JP2016047845A5 - - Google Patents
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- JP2016047845A5 JP2016047845A5 JP2015247222A JP2015247222A JP2016047845A5 JP 2016047845 A5 JP2016047845 A5 JP 2016047845A5 JP 2015247222 A JP2015247222 A JP 2015247222A JP 2015247222 A JP2015247222 A JP 2015247222A JP 2016047845 A5 JP2016047845 A5 JP 2016047845A5
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- 210000004027 cell Anatomy 0.000 claims description 59
- 150000007523 nucleic acids Chemical group 0.000 claims description 43
- 102100038449 Claudin-6 Human genes 0.000 claims description 41
- 101000882898 Homo sapiens Claudin-6 Proteins 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 18
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 8
- 102000036639 antigens Human genes 0.000 claims description 8
- 108091007433 antigens Proteins 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 25
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 16
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 16
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 16
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 16
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 16
- 239000013604 expression vector Substances 0.000 claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 241000238631 Hexapoda Species 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
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- 210000004698 lymphocyte Anatomy 0.000 claims 2
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- 101100370002 Mus musculus Tnfsf14 gene Proteins 0.000 claims 1
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- 238000012258 culturing Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000008488 polyadenylation Effects 0.000 claims 1
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- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
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- 206010004146 Basal cell carcinoma Diseases 0.000 description 2
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- 206010008342 Cervix carcinoma Diseases 0.000 description 2
- 102100038423 Claudin-3 Human genes 0.000 description 2
- 102100038447 Claudin-4 Human genes 0.000 description 2
- 208000019487 Clear cell papillary renal cell carcinoma Diseases 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 208000032320 Germ cell tumor of testis Diseases 0.000 description 2
- 101000882908 Homo sapiens Claudin-3 Proteins 0.000 description 2
- 101000882890 Homo sapiens Claudin-4 Proteins 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061328 Ovarian epithelial cancer Diseases 0.000 description 2
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- 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 description 2
- 208000033133 Testicular seminomatous germ cell tumor Diseases 0.000 description 2
- 206010057644 Testis cancer Diseases 0.000 description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
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- 201000001441 melanoma Diseases 0.000 description 2
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- 208000013371 ovarian adenocarcinoma Diseases 0.000 description 2
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- 208000001608 teratocarcinoma Diseases 0.000 description 2
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- 208000024662 testicular seminoma Diseases 0.000 description 2
- 208000004238 testicular teratoma Diseases 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 206010044412 transitional cell carcinoma Diseases 0.000 description 2
