JP2015530867A - 抗ｐｃｓｋ９抗体、製剤、投薬、及び使用方法 - Google Patents

抗ｐｃｓｋ９抗体、製剤、投薬、及び使用方法 Download PDF

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Publication number
JP2015530867A
JP2015530867A JP2015517471A JP2015517471A JP2015530867A JP 2015530867 A JP2015530867 A JP 2015530867A JP 2015517471 A JP2015517471 A JP 2015517471A JP 2015517471 A JP2015517471 A JP 2015517471A JP 2015530867 A JP2015530867 A JP 2015530867A
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JP
Japan
Prior art keywords
seq
antibody
hvr
amino acid
pcsk9
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Pending
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JP2015517471A
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Japanese (ja)
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JP2015530867A5 (OSRAM
Inventor
イェン ウー，
イェン ウー，
セシリア プイ チー チウ，
セシリア プイ チー チウ，
ダニエル ケー． キルヒホーファー，
ダニエル ケー． キルヒホーファー，
アンドリュー ピーターソン，
アンドリュー ピーターソン，
ガネーシュ， エー． コルマム，
ガネーシュ， エー． コルマム，
モニカ コング ベルトラン，
モニカ コング ベルトラン，
ポール モラン，
ポール モラン，
ウェイ リー，
ウェイ リー，
ザンジー ラム，
ザンジー ラム，
リン ルイス，
リン ルイス，
アダ ヒュイ，
アダ ヒュイ，
ホイットモア ティングリー，
ホイットモア ティングリー，
ジョン ダグラス デイヴィス，
ジョン ダグラス デイヴィス，
ナーゲーシュワル アール． ブッダ，
ナーゲーシュワル アール． ブッダ，
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Genentech Inc
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Genentech Inc
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Publication of JP2015530867A publication Critical patent/JP2015530867A/ja
Publication of JP2015530867A5 publication Critical patent/JP2015530867A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2015517471A 2012-06-15 2013-06-14 抗ｐｃｓｋ９抗体、製剤、投薬、及び使用方法 Pending JP2015530867A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261660605P 2012-06-15 2012-06-15
US61/660,605 2012-06-15
US201361786280P 2013-03-14 2013-03-14
US61/786,280 2013-03-14
PCT/US2013/046032 WO2013188855A1 (en) 2012-06-15 2013-06-14 Anti-pcsk9 antibodies, formulations, dosing, and methods of use

Publications (2)

Publication Number Publication Date
JP2015530867A true JP2015530867A (ja) 2015-10-29
JP2015530867A5 JP2015530867A5 (OSRAM) 2016-08-04

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Country Status (13)

Country Link
US (2) US9266961B2 (OSRAM)
EP (1) EP2861624A1 (OSRAM)
JP (1) JP2015530867A (OSRAM)
KR (1) KR20150023711A (OSRAM)
CN (1) CN104364266A (OSRAM)
AR (1) AR091462A1 (OSRAM)
BR (1) BR112014031310A2 (OSRAM)
CA (1) CA2875096A1 (OSRAM)
HK (1) HK1205141A1 (OSRAM)
MX (1) MX2014014830A (OSRAM)
RU (1) RU2015101113A (OSRAM)
TW (1) TW201410706A (OSRAM)
WO (1) WO2013188855A1 (OSRAM)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019500411A (ja) * 2015-11-27 2019-01-10 上海君▲実▼生物医▲薬▼科技股▲分▼有限公司 抗ｐｃｓｋ９抗体およびその使用
JP2019509254A (ja) * 2015-12-31 2019-04-04 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途
JP2019518472A (ja) * 2016-04-07 2019-07-04 ▲邁▼博斯（香港）科技有限公司 プロタンパク質転換酵素サブチリシンケキシン９型の結合タンパク質及びその使用
JP2019523235A (ja) * 2016-06-24 2019-08-22 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 心血管疾患を治療するための組成物及び方法
JP2019527562A (ja) * 2016-06-08 2019-10-03 常州博嘉生物医▲薬▼科技有限公司 長時間作用性ｐｃｓｋ９特異的結合タンパク質及びその応用

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JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
EP3169710A1 (en) * 2014-07-14 2017-05-24 Amgen Inc. Crystalline antibody formulations
CN105461809B (zh) * 2015-02-11 2018-10-12 康融东方（广东）医药有限公司 Pcsk9抗体、其药物组合物及其用途
CN107531795B (zh) * 2016-01-05 2021-01-19 江苏恒瑞医药股份有限公司 Pcsk9抗体、其抗原结合片段及其医药用途
EP3515949A4 (en) * 2016-09-20 2020-10-28 Wuxi Biologics Ireland Limited. NEW ANTI-PCSK9 ANTIBODIES
CN107698679B (zh) * 2017-01-22 2019-03-01 北京东方百泰生物科技有限公司 抗pcsk9单克隆抗体
US11325945B2 (en) 2017-04-12 2022-05-10 Cadila Healthcare Limited Peptide based PCSK9 vaccine
CN107177003A (zh) * 2017-06-27 2017-09-19 上海海玫生物科技有限公司 一种特异性抗人pcsk9的抗体及其应用
US20200223941A1 (en) 2017-06-30 2020-07-16 Jiangsu Hengrui Medicine Co., Ltd. Pharmaceutical composition comprising pcsk-9 antibody and use thereof
GB201820687D0 (en) * 2018-12-19 2019-01-30 Kymab Ltd Antagonists
BR112021013807A2 (pt) 2019-01-18 2021-11-30 Astrazeneca Ab Inibidores de pcsk9 e seus métodos de uso
CN109776680B (zh) * 2019-01-25 2020-05-12 浙江蓝盾药业有限公司 抗人pcsk9单克隆抗体及其用途
EP4640848A2 (en) 2019-05-17 2025-10-29 Regeneron Pharmaceuticals, Inc. Genome-based methods for reducing cardiovascular risk
US20230167188A1 (en) * 2020-07-02 2023-06-01 Biolojic Design Ltd. Anti-tumor necrosis factor receptor (tnfr2) antibodies and uses thereof

Citations (2)

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WO2011072263A1 (en) * 2009-12-11 2011-06-16 Irm Llc Pcsk9 antagonists
JP2012511913A (ja) * 2008-12-15 2012-05-31 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｐｃｓｋ９に対する高親和性ヒト抗体

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