JP2013519364A5 - - Google Patents

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Publication number
JP2013519364A5
JP2013519364A5 JP2012552395A JP2012552395A JP2013519364A5 JP 2013519364 A5 JP2013519364 A5 JP 2013519364A5 JP 2012552395 A JP2012552395 A JP 2012552395A JP 2012552395 A JP2012552395 A JP 2012552395A JP 2013519364 A5 JP2013519364 A5 JP 2013519364A5
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JP
Japan
Prior art keywords
sequence
seq
polypeptide
amino acid
variable domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012552395A
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English (en)
Japanese (ja)
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JP2013519364A (ja
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Publication date
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Priority claimed from PCT/EP2011/051958 external-priority patent/WO2011098520A1/en
Publication of JP2013519364A publication Critical patent/JP2013519364A/ja
Publication of JP2013519364A5 publication Critical patent/JP2013519364A5/ja
Pending legal-status Critical Current

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JP2012552395A 2010-02-10 2011-02-10 アゴニストdr5結合ポリペプチド Pending JP2013519364A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30317310P 2010-02-10 2010-02-10
US61/303,173 2010-02-10
US30859910P 2010-02-26 2010-02-26
US61/308,599 2010-02-26
PCT/EP2011/051958 WO2011098520A1 (en) 2010-02-10 2011-02-10 Agonist dr5 binding polypeptides

Publications (2)

Publication Number Publication Date
JP2013519364A JP2013519364A (ja) 2013-05-30
JP2013519364A5 true JP2013519364A5 (cg-RX-API-DMAC7.html) 2014-03-27

Family

ID=43877025

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012552395A Pending JP2013519364A (ja) 2010-02-10 2011-02-10 アゴニストdr5結合ポリペプチド

Country Status (31)

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US (2) US9120855B2 (cg-RX-API-DMAC7.html)
EP (1) EP2534176A1 (cg-RX-API-DMAC7.html)
JP (1) JP2013519364A (cg-RX-API-DMAC7.html)
KR (1) KR20130031241A (cg-RX-API-DMAC7.html)
CN (1) CN102884083A (cg-RX-API-DMAC7.html)
AR (1) AR080158A1 (cg-RX-API-DMAC7.html)
AU (1) AU2011214355B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012019924A2 (cg-RX-API-DMAC7.html)
CA (1) CA2789251A1 (cg-RX-API-DMAC7.html)
CL (1) CL2012002217A1 (cg-RX-API-DMAC7.html)
CO (1) CO6561836A2 (cg-RX-API-DMAC7.html)
CR (1) CR20120415A (cg-RX-API-DMAC7.html)
CU (1) CU24133B1 (cg-RX-API-DMAC7.html)
EA (1) EA201201114A1 (cg-RX-API-DMAC7.html)
GE (1) GEP20146176B (cg-RX-API-DMAC7.html)
GT (1) GT201200236A (cg-RX-API-DMAC7.html)
IL (1) IL221289A0 (cg-RX-API-DMAC7.html)
MA (1) MA34053B1 (cg-RX-API-DMAC7.html)
MX (1) MX2012009328A (cg-RX-API-DMAC7.html)
MY (1) MY156337A (cg-RX-API-DMAC7.html)
NI (1) NI201200134A (cg-RX-API-DMAC7.html)
NZ (1) NZ601582A (cg-RX-API-DMAC7.html)
PE (1) PE20121703A1 (cg-RX-API-DMAC7.html)
PH (1) PH12012501613A1 (cg-RX-API-DMAC7.html)
SG (1) SG183210A1 (cg-RX-API-DMAC7.html)
TN (1) TN2012000393A1 (cg-RX-API-DMAC7.html)
TW (1) TWI480051B (cg-RX-API-DMAC7.html)
UA (1) UA106900C2 (cg-RX-API-DMAC7.html)
UY (1) UY33222A (cg-RX-API-DMAC7.html)
WO (1) WO2011098520A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201205864B (cg-RX-API-DMAC7.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5918143B2 (ja) 2010-10-29 2016-05-18 第一三共株式会社 新規抗dr5抗体
GB201118359D0 (en) 2011-10-25 2011-12-07 Univ Sheffield Pulmonary hypertension
US20150056204A1 (en) * 2012-03-28 2015-02-26 Amgen Inc. Dr5 receptor agonist combinations
DK2970473T3 (da) 2013-03-14 2017-11-27 Bristol Myers Squibb Co Kombination af dr5-agonist og anti-pd-1-antagonist og fremgangsmåder til anvendelse heraf
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
WO2015100409A2 (en) * 2013-12-26 2015-07-02 Tufts University Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein
EP3093338B1 (en) * 2014-01-10 2021-02-17 Teikyo Heisei University Recombinant anaerobic gram-positive bacteria
RU2017129236A (ru) * 2015-01-26 2019-03-07 Макродженикс, Инк. Мультивалентные молекулы, содержащие dr5-связывающие домены
CN104826121A (zh) * 2015-02-11 2015-08-12 嘉兴学院 肿瘤靶向基因递送系统及其应用
RS61062B1 (sr) 2015-07-16 2020-12-31 Inhibrx Inc Multivalentni i multispecifični dr5-vezujući fuzioni proteini
JP6869553B2 (ja) * 2015-10-30 2021-05-12 ギャラクシー バイオテック, エルエルシーGalaxy Biotech, Llc デスレセプター4及びデスレセプター5に結合する非常に強力な抗体
NO2768984T3 (cg-RX-API-DMAC7.html) 2015-11-12 2018-06-09
KR101926834B1 (ko) 2017-03-21 2018-12-07 동아에스티 주식회사 항-dr5 항체 및 그의 용도
JP2021502810A (ja) * 2017-11-13 2021-02-04 クレッシェンド、バイオロジックス、リミテッドCrescendo Biologics Limited Cd137およびpsmaに結合する分子
US20190234933A1 (en) * 2018-02-01 2019-08-01 Genadam Therapeutics, Inc. Compositions and assays
CN117285643A (zh) 2022-06-16 2023-12-26 清华大学 一种相变调节套件及其用途
EP4554677A1 (en) 2022-07-15 2025-05-21 Boehringer Ingelheim International GmbH Binding molecules for the treatment of cancer
TW202440614A (zh) 2022-12-23 2024-10-16 比利時商艾伯霖克斯公司 基於蛋白質的接合載體
CN120530143A (zh) * 2023-01-17 2025-08-22 苏州永心生物科技有限公司 Dr5结构域变体及其应用
WO2025006846A2 (en) * 2023-06-29 2025-01-02 Odyssey Therapeutics, Inc. Anti-trailr2 antigen-binding proteins and uses thereof
WO2025206402A1 (ja) * 2024-03-29 2025-10-02 株式会社沖縄Ukami養蚕 アフリカ豚熱ワクチン産生組換えエリ蚕及びその利用

