MX2021013695A - Composición farmacéutica que contiene brexanolona, ganaxolona y zuranolona y usos de esta. - Google Patents
Composición farmacéutica que contiene brexanolona, ganaxolona y zuranolona y usos de esta.Info
- Publication number
- MX2021013695A MX2021013695A MX2021013695A MX2021013695A MX2021013695A MX 2021013695 A MX2021013695 A MX 2021013695A MX 2021013695 A MX2021013695 A MX 2021013695A MX 2021013695 A MX2021013695 A MX 2021013695A MX 2021013695 A MX2021013695 A MX 2021013695A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- zuranolone
- brexanolone
- ganaxolone
- composition containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
En la presente se describe una composición farmacéutica que comprende una cantidad farmacéuticamente eficaz de un esteroide neuroactivo que es un modulador positivo de los receptores del ácido ? aminobutírico tipo A (GABAA). También se describen métodos para tratar enfermedades al usar la composición farmacéutica y procesos para producir la composición farmacéutica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962846576P | 2019-05-10 | 2019-05-10 | |
US202063018815P | 2020-05-01 | 2020-05-01 | |
PCT/US2020/032172 WO2020231837A1 (en) | 2019-05-10 | 2020-05-08 | Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021013695A true MX2021013695A (es) | 2022-01-26 |
Family
ID=73288816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021013695A MX2021013695A (es) | 2019-05-10 | 2020-05-08 | Composición farmacéutica que contiene brexanolona, ganaxolona y zuranolona y usos de esta. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220241295A1 (es) |
EP (1) | EP3965772A4 (es) |
JP (1) | JP2022532710A (es) |
KR (1) | KR20220006565A (es) |
CN (1) | CN113939299A (es) |
AU (1) | AU2020275291A1 (es) |
BR (1) | BR112021022527A2 (es) |
CA (1) | CA3138901A1 (es) |
IL (1) | IL287905A (es) |
MX (1) | MX2021013695A (es) |
SG (1) | SG11202112111WA (es) |
TW (2) | TW202344255A (es) |
WO (1) | WO2020231837A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023514873A (ja) * | 2020-02-27 | 2023-04-11 | ブリー バイオサイエンシーズ, インコーポレイテッド | 神経活性ステロイドのプロドラッグ |
TW202227092A (zh) * | 2020-08-17 | 2022-07-16 | 美商布里生物科學股份有限公司 | 含有神經活性類固醇之醫藥組合物及其用途 |
CN112516086B (zh) * | 2020-12-08 | 2022-05-20 | 武汉久安药物研究院有限公司 | 注射用布瑞诺龙脂肪乳及其制备方法 |
WO2022155507A1 (en) * | 2021-01-15 | 2022-07-21 | Jubilant Pharma Holdings Inc. | Transmucosal dosage forms of brexanolone |
US20230149425A1 (en) * | 2021-11-18 | 2023-05-18 | Brii Biosciences, Inc. | Process and therapeutic composition for treating and preventing severe injection site reactions |
US11969434B1 (en) | 2022-08-29 | 2024-04-30 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
WO2024085245A1 (ja) * | 2022-10-21 | 2024-04-25 | 国立大学法人高知大学 | 術後せん妄の抑制薬 |
CN115957332B (zh) * | 2022-11-01 | 2023-10-10 | 北京华睿鼎信科技有限公司 | 透明质酸酶稳定的布瑞诺龙纳米晶及其制备方法与应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006318349B2 (en) * | 2005-11-28 | 2010-08-19 | Marinus Pharmaceuticals | Ganaxolone formulations and methods for the making and use thereof |
AU2016214996B2 (en) * | 2015-02-06 | 2021-03-04 | Marinus Pharmaceuticals, Inc. | Intravenous ganaxolone formulations and their use in treating status epilepticus and other seizure disorders |
CA3001722A1 (en) * | 2015-10-16 | 2017-04-20 | Marinus Pharmaceuticals, Inc. | Injectable neurosteroid formulations containing nanoparticles |
KR20190137839A (ko) * | 2017-04-18 | 2019-12-11 | 마리누스 파마슈티컬스 인코포레이티드 | 지속 방출 주사용 뉴로스테로이드 제제 |
-
2020
- 2020-05-08 KR KR1020217039658A patent/KR20220006565A/ko unknown
- 2020-05-08 WO PCT/US2020/032172 patent/WO2020231837A1/en unknown
- 2020-05-08 CN CN202080042380.9A patent/CN113939299A/zh active Pending
- 2020-05-08 SG SG11202112111WA patent/SG11202112111WA/en unknown
- 2020-05-08 BR BR112021022527A patent/BR112021022527A2/pt unknown
- 2020-05-08 JP JP2021566976A patent/JP2022532710A/ja active Pending
- 2020-05-08 MX MX2021013695A patent/MX2021013695A/es unknown
- 2020-05-08 CA CA3138901A patent/CA3138901A1/en active Pending
- 2020-05-08 US US17/610,236 patent/US20220241295A1/en active Pending
- 2020-05-08 AU AU2020275291A patent/AU2020275291A1/en active Pending
- 2020-05-08 EP EP20805552.5A patent/EP3965772A4/en active Pending
- 2020-05-11 TW TW112103512A patent/TW202344255A/zh unknown
- 2020-05-11 TW TW109115629A patent/TWI793419B/zh active
-
2021
- 2021-11-08 IL IL287905A patent/IL287905A/en unknown
Also Published As
Publication number | Publication date |
---|---|
TWI793419B (zh) | 2023-02-21 |
SG11202112111WA (en) | 2021-11-29 |
AU2020275291A1 (en) | 2021-11-25 |
CA3138901A1 (en) | 2020-11-19 |
BR112021022527A2 (pt) | 2021-12-28 |
KR20220006565A (ko) | 2022-01-17 |
WO2020231837A1 (en) | 2020-11-19 |
EP3965772A4 (en) | 2023-05-10 |
CN113939299A (zh) | 2022-01-14 |
JP2022532710A (ja) | 2022-07-19 |
EP3965772A1 (en) | 2022-03-16 |
TW202108146A (zh) | 2021-03-01 |
IL287905A (en) | 2022-01-01 |
US20220241295A1 (en) | 2022-08-04 |
TW202344255A (zh) | 2023-11-16 |
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