JP2016501876A - ステロイドの抗痙攣活性 - Google Patents

ステロイドの抗痙攣活性 Download PDF

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Publication number
JP2016501876A
JP2016501876A JP2015545458A JP2015545458A JP2016501876A JP 2016501876 A JP2016501876 A JP 2016501876A JP 2015545458 A JP2015545458 A JP 2015545458A JP 2015545458 A JP2015545458 A JP 2015545458A JP 2016501876 A JP2016501876 A JP 2016501876A
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JP
Japan
Prior art keywords
steroid
allopregnanolone
subject
seizure
neurosteroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2015545458A
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English (en)
Japanese (ja)
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JP2016501876A5 (enExample
Inventor
マイケル エイ． ロゴースキ
マイケル エイ． ロゴースキ
ドロタ ゾルコウスカ
ドロタ ゾルコウスカ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Los Angeles UCLA
Original Assignee
University of California San Diego UCSD
University of California Los Angeles UCLA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD, University of California Los Angeles UCLA filed Critical University of California San Diego UCSD
Publication of JP2016501876A publication Critical patent/JP2016501876A/ja
Publication of JP2016501876A5 publication Critical patent/JP2016501876A5/ja
Priority to JP2018131186A priority Critical patent/JP6966981B2/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015545458A 2012-11-30 2013-11-27 ステロイドの抗痙攣活性 Withdrawn JP2016501876A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018131186A JP6966981B2 (ja) 2012-11-30 2018-07-11 ステロイドの抗痙攣活性

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261732252P 2012-11-30 2012-11-30
US61/732,252 2012-11-30
PCT/US2013/072351 WO2014085668A1 (en) 2012-11-30 2013-11-27 Anticonvulsant activity of steroids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018131186A Division JP6966981B2 (ja) 2012-11-30 2018-07-11 ステロイドの抗痙攣活性

Publications (2)

Publication Number Publication Date
JP2016501876A true JP2016501876A (ja) 2016-01-21
JP2016501876A5 JP2016501876A5 (enExample) 2017-01-05

Family

ID=50828483

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2015545458A Withdrawn JP2016501876A (ja) 2012-11-30 2013-11-27 ステロイドの抗痙攣活性
JP2018131186A Active JP6966981B2 (ja) 2012-11-30 2018-07-11 ステロイドの抗痙攣活性
JP2021108255A Active JP7744166B2 (ja) 2012-11-30 2021-06-30 ステロイドの抗痙攣活性
JP2023125962A Pending JP2023133494A (ja) 2012-11-30 2023-08-02 ステロイドの抗痙攣活性

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2018131186A Active JP6966981B2 (ja) 2012-11-30 2018-07-11 ステロイドの抗痙攣活性
JP2021108255A Active JP7744166B2 (ja) 2012-11-30 2021-06-30 ステロイドの抗痙攣活性
JP2023125962A Pending JP2023133494A (ja) 2012-11-30 2023-08-02 ステロイドの抗痙攣活性

Country Status (7)

Country Link
US (6) US20150313915A1 (enExample)
EP (2) EP4335505A3 (enExample)
JP (4) JP2016501876A (enExample)
AU (4) AU2013352141B2 (enExample)
DK (1) DK2925327T3 (enExample)
ES (1) ES2973320T3 (enExample)
WO (1) WO2014085668A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023055802A (ja) * 2017-09-05 2023-04-18 イーグル ファーマスーティカルズ、インク． ダントロレンを使用して神経薬暴露を治療する方法
JP2026501665A (ja) * 2023-01-19 2026-01-16 湖南明瑞制薬股▲ふん▼有限公司 神経ステロイド誘導体及びその用途

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