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE102631T1 (de) 1988-11-11 1994-03-15 Medical Res Council Klonierung von immunglobulin sequenzen aus den variabelen domaenen.
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
CA2135408A1 (en) 1992-05-08 1993-11-25 Peter C. Keck Chimeric multivalent protein analogues and methods of use thereof
AU687010B2 (en) 1992-07-17 1998-02-19 Dana-Farber Cancer Institute Method of intracellular binding of target molecules
PT1589107E (pt) 1992-08-21 2010-03-29 Univ Bruxelles Imunoglobulinas desprovidas de cadeias leves
ATE198490T1 (de) 1993-06-09 2001-01-15 Unilever Nv Verfahren zur herstellung von fusionsproteinen, die scfv fragmente enthalten, in transformierten schimmelpilzen
US6091639A (en) 1993-08-27 2000-07-18 Kabushiki Kaisha Toshiba Non-volatile semiconductor memory device and data programming method
AU1925195A (en) 1994-02-22 1995-09-04 Dana-Farber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
EP1027073A2 (en) 1996-11-19 2000-08-16 Sangstat Medical Corporation Enhanced effects for hapten conjugated therapeutics
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
ATE461282T1 (de) 1997-10-27 2010-04-15 Bac Ip Bv Multivalente antigenbindende proteine
AU3596599A (en) 1998-01-26 1999-08-09 Unilever Plc Method for producing antibody fragments
CN1316910A (zh) 1998-02-19 2001-10-10 埃克斯西特治疗公司 用于调节淋巴细胞活化的组合物及方法
GB9824632D0 (en) 1998-11-10 1999-01-06 Celltech Therapeutics Ltd Biological compounds
ATE276359T1 (de) 1999-01-19 2004-10-15 Unilever Nv Verfahren zur herstellung von antikörperfragmenten
EP1240337B1 (en) 1999-12-24 2006-08-23 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
EP1272647B1 (en) 2000-04-11 2014-11-12 Genentech, Inc. Multivalent antibodies and uses therefor
EP1983055A1 (en) 2000-04-12 2008-10-22 Human Genome Sciences, Inc. Albumin fusion proteins
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
EP1328626B1 (en) 2000-05-26 2013-04-17 National Research Council Of Canada Single-domain brain-targeting antibody fragments derived from llama antibodies
CA2380443C (en) 2000-05-26 2013-03-12 Ginette Dubuc Single-domain antigen-binding antibody fragments derived from llama antibodies
US6741957B1 (en) 2000-07-21 2004-05-25 Daimlerchrysler Corporation Analytical tire model for vehicle durability and ride comfort analysis
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7211395B2 (en) 2001-03-09 2007-05-01 Dyax Corp. Serum albumin binding moieties
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
US20060073141A1 (en) 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
DK1399484T3 (da) 2001-06-28 2010-11-08 Domantis Ltd Dobbelt-specifik ligand og anvendelse af denne
JP2004538324A (ja) 2001-08-03 2004-12-24 メディカル リサーチ カウンシル 細胞内抗体
US7371849B2 (en) 2001-09-13 2008-05-13 Institute For Antibodies Co., Ltd. Methods of constructing camel antibody libraries
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
ES2357225T3 (es) 2001-11-01 2011-04-20 Uab Research Foundation Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos.
NZ533164A (en) 2001-11-01 2008-09-26 Uab Research Foundation Combinations of antibodies selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and other therapeutic agents
KR100599789B1 (ko) 2001-12-03 2006-07-12 삼성에스디아이 주식회사 방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법
EP1456410A2 (en) 2001-12-11 2004-09-15 AlgoNomics N.V. Method for displaying loops from immunoglobulin domains in different contexts
AU2002360068B2 (en) 2001-12-21 2009-09-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Method for cloning of variable domain sequences
CA2471645A1 (en) 2002-01-03 2003-07-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Immunoconjugates useful for treatment of tumours
