteins |
| JP2021530552A (ja) | 2018-07-31 | 2021-11-11 | イーライ リリー アンド カンパニー | 併用療法 |
| KR20210081356A (ko) * | 2018-10-19 | 2021-07-01 | 얀센 백신스 앤드 프리벤션 비.브이. | 항-시누클레인 항체 |
| US20220089704A1 (en) | 2018-10-29 | 2022-03-24 | Biogen Ma Inc. | Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport |
| EP3877410A4 (en) * | 2018-11-08 | 2022-08-10 | Prothena Biosciences Limited | ANTIBODIES RECOGNIZING TAU PROTEIN |
| JP7291250B2 (ja) * | 2019-05-31 | 2023-06-14 | イーライ リリー アンド カンパニー | ヒトタウを標的とする化合物および方法 |
| WO2020252394A2 (en) * | 2019-06-13 | 2020-12-17 | Arizona Board Of Regents On Behalf Of Arizona State University | Targets and methods of diagnosing, monitoring and treating frontotemporal dementia |
| US20230287107A1 (en) * | 2019-07-23 | 2023-09-14 | Shanghaitech University | Asic1 channel antagonist antibody |
| CA3148740A1 (en) | 2019-08-06 | 2021-02-11 | Aprinoia Therapeutics Limited | Antibodies that bind to pathological tau species and uses thereof |
| WO2021079868A1 (ja) * | 2019-10-25 | 2021-04-29 | 東洋紡株式会社 | レーザー印字可能なフィルムおよびそれを用いた包装体 |
| CN116723856A (zh) | 2020-06-25 | 2023-09-08 | 默沙东有限责任公司 | 靶向丝氨酸413处磷酸化的tau的高亲和力抗体 |
| GB202010652D0 (en) * | 2020-07-10 | 2020-08-26 | Wista Lab Ltd | Anti-tau antibodies |
| CN117098771A (zh) * | 2020-10-26 | 2023-11-21 | 索拉生物科学有限公司 | 用于治疗阿尔茨海默病的组合物和方法 |
| WO2022132923A1 (en) * | 2020-12-16 | 2022-06-23 | Voyager Therapeutics, Inc. | Tau binding compounds |
| CL2021001380A1 (es) | 2021-05-26 | 2022-01-14 | Corporacion Centro Int De Biomedicina Icc | Generación de un nuevo anticuerpo monoclonal sitio específico para la proteína tau y su uso como herramienta en biomarcadores específicos para la detección temprana de enfermedades neurodegenerativas y patologías involucradas con la proteína tau como alzheimer y otras demencias. |
| CA3228359A1 (en) | 2021-08-27 | 2023-03-02 | Genentech, Inc. | Methods of treating tau pathologies |
| WO2023099788A1 (en) | 2021-12-03 | 2023-06-08 | Neurimmune Ag | Novel potency assay for antibody-based drugs and useful means therefor |
| WO2023178049A1 (en) | 2022-03-14 | 2023-09-21 | Genentech, Inc. | Predicting neurodegenerative diseases based on speech analyses |
| CN119404251A (zh) | 2022-06-21 | 2025-02-07 | 基因泰克公司 | 基于言语分析检测阿尔茨海默病(ad)的纵向进展 |
| JP2025535203A (ja) | 2022-09-15 | 2025-10-23 | ボイジャー セラピューティクス インコーポレイテッド | タウ結合化合物 |
| WO2025090985A1 (en) * | 2023-10-27 | 2025-05-01 | Duke University | Compositions comprising chimeric antigen receptors targeting citrullinated vimentin and methods of use thereof |
| CN117946264B (zh) * | 2024-03-21 | 2024-06-04 | 江西赛基生物技术有限公司 | 一种抗Tau蛋白单克隆抗体及其应用 |
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-
2013
- 2013-12-20 AU AU2013361107A patent/AU2013361107B2/en not_active Ceased
- 2013-12-20 SG SG10201705104UA patent/SG10201705104UA/en unknown
- 2013-12-20 LT LTEP13818637.4T patent/LT2935326T/lt unknown
- 2013-12-20 KR KR1020157019330A patent/KR102234324B1/ko active Active
- 2013-12-20 US US14/654,176 patent/US9598484B2/en not_active Expired - Fee Related
- 2013-12-20 DK DK13818637.4T patent/DK2935326T3/da active
- 2013-12-20 HR HRP20201422TT patent/HRP20201422T1/hr unknown
- 2013-12-20 EA EA201591020A patent/EA035932B1/ru unknown
- 2013-12-20 MX MX2015008024A patent/MX2015008024A/es active IP Right Grant
- 2013-12-20 SI SI201331780T patent/SI2935326T1/sl unknown
- 2013-12-20 CN CN201911004609.5A patent/CN111205368B/zh not_active Expired - Fee Related
- 2013-12-20 RS RS20201060A patent/RS60899B1/sr unknown
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2015
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2017
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2018
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2019
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2020
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