JP2015536157A5 - - Google Patents
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- Publication number
- JP2015536157A5 JP2015536157A5 JP2015545996A JP2015545996A JP2015536157A5 JP 2015536157 A5 JP2015536157 A5 JP 2015536157A5 JP 2015545996 A JP2015545996 A JP 2015545996A JP 2015545996 A JP2015545996 A JP 2015545996A JP 2015536157 A5 JP2015536157 A5 JP 2015536157A5
- Authority
- JP
- Japan
- Prior art keywords
- mogroside
- cyp
- recombinant host
- host cell
- cucurbitadienol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261733220P | 2012-12-04 | 2012-12-04 | |
| US61/733,220 | 2012-12-04 | ||
| PCT/EP2013/075510 WO2014086842A1 (en) | 2012-12-04 | 2013-12-04 | Methods and materials for biosynthesis of mogroside compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015536157A JP2015536157A (ja) | 2015-12-21 |
| JP2015536157A5 true JP2015536157A5 (enExample) | 2017-01-19 |
Family
ID=49709683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545996A Pending JP2015536157A (ja) | 2012-12-04 | 2013-12-04 | モグロシド化合物の生合成のための方法および材料 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9932619B2 (enExample) |
| EP (1) | EP2929043A1 (enExample) |
| JP (1) | JP2015536157A (enExample) |
| AU (3) | AU2015200486A1 (enExample) |
| BR (1) | BR112015013129A2 (enExample) |
| CA (1) | CA2893462A1 (enExample) |
| HK (1) | HK1215053A1 (enExample) |
| MX (1) | MX367859B (enExample) |
| SG (2) | SG10201704575XA (enExample) |
| WO (1) | WO2014086842A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2783009B1 (en) | 2011-11-23 | 2016-04-13 | Evolva SA | Methods and materials for enzymatic synthesis of mogroside compounds |
| EP2929043A1 (en) | 2012-12-04 | 2015-10-14 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
| IL287789B2 (en) | 2014-09-11 | 2024-05-01 | The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo | Mogroside compounds, methods for their preparation, preparations including them and their uses |
| CN107466320B (zh) | 2014-10-01 | 2021-11-05 | 埃沃尔瓦公司 | 用于生物合成罗汉果苷化合物的方法和材料 |
| EP3208342A4 (en) | 2014-10-17 | 2018-07-04 | Suntory Holdings Limited | Mogrol glycosyltransferase and gene encoding same |
| CN104988167A (zh) * | 2014-11-21 | 2015-10-21 | 中国科学院天津工业生物技术研究所 | 罗汉果葫芦二烯醇合成酶基因SgCbQ及其应用 |
| CN105801658B (zh) * | 2014-12-30 | 2019-03-19 | 北京农学院 | 甜甙及其类似物的制备及作为stat3、erk信号通路靶位点药物在抗肿瘤中的应用 |
| CN106350564A (zh) * | 2015-07-20 | 2017-01-25 | 中国科学院天津工业生物技术研究所 | 罗汉果醇合成途径中萜类化合物及其糖基化产物的合成方法 |
| JP6949838B2 (ja) | 2015-10-29 | 2021-10-13 | フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | 高甘味度甘味料 |
| CN105713060A (zh) * | 2016-01-29 | 2016-06-29 | 滁州润海甜叶菊高科有限公司 | 一种罗汉果中提取糖分工艺 |
| CN105713061A (zh) * | 2016-03-03 | 2016-06-29 | 湖南绿蔓生物科技股份有限公司 | 一种罗汉果苷v含量≥95％的罗汉果提取物的制备方法 |
| CN105777837A (zh) * | 2016-05-06 | 2016-07-20 | 深圳以诺生物制药有限公司 | 一种新型罗汉果醇衍生物单体 |
| EP3458598A1 (en) * | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| JP6605179B2 (ja) * | 2017-03-01 | 2019-11-13 | 桂林莱菌生物科技股▲ふん▼有限公司 | ラカンカ懸濁細胞中のモグロシドｖ含有量を高める方法 |
