JP2015533810A5 - - Google Patents
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- JP2015533810A5 JP2015533810A5 JP2015533142A JP2015533142A JP2015533810A5 JP 2015533810 A5 JP2015533810 A5 JP 2015533810A5 JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015533810 A5 JP2015533810 A5 JP 2015533810A5
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- JP
- Japan
- Prior art keywords
- compound
- salt
- formula
- methoxy
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(*)C(*)NS(*)(=O)=O Chemical compound *C(*)C(*)NS(*)(=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703368P | 2012-09-20 | 2012-09-20 | |
| US61/703,368 | 2012-09-20 | ||
| PCT/US2013/060294 WO2014047110A2 (en) | 2012-09-20 | 2013-09-18 | Substituted alkyl diaryl derivatives, methods of preparation and uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533810A JP2015533810A (ja) | 2015-11-26 |
| JP2015533810A5 true JP2015533810A5 (https=) | 2016-11-04 |
| JP6348904B2 JP6348904B2 (ja) | 2018-06-27 |
Family
ID=50342061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533142A Active JP6348904B2 (ja) | 2012-09-20 | 2013-09-18 | 置換アルキルジアリール誘導体、その製造方法及び使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10207989B2 (https=) |
| EP (1) | EP2897599B1 (https=) |
| JP (1) | JP6348904B2 (https=) |
| KR (1) | KR101992929B1 (https=) |
| CN (2) | CN104812382A (https=) |
| AU (1) | AU2013318206B2 (https=) |
| CA (1) | CA2885217C (https=) |
| ES (1) | ES2863538T3 (https=) |
| IL (1) | IL237699B (https=) |
| WO (1) | WO2014047110A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| ES2608474T3 (es) | 2010-04-22 | 2017-04-11 | Vertex Pharmaceuticals Incorporated | Proceso de producción de compuestos indol cycloalkylcarboxamido |
| ES2885181T3 (es) | 2014-04-15 | 2021-12-13 | Vertex Pharma | Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística |
| US9840482B2 (en) | 2014-04-19 | 2017-12-12 | Sunshine Lake Pharma Co., Ltd. | Sulfonamide derivatives and pharmaceutical applications thereof |
| CN107405318A (zh) * | 2014-12-16 | 2017-11-28 | 格卢科克斯生物科技有限公司 | 用于治疗与nadph氧化酶相关的病况的化合物 |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| NZ770757A (en) | 2018-05-09 | 2026-03-27 | Glucox Biotech Ab | Novel sulfonamide derivatives having selective nox inhibiting activity |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| AU2021212395B2 (en) | 2020-01-31 | 2026-04-23 | Resmed Sensor Technologies Limited | Sleep status detection for apnea-hypopnea index calculation |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3000377A1 (de) | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| GB8311678D0 (en) * | 1983-04-28 | 1983-06-02 | Ici Plc | Phenol derivatives |
| US5070099A (en) * | 1988-10-31 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use |
| JP3660395B2 (ja) | 1995-06-22 | 2005-06-15 | 大鵬薬品工業株式会社 | フェニルスルホン誘導体及びその製造方法 |
| GB9717576D0 (en) | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
| AU741042B2 (en) | 1997-10-03 | 2001-11-22 | Temple University - Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| US6548553B2 (en) | 1997-10-03 | 2003-04-15 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| US6201154B1 (en) | 1999-03-31 | 2001-03-13 | Temple University-Of The Commonwealth Of Higher Education | Z-styryl sulfone anticancer agents |
| US6762207B1 (en) | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
| AU778825B2 (en) | 1999-06-16 | 2004-12-23 | Temple University - Of The Commonwealth System Of Higher Education | (Z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors |
| US6767926B1 (en) | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| US6486210B2 (en) | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
| US6541475B2 (en) | 2000-04-14 | 2003-04-01 | Temple University - Of The Commonwealth System Of Higher Education | α, β-unsaturated sulfones for treating proliferative disorders |
| WO2002028828A1 (en) | 2000-10-05 | 2002-04-11 | Temple University - Of The Commonwealth System Of Higher Education | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
