JP2015531376A5 - - Google Patents
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- Publication number
- JP2015531376A5 JP2015531376A5 JP2015534652A JP2015534652A JP2015531376A5 JP 2015531376 A5 JP2015531376 A5 JP 2015531376A5 JP 2015534652 A JP2015534652 A JP 2015534652A JP 2015534652 A JP2015534652 A JP 2015534652A JP 2015531376 A5 JP2015531376 A5 JP 2015531376A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ether
- amine
- aryl
- thioether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MSRNTUGCBABLOL-RTORTDFLSA-N CC(C1O)C(C(C=C2C3(C)CC[C@]4(C)C2(C)CCC(C)(CC2)C4C[C@]2(C)C(O)=O)SCCC(O)=O)=C3C=C1O Chemical compound CC(C1O)C(C(C=C2C3(C)CC[C@]4(C)C2(C)CCC(C)(CC2)C4C[C@]2(C)C(O)=O)SCCC(O)=O)=C3C=C1O MSRNTUGCBABLOL-RTORTDFLSA-N 0.000 description 1
- HFQYCOVCSAAXGR-SZVMNPOISA-N CC(C1O)C(C(C=C2C3(C)CC[C@]4(C)[C@]2(C)CCC(C)(CC2)[C@H]4C[C@]2(C)C(C2)C2O)SCCN)=C3C=C1O Chemical compound CC(C1O)C(C(C=C2C3(C)CC[C@]4(C)[C@]2(C)CCC(C)(CC2)[C@H]4C[C@]2(C)C(C2)C2O)SCCN)=C3C=C1O HFQYCOVCSAAXGR-SZVMNPOISA-N 0.000 description 1
- FNDCGTSZMYUGAF-FVTMPYKVSA-N CC(CCC1(C)CC2)(C[C@H]1[C@](C)(CCC13C)C2(C)C1=CC=C(C(C)=C1O)C3=CC1=O)C(O)O Chemical compound CC(CCC1(C)CC2)(C[C@H]1[C@](C)(CCC13C)C2(C)C1=CC=C(C(C)=C1O)C3=CC1=O)C(O)O FNDCGTSZMYUGAF-FVTMPYKVSA-N 0.000 description 1
- WZPJRIBAQKAUTP-YYJBQZGJSA-N C[C@@](CC[C@](C)(C1)C(O)=O)(CC2)[C@@H]1[C@](C)(CCC1(C)c(c3c4C)cc(O)c4O)[C@@]2(C)C1=CC3SCCO Chemical compound C[C@@](CC[C@](C)(C1)C(O)=O)(CC2)[C@@H]1[C@](C)(CCC1(C)c(c3c4C)cc(O)c4O)[C@@]2(C)C1=CC3SCCO WZPJRIBAQKAUTP-YYJBQZGJSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706153P | 2012-09-27 | 2012-09-27 | |
| US61/706,153 | 2012-09-27 | ||
| PCT/US2013/061911 WO2014052583A1 (en) | 2012-09-27 | 2013-09-26 | Compounds for the treatment of obesity and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019021437A Division JP6743211B2 (ja) | 2012-09-27 | 2019-02-08 | 肥満の処置のための化合物およびそれの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531376A JP2015531376A (ja) | 2015-11-02 |
| JP2015531376A5 true JP2015531376A5 (OSRAM) | 2016-11-10 |
| JP6480864B2 JP6480864B2 (ja) | 2019-03-13 |
Family
ID=49304418
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534652A Active JP6480864B2 (ja) | 2012-09-27 | 2013-09-26 | 肥満の処置のための化合物およびそれの使用方法 |
| JP2019021437A Active JP6743211B2 (ja) | 2012-09-27 | 2019-02-08 | 肥満の処置のための化合物およびそれの使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019021437A Active JP6743211B2 (ja) | 2012-09-27 | 2019-02-08 | 肥満の処置のための化合物およびそれの使用方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US9968575B2 (OSRAM) |
| EP (3) | EP3434268B1 (OSRAM) |
| JP (2) | JP6480864B2 (OSRAM) |
| CN (3) | CN111529535A (OSRAM) |
| AU (3) | AU2013323528B2 (OSRAM) |
| BR (1) | BR112015006848A2 (OSRAM) |
| CA (2) | CA3030272C (OSRAM) |
| CY (1) | CY1121166T1 (OSRAM) |
| DK (1) | DK2900230T3 (OSRAM) |
| ES (1) | ES2696626T3 (OSRAM) |
| HR (1) | HRP20181879T1 (OSRAM) |
