|
US4166452A
(en)
|
1976-05-03 |
1979-09-04 |
Generales Constantine D J Jr |
Apparatus for testing human responses to stimuli
|
|
US4256108A
(en)
|
1977-04-07 |
1981-03-17 |
Alza Corporation |
Microporous-semipermeable laminated osmotic system
|
|
US4265874A
(en)
|
1980-04-25 |
1981-05-05 |
Alza Corporation |
Method of delivering drug with aid of effervescent activity generated in environment of use
|
|
LU86084A1
(fr)
|
1985-09-20 |
1987-04-02 |
Faco Sa |
Apparei de massage electrique
|
|
US5102417A
(en)
|
1985-11-07 |
1992-04-07 |
Expandable Grafts Partnership |
Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
|
|
US4800882A
(en)
|
1987-03-13 |
1989-01-31 |
Cook Incorporated |
Endovascular stent and delivery system
|
|
US4886062A
(en)
|
1987-10-19 |
1989-12-12 |
Medtronic, Inc. |
Intravascular radially expandable stent and method of implant
|
|
WO1990013332A1
(en)
|
1989-05-11 |
1990-11-15 |
Cedars-Sinai Medical Center |
Stent with sustained drug delivery
|
|
WO1991012779A1
(en)
|
1990-02-28 |
1991-09-05 |
Medtronic, Inc. |
Intralumenal drug eluting prosthesis
|
|
US5429634A
(en)
|
1993-09-09 |
1995-07-04 |
Pdt Systems |
Biogenic implant for drug delivery and method
|
|
US5419760A
(en)
|
1993-01-08 |
1995-05-30 |
Pdt Systems, Inc. |
Medicament dispensing stent for prevention of restenosis of a blood vessel
|
|
US6774278B1
(en)
|
1995-06-07 |
2004-08-10 |
Cook Incorporated |
Coated implantable medical device
|
|
JPH11513382A
(ja)
|
1995-10-20 |
1999-11-16 |
ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング |
5員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
|
|
DE19539091A1
(de)
|
1995-10-20 |
1997-04-24 |
Thomae Gmbh Dr K |
5-gliedrige Heterocyclen, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zur ihrer Herstellung
|
|
US5833651A
(en)
|
1996-11-08 |
1998-11-10 |
Medtronic, Inc. |
Therapeutic intraluminal stents
|
|
US6294192B1
(en)
|
1999-02-26 |
2001-09-25 |
Lipocine, Inc. |
Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
|
|
US6756385B2
(en)
|
2000-07-31 |
2004-06-29 |
Pfizer Inc. |
Imidazole derivatives
|
|
GT200100147A
(es)
|
2000-07-31 |
2002-06-25 |
|
Derivados de imidazol
|
|
US20040043904A1
(en)
|
2000-09-22 |
2004-03-04 |
Hiroshi Yamaguchi |
N-(4-pyrazolyl) amide derivatives, chemicals for agricultural and horticultural use, and usage of the same
|
|
US7842693B2
(en)
|
2002-06-12 |
2010-11-30 |
Chemocentryx, Inc. |
Substituted piperazines
|
|
US20050256130A1
(en)
*
|
2002-06-12 |
2005-11-17 |
Chemocentryx, Inc. |
Substituted piperazines
|
|
US7589199B2
(en)
|
2002-06-12 |
2009-09-15 |
Chemocentryx, Inc. |
Substituted piperazines
|
|
US6770729B2
(en)
|
2002-09-30 |
2004-08-03 |
Medtronic Minimed, Inc. |
Polymer compositions containing bioactive agents and methods for their use
|
|
ES2350837T3
(es)
|
2003-05-01 |
2011-01-27 |
Bristol-Myers Squibb Company |
Compuestos de pirazol-amida sustituidos con arilo útiles como inhibidores de quinasas.
