IL287905A - Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereof - Google Patents
Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereofInfo
- Publication number
- IL287905A IL287905A IL287905A IL28790521A IL287905A IL 287905 A IL287905 A IL 287905A IL 287905 A IL287905 A IL 287905A IL 28790521 A IL28790521 A IL 28790521A IL 287905 A IL287905 A IL 287905A
- Authority
- IL
- Israel
- Prior art keywords
- zuranolone
- brexanolone
- ganaxolone
- pharmaceutical composition
- composition containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962846576P | 2019-05-10 | 2019-05-10 | |
| US202063018815P | 2020-05-01 | 2020-05-01 | |
| PCT/US2020/032172 WO2020231837A1 (en) | 2019-05-10 | 2020-05-08 | Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL287905A true IL287905A (en) | 2022-01-01 |
Family
ID=73288816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL287905A IL287905A (en) | 2019-05-10 | 2021-11-08 | Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220241295A1 (en) |
| EP (1) | EP3965772A4 (en) |
| JP (1) | JP2022532710A (en) |
| KR (1) | KR20220006565A (en) |
| CN (1) | CN113939299A (en) |
| AU (1) | AU2020275291A1 (en) |
| BR (1) | BR112021022527A2 (en) |
| CA (1) | CA3138901A1 (en) |
| IL (1) | IL287905A (en) |
| MX (1) | MX2021013695A (en) |
| SG (1) | SG11202112111WA (en) |
| TW (2) | TW202344255A (en) |
| WO (1) | WO2020231837A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230416298A1 (en) * | 2020-02-27 | 2023-12-28 | Brii Biosciences, Inc. | Prodrugs of neuroactive steroids |
| TW202227092A (en) * | 2020-08-17 | 2022-07-16 | 美商布里生物科學股份有限公司 | Pharmaceutical composition containing neuroactive steroid and use thereof |
| CN112516086B (en) * | 2020-12-08 | 2022-05-20 | 武汉久安药物研究院有限公司 | Breynolone fat emulsion for injection and preparation method thereof |
| WO2022155507A1 (en) * | 2021-01-15 | 2022-07-21 | Jubilant Pharma Holdings Inc. | Transmucosal dosage forms of brexanolone |
| CA3236407A1 (en) * | 2021-11-18 | 2023-05-25 | Zhi Hong | Process and therapeutic composition for treating and preventing severe injection site reactions |
| US11969434B1 (en) | 2022-08-29 | 2024-04-30 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
| WO2024085245A1 (en) * | 2022-10-21 | 2024-04-25 | 国立大学法人高知大学 | Post-operative delirium suppressant |
| CN115957332B (en) * | 2022-11-01 | 2023-10-10 | 北京华睿鼎信科技有限公司 | Hyaluronidase-stable breinox Long Nami crystal and preparation method and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1959966B1 (en) * | 2005-11-28 | 2020-06-03 | Marinus Pharmaceuticals, Inc. | Ganaxolone formulations and methods for the making and use thereof |
| CN107427458A (en) * | 2015-02-06 | 2017-12-01 | 马瑞纳斯制药公司 | Intravenous ganaxolone preparation and its purposes in treatment status epilepticus and other seizure disorders |
| AU2016338672A1 (en) * | 2015-10-16 | 2018-04-12 | Marinus Pharmaceuticals, Inc. | Injectable neurosteroid formulations containing nanoparticles |
| KR20190137839A (en) * | 2017-04-18 | 2019-12-11 | 마리누스 파마슈티컬스 인코포레이티드 | Neurosteroid preparations for sustained release injection |
-
2020
- 2020-05-08 KR KR1020217039658A patent/KR20220006565A/en unknown
- 2020-05-08 AU AU2020275291A patent/AU2020275291A1/en active Pending
- 2020-05-08 WO PCT/US2020/032172 patent/WO2020231837A1/en unknown
- 2020-05-08 MX MX2021013695A patent/MX2021013695A/en unknown
- 2020-05-08 US US17/610,236 patent/US20220241295A1/en active Pending
- 2020-05-08 SG SG11202112111WA patent/SG11202112111WA/en unknown
- 2020-05-08 EP EP20805552.5A patent/EP3965772A4/en active Pending
- 2020-05-08 BR BR112021022527A patent/BR112021022527A2/en unknown
- 2020-05-08 CA CA3138901A patent/CA3138901A1/en active Pending
- 2020-05-08 CN CN202080042380.9A patent/CN113939299A/en active Pending
- 2020-05-08 JP JP2021566976A patent/JP2022532710A/en active Pending
- 2020-05-11 TW TW112103512A patent/TW202344255A/en unknown
- 2020-05-11 TW TW109115629A patent/TWI793419B/en active
-
2021
- 2021-11-08 IL IL287905A patent/IL287905A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3965772A1 (en) | 2022-03-16 |
| CA3138901A1 (en) | 2020-11-19 |
| JP2022532710A (en) | 2022-07-19 |
| US20220241295A1 (en) | 2022-08-04 |
| SG11202112111WA (en) | 2021-11-29 |
| BR112021022527A2 (en) | 2021-12-28 |
| AU2020275291A1 (en) | 2021-11-25 |
| WO2020231837A1 (en) | 2020-11-19 |
| CN113939299A (en) | 2022-01-14 |
| EP3965772A4 (en) | 2023-05-10 |
| TWI793419B (en) | 2023-02-21 |
| TW202108146A (en) | 2021-03-01 |
| KR20220006565A (en) | 2022-01-17 |
| MX2021013695A (en) | 2022-01-26 |
| TW202344255A (en) | 2023-11-16 |
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