| HU (1) | HUE040496T2 (OSRAM) |
| LT (1) | LT2900230T (OSRAM) |
| PL (1) | PL2900230T3 (OSRAM) |
| PT (1) | PT2900230T (OSRAM) |
| RS (1) | RS58010B1 (OSRAM) |
| RU (2) | RU2768868C2 (OSRAM) |
| SI (1) | SI2900230T1 (OSRAM) |
| SM (1) | SMT201800604T1 (OSRAM) |
| TR (1) | TR201815668T4 (OSRAM) |
| WO (1) | WO2014052583A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3434268B1 (en) * | 2012-09-27 | 2022-04-20 | The Children's Medical Center Corporation | Compounds for the treatment of obesity and methods of use thereof |
| CN117357538A (zh) * | 2014-03-26 | 2024-01-09 | 儿童医学中心公司 | 用于治疗肥胖症的雷公藤红素和衍生物 |
| WO2015153933A1 (en) * | 2014-04-03 | 2015-10-08 | The Children's Medical Center Corporation | Hsp90 inhibitors for the treatment of obesity and methods of use thereof |
| CN105985401B (zh) * | 2015-02-16 | 2020-10-09 | 上海华拓医药科技发展有限公司 | 一种雷公藤红素衍生物、其制备方法及用途 |
| US10662218B2 (en) * | 2015-10-23 | 2020-05-26 | Erx Pharmaceuticals, Inc. | Analogs of celastrol |
| CN106905404B (zh) * | 2017-01-13 | 2019-08-27 | 广东工业大学 | 熊果酸衍生物及其制备方法和应用 |
| CN116509842B (zh) * | 2021-09-09 | 2024-09-20 | 厦门君德医药科技有限公司 | 药物组合物及其制备方法和应用 |
| KR102470686B1 (ko) * | 2022-06-07 | 2022-11-23 | 서울대학교산학협력단 | 디메틸제일아스테럴을 포함하는 대사성 질환 예방 또는 치료용 약학 조성물 |
| CN119431489A (zh) * | 2024-11-13 | 2025-02-14 | 肇源县总医院 | 一种雷公藤红素衍生物及其制备方法 |
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| ZA791659B (en) | 1978-04-17 | 1980-04-30 | Ici Ltd | Process and apparatus for spraying liquid |
| GB8504253D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
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| US6429290B1 (en) | 1994-08-17 | 2002-08-06 | The Rockefeller University | OB polypeptides, modified forms and derivatives |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US6001968A (en) | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
| US6350730B1 (en) | 1994-08-17 | 2002-02-26 | The Rockefeller University | OB polypeptides and modified forms as modulators of body weight |
| US5827734A (en) | 1995-01-20 | 1998-10-27 | University Of Washington | Materials and methods for determining ob protein in a biological sample |
| US5552523A (en) | 1995-01-31 | 1996-09-03 | Eli Lilly And Company | Anti-obesity proteins |
| US5532336A (en) | 1995-01-31 | 1996-07-02 | Eli Lilly And Company | Anti-obesity proteins |
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| US5650167A (en) * | 1995-11-16 | 1997-07-22 | Dawa Incorporated | Method and composition for treating hepatitis B |
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| BR9711513A (pt) | 1996-09-20 | 1999-08-24 | Hoechst Ag | Uso de antagonistas de leptina para o tratamento de resistencia a insulina em diabete do tipo ii |
| EP0839525B1 (en) | 1996-10-31 | 2004-08-04 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US5880116A (en) * | 1996-12-13 | 1999-03-09 | Neurocal International | Use of celastrol to treat alzheimer's disease |
