JP2015524792A5 - - Google Patents
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- Publication number
- JP2015524792A5 JP2015524792A5 JP2015519044A JP2015519044A JP2015524792A5 JP 2015524792 A5 JP2015524792 A5 JP 2015524792A5 JP 2015519044 A JP2015519044 A JP 2015519044A JP 2015519044 A JP2015519044 A JP 2015519044A JP 2015524792 A5 JP2015524792 A5 JP 2015524792A5
- Authority
- JP
- Japan
- Prior art keywords
- gas
- mixing device
- protein
- protein solution
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012460 protein solution Substances 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 238000004925 denaturation Methods 0.000 description 8
- 230000036425 denaturation Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12173606.0 | 2012-06-26 | ||
| EP12173606 | 2012-06-26 | ||
| PCT/EP2013/063218 WO2014001297A2 (en) | 2012-06-26 | 2013-06-25 | Preparation of composition comprising gas microbubbles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524792A JP2015524792A (ja) | 2015-08-27 |
| JP2015524792A5 true JP2015524792A5 (enExample) | 2017-09-21 |
| JP6420761B2 JP6420761B2 (ja) | 2018-11-07 |
Family
ID=48699026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015519044A Active JP6420761B2 (ja) | 2012-06-26 | 2013-06-25 | 気体マイクロバブルを含む組成物の調製 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10350314B2 (enExample) |
| EP (1) | EP2864033B1 (enExample) |
| JP (1) | JP6420761B2 (enExample) |
| KR (1) | KR102139393B1 (enExample) |
| CN (1) | CN104519989B (enExample) |
| AU (2) | AU2013283409B2 (enExample) |
| BR (1) | BR112014032254B1 (enExample) |
| CA (1) | CA2876950C (enExample) |
| DK (1) | DK2864033T3 (enExample) |
| ES (1) | ES2571481T3 (enExample) |
| IN (1) | IN2014DN10714A (enExample) |
| MX (1) | MX354719B (enExample) |
| RU (1) | RU2640078C2 (enExample) |
| WO (1) | WO2014001297A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014001297A2 (en) | 2012-06-26 | 2014-01-03 | Ge Healthcare As | Preparation of composition comprising gas microbubbles |
| NL2014178B1 (en) * | 2015-01-22 | 2017-01-05 | Tide Microfluidics B V | System and method for controlled manufacturing of mono-disperse microbubbles. |
| JP7104709B2 (ja) | 2016-10-11 | 2022-07-21 | トーマス・ジェファーソン・ユニバーシティ | 圧力測定のための非侵襲法 |
| JP7220567B2 (ja) * | 2017-02-10 | 2023-02-10 | キリンホールディングス株式会社 | スパージャー及び培養装置 |
| CN112808187B (zh) * | 2021-01-19 | 2023-05-30 | 浙江省林业科学研究院 | 一种生产气泡胶囊菌剂的自动化设备及方法 |
| CA3238203A1 (en) | 2021-11-19 | 2023-05-25 | Sundance Spas, Inc. | Self-maintaining hot tub or spa |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
| US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
| US4957656A (en) | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
| US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US20080063603A1 (en) | 1990-04-02 | 2008-03-13 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| JP3231768B2 (ja) | 1991-09-17 | 2001-11-26 | ソーナス ファーマシューティカルス，インコーポレイテッド | 気体状超音波造影剤及び超音波造影剤として使用する気体の選定方法 |
| US5855865A (en) * | 1993-07-02 | 1999-01-05 | Molecular Biosystems, Inc. | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
| AU722742B2 (en) | 1993-07-02 | 2000-08-10 | Molecular Biosystems, Inc. | Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation |
| CZ350895A3 (en) * | 1993-07-02 | 1996-10-16 | Molecular Biosystems Inc | In protein encapsulated micro-spheres containing insoluble gas as well as their preparation and use as ultrasonic diagnostic |
| JPH0747251A (ja) | 1993-08-06 | 1995-02-21 | Toho Asechiren Kk | 混合ガス発生方法 |
| US5370955A (en) | 1993-09-27 | 1994-12-06 | Xerox Corporation | Electrophotographic elements with arylamine polycondensation polymers |
| US5730955A (en) * | 1994-08-02 | 1998-03-24 | Molecular Biosystems, Inc. | Process for making gas-filled microspheres containing a liquid hydrophobic barrier |
| NZ292980A (en) | 1994-09-29 | 1999-02-25 | Andaris Ltd | Smooth, spherical water-soluble microparticles as therapeutic or diagnostic vehicles |
| EA001135B1 (ru) | 1996-02-19 | 2000-10-30 | Нюкомед Имагинг А/С | Усовершенствования в области контрастных агентов |
| US5976501A (en) | 1996-06-07 | 1999-11-02 | Molecular Biosystems, Inc. | Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion |
| ID21681A (id) * | 1996-10-21 | 1999-07-08 | Nycomed Imaging As | Peningkatan pada atau berkenaan dengan zat-zat kontras |
| JP3693276B2 (ja) | 1998-09-17 | 2005-09-07 | 東京瓦斯株式会社 | 温度差を有する気液を配管上で混合するための装置 |
| AR035779A1 (es) | 2001-02-06 | 2004-07-14 | Genetics Inst Llc | Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos |
| DE102005063620B3 (de) | 2004-11-09 | 2017-03-09 | Denso Corporation | Doppelwandiges Rohr |
| JP4350058B2 (ja) * | 2004-11-09 | 2009-10-21 | 株式会社デンソー | 冷媒用二重管 |
| DE102005020727A1 (de) | 2005-05-04 | 2006-11-09 | Dr.Ing.H.C. F. Porsche Ag | Stranggepresstes Mehrkammerrohr, insbesondere für einen Wärmeübertrager |
| CN101130094A (zh) * | 2007-09-06 | 2008-02-27 | 上海新兴医药股份有限公司 | 一种超声造影剂及其制备方法 |
| CN101507908B (zh) * | 2009-04-09 | 2010-12-01 | 北京化工大学 | 微通道套管式装置及其应用 |
| WO2014001297A2 (en) | 2012-06-26 | 2014-01-03 | Ge Healthcare As | Preparation of composition comprising gas microbubbles |
-
2013
- 2013-06-25 WO PCT/EP2013/063218 patent/WO2014001297A2/en not_active Ceased
- 2013-06-25 CN CN201380033735.8A patent/CN104519989B/zh active Active
- 2013-06-25 KR KR1020157001732A patent/KR102139393B1/ko active Active
- 2013-06-25 MX MX2014015717A patent/MX354719B/es active IP Right Grant
- 2013-06-25 IN IN10714DEN2014 patent/IN2014DN10714A/en unknown
- 2013-06-25 DK DK13731334.2T patent/DK2864033T3/en active
- 2013-06-25 BR BR112014032254-6A patent/BR112014032254B1/pt active IP Right Grant
- 2013-06-25 RU RU2014150473A patent/RU2640078C2/ru active
- 2013-06-25 ES ES13731334T patent/ES2571481T3/es active Active
- 2013-06-25 JP JP2015519044A patent/JP6420761B2/ja active Active
- 2013-06-25 EP EP13731334.2A patent/EP2864033B1/en active Active
- 2013-06-25 AU AU2013283409A patent/AU2013283409B2/en active Active
- 2013-06-25 CA CA2876950A patent/CA2876950C/en active Active
- 2013-06-25 US US14/579,905 patent/US10350314B2/en active Active
-
2017
- 2017-08-18 AU AU2017216553A patent/AU2017216553B2/en active Active
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