| CN111108213B (zh) * | 2017-05-03 | 2024-12-13 | 弗门尼舍公司 | 制备高强度甜味剂的方法 |
| CA3064334A1 (en) | 2017-06-02 | 2018-12-06 | Givaudan Sa | Compositions |
| EP3638804A1 (en) | 2017-06-15 | 2020-04-22 | Evolva SA | Production of mogroside compounds in recombinant hosts |
| CN109385377A (zh) * | 2017-08-04 | 2019-02-26 | 中国科学院天津工业生物技术研究所 | 用于生产葫芦二烯醇的工程菌及其制备方法与应用 |
| US12351849B2 (en) * | 2018-02-27 | 2025-07-08 | Manus Bio Inc. | Microbial production of triterpenoids including mogrosides |
| JP6814182B2 (ja) * | 2018-09-10 | 2021-01-13 | アナリティコン ディスカバリー ゲーエムベーハー | 甘味料または甘味増強剤として使用される新規なトリペルテングリコシド |
| CN109679987A (zh) * | 2018-09-27 | 2019-04-26 | 怀化兴科创生物技术有限公司 | 一个提高甜甙含量相关基因的应用 |
| US12338476B2 (en) | 2018-11-07 | 2025-06-24 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| CN113286523A (zh) | 2018-11-07 | 2021-08-20 | 弗门尼舍公司 | 制备高强度甜味剂的方法 |
| CA3118924A1 (en) | 2018-11-09 | 2020-05-14 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN110066785B (zh) * | 2019-01-30 | 2021-01-26 | 中国医学科学院药用植物研究所 | 一种罗汉果葫芦二烯醇合酶突变体及其构建方法和应用 |
| CN113646321B (zh) * | 2019-02-26 | 2026-04-21 | 可口可乐公司 | 罗汉果苷及其用途 |
| BR112021026302A2 (pt) * | 2019-06-25 | 2022-03-03 | Univ California | Método para fazer um triterpeno oxidado a partir de beta-amirina, e, célula microbiana engenheirada para fazer um triterpeno oxidado |
| CN112194568B (zh) * | 2019-07-08 | 2023-04-14 | 福建中医药大学 | 一种长链三萜类化合物及其制备方法和用途 |
| CN110283224B (zh) * | 2019-07-16 | 2020-08-28 | 湖南华诚生物资源股份有限公司 | 一种罗汉果甜苷v的半合成方法 |
| US12480146B2 (en) | 2019-12-16 | 2025-11-25 | Manus Bio Inc. | Microbial production of mogrol and mogrosides |
| CN120230785A (zh) * | 2020-03-17 | 2025-07-01 | 可口可乐公司 | 新的罗汉果苷生产系统和方法 |
| CA3179775A1 (en) | 2020-04-20 | 2021-10-28 | Givaudan Sa | Compositions |
| GB202007984D0 (en) | 2020-05-28 | 2020-07-15 | Givaudan Sa | Compositions |
| CN112903835B (zh) * | 2021-01-12 | 2022-08-12 | 广州泽力医药科技有限公司 | 罗汉果橘红固体饮料的指纹图谱构建方法及检测方法 |
| US20240218403A1 (en) * | 2021-04-02 | 2024-07-04 | Ginkgo Bioworks, Inc. | Biosynthesis of isoprenoids and precursors thereof |
| EP4314272A1 (en) * | 2021-04-02 | 2024-02-07 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| EP4314316A2 (en) | 2021-06-29 | 2024-02-07 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| WO2023278226A1 (en) * | 2021-06-29 | 2023-01-05 | Firmenich Incorporated | Mogroside compounds and their comestible use |
| CN113755355A (zh) * | 2021-09-30 | 2021-12-07 | 河北维达康生物科技有限公司 | 一种以葡萄糖为底物生物合成罗汉果醇的工程菌株、构建及其应用 |
| JP7873511B2 (ja) * | 2022-03-31 | 2026-06-12 | 国立台湾大学 | トリテルペノイド化合物の調製方法 |
| CN114854722B (zh) * | 2022-05-11 | 2024-01-09 | 成都普睿法药物研发有限公司 | 一种季也蒙念珠菌外切β-1,3-葡聚糖酶及其突变体及应用 |
| CN115896136B (zh) * | 2022-12-22 | 2025-12-16 | 云南农业大学 | 与葫芦二烯醇羟化相关的细胞色素p450基因及其编码产物 |
| EP4698673A1 (en) | 2023-04-20 | 2026-02-25 | DSM IP Assets B.V. | Strains and methods for the production of mogrosides |