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| KR20150010793A (ko) | 2012-05-25 | 2015-01-28 | 버그 엘엘씨 | 열 충격 단백질 (hsp) 90-베타의 조절에 의한 대사 증후군의 치료 방법들 |
| EP3434268B1 (en) * | 2012-09-27 | 2022-04-20 | The Children's Medical Center Corporation | Compounds for the treatment of obesity and methods of use thereof |
| CN103524592B (zh) | 2013-09-27 | 2015-08-05 | 安徽医科大学 | 一种雷公藤红素衍生物、该衍生物的生物盐及其制备方法与用途 |
| US9601471B2 (en) | 2015-04-23 | 2017-03-21 | Apple Inc. | Three layer stack structure |
-
2013
- 2013-09-26 EP EP18181547.3A patent/EP3434268B1/en active Active
- 2013-09-26 RS RS20181365A patent/RS58010B1/sr unknown
- 2013-09-26 AU AU2013323528A patent/AU2013323528B2/en active Active
- 2013-09-26 PL PL13773562T patent/PL2900230T3/pl unknown
- 2013-09-26 HU HUE13773562A patent/HUE040496T2/hu unknown
- 2013-09-26 SM SM20180604T patent/SMT201800604T1/it unknown
- 2013-09-26 EP EP22168909.4A patent/EP4082541A1/en active Pending
- 2013-09-26 ES ES13773562T patent/ES2696626T3/es active Active
- 2013-09-26 US US14/431,412 patent/US9968575B2/en active Active
- 2013-09-26 CN CN202010540739.7A patent/CN111529535A/zh active Pending
- 2013-09-26 CN CN202010540726.XA patent/CN111529534A/zh active Pending
- 2013-09-26 CA CA3030272A patent/CA3030272C/en active Active
- 2013-09-26 WO PCT/US2013/061911 patent/WO2014052583A1/en not_active Ceased
- 2013-09-26 TR TR2018/15668T patent/TR201815668T4/tr unknown
- 2013-09-26 CA CA2886393A patent/CA2886393C/en active Active
- 2013-09-26 EP EP13773562.7A patent/EP2900230B1/en active Active
- 2013-09-26 DK DK13773562.7T patent/DK2900230T3/en active
- 2013-09-26 BR BR112015006848A patent/BR112015006848A2/pt not_active Application Discontinuation
- 2013-09-26 RU RU2018112067A patent/RU2768868C2/ru active
- 2013-09-26 RU RU2015115696A patent/RU2650646C2/ru active
- 2013-09-26 JP JP2015534652A patent/JP6480864B2/ja active Active
- 2013-09-26 SI SI201331170T patent/SI2900230T1/sl unknown
- 2013-09-26 LT LTEP13773562.7T patent/LT2900230T/lt unknown
- 2013-09-26 PT PT13773562T patent/PT2900230T/pt unknown
- 2013-09-26 CN CN201380061929.9A patent/CN104822374A/zh active Pending
- 2013-09-26 HR HRP20181879TT patent/HRP20181879T1/hr unknown
-
2016
- 2016-10-21 AU AU2016247206A patent/AU2016247206B2/en active Active
-
2017
- 2017-07-07 US US15/644,247 patent/US9925161B2/en active Active
-
2018
- 2018-02-28 US US15/908,571 patent/US10653654B2/en active Active
- 2018-11-01 AU AU2018256619A patent/AU2018256619B2/en not_active Ceased
- 2018-11-08 CY CY20181101181T patent/CY1121166T1/el unknown
-
2019
- 2019-02-08 JP JP2019021437A patent/JP6743211B2/ja active Active
-
2020
- 2020-04-28 US US16/860,232 patent/US11045439B2/en active Active
-
2021
- 2021-05-21 US US17/326,944 patent/US12064408B2/en active Active
-
2024
- 2024-07-09 US US18/767,788 patent/US20250161252A1/en active Pending
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