DK2900230T3 - RELATIONSHIPS FOR TREATING ADIPOSITAS AND PROCEDURES FOR USING THEREOF - Google Patents

RELATIONSHIPS FOR TREATING ADIPOSITAS AND PROCEDURES FOR USING THEREOF Download PDF

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Publication number
DK2900230T3
DK2900230T3 DK13773562.7T DK13773562T DK2900230T3 DK 2900230 T3 DK2900230 T3 DK 2900230T3 DK 13773562 T DK13773562 T DK 13773562T DK 2900230 T3 DK2900230 T3 DK 2900230T3
Authority
DK
Denmark
Prior art keywords
celastrol
mice
obese
leptin
day
Prior art date
Application number
DK13773562.7T
Other languages
Danish (da)
English (en)
Inventor
Umut Ozcan
Joseph Majzoub
Ralph Mazitschek
Isin Cakir
Serkan Cabi
Original Assignee
Childrens Medical Ct Corp
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49304418&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2900230(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Childrens Medical Ct Corp, Massachusetts Gen Hospital filed Critical Childrens Medical Ct Corp
Application granted granted Critical
Publication of DK2900230T3 publication Critical patent/DK2900230T3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK13773562.7T 2012-09-27 2013-09-26 RELATIONSHIPS FOR TREATING ADIPOSITAS AND PROCEDURES FOR USING THEREOF DK2900230T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261706153P 2012-09-27 2012-09-27
PCT/US2013/061911 WO2014052583A1 (en) 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof

Publications (1)

Publication Number Publication Date
DK2900230T3 true DK2900230T3 (en) 2018-11-12

Family

ID=49304418

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13773562.7T DK2900230T3 (en) 2012-09-27 2013-09-26 RELATIONSHIPS FOR TREATING ADIPOSITAS AND PROCEDURES FOR USING THEREOF

Country Status (21)

Country Link
US (6) US9968575B2 (OSRAM)
EP (3) EP3434268B1 (OSRAM)
JP (2) JP6480864B2 (OSRAM)
CN (3) CN111529535A (OSRAM)
AU (3) AU2013323528B2 (OSRAM)
BR (1) BR112015006848A2 (OSRAM)
CA (2) CA3030272C (OSRAM)
CY (1) CY1121166T1 (OSRAM)
DK (1) DK2900230T3 (OSRAM)
ES (1) ES2696626T3 (OSRAM)
HR (1) HRP20181879T1 (OSRAM)
HU (1) HUE040496T2 (OSRAM)
LT (1) LT2900230T (OSRAM)
PL (1) PL2900230T3 (OSRAM)
PT (1) PT2900230T (OSRAM)
RS (1) RS58010B1 (OSRAM)
RU (2) RU2768868C2 (OSRAM)
SI (1) SI2900230T1 (OSRAM)
SM (1) SMT201800604T1 (OSRAM)
TR (1) TR201815668T4 (OSRAM)
WO (1) WO2014052583A1 (OSRAM)

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CN117357538A (zh) * 2014-03-26 2024-01-09 儿童医学中心公司 用于治疗肥胖症的雷公藤红素和衍生物
WO2015153933A1 (en) * 2014-04-03 2015-10-08 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
CN105985401B (zh) * 2015-02-16 2020-10-09 上海华拓医药科技发展有限公司 一种雷公藤红素衍生物、其制备方法及用途
US10662218B2 (en) * 2015-10-23 2020-05-26 Erx Pharmaceuticals, Inc. Analogs of celastrol
CN106905404B (zh) * 2017-01-13 2019-08-27 广东工业大学 熊果酸衍生物及其制备方法和应用
CN116509842B (zh) * 2021-09-09 2024-09-20 厦门君德医药科技有限公司 药物组合物及其制备方法和应用
KR102470686B1 (ko) * 2022-06-07 2022-11-23 서울대학교산학협력단 디메틸제일아스테럴을 포함하는 대사성 질환 예방 또는 치료용 약학 조성물
CN119431489A (zh) * 2024-11-13 2025-02-14 肇源县总医院 一种雷公藤红素衍生物及其制备方法

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Also Published As

Publication number Publication date
US20210275482A1 (en) 2021-09-09
BR112015006848A2 (pt) 2018-05-22
EP2900230B1 (en) 2018-08-15
RU2650646C2 (ru) 2018-04-16
US20180185314A1 (en) 2018-07-05
CA2886393A1 (en) 2014-04-03
CN111529534A (zh) 2020-08-14
HK1213190A1 (en) 2016-06-30
RU2018112067A3 (OSRAM) 2021-06-24
AU2018256619A1 (en) 2018-11-22
TR201815668T4 (tr) 2018-11-21
AU2016247206A1 (en) 2016-11-10
SI2900230T1 (sl) 2019-01-31
RU2768868C2 (ru) 2022-03-25
WO2014052583A1 (en) 2014-04-03
EP2900230A1 (en) 2015-08-05
AU2013323528A1 (en) 2015-04-09
JP2015531376A (ja) 2015-11-02
CA3030272C (en) 2021-09-28
US12064408B2 (en) 2024-08-20
ES2696626T3 (es) 2019-01-17
US20250161252A1 (en) 2025-05-22
CN111529535A (zh) 2020-08-14
PL2900230T3 (pl) 2019-02-28
US20210008019A1 (en) 2021-01-14
US11045439B2 (en) 2021-06-29
EP3434268B1 (en) 2022-04-20
SMT201800604T1 (it) 2019-01-11
CA2886393C (en) 2019-02-26
HRP20181879T1 (hr) 2019-02-08
PT2900230T (pt) 2018-11-26
EP3434268A1 (en) 2019-01-30
JP2019070052A (ja) 2019-05-09
JP6743211B2 (ja) 2020-08-19
CY1121166T1 (el) 2020-05-29
AU2018256619B2 (en) 2020-07-23
US9968575B2 (en) 2018-05-15
CA3030272A1 (en) 2014-04-03
AU2013323528B2 (en) 2016-11-10
RU2015115696A (ru) 2016-11-20
RS58010B1 (sr) 2019-02-28
US9925161B2 (en) 2018-03-27
US20150250753A1 (en) 2015-09-10
CN104822374A (zh) 2015-08-05
LT2900230T (lt) 2019-01-10
AU2016247206B2 (en) 2018-08-02
EP4082541A1 (en) 2022-11-02
HUE040496T2 (hu) 2019-03-28
JP6480864B2 (ja) 2019-03-13
RU2018112067A (ru) 2019-03-07
US20170304245A1 (en) 2017-10-26
US10653654B2 (en) 2020-05-19

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