EP2135879A3 (en) 2002-06-28 2010-06-23 Domantis Limited Ligand
US7004940B2 (en) 2002-10-10 2006-02-28 Ethicon, Inc. Devices for performing thermal ablation having movable ultrasound transducers
CA2505326A1 (en) 2002-11-08 2004-05-21 Ablynx N.V. Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders
AU2003286003B2 (en) 2002-11-08 2011-05-26 Ablynx N.V. Stabilized single domain antibodies
EP1576179B1 (en) 2002-11-27 2010-09-15 Irm Llc Methods and compositions for inducing apoptosis in cancer cells
GB0228210D0 (en) 2002-12-03 2003-01-08 Babraham Inst Single chain antibodies
EP1570267B1 (en) 2002-12-03 2011-10-12 UCB Pharma, S.A. Assay for identifying antibody producing cells
GB0230203D0 (en) 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
MXPA05007151A (es) 2002-12-31 2005-09-21 Nektar Therapeutics Al Corp Polimeros terminados en maleimida hidroliticamente estables.
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
DE602004017726D1 (de) 2003-06-30 2008-12-24 Domantis Ltd Pegylierte Single-domain-antikörper (dAb)
JP2007521234A (ja) 2003-08-12 2007-08-02 ウィリアム エム ヤーブロー 尋常性ざ瘡の治療薬及び使用方法
WO2005019824A1 (en) 2003-08-20 2005-03-03 Celltech R & D Limited Methods for obtaining antibodies
GB0328261D0 (en) * 2003-12-05 2004-01-07 Univ Groningen Improved cytokine design
KR20070010046A (ko) 2004-04-06 2007-01-19 제넨테크, 인크. Dr5 항체 및 그의 용도
WO2005114187A2 (en) 2004-04-23 2005-12-01 The United States Of America As Represented By Thesecretary, Department Of Health And Human Services Methods and compositions for diagnosing aids and other diseases and conditions involving immune system activation
WO2005122741A2 (en) 2004-06-21 2005-12-29 Washington University Antibodies against west nile virus and therapeutic and prophylactic uses thereof
US20060008601A1 (en) 2004-06-25 2006-01-12 Zeik Douglas B Flexible laminate having an integrated pressure release valve
ES2440990T5 (es) 2004-07-22 2022-10-25 Univ Erasmus Med Ct Rotterdam Moléculas de unión
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
WO2006040153A2 (en) 2004-10-13 2006-04-20 Ablynx N.V. Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
WO2006040154A2 (en) 2004-10-14 2006-04-20 Dublin City University Prokaryotic two hybrid system
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
CA2595682A1 (en) 2005-01-31 2006-08-03 Ablynx N.V. Method for generating variable domain sequences of heavy chain antibodies
GB2424983A (en) 2005-04-07 2006-10-11 Autoliv Dev Seatbelt pretensioner control system
DK1888641T3 (da) 2005-05-18 2012-04-23 Ablynx Nv Serumalbuminbindende proteiner
BRPI0609797B8 (pt) 2005-05-20 2021-05-25 Ablynx Nv nanocorpos melhorados para o tratamento de desordens mediadas por agregação
WO2007112940A2 (en) 2006-03-31 2007-10-11 Ablynx N.V. Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same
US20090286727A1 (en) 2006-04-14 2009-11-19 Ablynx N.V. DP-78-Like Nanobodies
US8629244B2 (en) 2006-08-18 2014-01-14 Ablynx N.V. Interleukin-6 receptor binding polypeptides
CA2663042A1 (en) 2006-09-08 2008-03-13 Ablynx N.V. Serum albumin binding proteins with long half-lives
US20100129368A9 (en) 2006-10-11 2010-05-27 Ablynx N.V. Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and uses thereof
WO2008066854A2 (en) 2006-11-28 2008-06-05 Novartis Ag Methods and compositions for inducing apoptosis in cancer cells
US20080267949A1 (en) 2006-12-05 2008-10-30 Ablynx N.V. Peptides capable of binding to serum proteins
JP5302519B2 (ja) 2007-08-03 2013-10-02 倉敷紡績株式会社 ヒトパピローマウイルスを検出するためのプライマーセット及びプローブ
WO2009030285A1 (en) 2007-09-07 2009-03-12 Ablynx N.V. Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
JP2011516603A (ja) 2008-04-17 2011-05-26 アブリンクス エン.ヴェー. 血清タンパク質と結合することが可能なペプチド、並びにこれを含む化合物、構築物及びポリペプチド

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