| JP2004521126A (ja) | 2001-02-27 | 2004-07-15 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | （ｚ）−スチリルベンジルスルホン及びそれらの医薬としての使用 |
| AU2002305942B2 (en) | 2001-02-28 | 2006-10-26 | Onconova Therapeutics, Inc. | Method for protecting cells and tissues from ionizing radiation toxicity with Alpha, Beta unsaturated aryl sulfones |
| US6646009B2 (en) | 2001-02-28 | 2003-11-11 | Temple University — Of Commonwealth System of Higher Education | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
| EP1534284B1 (en) | 2002-02-28 | 2011-07-27 | Temple University - Of The Commonwealth System of Higher Education | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
| WO2003072062A2 (en) | 2002-02-28 | 2003-09-04 | Temple University-Of The Commonwealth System Of Higher Education | Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
| US7482488B2 (en) | 2002-08-29 | 2009-01-27 | Temple University - Of The Commonwealth System Of Higher Education | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
| AU2003282726B2 (en) | 2002-10-03 | 2010-10-07 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| JP5196787B2 (ja) | 2003-11-14 | 2013-05-15 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 増殖性疾患を治療するためのα，β−不飽和スルホキシド |
| KR101274524B1 (ko) | 2004-03-16 | 2013-06-19 | 온코노바 테라퓨틱스, 인코포레이티드 | 증식성 질병 치료용 치환 페녹시- 및 페닐티오- 유도체 |
| MXPA06014230A (es) | 2004-06-08 | 2007-02-14 | Univ Temple | Heteroarilsulfonas y sulfonamidas y usos terapeuticos de las mismas. |
| EP1773310B9 (en) | 2004-06-24 | 2012-04-25 | Temple University - Of The Commonwealth System of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
| US20090306207A1 (en) | 2005-01-05 | 2009-12-10 | Reddy M V Ramana | Treatment of Drug-Resistant Proliferative Disorders |
| AU2006216544B2 (en) * | 2005-02-25 | 2012-04-05 | Onconova Therapeutics, Inc. | Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis |
| WO2006104668A2 (en) | 2005-03-11 | 2006-10-05 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
| US7691858B2 (en) | 2006-04-25 | 2010-04-06 | Targegen, Inc. | Kinase inhibitors and methods of use thereof |
| JP5278968B2 (ja) | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| CL2007003591A1 (es) | 2006-12-12 | 2008-02-29 | Wyeth Corp | Compuestos derivados de sulfonamida ciclicos, inhibidores de retoma de monoamina; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de disfuncion sexual, trastorno gastrointestinal, trastorno genitourinari |
| CL2007003874A1 (es) | 2007-01-03 | 2008-05-16 | Boehringer Ingelheim Int | Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio |
| US8124605B2 (en) * | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009126551A2 (en) * | 2008-04-10 | 2009-10-15 | The Uab Research Foundation | Bis-aromatic anticancer agents |
| US8071807B2 (en) * | 2008-07-03 | 2011-12-06 | Panmira Pharmaceuticals, Llc | Antagonists of prostaglandin D2 receptors |
| EP2226329B1 (en) | 2009-03-02 | 2013-07-10 | Ruhr-Universität Bochum | Metal-containing platensimycin analogues |
| GB0908293D0 (en) | 2009-05-14 | 2009-06-24 | Syngenta Ltd | Herbicidal compounds |
-
2013
- 2013-09-18 KR KR1020157010016A patent/KR101992929B1/ko active Active
- 2013-09-18 CA CA2885217A patent/CA2885217C/en active Active
- 2013-09-18 CN CN201380056016.8A patent/CN104812382A/zh active Pending
- 2013-09-18 EP EP13839254.3A patent/EP2897599B1/en not_active Not-in-force
- 2013-09-18 ES ES13839254T patent/ES2863538T3/es active Active
- 2013-09-18 US US14/429,223 patent/US10207989B2/en active Active
- 2013-09-18 WO PCT/US2013/060294 patent/WO2014047110A2/en not_active Ceased
- 2013-09-18 JP JP2015533142A patent/JP6348904B2/ja active Active
- 2013-09-18 AU AU2013318206A patent/AU2013318206B2/en active Active
- 2013-09-18 CN CN201910975554.6A patent/CN110776447A/zh active Pending
-
2015
- 2015-03-12 IL IL237699A patent/IL237699B/en active IP Right Grant
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