JP2016501876A5 - - Google Patents
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- JP2016501876A5 JP2016501876A5 JP2015545458A JP2015545458A JP2016501876A5 JP 2016501876 A5 JP2016501876 A5 JP 2016501876A5 JP 2015545458 A JP2015545458 A JP 2015545458A JP 2015545458 A JP2015545458 A JP 2015545458A JP 2016501876 A5 JP2016501876 A5 JP 2016501876A5
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- steroid
- seizure
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- 150000003431 steroids Chemical class 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 20
- 206010010904 Convulsion Diseases 0.000 claims description 16
- AURFZBICLPNKBZ-FZCSVUEKSA-N 3beta-hydroxy-5alpha-pregnan-20-one Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-FZCSVUEKSA-N 0.000 claims description 13
- AURFZBICLPNKBZ-UHFFFAOYSA-N Pregnanolone Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 AURFZBICLPNKBZ-UHFFFAOYSA-N 0.000 claims description 13
- 206010015037 epilepsy Diseases 0.000 claims description 13
- 229920000858 Cyclodextrin Polymers 0.000 claims description 11
- 208000024891 symptom Diseases 0.000 claims description 10
- -1 alphadrone Chemical compound 0.000 claims description 8
- DUHUCHOQIDJXAT-OLVMNOGESA-N 3-hydroxy-(3-α,5-α)-Pregnane-11,20-dione Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1=O DUHUCHOQIDJXAT-OLVMNOGESA-N 0.000 claims description 6
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 6
- BWOPOAOBPJWDBF-UHFFFAOYSA-N 1,11-bis-epi-artesin Natural products C1CC2(C)C(O)CCC(C)=C2C2C1C(C)C(=O)O2 BWOPOAOBPJWDBF-UHFFFAOYSA-N 0.000 claims description 5
- USPYDUPOCUYHQL-VEVMSBRDSA-N 5beta-dihydrodeoxycorticosterone Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 USPYDUPOCUYHQL-VEVMSBRDSA-N 0.000 claims description 5
- BWOPOAOBPJWDBF-UWSPEPLBSA-N Artesin Natural products O[C@@H]([C@]1(C)CC2)CCC(C)=C1[C@@H]1[C@@H]2[C@H](C)C(=O)O1 BWOPOAOBPJWDBF-UWSPEPLBSA-N 0.000 claims description 5
- PGTVWKLGGCQMBR-FLBATMFCSA-N Ganaxolone Chemical compound C([C@@H]1CC2)[C@](C)(O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 PGTVWKLGGCQMBR-FLBATMFCSA-N 0.000 claims description 5
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims description 5
- 229950006567 ganaxolone Drugs 0.000 claims description 5
- NCGLTZSBTFVVAW-KNXRZYMVSA-N minaxolone Chemical compound C1[C@@H](N(C)C)[C@@H]2[C@@]3(C)C[C@H](OCC)[C@@H](O)C[C@@H]3CC[C@H]2[C@@H]2CC[C@H](C(C)=O)[C@]21C NCGLTZSBTFVVAW-KNXRZYMVSA-N 0.000 claims description 5
- 229960004798 minaxolone Drugs 0.000 claims description 5
- 159000000000 sodium salts Chemical class 0.000 claims description 5
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims description 5
- CYKYBWRSLLXBOW-GDYGHMJCSA-N 5-alpha-THDOC Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CC[C@H]21 CYKYBWRSLLXBOW-GDYGHMJCSA-N 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 4
- 208000005809 status epilepticus Diseases 0.000 claims description 4
- 238000007920 subcutaneous administration Methods 0.000 claims description 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 3
- 238000007918 intramuscular administration Methods 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 230000009529 traumatic brain injury Effects 0.000 claims description 3
- 208000007848 Alcoholism Diseases 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 208000001914 Fragile X syndrome Diseases 0.000 claims description 2
- 208000015439 Lysosomal storage disease Diseases 0.000 claims description 2
- 208000036572 Myoclonic epilepsy Diseases 0.000 claims description 2
- 201000009916 Postpartum depression Diseases 0.000 claims description 2
- 208000027030 Premenstrual dysphoric disease Diseases 0.000 claims description 2
- 206010071350 Seizure cluster Diseases 0.000 claims description 2
- 206010043994 Tonic convulsion Diseases 0.000 claims description 2
- 230000036506 anxiety Effects 0.000 claims description 2
- 208000028502 clonic seizure Diseases 0.000 claims description 2
- 201000009028 early myoclonic encephalopathy Diseases 0.000 claims description 2
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 2
- 239000002243 precursor Substances 0.000 claims description 2
- 208000028500 tonic seizure Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 208000014060 Niemann-Pick disease Diseases 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 22
- 239000002858 neurotransmitter agent Substances 0.000 description 3