|
|
JP5042996B2
(ja)
|
2005-05-19 |
2012-10-03 |
ギリアード・パロ・アルト・インコーポレイテッド |
A1アデノシンレセプターアゴニスト
|
|
ZA200800309B
(en)
*
|
2005-06-22 |
2009-10-28 |
Chemocentryx Inc |
Azaindazole compounds and methods of use
|
|
US7777035B2
(en)
*
|
2005-06-22 |
2010-08-17 |
Chemocentryx, Inc. |
Azaindazole compounds and methods of use
|
|
FR2887450B1
(fr)
|
2005-06-23 |
2007-08-24 |
Rhodia Chimie Sa |
Ingredient concentre pour le traitement et/ou la modification de surfaces, et son utilisation dans des compositions cosmetiques
|
|
WO2007026834A1
(ja)
*
|
2005-09-01 |
2007-03-08 |
Kumiai Chemical Industry Co., Ltd. |
ピラゾール誘導体及び農園芸用除草剤
|
|
WO2007044885A2
(en)
|
2005-10-11 |
2007-04-19 |
Chemocentryx, Inc. |
Piperidine derivatives and methods of use
|
|
US20090252779A1
(en)
*
|
2006-06-22 |
2009-10-08 |
Chemocentryx, Inc. |
Azaindazole compounds and methods of use
|
|
JP2010505957A
(ja)
|
2006-10-10 |
2010-02-25 |
アムゲン インコーポレイティッド |
糖尿病に対して使用されるn−アリールピラゾール化合物
|
|
WO2008072724A1
(ja)
*
|
2006-12-14 |
2008-06-19 |
Taisho Pharmaceutical Co., Ltd. |
ピラゾール誘導体
|
|
US7786157B2
(en)
*
|
2007-03-16 |
2010-08-31 |
Chemocentryx, Inc. |
OXO-imidazolidines as modulators of chemokine receptors
|
|
NZ581405A
(en)
*
|
2007-05-22 |
2011-06-30 |
Chemocentryx Inc |
3-(Imidazolyl)-pyrazolo[3,4-b]pyridines and their use in treating CCR1-mediated disorders
|
|
KR101586617B1
(ko)
|
2007-06-18 |
2016-01-20 |
머크 샤프 앤 도메 비.브이. |
사람 프로그램된 사멸 수용체 pd-1에 대한 항체
|
|
CN101801362B
(zh)
|
2007-06-22 |
2014-01-22 |
海德拉生物科学公司 |
用于治疗病症的方法和组合物
|
|
MX2010005225A
(es)
*
|
2007-11-13 |
2010-05-27 |
Taisho Pharmaceutical Co Ltd |
Derivados de fenilpirazol.
|
|
US8168757B2
(en)
|
2008-03-12 |
2012-05-01 |
Merck Sharp & Dohme Corp. |
PD-1 binding proteins
|
|
WO2009137338A1
(en)
|
2008-05-06 |
2009-11-12 |
Boehringer Ingelheim International Gmbh |
Pyrazole compounds as ccr1 antagonists
|
|
WO2009140519A1
(en)
|
2008-05-14 |
2009-11-19 |
Hydra Biosciences, Inc. |
Compounds and compositions for treating chemical warfare agent-induced injuries
|
|
MX2011002636A
(es)
*
|
2008-09-11 |
2011-04-05 |
Chemocentryx Inc |
4-amino-3-(imidazoil)-pirazolo[3,4-d]pirimidinas.
|
|
PL2342226T3
(pl)
|
2008-09-26 |
2017-01-31 |
Dana-Farber Cancer Institute, Inc. |
Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania
|
|
JP2012508238A
(ja)
|
2008-11-07 |
2012-04-05 |
ハー・ルンドベック・アクチエゼルスカベット |
生物活性を有するアミド
|
|
EP3192811A1
(en)
|
2009-02-09 |
2017-07-19 |
Université d'Aix-Marseille |
Pd-1 antibodies and pd-l1 antibodies and uses thereof
|
|
GB0915892D0
(en)
|
2009-09-10 |
2009-10-14 |
Smithkline Beecham Corp |
Compounds
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
US9096642B2
(en)
|
2011-06-08 |
2015-08-04 |
Aurigene Discovery Technologies Limited |
Therapeutic compounds for immunomodulation
|
|
US9624298B2
(en)
|
2011-11-28 |
2017-04-18 |
Merck Patent Gmbh |
Anti-PD-L1 antibodies and uses thereof
|
|
CN104159911A
(zh)
|
2012-03-07 |
2014-11-19 |
奥瑞基尼探索技术有限公司 |
作为免疫调节剂的模拟肽化合物
|
|
EP2831108A1
(en)
|
2012-03-29 |
2015-02-04 |
Aurigene Discovery Technologies Limited |
Immunomodulating cyclic compounds from the bc loop of human pd1
|
|
AU2013263076B2
(en)
|
2012-05-15 |
2017-08-31 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
JP6312659B2
(ja)
|
2012-05-31 |
2018-04-18 |
ジェネンテック, インコーポレイテッド |
Pd−1系結合アンタゴニスト及びvegfアンタゴニストを用いた癌の治療方法
|
|
US9682143B2
(en)
|
2012-08-14 |
2017-06-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