| WO2025144785A2 (en) | 2023-12-28 | 2025-07-03 | Dsm Ip Assets B.V. | Cells and methods for the production of glycosylated compounds |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399321B1 (en) | 1999-08-18 | 2002-06-04 | National Research Council Of Canada | Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT |
| EP1510573A1 (en) | 2003-09-01 | 2005-03-02 | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung | Method for detoxification of mycotoxins |
| US7569389B2 (en) * | 2004-09-30 | 2009-08-04 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| EP2096177A3 (en) * | 2004-12-17 | 2010-01-13 | Metanomics GmbH | Process for the production of lutein |
| WO2006092449A2 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| US8257948B1 (en) | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8956677B2 (en) | 2005-11-23 | 2015-02-17 | The Coca-Cola Company | High-potency sweetener composition with glucosamine and compositions sweetened therewith |
| RU2425590C2 (ru) | 2005-11-23 | 2011-08-10 | Дзе Кока-Кола Компани | Интенсивный подсластитель для гидратации и подслащенная гидратирующая композиция |
| US7927851B2 (en) * | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| WO2008062165A2 (en) | 2006-11-22 | 2008-05-29 | The University Of York | Monoterpenoid modifying enzymes |
| US20100132073A1 (en) | 2006-12-01 | 2010-05-27 | The University Of York | Sesquiterpenoid modifying enzymes |
| EP2594645A3 (en) * | 2007-09-21 | 2013-11-06 | BASF Plant Science GmbH | Plants with increased yield |
| GB0904639D0 (en) | 2009-03-18 | 2009-04-29 | Univ York | Assay |
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| EP2783009B1 (en) | 2011-11-23 | 2016-04-13 | Evolva SA | Methods and materials for enzymatic synthesis of mogroside compounds |
| EP2929043A1 (en) | 2012-12-04 | 2015-10-14 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
-
2013
- 2013-12-04 EP EP13799312.7A patent/EP2929043A1/en active Pending
- 2013-12-04 MX MX2015007039A patent/MX367859B/es active IP Right Grant
- 2013-12-04 US US14/442,694 patent/US9932619B2/en active Active
- 2013-12-04 JP JP2015545996A patent/JP2015536157A/ja active Pending
- 2013-12-04 SG SG10201704575XA patent/SG10201704575XA/en unknown
- 2013-12-04 SG SG11201503757RA patent/SG11201503757RA/en unknown
- 2013-12-04 CA CA2893462A patent/CA2893462A1/en active Pending
- 2013-12-04 BR BR112015013129A patent/BR112015013129A2/pt not_active Application Discontinuation
- 2013-12-04 WO PCT/EP2013/075510 patent/WO2014086842A1/en not_active Ceased
- 2013-12-04 HK HK16102919.6A patent/HK1215053A1/zh unknown
-
2014
- 2014-10-01 US US14/504,109 patent/US10011859B2/en active Active
-
2015
- 2015-02-02 AU AU2015200486A patent/AU2015200486A1/en not_active Abandoned
-
2018
- 2018-02-20 US US15/900,557 patent/US10662458B2/en active Active
- 2018-05-08 US US15/974,429 patent/US10465222B2/en active Active
-
2019
- 2019-10-16 AU AU2019250137A patent/AU2019250137B2/en active Active
-
2022
- 2022-06-23 AU AU2022204430A patent/AU2022204430A1/en not_active Abandoned
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