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 2
- 108090000839 GABA-A Receptors Proteins 0.000 description 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 description 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
- 108090000590 Neurotransmitter Receptors Proteins 0.000 description 1
- 102000004108 Neurotransmitter Receptors Human genes 0.000 description 1
- 102000001584 Neurotransmitter-gated ion-channels Human genes 0.000 description 1
- 108050009804 Neurotransmitter-gated ion-channels Proteins 0.000 description 1
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 description 1
- 230000003281 allosteric effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000008587 neuronal excitability Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 108010085082 sigma receptors Proteins 0.000 description 1
- 230000005586 smoking cessation Effects 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000033556 type C1 Niemann-Pick disease Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018131186A JP6966981B2 (ja) | 2012-11-30 | 2018-07-11 | ステロイドの抗痙攣活性 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261732252P | 2012-11-30 | 2012-11-30 | |
| US61/732,252 | 2012-11-30 | ||
| PCT/US2013/072351 WO2014085668A1 (en) | 2012-11-30 | 2013-11-27 | Anticonvulsant activity of steroids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018131186A Division JP6966981B2 (ja) | 2012-11-30 | 2018-07-11 | ステロイドの抗痙攣活性 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016501876A JP2016501876A (ja) | 2016-01-21 |
| JP2016501876A5 true JP2016501876A5 (enExample) | 2017-01-05 |
Family
ID=50828483
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545458A Withdrawn JP2016501876A (ja) | 2012-11-30 | 2013-11-27 | ステロイドの抗痙攣活性 |
| JP2018131186A Active JP6966981B2 (ja) | 2012-11-30 | 2018-07-11 | ステロイドの抗痙攣活性 |
| JP2021108255A Active JP7744166B2 (ja) | 2012-11-30 | 2021-06-30 | ステロイドの抗痙攣活性 |
| JP2023125962A Pending JP2023133494A (ja) | 2012-11-30 | 2023-08-02 | ステロイドの抗痙攣活性 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018131186A Active JP6966981B2 (ja) | 2012-11-30 | 2018-07-11 | ステロイドの抗痙攣活性 |
| JP2021108255A Active JP7744166B2 (ja) | 2012-11-30 | 2021-06-30 | ステロイドの抗痙攣活性 |
| JP2023125962A Pending JP2023133494A (ja) | 2012-11-30 | 2023-08-02 | ステロイドの抗痙攣活性 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US20150313915A1 (enExample) |
| EP (2) | EP4335505A3 (enExample) |
| JP (4) | JP2016501876A (enExample) |
| AU (4) | AU2013352141B2 (enExample) |
| CA (1) | CA2892811A1 (enExample) |
| DK (1) | DK2925327T3 (enExample) |
| ES (1) | ES2973320T3 (enExample) |
| WO (1) | WO2014085668A1 (enExample) |
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| EP1959966B1 (en) | 2005-11-28 | 2020-06-03 | Marinus Pharmaceuticals, Inc. | Ganaxolone formulations and methods for the making and use thereof |
| US10478505B2 (en) | 2011-09-23 | 2019-11-19 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| CA2862076C (en) | 2012-01-23 | 2020-04-21 | Sage Therapeutics, Inc. | Neuroactive steroid formulations and methods of treating cns disorders |
| WO2014028398A2 (en) | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids |
| PL2887944T3 (pl) | 2012-08-21 | 2022-02-21 | Sage Therapeutics, Inc. | Allopregnanolon do leczenia lekoopornego stanu padaczkowego |
| JP2016501876A (ja) | 2012-11-30 | 2016-01-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ステロイドの抗痙攣活性 |
| MX362543B (es) | 2013-04-17 | 2019-01-24 | Sage Therapeutics Inc | Esteroides c21-n-pirazolilo 19-nor c3,3- disustituidos y metodos de uso de los mismos. |
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| MX2017006388A (es) * | 2014-11-18 | 2017-08-21 | Pixarbio Corp | Composiciones para tratar dolor agudo, postoperatorio o cronico y metodo y uso de las mismas. |
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2013
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- 2013-11-27 ES ES13857993T patent/ES2973320T3/es active Active
- 2013-11-27 DK DK13857993.3T patent/DK2925327T3/da active
- 2013-11-27 WO PCT/US2013/072351 patent/WO2014085668A1/en not_active Ceased
- 2013-11-27 EP EP23211768.9A patent/EP4335505A3/en active Pending
- 2013-11-27 US US14/646,886 patent/US20150313915A1/en not_active Abandoned
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2017
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