|
US20140164267A1
(en)
|
2012-12-07 |
2014-06-12 |
Optionality Holdings Inc. |
Compliance service
|
|
AU2013355054B2
(en)
|
2012-12-07 |
2017-08-24 |
Chemocentryx, Inc. |
Diazole lactams
|
|
US9169248B2
(en)
|
2012-12-21 |
2015-10-27 |
Chemocentryx, Inc. |
Diazole amides
|
|
US9308236B2
(en)
|
2013-03-15 |
2016-04-12 |
Bristol-Myers Squibb Company |
Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
|
|
TWI888366B
(zh)
|
2013-07-16 |
2025-07-01 |
美商建南德克公司 |
利用pd-1軸結合拮抗劑及tigit抑制劑治療癌症之方法
|
|
US9827309B2
(en)
|
2013-08-20 |
2017-11-28 |
Merck Sharp & Dohme Corp. |
Treating cancer with a combination of a PD-1 antagonist and dinaciclib
|
|
ES2642074T3
(es)
|
2013-09-04 |
2017-11-15 |
Bristol-Myers Squibb Company |
Compuestos útiles como inmunomoduladores
|
|
ES2683356T3
(es)
|
2013-09-06 |
2018-09-26 |
Aurigene Discovery Technologies Limited |
Compuestos peptidomiméticos cíclicos como inmunomoduladores
|
|
CN105814028B
(zh)
|
2013-09-06 |
2018-02-16 |
奥瑞基尼探索技术有限公司 |
作为免疫调节剂的1,2,4‑*二唑衍生物
|
|
EP3385257A1
(en)
|
2013-09-06 |
2018-10-10 |
Aurigene Discovery Technologies Limited |
1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
|
|
WO2015036927A1
(en)
|
2013-09-10 |
2015-03-19 |
Aurigene Discovery Technologies Limited |
Immunomodulating peptidomimetic derivatives
|
|
WO2015044900A1
(en)
|
2013-09-27 |
2015-04-02 |
Aurigene Discovery Technologies Limited |
Therapeutic immunomodulating compounds
|
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗pd-l1之人類抗體
|
|
US9850225B2
(en)
|
2014-04-14 |
2017-12-26 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
DK3149045T3
(da)
|
2014-05-27 |
2023-03-06 |
Academia Sinica |
Sammensætninger og fremgangsmåder vedrørende universelle glycoformer til forbedret antistofeffekt
|
|
TN2017000084A1
(en)
|
2014-09-11 |
2018-07-04 |
Bristol Myers Squibb Co |
Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions
|
|
US9732119B2
(en)
|
2014-10-10 |
2017-08-15 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9856292B2
(en)
|
2014-11-14 |
2018-01-02 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9861680B2
(en)
|
2014-12-18 |
2018-01-09 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9944678B2
(en)
|
2014-12-19 |
2018-04-17 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US20160222060A1
(en)
|
2015-02-04 |
2016-08-04 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
WO2016142835A1
(en)
|
2015-03-10 |
2016-09-15 |
Aurigene Discovery Technologies Limited |
Therapeutic cyclic compounds as immunomodulators
|
|
JP2018507894A
(ja)
|
2015-03-10 |
2018-03-22 |
オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited |
免疫調節剤としての3−置換−1,2,4−オキサジアゾールおよびチアジアゾール化合物
|
|
AU2016230767A1
(en)
|
2015-03-10 |
2017-09-07 |
Aurigene Discovery Technologies Limited |
3-substituted 1,3,4-oxadiazole and thiadiazole compounds as immunomodulators
|
|
KR102894264B1
(ko)
|
2015-03-10 |
2025-12-02 |
오리진 온콜로지 리미티드 |
면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물
|
|
JP2018507885A
(ja)
|
2015-03-10 |
2018-03-22 |
オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited |
免疫調節剤としての1,3,4−オキサジアゾールおよびチアジアゾール化合物
|
|
US9809625B2
(en)
|
2015-03-18 |
2017-11-07 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
IL261998B2
(en)
|
2016-04-07 |
2023-03-01 |
Chemocentryx Inc |
Reducing your burden by giving ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors
|