JP2015533810A5 - - Google Patents

Download PDF

Info

Publication number
JP2015533810A5
JP2015533810A5 JP2015533142A JP2015533142A JP2015533810A5 JP 2015533810 A5 JP2015533810 A5 JP 2015533810A5 JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015533810 A5 JP2015533810 A5 JP 2015533810A5
Authority
JP
Japan
Prior art keywords
compound
salt
formula
methoxy
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015533142A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015533810A (ja
JP6348904B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/060294 external-priority patent/WO2014047110A2/en
Publication of JP2015533810A publication Critical patent/JP2015533810A/ja
Publication of JP2015533810A5 publication Critical patent/JP2015533810A5/ja
Application granted granted Critical
Publication of JP6348904B2 publication Critical patent/JP6348904B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015533142A 2012-09-20 2013-09-18 置換アルキルジアリール誘導体、その製造方法及び使用 Active JP6348904B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261703368P 2012-09-20 2012-09-20
US61/703,368 2012-09-20
PCT/US2013/060294 WO2014047110A2 (en) 2012-09-20 2013-09-18 Substituted alkyl diaryl derivatives, methods of preparation and uses

Publications (3)

Publication Number Publication Date
JP2015533810A JP2015533810A (ja) 2015-11-26
JP2015533810A5 true JP2015533810A5 (https=) 2016-11-04
JP6348904B2 JP6348904B2 (ja) 2018-06-27

Family

ID=50342061

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015533142A Active JP6348904B2 (ja) 2012-09-20 2013-09-18 置換アルキルジアリール誘導体、その製造方法及び使用

Country Status (10)

Country Link
US (1) US10207989B2 (https=)
EP (1) EP2897599B1 (https=)
JP (1) JP6348904B2 (https=)
KR (1) KR101992929B1 (https=)
CN (2) CN104812382A (https=)
AU (1) AU2013318206B2 (https=)
CA (1) CA2885217C (https=)
ES (1) ES2863538T3 (https=)
IL (1) IL237699B (https=)
WO (1) WO2014047110A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX353408B (es) 2010-04-22 2018-01-11 Vertex Pharma Proceso para producir compuestos de cicloalquilcarboxamido-indol.
RU2744460C2 (ru) 2014-04-15 2021-03-09 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости
WO2015158313A1 (en) 2014-04-19 2015-10-22 Sunshine Lake Pharma Co., Ltd. Sulfonamide derivatives and pharmaceutical applications thereof
EP3233072A1 (en) * 2014-12-16 2017-10-25 Glucox Biotech AB Compounds for use in the treatment of conditions associated with nadph oxidase
US10383831B2 (en) 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
CA3099093A1 (en) 2018-05-09 2019-11-14 Glucox Biotech Ab Novel sulfonamide derivatives having selective nox inhibiting activity
CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
WO2021152551A1 (en) 2020-01-31 2021-08-05 Resmed Sensor Technologies Limited Sleep status detection for apnea-hypopnea index calculation
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3000377A1 (de) 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
GB8311678D0 (en) * 1983-04-28 1983-06-02 Ici Plc Phenol derivatives
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
JP3660395B2 (ja) 1995-06-22 2005-06-15 大鵬薬品工業株式会社 フェニルスルホン誘導体及びその製造方法
GB9717576D0 (en) 1997-08-19 1997-10-22 Xenova Ltd Pharmaceutical compounds
CN1163480C (zh) 1997-10-03 2004-08-25 坦普尔大学 苯乙烯砜抗癌剂
US6548553B2 (en) 1997-10-03 2003-04-15 Temple University-Of The Commonwealth System Of Higher Education Styryl sulfone anticancer agents
US6201154B1 (en) 1999-03-31 2001-03-13 Temple University-Of The Commonwealth Of Higher Education Z-styryl sulfone anticancer agents
US6762207B1 (en) 1999-04-02 2004-07-13 Temple University - Of The Commonwealth System Of Higher Education (E)-styryl sulfone anticancer agents
EP1191929A4 (en) 1999-06-16 2005-02-16 Univ Temple (Z) -STYRYL ACETOXYPHENYL SULFIDES AS INHIBITORS OF CYCLO-OXYGENASE
US6767926B1 (en) 1999-10-12 2004-07-27 Temple University - Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US6486210B2 (en) 2000-04-14 2002-11-26 Temple University—Of the Commonwealth System of Higher Education Substituted styryl benzylsulfones for treating proliferative disorders
US6541475B2 (en) 2000-04-14 2003-04-01 Temple University - Of The Commonwealth System Of Higher Education α, β-unsaturated sulfones for treating proliferative disorders
AU2001296677A1 (en) 2000-10-05 2002-04-15 Temple University - Of The Commonwealth System Of Higher Education Substituted (e)-styryl benzylsulfones for treating proliferative disorders
JP2004521126A (ja) 2001-02-27 2004-07-15 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション （ｚ）−スチリルベンジルスルホン及びそれらの医薬としての使用
WO2002069892A2 (en) 2001-02-28 2002-09-12 Temple University Of The Commonwealth System Of Higher Education METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES
AU2002306604B2 (en) 2001-02-28 2007-09-13 Onconova Therapeutics, Inc. N-(Aryl)-2-arylethenesulfonamides and therapeutic uses thereof
EP1534284B1 (en) 2002-02-28 2011-07-27 Temple University - Of The Commonwealth System of Higher Education Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
NZ535232A (en) 2002-02-28 2007-05-31 Univ Temple Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
AU2003298567B9 (en) 2002-08-29 2009-07-23 Temple University - Of The Commonwealth System Of Higher Education Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
KR20120032574A (ko) 2002-10-03 2012-04-05 탈자진 인코포레이티드 혈관항상성 유지제 및 그의 사용 방법
WO2005046599A2 (en) 2003-11-14 2005-05-26 Temple University - Of The Commonwealth System Of Higher Education Alpha, beta-unsaturated sulfoxides for treating proliferative disorders
NZ549962A (en) 2004-03-16 2010-04-30 Univ Temple Substituted phenoxy-and phenylthio-derivatives for treating proliferative disorders
US8143428B2 (en) 2004-06-08 2012-03-27 Temple University-Of The Commonwealth System Of Higher Education Heteroaryl sulfones and sulfonamides and therapeutic uses thereof
US8058313B2 (en) 2004-06-24 2011-11-15 Temple University—Of the Commonwealth System of Higher Education Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof
JP5156389B2 (ja) 2005-01-05 2013-03-06 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 薬剤耐性増殖性疾患の治療剤
EP1896401B1 (en) * 2005-02-25 2013-04-10 Temple University - Of The Commonwealth System of Higher Education Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
WO2006104668A2 (en) 2005-03-11 2006-10-05 Temple University - Of The Commonwealth System Of Higher Education Composition and methods for the treatment of proliferative diseases
US7691858B2 (en) 2006-04-25 2010-04-06 Targegen, Inc. Kinase inhibitors and methods of use thereof
JP5278968B2 (ja) 2006-08-30 2013-09-04 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法
CL2007003591A1 (es) 2006-12-12 2008-02-29 Wyeth Corp Compuestos derivados de sulfonamida ciclicos, inhibidores de retoma de monoamina; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de disfuncion sexual, trastorno gastrointestinal, trastorno genitourinari
CL2007003874A1 (es) 2007-01-03 2008-05-16 Boehringer Ingelheim Int Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio
US8124605B2 (en) * 2007-07-06 2012-02-28 Kinex Pharmaceuticals, Llc Compositions and methods for modulating a kinase cascade
CA2709784A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009126551A2 (en) * 2008-04-10 2009-10-15 The Uab Research Foundation Bis-aromatic anticancer agents
EP2307362A4 (en) 2008-07-03 2012-05-09 Panmira Pharmaceuticals Llc ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
EP2226329B1 (en) 2009-03-02 2013-07-10 Ruhr-Universität Bochum Metal-containing platensimycin analogues
GB0908293D0 (en) 2009-05-14 2009-06-24 Syngenta Ltd Herbicidal compounds