- 201000005112 urinary bladder cancer Diseases 0.000 description 2
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- 208000006332 Choriocarcinoma Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
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- 210000004252 chorionic villi Anatomy 0.000 description 1
- 230000005757 colony formation Effects 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
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- 239000003053 toxin Substances 0.000 description 1
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- 210000004881 tumor cell Anatomy 0.000 description 1
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26020209P | 2009-11-11 | 2009-11-11 | |
| EP09014136A EP2322555A1 (en) | 2009-11-11 | 2009-11-11 | Antibodies specific for claudin 6 (CLDN6) |
| US61/260,202 | 2009-11-11 | ||
| EP09014136.7 | 2009-11-11 | ||
| US36161810P | 2010-07-06 | 2010-07-06 | |
| EP10006956.6 | 2010-07-06 | ||
| US61/361,618 | 2010-07-06 | ||
| EP10006956 | 2010-07-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538239A Division JP5889196B2 (ja) | 2009-11-11 | 2010-11-11 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017075017A Division JP6502992B2 (ja) | 2009-11-11 | 2017-04-05 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016047845A JP2016047845A (ja) | 2016-04-07 |
| JP2016047845A5 true JP2016047845A5 (cg-RX-API-DMAC7.html) | 2016-06-23 |
| JP6125604B2 JP6125604B2 (ja) | 2017-05-10 |
Family
ID=43480734
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538239A Active JP5889196B2 (ja) | 2009-11-11 | 2010-11-11 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
| JP2015247222A Active JP6125604B2 (ja) | 2009-11-11 | 2015-12-18 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
| JP2017075017A Active JP6502992B2 (ja) | 2009-11-11 | 2017-04-05 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538239A Active JP5889196B2 (ja) | 2009-11-11 | 2010-11-11 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017075017A Active JP6502992B2 (ja) | 2009-11-11 | 2017-04-05 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Country Status (29)
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6358588A (ja) * | 1986-08-29 | 1988-03-14 | Toshiba Corp | バ−コ−ド読取装置 |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| US12492253B1 (en) * | 2008-02-25 | 2025-12-09 | Xencor, Inc. | Anti-human C5 antibodies |
| JP5808254B2 (ja) | 2009-02-20 | 2015-11-10 | ガニメド ファーマシューティカルズ アーゲー | 癌の診断および治療のための方法および組成物 |
| LT2499161T (lt) | 2009-11-11 | 2017-11-27 | Ganymed Pharmaceuticals Gmbh | Specifiniai antikūnai, skirti klaudinui 6 (cldn6) |
| EP2404936A1 (en) | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| ES2693232T3 (es) | 2010-11-30 | 2018-12-10 | Chugai Seiyaku Kabushiki Kaisha | Agente terapéutico que induce citotoxicidad |
| DK2707390T3 (en) * | 2011-05-13 | 2016-02-29 | Ganymed Pharmaceuticals Ag | ANTIBODIES TO TREAT CANCER EXPRESSING CLAUDIN 6 |
| TR201821021T4 (tr) * | 2011-05-13 | 2019-01-21 | Ganymed Pharmaceuticals Gmbh | Kanser tedavi̇si̇ne yöneli̇k claudin 6 ekspresyonlu anti̇korlar. |
| CN103320381B (zh) * | 2012-03-23 | 2015-04-15 | 上海市儿童医院 | 一种多能干细胞表面标志物及其用途 |
| ES2992753T3 (en) | 2012-08-24 | 2024-12-17 | Univ California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
| EP3766903A3 (en) * | 2012-11-13 | 2021-02-17 | BioNTech SE | Bispecific anti claudin xcd3 antibodies for treatment of claudin expressing cancer diseases |
| NZ707831A (en) * | 2012-11-13 | 2018-11-30 | Astellas Pharma Inc | Agents for treatment of claudin expressing cancer diseases |
| WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| EP3738611B1 (en) * | 2013-07-31 | 2025-09-03 | BioNTech SE | Diagnosis and therapy of cancer involving cancer stem cells |
| BR112016010169A2 (pt) * | 2013-11-06 | 2017-12-05 | Stemcentrx Inc | anticorpos anticlaudina e métodos de uso |
| KR102551410B1 (ko) | 2013-11-11 | 2023-07-04 | 추가이 세이야쿠 가부시키가이샤 | 개변된 항체 가변영역을 포함하는 항원 결합 분자 |
| CA2942459C (en) * | 2014-04-01 | 2023-03-07 | Biontech Cell & Gene Therapies Gmbh | Claudin-6-specific immunoreceptors and t cell epitopes |
| MA40921A (fr) * | 2014-11-05 | 2017-09-12 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation |
| US11154615B2 (en) | 2014-11-11 | 2021-10-26 | Chugai Seiyaku Kabushiki Kaisha | Library of antigen-binding molecules including modified antibody variable region |
| KR20240113990A (ko) | 2016-06-27 | 2024-07-23 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 암 치료 조합 |
| JP6900051B2 (ja) * | 2016-12-07 | 2021-07-07 | 国立大学法人大阪大学 | Ｃｌａｕｄｉｎ ５抗体、及びその抗体を含有する医薬 |
| WO2018207638A1 (ja) * | 2017-05-08 | 2018-11-15 | 国立大学法人大阪大学 | 抗ｃｌｄｎ－５抗体、及びその抗体を含有する医薬 |
| WO2019048040A1 (en) * | 2017-09-06 | 2019-03-14 | Ganymed Pharmaceuticals Gmbh | ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER |
| IL273471B2 (en) | 2017-09-29 | 2023-09-01 | Daiichi Sankyo Co Ltd | Conjugation of an antibody with a pyrrolobenzodiazepine derivative |
| JP7357616B2 (ja) | 2017-12-05 | 2023-10-06 | 中外製薬株式会社 | Ｃｄ３およびｃｄ１３７に結合する改変された抗体可変領域を含む抗原結合分子 |
| WO2019135404A1 (en) * | 2018-01-05 | 2019-07-11 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| US12493039B2 (en) * | 2018-10-09 | 2025-12-09 | Fukushima Medical University | Biomarker for predicting the prognosis for an endometrial cancer patient |
| SG11202108281UA (en) * | 2019-02-15 | 2021-08-30 | Integral Molecular Inc | Claudin 6 antibodies and uses thereof |
| JP7682798B2 (ja) | 2019-03-20 | 2025-05-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | クローディン６抗体及び薬物複合体 |
| TWI856078B (zh) | 2019-03-25 | 2024-09-21 | 日商第一三共股份有限公司 | 抗體–吡咯并苯二氮呯衍生物結合物、其製造方法及其用途 |
| US20230057904A1 (en) * | 2019-07-10 | 2023-02-23 | Chugai Seiyaku Kabushiki Kaisha | Claudin-6 binding molecules and uses thereof |
| CN111087465B (zh) * | 2019-12-24 | 2020-12-08 | 广州医科大学 | 一种针对密蛋白6的抗体偶联药物及应用 |
| IL296478A (en) | 2020-03-31 | 2022-11-01 | Chugai Pharmaceutical Co Ltd | Claudin-6-targeted multispecific antigen-binding molecules and uses thereof |
| US20240150455A1 (en) * | 2021-03-05 | 2024-05-09 | Shanghai GenBase Biotechnology Co., Ltd. | Anti-cldn6 antibody and use thereof |
| CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| WO2023053282A1 (ja) | 2021-09-29 | 2023-04-06 | 中外製薬株式会社 | がんの治療に用いるための細胞傷害誘導治療剤 |
| KR20250046264A (ko) * | 2022-07-29 | 2025-04-02 | 레전드 바이오테크 아일랜드 리미티드 | 클라우딘6 겹합 모이어티 및 이의 용도 |
| TW202434302A (zh) | 2022-10-31 | 2024-09-01 | 日商安斯泰來製藥股份有限公司 | 包含類鐸受體７／８雙重促效劑化合物之抗體藥物複合體 |
| CN120282987A (zh) | 2022-11-30 | 2025-07-08 | 因特格尔莫来库乐有限公司 | 包括双特异性型式的针对紧密连接蛋白6的抗体 |
| CN116064622B (zh) * | 2023-02-13 | 2023-10-13 | 优睿赛思(武汉)生物科技有限公司 | Claudin6-mCherry报告基因CHO-K1稳转细胞株制备及应用 |
| WO2024235175A1 (zh) | 2023-05-12 | 2024-11-21 | 智泽童康(广州)生物科技有限公司 | 抗cldn6抗体及其用途 |
| US12403202B2 (en) | 2023-05-25 | 2025-09-02 | The Regents Of The University Of California | Dosage of claudin-6 conjugates for cancer treatment |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| CN119320451B (zh) * | 2024-08-21 | 2025-05-16 | 百吉生物医药(广州)股份有限公司 | 一种紧密连接蛋白抗体d03及其应用 |
| CN118754987B (zh) * | 2024-08-21 | 2025-02-11 | 广州百吉生物制药有限公司 | 一种紧密连接蛋白抗体h04及其应用 |
| CN119371534B (zh) * | 2024-08-21 | 2025-05-27 | 百吉生物医药(广州)股份有限公司 | 一种紧密连接蛋白抗体e02及其应用 |
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