Similar Documents

Publication Publication Date Title
JP2015533810A5 (https=)
RU2477723C2 (ru) Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
JP2014508811A5 (https=)
CN105906617B (zh) Hec1活性调节剂及其方法
JP2008523069A5 (https=)
CO5580820A2 (es) Derivados novedosos de acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico procesos para su preparacion y composiciones farmaceuticas que los contienen
AR089134A1 (es) Arilos y heteroarilos biciclicos inhibidores de los canales de sodio
JP6635562B2 (ja) アルキニルピリジンプロリルヒドロキシラーゼ阻害剤、及びその製造法及び医薬用途
HRP20120202T1 (hr) AMIDOFENOKSIINDAZOLI, KORISNI KAO INHIBITORI c-MET
JP2016534134A5 (https=)
RU2015107550A (ru) Новые фенилпиридин/пиразинамиды для лечения рака
RU2015107803A (ru) Производные дигидроксипиримидинкарбоновой кислоты и их применение в лечении, облегчении или предотвращении вирусного заболевания
JP2007515465A5 (https=)
JP2016500661A5 (https=)
JP2017535559A5 (https=)
HRP20171517T1 (hr) 1-hidroksibenzooksaboroli kao antiparazitska sredstva
PT1658263E (pt) Novos compostos de aminobenzofenona
AR114886A1 (es) Proceso para preparar ácido 2-[[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino]acético
RU2016151420A (ru) Новое терапевтическое применение производных бензилиденгуанидина для лечения протеинопатий
RU2019115059A (ru) Модуляторы ror-гамма
JP2013508384A5 (https=)
RU2008149936A (ru) (2r)-2-[(4-сульфонил)аминофенил]пропанамиды и содержащие их фармацевтические композиции
RU2019128534A (ru) Химические соединения для лечения туберкулеза
AR076516A1 (es) Derivados de oxa-azaespiro[3.3]heptan-6-ilo, metodo e intermediarios para su preparacion, composiciones farmaceuticas que los comprenden y su uso en el tratamiento de enfermedades mediadas por el receptor mch1.
JP2007518798A5 (https=)